General characteristics of Cefazolin
cefazolin - antimicrobial agent of the first generation. In the pharmaceutical practice Cefazolin has been used for 30 years. It is most effective against streptococci and staphylococcal infections, has a destructive effect on the cell membrane of pathogenic bacteria. Cefazolin is ineffective with respect to Lister, pneumococcus, meningococcus, and enterococci.
Cephalosporin antimicrobial agents (e.g., cefazolin and ceftriaxone) are assigned, generally inefficient when applying penicillins. Cefazolin and ceftriaxone are often used in surgical, gynecological, urological and pediatric patients for the treatment of complicated bacterial pathologies. Cefazolin Ceftriaxone is different from the only active ingredient.
Cefazolin copes with inflammatory reactions in the paranasal sinuses. Compared with other cephalosporins II and III generation of less toxic, more easily tolerated by the body and exerts less adverse effects. Cefazolin should not be used for treatment of influenza, acute respiratory and other viral infections.
Cefazolin injections significant drawback is that Intramuscular patient develops severe pain. In this regard, medical practitioners recommend Cefazolin diluted with anesthetic (Novocaine, Lidocaine). When using Cefazolin main part (about 90%) is excreted in the urine, the situation with ceftriaxone is somewhat different - only 60% is excreted in the urine, and the remainder is excreted in the bile.
Like any other drug Cefazolin may trigger the development of adverse reactions:
- nausea;
- vomiting;
- dizziness;
- leukopenia;
- liver dysfunction;
- allergy;
- candidiasis, colitis, angioedema (in rare cases).
When the inability to use the above-described antibacterial agent, can be applied substitutes Cefazolin.
The pharmacy offers a wide selection of unique Cefazolin:
- Intrazolin;
- Tsefzolin;
- cephalexin;
- Orizolin;
- Rocephin;
- Ekotsefron;
- Zolin;
- Totatsef;
- cephalothin;
- Antsef;
- Natsef;
- Lizolin;
- kefzol;
- Orpin.
Characteristics Ceftriaxone
ceftriaxone - a semi-synthetic antimicrobial drug. Effectively fights anaerobic and aerobic bacteria. Only applicable for parenteral administration. Ceftriaxone as Cefazolin produced in vials, which contains from 0.5 to 1 g of sterile salt antibiotic.
The instructions for use Ceftriaxone stated that this agent can be used for treating bacterial infections:
- syphilis;
- bacterial septicemia;
- chancroid;
- genitourinary disease;
- peritonitis;
- angiocholitis;
- tick-borne Lyme disease;
- empyema of the gallbladder;
- uncomplicated gonorrhea;
- pleurisy;
- bronchopneumonia;
- empyema;
- mastitis;
- sepsis;
- typhoid fever;
- lung abscess;
- bacterial meningitis;
- infections of joints and bones;
- salmonellosis;
- endocarditis, a bacterial etiology.
As seen, the range of applications compared with Ceftriaxone cefazolin much wider. Doctors also recommend the use of Ceftriaxone for perioperative prophylaxis and for treatment of patients with weakened immune systems.
Features of the application
According to the instructions, Ceftriaxone used only for in /, or / m administration. Dose for adults and children over 12 years of age is 1 to 2 grams. Ceftriaxone injection can be applied once a day. In severe cases, the daily dose may be increased to 4 grams. Duration of therapy depends on the shape, the severity and etiology of the disease. It is unacceptable that antibiotic treatment alone.
Many patients want to know what more Cefazolin or ceftriaxone. You can answer with certainty that cephalosporins III third generation is much more powerful than the I-generation drugsBut they exhibit more side effects. In fact it is the same thing. Use these drugs only on prescription, after determining the sensitivity to them pathogenic microflora.
Ceftriaxone is an analogue of the following drugs:
- Azitsin;
- vilprafen;
- nystatin;
- Rovamycinum;
- Sultsef;
- macrofoams;
- tsifran;
- tiberal;
- Zitroks;
- Zatsef;
- Pantsef;
- Sefpotek;
- cefotaxime;
- Tsemideksor;
- Tsefson;
- Tsefatrin;
- Medakson;
- Steritsef.
Contraindications to the appointment of cephalosporins
Cephalosporins low toxicity, however, and they have a contraindication to the use of:
- dysfunction of the central nervous system;
- during childbearing and nursing his chest;
- gastrointestinal disease (especially colitis);
- renal failure;
- the propensity to thrombosis.
During pregnancy, cefazolin and ceftriaxone assign extremely dangerousAs these compounds are easily overcome vnutriplatsentarny barrier that may affect the baby's health.
The instructions for use Ceftriaxone and Cefazolin stated that these funds can not be used only in the I trimester pregnancy, but most experts are reinsured and do not recommend using them at all in this period. If necessary, medication can be replaced with analogs.
In the appointment of cephalosporins in the lactation period, the baby is transferred to artificial feeding, as bioactive component preparations (cefazolin, ceftriaxone) is deposited in the body and in high concentrations recovered with milk. By drinking this milk the baby may exhibit an allergic reaction (itching, skin flushing, urticaria).
If the patient has problems with intolerance to penicillin, then assign Cefazolin it is also impossible. Practicing doctors recommend the use of ceftriaxone, as it has a lesser degree of sensitization of the organism. If an allergic reaction manifested by Ceftriaxone, you should contact your doctor for help.
joint reception
When ineffective therapy Cefazolin Ceftriaxone administered with drugs that reduce platelet aggregation is impossible, as there is a high probability of bleeding. Assignment "loop" diuretics (Torasemide, Bufenoks, Furosemide, Britomar, Diuver, Fursemid, Lasix, ethacrynic acid) together with ceftriaxone gives renal functional activity. In the interaction of antibiotics with the anticoagulant effect of the latter is enhanced, it is dangerous to health. Also cephalosporins can not be mixed with calcium-antimicrobials.
Cefazolin and ceftriaxone - This medicated drugs from the same group, but they have a different composition and effectiveness. If we compare with ceftriaxone, cefazolin, the latter drug significantly superior to the first. However, it requires more careful control over the application.
Found a bug? Select it and press Ctrl + Enter
