Pharmacological properties Ceftriaxone
Combination of several antimicrobial drugs - one of the modern methods of treatment of diseases caused by bacterial infections. The combination of therapeutic properties of drugs provides rapid treatment effect and to improve the patient's well-being.
To make the right choice, you should consider the possibility of combining the properties of drugs. If you want to compare with ceftriaxone, ciprofloxacin, is sufficient to evaluate the possibility of pharmacological spectrum of action and indications for use of each drug.
Ceftriaxone belongs to the beta-lactam antibiotic of the third generation of cephalosporin group. An important pharmacological properties of the drug is considered to be the ability of ceftriaxone sodium salt, active substance in its composition, block enzymes which vital activity of bacteria without becoming impossible.
As a result of Ceftriaxone on bacteria inhibited their ability to live, micro-organisms are killed, and this leads to the elimination of pathological processes.
Means produced in the form of powder for solution for injection is not intended for oral administration. Ceftriaxone absorption is not through the mucosa of the digestive tract, as through the inner shell vessel wall directly. Small vessels are penetrated all organs and tissues, and the drug enters the body at any point.
The maximum concentration of active substance in the blood Ceftriaxone observed already two hours after administration, and rate of bioavailability is 100%. Thus, we achieve a rapid therapeutic result.
But if you drink Ciprofloxacin together with ceftriaxone, the intensity of treatment increases significantly. On pathogens is enhanced and all foci of infection quickly cease.
Indications for admission Ceftriaxone
The antimicrobial properties of the drug have a wide range of effects.
Ceftriaxone important in bacterial lesions:
- Gastrointestinal tract and biliary tract organs;
- the respiratory system;
- departments of the musculoskeletal system;
- urogenital system;
- leather;
- brain.
Application Ceftriaxone important when treating infected wounds and as a prophylactic agent for postoperative patients.
Usually Ceftriaxone is well tolerated by patients. Adverse or allergic reactions are rare, but differ in intensity. Therefore, the appearance of any abnormal reactions after injection Ceftriaxone should stop taking the drug and to replace its analogue.
Pharmacological properties of Ciprofloxacin
Ciprofloxacin - one of the most active fluoroquinolone antibiotics second generation group. High effectiveness of Ciprofloxacin is due to its ability to dissolve the cell walls of Gram-positive and Gram-negative bacteria, disrupt DNA synthesis and prevent their growth and reproduction.
In this formulation ensures the effectiveness of impact even on the types of microorganisms which are resistant to the aminoglycoside antibiotics, penicillins and cephalosporins. This is the main difference between the drugs ceftriaxone and ciprofloxacin.
Moreover, the effect of the drug does not cause pathogenic microbial resistance toward other types of antibacterial agents. Ciprofloxacin has good compatibility with other antibacterial drugsContributing to strengthening their impact.
On the basis of the active substance ciprofloxacin created many unique products. For example, Ciprofloxacin and Tsiprolet - it's the same thing. Also it possesses similar properties other antibiotic from the group of the second generation quinolones - Ofloxacin.
Ciprofloxacin is produced in the form of capsules, tablets and injectable solution. The most pronounced therapeutic effect was observed by intravenous administration means. Possessing good absorbability, Ciprofloxacin provides a maximum blood concentration after half an hour after administration.
When administered orally, the rate of absorption of the drug is slowed by the presence of food in the stomach. Therefore the maximum concentration of ciprofloxacin in blood after taking the capsules or tablets is observed 1-2 hours after ingestion.
Indications to receive Ciprofloxacin
Appropriate use of the drug in infectious diseases caused by pathogenic microorganisms.
Among the major indications:
- diseases of the respiratory tract - bronchitis, pneumonia, cystic fibrosis;
- diseases of upper respiratory tract - tonsillitis, sinusitis, otitis, sinusitis;
- kidney infections and urinary systems - cystitis, pyelonephritis, prostatitis, as well as gonorrhea and chlamydia;
- bacterial lesions of the abdominal cavity - gastrointestinal tract, biliary tract, as well as typhoid fever and salmonellosis;
- infections of the skin, bones and joints - cellulitis, abscesses, arthritis, sepsis.
According to the instructions, the dosing regimen is assigned in accordance with individual characteristics and when administered orally is from 250 to 750 mg twice daily. Single dose for intravenous administration is from 200 to 400 mg.
Children under 18 years of age, and pregnant and nursing the drug is contraindicated.
Comparison of Ceftriaxone and ciprofloxacin
If we compare what is best - or Ceftriaxone Ciprofloxacin is difficult to answer unequivocally. The drugs belong to different groups and are effective in relation to certain pathologies.
Despite the overall similarity of indications to the treatment facilities, their characteristics differ significantly:
- Bioavailability levels in Tseftriksona above;
- Ciprofloxacin is very varied dosage forms;
- Ceftriaxone is indicated for children of any age, whereas treatment with ciprofloxacin permitted only after reaching 18 years of age.
Nevertheless, the overall compatibility of products is good, that provides a higher outcome. When an allergic reaction to the components of any of the drugs, they can be replaced analog Ceftriaxone - cefotaxime, ciprofloxacin or analogue - tsiprolet.
Found a bug? Select it and press Ctrl + Enter
