Amikacin and Ceftriaxone what better compatibility comparison

Pharmacological properties, shapes, testimonies

Amikacin can be compared with ceftriaxone. Drugs belong to different groups. Amikacin is an aminoglycoside antibiotic (AHA). Ceftriaxone 3 relates to generation cephalosporin drugs group. It has a very extensive range of effects and can be combined with other antibiotics.

sign	ceftriaxone	amikacin
pharmacological properties	The drug prevents the formation of membranes agent prevents the growth and reproduction.	Communicating with the 30S ribosomal subunit, does not form RNA molecules, inhibits the formation of protein molecules of the pathogen damages the protective sheath organelles.
area of ​​Effect	Gram-positive, Gram-negative bacterial agents, anaerobes.	Gram-positive, gram-negative bacterial pathogens. It has no effect on the anaerobic bacteria.
The form	Injection (vials with powder - 1 g, 2 g).	Injection: powder (1 g in a vial), a solution (2 ml - 500 mg, 4 ml - 1 g).
analogs	Structural: Triakson, Tseftriakson- Agos. Related drugs: cefotaxime.
Ceftriaxone compatibility with amikacin	not compatible

Indications for use Ceftriaxone:

• sepsis;
• bacterial lesion tissue and the meninges;
• peritonitis;
• loss of bone, joint, connective tissue bacterial origin;
• bacterial disease, combined with immune deficiencies;
• ENT diseases, respiratory, urogenital bacterial systems;
• postoperative period.

Amikacin is indicated for the treatment of bacterial infections: pulmonary diseases (bronchitis, pneumonia, empyema, lung abscess), otitis media, sepsis, bacterial endocardial lesions, meningitis, peritonitis, urinary tract infection, lesion of bone and articular joints, postoperative infection wounds.

Terms of use of medicines

Ceftriaxone adults appoint 1-2 g intravenously or intramuscularly. The drug is administered every 24 hours. The medicine is produced in powder, so before using it need to breed.

Newborns	Infants, children under 12 years of age
20-50 mg per 1 kg of body weight per day baby.	By 20-80 mg per 1 kg of weight of the child. If the weight is over 50 kg adult dosage is assigned.

Term therapy can be varied depending on the severity and type of disease.

Amikacin also administered intravenously or intramuscularly. dosage calculation is carried out on the patient's weight. The drug is administered at 5 mg per 1 kg of weight (every 8 hours) at 7.5 mg per 1 kg of weight (every 12 hours). Coursework therapy is 3-7 days (iv), 10 days (im). Premature babies shown at 10 mg per 1 kg of weight during the first day maintenance dose is 7.5 mg per 1 kg. Prick do every 18-24 hours. Term infants - first at 10 mg per 1 kg of weight, maintenance dose - 7.5 mg per 1 kg of body weight every 12 hours for 7-10 days.

Simultaneously with ceftriaxone can not take Amikacin. Combination of Amikacin and Ceftriaxone undesirable because the simultaneous use of these drugs is observed renal impairment. Application of Amikacin and Ceftriaxone is also prohibited in the same syringe.

conclusion

Both drugs well established in the treatment of bacterial diseases. The effectiveness of drugs is very high. Preparations are actively administered in pediatric and neonatal practice. Medicines can only be replaced with each other, as they are incompatible. You can not use antibiotics on their own. Incorrect dosage can harm.

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