Antibiotics in pancreatitis
Metronidazole and other antibacterial agents are prescribed to treat acute and chronic pancreatitis in the following cases:
- in the development of infectious complications, in particular necrosis, parapankreatite, the formation of cysts, etc. cholangitis;
- for prophylaxis of inflammation caused by bacteria;
- in predicting serious bacterial complications of pancreatitis.
It should be noted, in the latter case, Metronidazole pancreatitis prescribed for therapy with severe, over 30% of their total volume with the necrotic lesion tissue gland.
pharmacological properties
metronidazole - an antibacterial agent, to take an active antimicrobial and protivoprotozoynoe impact. During the interaction with deoxyribonucleic acid (DNA), located in the bacterial cells Metronidazole blocks the production of nucleic acids, which causes the death of harmful germs.
appointment
Treatment Metronidazole pancreatitis is performed only in severe disease. In milder forms of inflammation antibiotics is not advisable.
For the prophylactic treatment of severe complications of pancreatitis purulent The most commonly used combination of drugs:
- Metronidazole + fluoroquinolones (peptofloksatsin);
- Metronidazole + third generation cephalosporins (ceftriaxone or ceftazidime);
- Metronidazole + fourth generation cephalosporin (cefepime, cefoperazone or sulbactam).
If necessary Metronidazole can be replaced Trichopolum because both drugs have the same active substance, a similar mechanism of action and the indications.
Before starting treatment of pancreatitis, it is necessary to carry out an appropriate examination and to consult a doctor, who will appoint an individual scheme of therapy. Also make sure there are no contraindications to the use of antibiotics.
Metronidazole standard regimen for treating pancreatitis in adults patients: 1 tablet (250 mg) 3 times a day. The duration of treatment is from 5 to 7 days. Sometimes the doctor recommends an individual course of treatment.
If necessary, the treatment is repeated, but only after 3-6 weeks after the previous course. Before taking metronidazole must assign blood test patient - pay particular attention to the level of white blood cells and their factions in the blood.
Contraindications
Before the start of complex treatment of pancreatitis, which includes Metronidazole, must be inspected for the following contraindications:
- loss of coordination;
- reduced concentration of leukocytes in a patient's blood (anemia);
- organic pathology of the central nervous system;
- disorders in liver function;
- the first three months of pregnancy and during breast-feeding;
- presence of hypersensitivity to the components forming part of metronidazole.
If any one of the above contraindications, the use of antibacterial drugs is prohibited.
Side effect
Metronidazole pancreatitis can cause side effects from the various systems of the body:
- functional disorders of the digestive system: nausea, retching, anorexia, discomfort in the epigastric, intestinal colic, constipation;
- dysfunction of the nervous system: headache, encephalopathy, convulsive manifestations, hyperexcitability, irritability, and the occurrence of hallucinations, weakness;
- disorders of the immune system: allergic reactions;
- diseases of the urinary system.
With the development of the above-described effects, or any other discomforts should consult a doctor for advice. After clarification of the reasons for the doctor to change the treatment regimen will replace pancreatitis or drug on its counterpart.
Overdose
During pancreatitis treatment it is important to prevent an overdose of the drug.
Since when exceeding the permissible therapeutic dose, the following negative effects:
- convulsions;
- disorders of peripheral nerve function (peripheral neuropathy);
- development sensations of nausea;
- retching;
- coordination disorder.
For the treatment of metronidazole overdose being symptomatic therapy, which may include hemodialysis.
conclusion
Currently, many patients concerned with the question: Is it possible to drink Metronidazole pancreatitis? We have found that antibiotic use in severe form of the disease, as well as for the prevention of bacterial complications of pancreatitis.
Before starting treatment, make sure there are no contraindications to the drug, as well as undergo an appropriate examination by a medical specialist.
If the pharmacy can not buy metronidazole can replace trihopol because funds are analogues.
sources:
Vidal: https://www.vidal.ru/drugs/metronidazole__18699
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = 34a165f5-cd6a-4420-ac87-4d044867cd64 & t =
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