For the treatment of infections caused ureplazmu (Ureaplasma urealyticum and Ureaplasma parvum), physicians frequently prescribed antibiotics. Therefore, in many patients the question arises whether it is possible to use together Vilprafen and Metronidazole?
Usually chronic nature of the disease or severe complications, treatment circuit consists of several drugs, in particular Vilprafen, metronidazole and, if necessary, antifungal funds.
pharmachologic effect
Not advisable to appoint with funds belonging to the same group and have the same mechanism of action as it may cause an overdose and serious negative phenomena. Let's find out what are and how to act on microbes described means.
Metronidazole enters nitroimidazole group. Interacting with deoxyribonucleic acid (DNA), located in the bacterial cells, the drug blocks the production of nucleic acids and causes the death of harmful bacteria.
The main active substance is Vilprafen Josamycin, belonging to the group of macrolide antibiotics. During exposure it violates ribosomal protein synthesis of bacteria cell.
Different mechanisms of drugs impact at the same time allow Vilprafenom take Metronidazole.
Indications
Both drugs are used for treatment of the following diseases:
- infectious-inflammatory processes of the urogenital system;
- inflammation of the respiratory system and ENT diseases caused by pathogens sensitive to the facility;
- infections in dentistry;
- infectious and inflammatory processes are localized to skin and soft tissue.
Dosage and method of use
According to the instructions, uncomplicated and chlamydia ureaplasmosis Vilprafen take 2 - 4 tablets (1 - 2 g of active substance), 2 - 3 times a day. In severe disease, if necessary, the dose can be increased to 3 years The drug is taken in between meals.
Complications in disease treatment regimen would be as follows:
- Vilprafen soljutab at a dose of 1 - 2 g three times a day.
- Metronidazole 250 mg three times a day.
The standard duration of treatment is from 5 to 7 days, however, the physician may prescribe an individual treatment, based on the severity of the disease and the patient's condition.
Contraindications
It is very important before treatment to make sure there are no contraindications for both drugs.
Both agents are contraindicated in case of:
- Hypersensitivity to the substances included in the composition of the drugs;
- pathological changes in the functional activity of the liver.
However, Metronidazole there are additional contraindications:
- lack of coordination;
- anemia;
- CNS pathology character organic functional activity (in particular epilepsy);
- the first months of the child's expectations (1 trimester);
- breastfeeding.
conclusion
We have compared the drugs and found that Metronidazole and Vilprafen have a different mechanism of actionThey relate to different groups of drugs, and are not peers. This confirms the absence of contraindications to share them.
However, it should be remembered that the appointment of metronidazole in a treatment regimen with Vilprafenom advisable only in the development of severe disease caused by bacterial complications.
So, the question is whether Vilprafen compatibility with metronidazole? You can answer with confidence: yes, it does. If necessary, both drugs can be used in a scheme of treatment.
sources:
Vidal: https://www.vidal.ru/drugs/metronidazole__18699
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = 34a165f5-cd6a-4420-ac87-4d044867cd64 & t =
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