Azithromycin is an effective broad-spectrum antibiotic belonging to the group of macrolides and azalides. Since the therapeutic concentration of the active substance is stored in the body long enough, many patients would like to know how much is derived from the body Azithromycin.
pharmacological properties
Active substance forms active connection with ribosomes microbial cells causing blockage peptidtranslokazu synthesis reactions. This causes inhibition of the process of development of harmful microorganisms. When the concentration of azithromycin exhibits bacteriostatic effects.
The preparation possesses properties of rapid absorption from the digestive system and is distributed to all tissues and body fluids. The maximum therapeutic concentration accumulated over the past two and a half - three hours. When about 40% bioavailability.
Antibacterial substance excreted from the body in two stages. Azithromycin elimination half-life can be regarded as 14 -20 and 41 hours after the internal use. This is due to the high concentration of the drug in less active tissues and binding to blood protein compounds. A feature of the drug is its increased concentration is in the focus of infection - 25 - 35% higher than in the healthy tissue.
Azithromycin is excreted through intestine with bile, unchanged (about 50%), and lower part of the kidneys (with about 6% of urine).
Indications for use
Long-term elimination of the antibacterial agent from the body, allowing it to successfully use short courses for the treatment of the following diseases:
- mnfektsii respiratory tract (upper and lower sections);
- infections, localized in the urogenital system;
- infectious and inflammatory lesions of the soft tissues;
- infections of the skin;
- stomach and intestine infection caused by exposure to Helicobacter pylori (Helicobacter pylori);
- the initial period of borreliosis (erythema migrans).
Dosage and method of use
According to the instructions, the standard dose of Azithromycin for patients who have reached 12 years of age is 500 mg once a day.
The dosage for children below 12 years, calculated from the 10 mg / kg weight of the child per day.
Due to the fact that Azithromycin prolonged period retains the desired therapeutic concentration in the infected tissues and excreted slowly, over the course of treatment is usually It is 3 days.
use Features
If you accidentally pass azithromycin it is strictly forbidden to use double the amount medication - this can cause an overdose because the partial Withdrawal is 14 - 40 hours.
Simultaneous use of antibacterial drugs and alcohol is prohibited. This is due to the fact that ethanol reduces the absorption properties of the drug, and hence, reduces its effect against pathogenic bacteria. As well as the combined use of ethanol increases the risk of toxic effects.
Before start taking alcohol, you need to wait for the full release of the antibiotic from the body. Azithromycin withdrawal period is considered to be equal to seven days. drinking alcohol is not recommended until this point.
conclusion
Azithromycin half-life is 14 - 40 hours, whereas complete removal of funds takes place over 7 days. This feature allows you to successfully use an antibiotic short three-day course.
sources:
Vidal: https://www.vidal.ru/drugs/azithromycin__24064
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = 464b69bc-52b8-420f-a2fd-5160efbe8523 & t =
Found a bug? Select it and press Ctrl + Enter
