Aktovegin - drug with neuroprotective, anti-hypoxic and metabolic effects. It is an extract from the blood of young calves, which is done by dialysis and ultrafiltration. Using Aktovegin drug intravenously shown to protect organs and organ systems from injury due to insufficient blood supply and oxygen starvation, as well as to improve the intracellular enzyme systems.
Release form of the drug
Aktovegin for intravenous administration is available as a ready solution for infusion. It is packaged in bottles of 250 ml. There are 2 dosage forms of this release:
- with a content of 4 mg gemoderivat deproteinized bovine blood of 1 ml of preparation;
- the content of the effective component 8 mg in 1 ml of product.
In a solvent in the data media can be used dextrose or 0.9% sodium chloride solution.
Additionally, Aktovegin produced in ampoules containing 2, 5 and 10 ml, each ml of which contains 40 mg of gemoderivat deproteinized bovine blood. Thus 1 ampoule contains 80, 200 or 400 mg of active ingredient. This form of drug release is also used for intravenous administration.
There Aktovegin and in the form of tablets, lotions, ointments and gels. But they are designed for indoor or outdoor use, and not for intravenous administration.
testimony
Application Aktovegin intravenous drug indicated for:
- disorders of cerebral blood flow;
- ischemic stroke;
- metabolic disorders;
- traumatic brain injury;
- diabetic polyneuropathy;
- burns, thermal and chemical origin;
- frostbite;
- peripheral vascular pathologies;
- Damage to skin and mucous membranes that have arisen because of exposure to radiation or radiation therapy.
In addition, athletes use Aktovegin to increase endurance and speed up the healing of injuries. Also, the drug can be used intravenously in other conditions at the doctor's discretion.
Preparation of the solution
If administered intravenously Aktovegin jet method, i.e. directly from the syringe, the used solution from ampoules, which does not require cooking.
If the funds will drip through the so-called "droppers" that require dilution vials.
Instructions on how to dilute intravenously Aktovegin:
- In a basic solution using 0.9% sodium chloride or 5% glucose solution;
- Regardless of the prescribing physician, to the vial containing 200-500 mL of the stock solution is added 10-20 ml Actovegin;
- Aktovegin thus prepared can be introduced into the vein through the system ( "emitter").
Important! The product does not contain a preservative, so open the ampoule and the prepared solution should be used immediately.
Never mix Aktovegin in one package with other medications other than those mentioned above.
intravenous injection
Aktovegin injected intravenously or jet. It is important that all manipulations were performed under sterile conditions. Prohibited apply turbid solution with precipitate signs. Contents of the vial should be clear, colorless to light yellow.
Due vozmozhnymogo development of anaphylactic reactions when applied medicines is recommended to check for sensitivity to the drug before intravenous administration.
Preparatory phase injection into a vein in any way the same:
- Before the procedure, you need to prepare all the necessary materials and medicines;
- Immediately prior to manipulation to wash hands and treat them with antiseptic.
Instructions on how to enter Aktovegin intravenously:
- First, the system is prepared and injected solution;
- If you use a ready solution for infusion, it can be immediately administered. Alternatively, the dilution is carried Actovegin, said doctor solution;
- The patient is placed horizontally and superimposed harness 5 cm above the venipuncture. Thereafter is asked several times to compress and decompress fist vein for filling;
- Puncture site is wiped with alcohol and the needle introduced in the vein to 1/3 of the length (before it is necessary to release a few drops of the solution to ensure the absence of air in the system);
- After the appearance of blood in the tube clamp open on the system and remove tourniquet fixed needle plaster;
- Adjust the speed of drug administration and monitor its consistency. Intravenous drip Actovegin should be conducted at a rate of 2 ml per minute;
- Stop infusion at a time when a little liquid left in the bottle. This is necessary to prevent the ingress of air into the vein;
- During the procedure you need to follow the needle insertion site. When the swelling of tissues, it is necessary to interrupt and resume intravenous it into another vein using a new sterile needle.
If the administration of a drug infusion will be carried out for several days, it is recommended the use of special intravenous catheters, which eliminates the need for daily venipuncture.
Intravenous drip Actovegin should only be administered by health professionals.
Aktovegin jet injected undiluted:
- After the preparatory stage, the patient is seated or laid horizontally;
- The required amount of medication in a syringe;
- On the patient's arm is applied a tourniquet. Human fist work asking for filling vein blood;
- Inserting the needle and place the elbow or treated cotton cloth dampened with alcohol;
- Injected needle into a vein in the 1/3 length, is removed and Harness medicament is administered;
- After the introduction to the injection site applied cotton wool moistened with alcohol, and ask the patient to bend the arm at the elbow until the bleeding stops.
According to responses of patients with this drug administration are noted soreness and discomfort. Therefore it is better to choose the infusion administration means into the body.
intraarterial
Separately, considered to be a method of using intraarterial medication, which involves the administration directly into the artery. This method is used in disorders of blood circulation. Typically, injection is performed in the radial or tibial arteries. But since such a technique of introducing a very complex, it is rarely used.
Applied dose of the drug
Dose is selected as a doctor in each case individually, taking into account the availability of evidence, the patient's condition, characteristics of the organism, and susceptibility to treatment. Injections can be administered intravenously Aktovegin in the following doses:
- From 20 to 50 ml Actovegin together with a solution of sodium chloride or glucose, every day during the first week of treatment of ischemic stroke. From the second week dose is reduced to 10-20 ml drug per day. It can be used infusion solution ready 250-500 ml per day;
- From 5 to 25 ml or 250 ml of the drug solution is for intravenous infusion in cerebrovascular and metabolic disorders;
- To accelerate wound tightening is commonly used daily administration of 10 ml of the drug;
- At disturbances of peripheral blood flow recommended dose - from 20 to 30 mL 1 bottle means or infusion solution every day;
- As a preventive measure when receiving radiotherapy appointed infusion 1 vial of solution daily. Intravenous injection is started 1 day prior to initiation of therapy and continued for 14 days;
- 50 ml of the drug required to be administered in diabetic polyneuropathy daily for 3 weeks;
- In other cases, the heavy use of 20-50 ml per 1 infusion in lighter - from 5 to 20 ml. Accordingly, in severe disease apply 2 bottle (500 ml) of the prepared solution for infusion, while lighter - just one bottle (250 ml) of this solution.
When drug use is forbidden
Aktovegin has a high degree of security, however, some contraindications he has. It:
- intolerance to medication components;
- pulmonary edema;
- disorders excretion from the body fluid;
- hypernatremia;
- anuria;
- oliguria;
- heart failure decompensation phase;
- chloruremia.
undesirable effects
Actovegin injections tolerated quite well. Occasionally at the injection site may occur redness and irritation.
If we talk about systemic adverse reactions on the body, the drug can cause:
- allergic reactions, up to angioedema;
- dizziness;
- swelling;
- difficulty breathing;
- chest pain;
- drop or rise in blood pressure;
- sore muscles and joints.
Perhaps the expression of other undesirable effects, with a complete list of which can be found in the package leaflet to aktovegin.
Use in special patient groups
according to Instructions for use Aktovegin not recommended for use in children, as it is not conducted clinical studies confirming such use. Increasingly, however, the drug is prescribed for a variety of blood disorders in children, the consequences of hypoxia, brain injuries and various neurological problems.
Women during pregnancy also means appointed. It is used to improve placental blood flow, reducing hypoxia, the threat of premature labor, detachment of the ovum.
sources:
Vidal: https://www.vidal.ru/drugs/actovegin__35582
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = d7775767-e199-4063-9531-bbe08c17f7c7 & t =
Found a bug? Select it and press Ctrl + Enter
