Azithromycin The antibacterial agent is included in the least toxic group of antibiotics - macrolides and possesses a broad spectrum of effects against harmful microorganisms. Since the drug is used short-course, let's find out how quickly begins to act Azithromycin. To do this, you must consider the pharmacological properties of the drug.
pharmachologic effect
Azithromycin, like the majority of macrolides, forms a bond with the ribosomes of microbial cells that can block them synthesize peptidtranslokazu. Through inhibition of the synthesis reactions is suppressed reproduction and the further growth of harmful bacteria.
The drug is rapidly absorbed from the digestive system and passes the process of distribution of tissues and body fluids. And a very important feature of Azithromycin is that the drug accumulates mostly in infected foci, so active in the microbial cells, without affecting healthy tissue.
Achieving maximum therapeutic concentration is reached during the two and a half - three hours. This means that the azithromycin begins to work through this time interval.
The half-excretion of the active substance takes place in two stages: 14 - 20 and 41 hours. A complete washout period is considered the time interval in 7 days. The entire period of the drug remains in effect on bacterial cells. That is what causes a single application of the drug per day and short therapeutic course - 3 days.
Contraindications
Despite the fact that the antibiotic is well tolerated and is effective with minimal toxicity before start drinking Azithromycin is necessary to find out whether the patient has the following contraindications:
- hypersensitivity to the macrolides and idiosyncrasy components that are part of the vehicle;
- severe disorders of kidney and liver functions.
The drug can negatively act in violation of the heart rate and QT-interval prolongation on electrocardiogram. In the presence of these pathologies treatment is carried out under the strict supervision of a physician.
Dosage and method of use
The antibiotic is applied once a day. This rare use due to the fact that after taking Azithromycin acts for a long time, and there is no need for its frequent use.
According to the description of the preparation, the standard treatment regimen for infectious and inflammatory diseases of the respiratory system (pharyngitis, tonsillitis, bronchitis and pneumonia) is assigned as follows:
- adult patients and children over 12 years - 500 mg Azithromycin tablets one-time per day;
- children up to 12 years - 10 mg / kg body weight per day.
The duration of the therapeutic course - 3 days.
If necessary, based on the condition of the patient and the nature of the disease, the doctor may change the duration of treatment, and the dosage means, because he knows exactly how many acts Azithromycin and how long the patient is required to recovery.
There is an alternative scheme for the treatment of severe infections called step-down or step therapy. At the same time in the early days of azithromycin therapy is administered as a parenteral injection. The drug takes effect faster than with oral use and after a few days there is a significant reduction or complete disappearance of symptoms.
After normalization of the patient, according to the instruction, starts to take tablet form drugs. This treatment regimen is much better tolerated by patients and is much less likely to cause adverse reactions.
sources:
Vidal: https://www.vidal.ru/drugs/azithromycin__24064
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = 464b69bc-52b8-420f-a2fd-5160efbe8523 & t =
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