Azithromycin - a drug belonging to the group of macrolide and azalide antibiotics. The drug has been used successfully for the treatment of infectious and inflammatory diseases caused by microbes susceptible thereto. Let's find out how often you can take Azithromycin.
pharmacological properties
Forming an active connection to the ribosomes of harmful bacteria cells Azithromycin blocks them peptidtranslokazu production, which inhibits the development and growth of microbes.
Once in the gastrointestinal tract, the drug is rapidly absorbed and then distributed to the tissues and fluids of the human body. Moreover, the accumulation of infection in the affected tissues, much higher than the amount of the drug in healthy cells.
The maximum therapeutic concentration is reached for 150 - 180 minutes at bioavailability index of about 40%.
Azithromycin half-life in two stages, 14 and 41 -20 h. That is why there is no need to use antibacterial agent more than once per day.
Full release period of the drug from the body occurs within 7 days. Such prolonged maintenance of therapeutic concentrations contributes to the fact that often Azithromycin can drink short day course.
Dosage and method of use
According to the instructions, the standard dosage of Azithromycin for patients who have reached 12 years of age is 500 mg once a day.
For children under the age of 12 years, the drug is administered in an amount of 10 mg / kg body weight of the child per day.
Most often, the duration of therapy for uncomplicated infections is 3 days.
Purulent angina, pneumonia and other serious infectious-inflammatory processes, the treatment may continue for 5 days or more, and the dose increase.
In some chronic diseases doctors believe that you can often take Azithromycin again.
For example, in cystic fibrosis drug is prescribed 1 time in three days during 6 months. This treatment regimen caused not only antibacterial drugs - Azithromycin possesses anti-inflammatory and immunomodulating effects, which are successfully used in the treatment of some diseases.
With infections of the heavy nature of the often used alternative treatment regimen - step-down or step therapy. The first few days are held parenteral injection of azithromycin, the effectiveness of slightly higher than after oral use. A few days later there is a significant reduction in symptoms, comorbidity. Subsequent use of the antibiotic already held in the form of capsules or tablets.
Contraindications
Before you start to drink Azithromycin for adults and children, it is important to ensure there are no contraindications to the drug:
- increased sensitivity to antibiotics, macrolide within the group;
- idiosyncrasy substances within the structure of the drug;
- severe functional liver and kidney pathology.
Side effects
Azithromycin is generally well tolerated, but in very rare cases may develop following negative phenomena:
- headache, a state of dizziness, nausea and retching;
- frequent heart rhythm;
- allergic reactions.
Features
Unlike other antibacterial agents, who drink often, Azithromycin is used once a day, which is its undoubted advantage.
The drug should be taken one hour before meals or two hours after it.
It is impossible to carry out the medication more often than prescribed by a doctor, as this can cause an overdose.
sources:
Vidal: https://www.vidal.ru/drugs/azithromycin__24064
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = 464b69bc-52b8-420f-a2fd-5160efbe8523 & t =
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