Folic acid arthritis: treatment, dosage, instructions for use

Rheumatoid arthritis - pathology of autoimmune type, causes the loss of joint tissues which is manifested in chronic inflammatory processes.

The primary symptoms of rheumatoid arthritis can be:

• state joint stiffness in the morning, which does not pass over 60 minutes;
• symmetrical joint damage;
• the presence of subcutaneous seal - nodules, which are localized in the area of ​​the elbows.

In rheumatoid arthritis the immune system determines healthy cells as patients and fights with them as well as viruses or infections. That is, over time, the organism kills healthy cells of the joints.

That is why for the treatment of rheumatoid arthritis using agents that block the activity of the immune system. One such drug is methotrexate. It has an overwhelming influence on the production of immune system cells, which are involved in rheumatoid arthritis. This helps to improve the patient's condition and to remove or alleviate the negative effects of arthritis.

Folic acid and methotrexate for rheumatoid arthritis typically used in the treatment of. This combination of drugs is due to the fact that methotrexate inhibits vitamin B9, and the manufacturing process can cause a deficiency in the body. Folic acid helps mitigate the negative symptoms during use of methotrexate. And also improve its portability patients during the treatment of arthritis.

The symptoms of folate deficiency

The primary signs of folic acid deficiency and its derivatives - folate in the body can be:

• general state of tiredness;
• emergence of irritability and aggressiveness;
• violation of the functional activity of the digestive system;
• reduction or complete lack of appetite;
• skin and hair;
• violations of blood;
• irregular heartbeat;
• retardation in children's development and growth.

It is these manifestations make most of patients treated with methotrexate to refuse treatment. According to numerous clinical trials of folinic failure can be prevented. For this purpose, the period of treatment of rheumatoid arthritis is necessary to use formulations containing a synthetic analogue of folic acid. However, it should be remembered that an appointment of vitamin B9 may only physician after proper examination.

The use of folic acid in the treatment of rheumatoid arthritis

Arthritis folic acid is administered after appropriate examination of the attending physician.

Studies conducted in several laboratories confirm the following positive effects which manifest themselves in the application of vitamin B9:

• reduction in adverse events in the treatment of rheumatoid arthritis standard drugs;
• improved patient tolerance of methotrexate and other medical devices that are used for the treatment of rheumatoid arthritis;
• It decreases the possibility of developing complications from the hematopoietic system;
• It decreases the probability of malignancy after immunosuppressive therapy;
• homocysteine ​​concentration is reduced, provoking cardiac activity;
• recovery occurs joint tissue caused by folic acid in the synthesis of proteins and other essential compounds.

Contraindications

Before starting treatment of rheumatoid arthritis with folic acid, it is important to ensure that no patient the following contraindications:

• presence of hypersensitivity to the substances included in the formulation;
• a lack of vitamin B12;
• lactase deficiency, lactose intolerance mndividualnaya or syndrome glucose-galactose malabsorption.

Dosage and method of use

Standard folic acid dosage for rheumatoid arthritis - 1 mg per day of active substance. An alternative and more successful treatment regimen is considered receiving 5 mg vitamin B9 odnorazovo a week.

Should take the drug after one day use of methotrexate. This is due to the fact that, according to clinical trials, methotrexate efficiency is reduced while reception with folic acid.

This application has another positive feature. It is considered that Rheumatoid arthritis causes an increase in homocysteine ​​level. This non-proteinogenic amino acid accumulates in the body attacks the walls of blood vessels (arteries) and damaging the flat cells (endothelium) lining the surface thereof. Damages that result from such an attack, trigger blood clots and atherosclerotic plaques.

The use of folic acid in arthritis, reducing homocysteine ​​concentration and to prevent the development of cardiovascular disease and severe vascular lesions.

However, as with all drugs, folic acid can cause adverse reactions during the treatment.

side effects

Typically, preparations containing folic acid, a synthetic analogue of a well-tolerated, but following the negative symptoms may occur in rare cases, or at high doses:

• disorders of the digestive system functions;
• allergic reactions;
• CNS disorders;
• pathology function of the urinary system.

With the development of adverse symptoms, patients should contact your doctor, who will change the scheme of therapy or reduce the dosage of a medicine.

Folic acid during pregnancy

rheumatoid arthritis treatment with folic acid during pregnancy is carried out under the strict supervision of a physician-rheumatologist. It is believed that the condition of women at this time, is significantly improved. The use of folic acid in such a situation is often a necessity.

It is important to develop properly diet and increase the dietary intake of nutrients into the body of the future mother.

folic acid during pregnancy dosage is from 0.4 to 1 mg. The drug is taken daily. The attending physician prescribes scheme of therapy individually, depending on the condition of the patient and regular surveys.

conclusion

Rheumatoid arthritis - a disease which in any case can not be ignored. If untreated, this disease can make the patient an invalid. Folic acid has been used successfully in the treatment of arthritis, In order to prevent negative phenomena caused quite aggressive drugs.

Using vitamin B9 is recommended only after appropriate analysis and testing, which confirm the necessity of taking the drug.

sources:

Vidal: https://www.vidal.ru/drugs/folic_acid__33566
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = 41e55b8d-98b2-40bf-8a79-92c1ecc3a912 & t =

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