Structure
ambrobene
Ambrobene - less popular drug than Mucosolvan, although both contain identical medicament active ingredient:
- Ambrobene solution discharged from smoked glass bottles of 100 ml. They 750 mg of ambroxol (derivative bromhexine);
- In the 1 ml containing 7.5 mg of ambroxol;
- The composition includes a 2 ml 15 mg of the active ingredient;
- The composition of 5 ml is 37.5 mg of active ingredient.
In addition, Ambrobene contains additional ingredients:
- Potassium sorbate;
- hydrochloric (hydrochloric acid);
- purified water.
Lasolvan
It has the same release form as Ambrobene:
- 750 mg of ambroxol is part of the vial volume of 100 ml;
- In the 1 ml Mucosolvan - 7.5 mg ambroxol;
- The drug composition 2 - 15 mg of the active ingredient;
- The composition means 5 ml of 37.5 mg of ambroxol.
The difference between Lazolvanom and Ambrobene mainly involves additional substances:
- Sodium chloride;
- Citric acid monohydrate (E330);
- Disodium hydrogenphosphate digidratat (E339);
- Benzalkonium chloride;
- Distilled water.
Determine which medication is better to take the child - or Ambrobene Lasolvan can pediatrician. Especially careful in the choice of drugs should be in children prone to drug allergy.
testimony
Both drugs are often used to facilitate the excretion of mucus at productive cough. These tools are used in the complex treatment of cold, its complications and conditions characterized by the formation in which a thick and viscous separated in the bronchi:
- Acute and chronic bronchitis phase flow;
- Bronchiectasis pulmonary disease;
- COPD;
- Bronchial asthma to form a viscous secretion.
If we compare the principle and Lasolvan Ambrobene their actions, it will be the same for both drugs and lies in the fact that ambroxol hydrochloride in their composition stimulates serous cells in the bronchial glands, which causes increased production of liquid effusion. Also under the influence of the active substance it is a synthesis of proteolytic enzymes that break down proteins in the composition of the sputum, and increased production surfactant which prevents atelectasis tissues, and increases the airway epithelium ciliate activity that contributes to the removal sputum.
Contraindications and precautions
Ambrobene Lasolvan and requires prior consultation before taking, if a person is suffering:
- Disorders of the kidneys and liver, as these authorities are responsible for processing and excretion of metabolic products of ambroxol. Before taking these medications need to consult a doctor with the selection of individual doses;
- Women who are pregnant or breastfeeding. An appointment can only be a doctor, if the expected benefit from taking the drug than the potential harm to the fetus or baby;
- When there is difficulty in the natural processes of sputum clearance (motor bronchi).
- If the disease leads to overproduction of mucus;
- Benzalkonium chloride can cause a spasm of the bronchial hyperreactivity with them.
Since Mucosolvan and Ambrobene contain the same substance, the same and contraindications for these tools:
- Severe liver failure or kidney;
- Intolerance to ambroxol or other components means
- Peptic ulcer disease, as well as during acute gastrointestinal diseases;
inhaled forms
As an inhalation permissible to use both drugs.
For this fit all types of nebulizers:
- Compression. Give particles 7-12 microns in diameter, which are formed during the passage of the dense air stream for inhalation solution turns into a slurry;
- Ultrasound. spray mist formation is achieved under the effect of ultrasound on the liquid. Allow to obtain particles of 1-5 microns;
- Electron-mesh inhalers. Allow to obtain a suspension of finely divided and are versatile enough to use.
IMPORTANT! You can not use steam inhalers for solutions Ambrobene or Lasolvan.
Since Mucosolvan Ambrobene only differs from the excipients, the proportions of solutions for inhalation or child Lazolvanom Ambrobene are identical.
Formulations distillate is diluted with sterile water or an isotonic sodium chloride solution in 1: 1 ratio. This mixture is poured into a special container nebulizer.
- 0-2 years: inhalation is prepared with 1 ml (7.5 mg) means for guiding them once or twice a day (daily dose of 7.5 to 15 mg);
- 2-6 years: a mixture is prepared from 2 ml (15 mg) for one inhalation of medicament. They conducted once or twice during the day (-15-30 mg daily dose);
- From 6 years: Mixer cooked in 2-3 ml drugs (15-22.5 mg) inhaled once or twice per day (15-45 mg / day).
Before performing inhalations should feed the baby and give warm drinks; also shows a lot of drinking and after the procedure. The course of treatment should be no more than 4-5 days.
drug interactions
ambroxol medications can not be used together with cough medicines (eg, codeine) because it It complicates the excretion of mucus, and provokes the development of lung congestion and the potential for bacterial attachment complications.
In the treatment of lung diseases requiring antibiotics (erythromycin, cefuroxime, amoxicillin) is widely used to improve the property of ambroxol last tropism (accumulation) to lung tissue.
Side effects
Typically Ambrobene Mucosolvan and well tolerated. There have been reports of severe manifestations single cutaneous allergic reactions (Lyell's syndrome or Stevens-Johnson), provoked by intake of drugs containing ambroxol.
Also among the cutaneous manifestations may develop erythema multiforme, urticaria, acute generalized exanthematous pustulosis.
On the side of the immune system may be various types of drug allergy.
Gastrointestinal side effects can manifest change in stool, vomiting or nausea, dyspepsia, pain in the stomach or intestines, dry mouth or increased salivation in the mouth.
Manifestations of the side of the respiratory system: bronchospasm (at inhalation of Lazolvanom), respiratory failure and sensitivity mucosa of the nose, runny nose, change the sensitivity of the pharynx (often these symptoms are part of the general symptoms of drug allergies).
You can change the perception of taste (dysgeusia) as a result of action on the nervous system.
For part of the urogenital system and kidneys: dysuria with a tendency to decrease in the excretion of urine.
Compare Lasolvan and Ambrobene inhalation
Ambrobene - analogue part Lasolvan. If we talk about the active component of these drugs - and Lasolvan Ambrobene - the same thing.
In principle, both the drug have the same list of indications, contraindications for use and an identical mechanism of action, because they contain ambroxol in equal doses. On this basis, you can replace Ambrobene Lazolvanom, and vice versa.
When choosing for the treatment often have to consider the cost of drugs, because it is usually the doctor prescribes several medications, and if medicines with the same active ingredient will vary greatly in price, it makes sense to consult a doctor as to whether the replacement of one drug may be others.
The difference in price between Ambrobene Lazolvanom and due to the fact that Manufacturers of these drugs are in different countries. So, Ambrobene released in Germany "Ratiopharm International GmbH", and Lasolvan - "Sanofi Aventis", Italy. Given that both drugs are manufactured abroad, it can be expected that, as Lasolvan and Ambrobene have the same high quality.
Due to the fact that both drugs contain ambroxol, Ambrobene and Lasolvan together to make no sense. In addition, it can confuse the patient. So, taking these medicines at the same time, the patient will receive a double dose of the drug that can cause the phenomenon of stagnation effusion in the lung due to the excessive strengthening of its production. Against this background, to the underlying disease may join vospalieniya due to a bacterial infection.
Although, according to user feedback a big difference between these drugs is not, and can not be said, that effectively Lasolvan or Ambrobene use Ambrobene instead Lasolvan in some cases better.
If we talk about inhalation, better for the child Ambrobene than Lasolvan as benzalkonium chloride is able to provoke bronchospasm. This is especially significant for children under 4 years of age, when the nervous regulation of the respiratory system are not yet fully formed. For the same reason, you should not take both of these medicines in children at the same time - unlike adults, children are not fully able to cough up large amounts of exudate from the lung tissue, which can lead to stagnant phenomena.
From the perspective of the likelihood of Ambrobene allergies can also be considered a security feature because that it contains a smaller number of additional components, and they are relatively safe for body.
However, before taking any medication or replacement is necessary to consult with your doctor, as he makes a choice of this or other drugs based on the comorbidities propensity for allergic manifestations and total reception rationality medicines.
sources:
Vidal: https://www.vidal.ru/drugs/lasolvan__433
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = 059eef4d-4dac-49a0-b5c3-a5c9a15182a8 & t =
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