Pharmacological properties, indications, limitations to the purpose
Omez refers to drugs which inhibit the proton pump. It is produced in the form of capsules (10 mg, 20 mg), a solution of the powder for injecting (1 vial - 40 mg). The drug is highly effective in the therapy of various digestive diseases. The active component of the drug is omeprazole.
Omeprazole cumulated in the mucosa of the digestive tract, particularly the stomach. Here the activation of the drug that leads to inhibition of proton pump operation. Omez helps reduce enzyme function H+/TO+-ATPase. The effectiveness of treatment depends on the dosage of the drug. The higher the dose, the greater the effect of therapy.
Omez reduces the secretory activity of the stomach. The therapy decreases the formation of hydrochloric acid. Maximum efficiency is observed after 4 days after the start of the reception. In patients with ulcerative lesions of the mucous duodenum 12 by using a dosage of 20 mg, a decrease stomach acidity by 80%. If the patient has an ulcer 12 duodenal ulcer drug (at a dose of 20 mg) maintains acidity with pH equal to 3.
Omez capable of reducing multiplication and vital activity of Helicobacter pylori bacteria. The treatment quickly go stomach pain, reduced symptoms of dyspepsia. In patients with reduced nausea and heartburn. The medicine helps to prolong remission in gastritis, ulcerative lesions of the stomach and other pathologies of the digestive tract. The drug contributes to relief of bleeding in the cavity of the intestine and stomach.
Against the background of long-term use may cause omez kistoobraznyh formations on the gastric mucosa. These structures eventually disappear on their own, do not cause any discomfort. Due to the low formation of hydrochloric acid, its protective function is reduced, so it can join the secondary pathogenic flora (Salmonella, Campylobacter, Clostridium). Most often this occurs with prolonged use of high doses omez. When using the drug in the bloodstream increases the amount of gastrin.
Omez enters the bloodstream through the lining of the stomach. The maximum drug concentration in the bloodstream is recorded after 30-60 minutes. Drug bioavailability is 30-60%. The presence of the bolus in the stomach does not affect the absorption of the drug.
Omez metabolized in the liver tissue. Derived drug with urine and feces. Patients with kidney disease omeprazole can be absorbed and metabolized by slightly less.
Indications for omez:
- canker of the stomach and intestine perstkoy 12 (also a drug used for preventive measures);
- reflux esophagitis;
- pathology manifested increased secretion of gastric acid and hydrochloric acid (Zollinger-Ellison Syndrome, hypersecretion and canker mucosa of the digestive tract of the stress);
- therapy of diseases of the stomach and duodenum 12 provoked bacterial agent Helicobacter pylori (treatment carried out in conjunction with anti-bacterial drugs);
- preventive measures defects of the gastric mucosa and 12 duodenal ulcer, provoked by non-steroidal anti-inflammatory drugs (NSAIDs) (mild diarrheal manifestations, removal of ulcerous defects).
- preventing the occurrence of Mendelson's syndrome;
- treatment of reflux disease in children older than 2 years of age, treatment of ulcers of the digestive tract mucosa (with the bacterium Helicobacter pylori) in a child older than 4 years of age.
Medication do not use in children under 2 years of age. If a child older than 2 years of age are no indications for the drug is not used. Omez not shown if there is an allergic reaction to the components of the drug. The capsules should not be used in the presence of lactase deficiency, malabsorption. Omez can not be combined with erlotinib, posaconazole, nelfinavir and atazanavir. Form solution is not administered during gestation, as well as children.
It should be very careful to use a medicine ulcerative defects which were already present before treatment. Omez need to use caution in patients with liver disease, the presence of jaundice syndrome, severe renal dysfunction. After operations on the stomach medication prescribed after recovery.
The drug is prescribed carefully in the presence of a strong weight loss, regular vomiting, abnormal swallowing reflex, there is light feces. The drug used in conjunction with carefully clopidogrel, digoxin, warfarin, clarithromycin, and other drugs. Omez carefully used in patients with osteoporosis, since there is evidence that the drug can cause fractures.
Application omez during gestation
Omez take for pain in the stomach can be during pregnancy. In studies of the drug it found that it does not have toxic effects on both mother and fetus. Treat stomach omez allowed breastfeeding. The drug can penetrate into breast milk, but does not affect the baby. Treatment of these groups of patients is performed in therapeutic dosages, depending on the disease. The average dose is 20-40 mg per day.
Terms of use of the drug
The drug has a strong enough effect, it penetrates quickly into the bloodstream, so it should be taken strictly under doctor's orders. Omez can be used in capsules and vials. The most common drug administered in capsules.
The capsules should be taken with water, they need to swallow completely. If the doctor has appointed dose of 20 mg for an adult, you can drink it once in the morning. When the dose increased to 40 mg or more, the dosage divided into 2 doses.
Children often can not swallow a capsule form completely. In this case, the capsule opens, the contents diluted with an acidic drink or juice. The prepared solution should immediately drink, can not be stored.
Adults in the presence of ulcerative lesions of the stomach and duodenum 12 appoint 20 mg. From stomach pains drink Omez be once per day. Coursework therapy is 14 days or 1 month. If necessary, you can extend the treatment for up to 2 months.
At reflux disease adults appoint 20-80 mg depending on the severity of symptoms (heartburn). Omez from heaviness in the stomach should be taken once or 2 times per day for 1-2 months.
Omez with severe pain in the stomach ulcer or gastritis caused by (with the presence of Helicobacter pylori) are administered in a dosage of 20 mg. The drug is combined with antibacterial agents (amoxicillin, clarithromycin). Treatment lasts 7-10 days. If necessary prolong therapy.
If there is increased production of hydrochloric acid in gastric juice and then the drug is used in a dosage of 60 mg. When drug therapy inefficiency dose increased to 80-120 mg. The daily dosage is divided into 2-3 doses.
The medicine can be used in the background of NSAID therapy. NSAID drugs can cause severe pain in the stomach. Omez administered 20 mg half an hour before the morning meal. If necessary dosage can be increased to 40 mg per day. The syndrome Mendelsohn shown drink 40 mg once. In addition to the capsules and injectable use another form of the drug. Prior to administration the powder is dissolved or 5% dextrose solution (100 mL).
The use of drugs in children, pregnant women and at GW
In children, the medicine may only be used according to indications described in the instructions. Child older than 2 years of age a medicine prescribed for reflux disease. Child with pain in the stomach helps Omez. It will allow to reduce pain, decrease the casting of gastric contents into the esophagus, reduce the symptoms of dyspepsia. The dose administered at the rate of 0,7-3,3 mg per 1 kg of weight of the child or 20 mg per day.
Children with pain in the stomach to take Omez possible to ulcerative damage to the digestive tract, as well as, if there is the bacterium Helicobacter pylori. The dosage is calculated by weight of the baby: 1-2 mg per 1 kg weight. Also, the child can take 20 mg per day. If, after receiving omez stomach ache, you should consult your doctor to stop using the drug.
Pregnant patients and women, lactating, treatment of gastric diseases and duodenum 12 is carried out in therapeutic dosages. When reflux esophagitis Omez prescribed 20 mg of the drug. In ulcerative lesions of the stomach and duodenum 12, you can take 20-40 mg. If necessary, increase the dosage. The injectable form of the drug in children and pregnant women is not being used.
conclusion
Omez can be used in both children and adults for pain in the stomach. The drug effectively treats Helicobacter pylori infection in the complex therapy. The medicine helps with excellent gastric ulcers and 12 duodenal ulcer, gastritis, hypersecretory neurotic states. You can use the drug in pregnant and lactating patients.
sources:
Vidal: https://www.vidal.ru/drugs/omez__619
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = 5ab108ba-8f63-4e81-982c-a6b4a1ec47ac & t =
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