Brief information about Furazolidone
To understand whether there is a difference between furazolidon Enterofurilom, you must take a closer look pharmacodynamics and pharmacokinetics of each drug. Furazolidone produced by Belarusian and Russian pharmaceutical companies in the dosage form as a tablet. Each tablet contains 50 mg of active ingredient and a large amount of auxiliary components.
Important in comparing two preparations have a spectrum of activity. Furazolidone has antimicrobial activity against Trichomonas, dysentery Shigella, Salmonella different species. The spectrum does not apply to purulent and anaerobic flora. The mechanism of action associated with suppression furazolidone bacteria basic chemical cycle required for formation of ATP energy. As a result, infectious agents cease to synthesize genetic material, membrane and cytoplasmic components. Ultimately bacterium dies stops secrete toxic substances, thereby improving the body condition.
Furazolidone does not inhibit the activity of the body's own immune system, stimulates the release of neutrophils and macrophages in the inflammatory focus, helps overcome the infectious process. The drug is well and rapidly absorbed in the lower digestive tract, penetrates the blood-brain barrier that allows use with inflammation furazolidone pia meninges.
Active ingredients furazolidone metabolized in the liver hepatocytes, which creates a certain load on it. Due to this fact, when using furazolidone in patients with decompensated liver disease dosage to be reduced by half. Output inactive metabolites by the kidneys and intestines. Summary concentration achieved in the digestive tract.
Indications for use Furazolidone:
- intestinal bacterial infection;
- dysentery caused by Shigella;
- paratyphoid;
- acute intestinal poisoning;
- salmonellosis;
- inflammation of the mucous membrane of the vagina in women chlamydial infection;
- bacterial inflammation of the urethra;
- giardiasis;
- skin infections, open wounds, burns.
Among the contraindications in the official instructions for use are mentioned clinical situations:
- Allergoanamnez weighed, allergic reaction in the past on the components of the drug to other antibiotics from the group of nitrofurans;
- Chronic renal disease is at an advanced stage when necessary replacement therapy or kidney transplantation;
- Enzyme deficiency, glucose-6-phosphate dehydrogenase;
- Age up to 3 years (contraindication due to the inability to swallow the tablet);
- Disorders of the central nervous system.
Possible side effects: dyspepsia and functional dyspepsia, nausea, vomiting, loss of appetite, allergic symptoms. With prolonged use of attachment means may neuritis. If furazolidone need to take a long time, you should use neuroprotective drugs such as vitamins of group B. It is also necessary appointment porbiotikov, eubiotics to restore the normal flora of the intestine (for example, Enterol).
On interaction with other components of the medicament drug is little information. It is known that furazolidone not recommended for use with drugs that increase urine pH, chloramphenicol, ristomycin. Assign Enterofuril together with furazolidone may be on the testimony. Such combination may enhance the antibacterial effect and lead to more rapid recovery.
A brief summary of Enterofurile
To compare the drug with Enterofuril Furazolidone can be used pharmacodynamic parameters pharmacokinetics, spectrum of antimicrobial action, indications, contraindications, side effects. Enterofuril refers to the same chemical group of antibiotics as furazolidone. Unlike the first drug in Enterofuril have a dosage form that can be used for the child's first month of life - oral suspension. Adult Enterofuril available in capsules.
Enterofuril (nifuroxazide, ersefuril) produced in Bosnia and Herzegovina, the manufacturer recommended as safe antimicrobial agent. Enterofuril is used most commonly in pediatrics, because children are more susceptible to infectious lesions of the gastrointestinal tract. Before the appointment Enterofuril must always be examined by a doctor to clarify the nature of the infection and the tactics of therapy.
Since Enterofuril furazolidone and belong to the same group of nitrofuran derivatives, their mechanism of action in relation to the same germs. Different medications spectrum antibacterial action. In Enterofuril he was against Enterobacteriaceae, but wider than Gram-positive microbes (Staphylococcus aureus, pyogenic streptococci). This is the main difference Enterofuril and furazolidone.
In connection with the spectrum assigned Enterofuril activity in conditions such as:
- Enteritis and gastritis caused by bacterial agents listed above.
- Diarrhea of bacterial etiology.
Replace Enterofuril Furazolidone to treat such pathologies can not be, since each drug its spectrum of activity. When these diseases and identify the causative reception furazolidon will not have a positive clinical effect. Improper and irrational use of antibiotics can lead to mutations and the emergence of bacteria resistant to antimicrobial drugs.
Enterofuril has fewer contraindicationsIt can be used in patients with impaired renal function, as deduced intestine and eliminates the burden on the body. Enterofuril also is not metabolized in the liver, it does not require supplemental hepatoprotectors neuroprotective drugs for restoring intestinal microflora. Side effects Enterofuril associated with allergic reactions to the main and auxiliary components, dyspeptic disorders in the intestinal level.
Enterofuril concurrently with furazolidone may be used when, after laboratory testing revealed bacteria, which has both antimicrobial activity Enterofuril and furazolidone. In other situations, a joint reception and Enterofuril furazolidon considered unreasonable, provokes more the burden on the liver and kidneys, increases the likelihood of the formation of bacteria and more resistant strains cause side effects.
conclusion
Many sources reported that Enterofuril can be considered analogous to furazolidone. If we compare the pharmacological properties of each drug, antimicrobial spectrum, and the opportunity to testify purpose, it becomes clear that Enterofuril and furazolidone completely different antibiotics, and medication to replace one another it is impossible.
sources:
Vidal: https://www.vidal.ru/drugs/enterofuryl__2734
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = 9c80dbb9-89f9-4129-bbb9-dfdafb9989e7 & t =
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