To compare with Novobismol De nolom need to study their composition, properties, indications and limitations to the destination. De-nol - similar Novobismola. According to the description, these drugs have the same dosage, the active constituents, pharmacological properties, as well as the indications and limitations for use. The difference between the drugs only in their value. Novobismol cost 318-371 rubles. The price for the De-Nol is 330-498 rubles. De-Nol Novobismola more about 50-100 rubles.
Medications are an intestinal antiseptic and astringent. They are manufactured in a tablet form (120 mg). Drugs active component is bismuth tripotassium dicitratobismuthate.
The pharmacokinetic properties of Novobismola and De-Nol
Both drugs reduce the size of ulcer formations on the lining of the digestive tract, combats microorganism Helicobacter pylori. Medicine relieve inflammatory reaction, have astringent effects. Due to the acidic environment of the stomach lining to settle oxychloride and citrate.
While taking medications formed proteinaceous substance forming a film on the mucosa of the digestive tract. It encapsulates all the damaged areas. Mucus is formed by exposure of the active drug component that increases the regenerative (reducing) the functions of the intestinal duct cells. Reduces the formation of pepsin and pepsinogen in the digestive tract.
The active component of drugs hardly penetrate through the stomach lining. In the blood gets a very small part of bismuth. From the digestive tube medicine is excreted in the feces, and blood - urine.
Indications and limitations to the appointment of drugs
Novobismol and De-Nol have the same indications and limitations, as they are structural analogs of each other.
Indications for use:
- ulcerative damages the alimentary tract;
- chronic form of gastritis and gastroduodenitis (during a relapse);
- dyspeptic symptoms not caused by abnormalities of the digestive tube;
- digestive diseases, provoked by infection Helicobacter pylori;
- irritable bowel syndrome, which is manifested loose stools.
Novobismol and De-Nol is not used under severe kidney disease, intolerance to medication components. Drugs are not administered during gestation, during lactation, and children up to 4 years of age. If treatment is given to the patient feeding, then breast-feeding should be suspended for the entire course of therapy. Medications are used interchangeably. Novobismol instead of De Nol take often due to the fact that the effect of the treatment is the same as it costs cheap.
Undesirable effects, the use of large doses of drugs combination with other medicines
When using De Nol and Novobismola may have undesirable effects. May cause dyspeptic reactions (nausea, vomiting, frequent stools, constipation). Such displays do not bear harm to humans. Some patients have allergies in the form of a rash, itching. If drugs are used for a long time, it may cause encephalopathy due to the accumulation of bismuth in the nerve cells.
When using high dosages of drugs sometimes develops changes in the kidneys. If you cancel the medicine symptoms gradually go away. If the patient is poisoned De nolom or Novobismolom should undergo a gastric lavage, drink activated charcoal, laxatives drugs (saline). When bismuth kidney disease and its metabolites hemodialysis patient.
You can not drink antacid medications, milk, fruit juice, half an hour before and after using the De-Nol or Novobismola. This reduces the effectiveness of treatment. The drugs can be combined with antibiotics for the treatment of infection Helicobacter pylori. Drugs do not slow down the nervous system, so they can be used for patients who work with machinery.
Terms of use of medicines
De Nol and Novobismol prescribed for various pathologies of the digestive tract (gastritis, ulcerative lesions of the stomach and duodenum 12, upon detection of the microorganism Helicobacter pylori). Allowed to use the drug in patients with dyspeptic symptoms.
De Nol and Novobismol should drink half an hour before a meal. Patients over 12 years of age and adults need to take medication for 1 tablet form four times per day. You can drink 3 tablets per day and 4 th tablet form taken at night. To wash down the pill need a small amount of liquid. This will increase the effectiveness of treatment. At night, the patient does not eat, so there is no damage to the mucous membrane of the exposure to the food, the film is stored for a long time.
Child 8-12 years of age is shown, take 1 tablet form twice per day. Children 4-8 years of age to drink medicines should be at the rate of 8 mg per 1 kg per day. The daily dose should be divided into 2 doses. Coursework therapy bismuth drugs is 1-2 months. Treatment for less than 1 month is considered inappropriate.
The formulations may be used in conjunction with antibacterial agents in the presence of Helicobacter pylori microorganism. Most often prescribe bismuth drugs, amoxicillin, furazolidone, tetracycline, clarithromycin. Coursework therapy is 7-10 days. After finishing the course of antibiotics bismuth drugs continue to drink for another 1.5 months.
The therapy in patients goes stomachalgia, reduced symptoms of dyspepsia (heartburn, loose stools). The bacterium is killed during treatment. On examination, the mucosa during EGD decreases bleeding ulcers, education reduced in size.
Simultaneous use of De Nol and Novobismola
Novobismol and De-Nol is a structural analogue. They have the same composition. When used drugs simultaneously possible overdose. If at the same time take Novobismolom De Nol may have encephalopathy, constipation, vomiting, nausea, kidney damage. Since drugs are analogues to replace De Nol can Novobismolom instead Novobismola allowed to take De-nol.
conclusion
Novobismol and De-Nol help restore well-lining of the digestive tract, improve the condition of patients. You can not use the drug in patients under 4 years of age, current as bismuth overdose can accumulate in the brain tissue to a greater extent than in adults. Do not use the medication in pregnant and lactating patients.
sources:
Vidal: https://www.vidal.ru/drugs/de-nol__6730
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = 7696368a-c3a6-4fd8-b73c-69a9af455d51 & t =
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