HCG at the double: an increase in multiple pregnancies in the early stages, the table is a daily, weekly, how to determine the level of IVF by 14 DPP pyatidnevok

When you double-hCG is 2-3 times higher than in the gonadotropin with the conception of a child. Hormonal substances in multiple pregnancy reduces the risk of rejection section of the ovum. HCG is constantly growing to 16-20 weeks. If considered on days, its concentration rises every 24-48 hours in 2 times.

How is the hormone and multiple pregnancy

In the development of the fertilized egg is divided into 2-4 parts. Each of the individual sheets coated embryos chorion. Embryonic membranes produce a hormone at the same time, because of what the hCG levels in multiple pregnancies in the blood and urine above the norm.

Indicators of hormonal compounds in biological fluids depend on the gestational age and number of fetuses. hormone content increases gradually. In the early stages the rapid pace of development of gonadotropin are not observed. But with a sharp increase in its conduct additional laboratory and instrumental examinations, ie. A. There is a possibility of fetal abnormalities, abnormalities of the reproductive organs.

Due to the high concentration of hCG all normal embryos are immersed in the lining of the uterus, get enough oxygen and nutrient compounds are developed in a timely manner. Gonadotropin reduced the risk of rejection of fetal eggs in the period of gestation.

During the first 14 days after conception number hormonal compound at 2 healthy embryos ranges from 50 to 110 mU / ml, with 3 6 month increased from 9,500 to 160,000 IU / ml, and 3 trimester begins to decrease, t. k. a female body prepares to I leave. As a result, it is kept in the range from 5000 to 155 000 IU / ml.

If the development of embryos 2-3 hormone content than normal values, it is necessary to conduct the differential diagnosis:

• gestational diabetes;
• hydatidiform mole;
• lesion thyroid, pancreas, adrenal gland;
• ovarian low functional activity;
• severe toxemia.

If IVF fertilized egg divides after replanting, venous blood samples taken almost every month.

Strict monitoring for hormonal pregnant performed due to gravity gestation.

With artificial insemination, there is a high probability of miscarriage or fetal fading while developing several embryos.

How do analysis

To detect hCG concentration required deliver venous blood from the cubital vein or urine. In the first case biomaterial abstracted from 8:00 to 10:00. By the analysis on delivery HCG Pregnancy you need to prepare:

• It is forbidden to eat food for 6-8 hours;
• no smoking during the day, drink alcoholic beverages;
• 48 hours should stop taking hormones, antimicrobials and other drugs that may affect the results;
• forbidden to engage in physical activity, the body subjected to rapid temperature changes, nervous.

When the planned study fence biomaterial is performed once. Re-analysis is necessary in cases of suspected development of intrauterine fetal anomalies or pathological processes in a woman's body. Additional research is carried out 1 day after the last. The test results will be ready within 2 days.

By hCG can timely detect the presence of fetal anomalies. If a twin pregnancy is normal has been a steady increase in the index. In certain situations, such as fading fetus, spontaneous abortion, hypoxia, component decreases sharply.

As the index grows

HCG level at the double increases constantly until 16-20 weeks of pregnancy, until it reaches a peak. After this period of gestation its level begins to decrease gradually.

The table shows how figures hCG changes in multiple pregnancy week by week:

Week of embryonic development	Dynamics hCG twins weekly, IU / ml	1 embryo mU / ml
Week 1	50-350	25-156
week 2	200-9700	100-4800
week 3	2200-63000	1100-31000
4 week	5100-164000	2500-82000
week 5	46000-302000	23000-150000
6 week	54500-465000	27000-230000
7-11 week	42000-580000	21000-290000
Up to 16 weeks	12200-205000	6150-105000
Up to 21 weeks	9400-160000	4700-80000
Up to 39-42 weeks	5400-156000	2700-78000

Features of dynamics after IVF

HCG at twins after IVF does not differ from the level of the compound in multiple hormonal conception naturally. Artificial replanting embryo does not affect the production of the hormone. When IVF possible later implantation, but the value of hormonal substances after immersing the separated fetal eggs will remain in the 2-3 times higher than normal for a single embryo.

In artificial insemination carried replanting ready embryos into the uterine cavity, so control over the content gonadotropin performed carefully. Laboratory examination in early pregnancy is carried out every 5 days after transplanting. adaptation period of the most severe - if the embryo will be weak, non-viable or not quickly adapt to the conditions in the female body, there will be his death. It can not be implanted into the endometrial layer leaves the body cavity together with the mucous secretions, or blood.

Monitoring is carried out from 10 to 16 week. The assay was performed every 7 days. When the indicator substance peak, it stabilizes. At the end of 20-30 days of hCG continues to grow. During this period, it is important to prevent its loss. Otherwise possible developmental disorder or fetal death.

The causes of false results

False-positive results do not always point to the development of pathologies in women. If twins pregnancy not confirmed by ultrasound, to increase in hCG can affect:

• use of hormonal drugs containing gonadotropin;
• malignant tumors involving the uterus, adrenal glands, ovaries;
• presence in the blood of organic compounds similar in structure to gonadotropin.

False-negative results can be due to a late implantation during IVF, the absence of pregnancy, possible medical error. In artificial conceiving the embryo may not be fixed, so the ejection of hCG in blood does not occur. In this situation, its level remains within 0-5 mU / ml for 3-5 days and then begins to rise.