Diaphlex is a drug that has an anti-inflammatory and restorative effect on the joints and cartilage.
Basically, the medication is used for the onset of primary and secondary osteoarthritis.
Also used for other inflammatory-dystrophic diseases of the joints.
Table of contents
- Composition
- Composition
- Pharmacokinetics
- Mechanism of action
- Scheme of application and dosage
- Limitations for use
- Possible adverse reactions
- Special instructions
- Drug interaction with other drugs
- From the practice of doctors. ..
- . .. and their patientsminuses
- Purchase and storage
- Analogues of the drug
Pharmacological action
Diaflex has the following pharmacologicalth effect when ingested:
- active capture of substances that cause inflammation;
- prevention of cartilage destruction in osteoarthritis;
- capture of hormone-like proteins provoking inflammation;
- cartilage restoration and stimulation of collagen production;
- recovery of bone metabolism and preservation of bone mineral density.
Composition of the drug
One capsule of Duflex contains 50 mg of active substance - diacerein. Also in the composition of the drug are such auxiliary substances: lactose monohydrate and magnesium stearate.
In the shell of the capsule contains titanium dioxide, gelatin and yellow iron oxide. The drug is available in capsules, weighing 50 mg each.
Pharmacokinetics
The drug has the following pharmacokinetic properties:
- Suction .After taking the drug, it begins to be rapidly absorbed from the gastrointestinal tract. Taking the drug concomitantly with food causes a delay in systemic absorption, but increases the amount of absorbed substance.
- Distribution .With prolonged admission, C max in the blood plasma increases. This is due to the cumulation of the drug itself. Rein immediately binds to plasma proteins at 100%.
- Metabolism and excretion of the body .Upon ingestion, the rhein is converted to sulfate or glucuronide. Unchanged rhein, whose mass fraction is 20%, is excreted from the body by the kidneys.
Mechanism of action
When the capsule enters the body, the active substance of the drug diacerein begins to act. It is metabolized to rhein and begins to inhibit the activity of interleukin-1.
The action of the drug develops two weeks after its regular adoption. The active substance of this drug has an analgesic effect.
In addition, the drug acts as an anti-inflammatory drug. If the Diaflex was once taken, its concentration in the plasma is about 3.15 mg / l. With simultaneous reception of the medicine with food, its bioavailability increases threefold.
If the medication is taken on a regular schedule, then a small accumulation of the drug in the body may occur.
Rein freely penetrates the placental barrier. The withdrawal of a part of the medicine occurs four hours after its adoption. Removal of the drug occurs both in an unchanged form, and in the form of sulfate and glucuronide.
Application and dosage regimen
Diaflex is prescribed for primary and secondary osteoarthritis and osteoarthritis. Take the medication twice in the 
day, while eating( lunch and dinner).
It is advisable to swallow the capsules whole, washing them with plenty of water. Since the active substance Duafleks can cause acceleration of the intestinal passage, then you need to start taking the drug with only one capsule, multiplicity once a day.
Moderate medication should be taken about the first four weeks. Next, the dose gradually increases to two capsules per day. The therapeutic effect manifests itself three weeks after the start of the drug.
The use of the medicine should be continuous. On average, the course of treatment with this drug is about four months.
Restrictions for the use of
Medication has some contraindications for use:
- presence of colopathy( ulcerative colitis or Crohn's disease);
- abnormal liver function, in this case, the dose of the drug should be reduced;
- presence of inflammatory diseases of the gastrointestinal tract;
- improper carbohydrate metabolism;
- lactose intolerance;
- presence of hepatic or renal insufficiency;
- sensitivity to a particular component of the drug;
- presence of occlusive syndrome;
- pregnancy and the period of breastfeeding.
Possible adverse reactions
In the long-term administration of a medicament, some side effects may occur:
- the onset of diarrhea;
- anaphylactic shock;
- development of hepatitis;
- vomiting, nausea and stomach pain.
It is possible and the emergence of allergies, which eventually turns into hives. When an overdose of the drug, there may be a general weakness of the body, accompanied by a liquid stool.
With such symptoms, you should wash the stomach using boiled water. It is also recommended to conduct general symptomatic therapy. If diarrhea has a pronounced shape, then the electrolyte composition of the plasma should be monitored.
Special instructions
Before the proper therapeutic effect occurs, you can take Duflex simultaneously with analgesic medications.
Also, during the course of treatment, you should periodically check all blood counts, functional tests of the liver and urine indicators. If the kidney function is disrupted during treatment, the dosage of the drug should be reduced.
Drug use is not recommended for pregnancy and lactation. If nevertheless there was an acute need for the use of this medication, then breastfeeding should be stopped.
Treatment with the drug is contraindicated until the age of eighteen.
Drug Interaction with Other Drugs
Diaflex should not be taken with drugs that can increase the volume of intestinal contents.
Antacids contribute to a decrease in drug absorption. Simultaneous reception of the drug with antibiotics, violates the intestinal microflora. The same applies to the use of physiotherapy drugs.
It is not recommended to use the medicine together with laxative medicines. Simultaneous use with preparations containing aluminum and magnesium, leads to a decrease in the bioavailability of the active substance of the drug.
From the practice of doctors. ..
Reviews of specialists who use in their practice Diaflex.
Preparation Diaflex Rompharm effectively removes inflammation and eliminates pain. Also, it has good patient tolerance. From the shortcomings I can note the high cost of the drug and the duration of the course of treatment.
Sometimes patients can have many side effects, but if you constantly monitor all the indicators of blood, liver and kidneys, then everything is not so terrible.
Vera Ivanovna, orthopedic physician
Of all the patients to whom I prescribed a course of treatment with this drug, it did not help only a few people. And then this is due to their age and the fact that the diseases were chronic and neglected. If we talk about the shortcomings and advantages of the medication, then I would take the advantages that it does not set the heart. And this despite the fact that the course of treatment is already four months. Also, Diaflex anesthetizes cartilage and almost completely restores it. With regard to deficiencies, these are side effects in the form of diarrhea, severity in the stomach and staining of urine.
Alexey Vladimirovich, orthopedic physician
. .. as well as their patients
She started taking Diaflex simply for prevention, as she tortured the crunch in the joints. Already after the second month of application, good results were observed. The drug is effective, but not very affordable, and the price bites a bit.
Alla Valentinovna, patient
When I had pain in the knee joint, I decided on chondroprotectors. But they did not bring any special results. When the doctor prescribed Diaflex to me, I did not particularly hope for him. But nevertheless I have passed all course of treatment up to the extremity or end. Pain in the joints, I do not feel any side effects, about which everyone is so actively talking, I have not experienced.
Oleg
My mother has long had knee pains. Not once she was given injections, after which as to an additional course of treatment was attributed to Diaphlex. My mother took one capsule twice a day. Already after three weeks of pain subsided, and my mother began to walk much better. They remained very satisfied, even despite the periodic malaise of the duration of the admission.
Irina
Pros VSs cons
The advantages of the drug include efficiency and a wide range of applications. 
Another great advantage of this medication is that it is the most effective among all non-steroidal anti-inflammatory drugs.
The disadvantages include the presence of many side effects. Also, the negative side of the drug is a ban on its use in renal failure.
Purchase and storage of
Diaflex is available in capsules of 50 mg, one package contains thirty capsules, the average price per package is 900 rubles.
The drug should be stored in a dark place at a temperature of not more than 25 degrees. The storage of the medicine should not be available to children. Shelf life of the drug is three years from the time it was manufactured.
Regarding the conditions of the drug dispensing in pharmacies, it is dispensed exclusively by prescription.
Analogues of the preparation
Analogues of Diaflex are such preparations as: Artrocore, Artrodarin and Arthra chondroitin, the latter is cheaper, but no less effective.
Also analogue of the drug is Teraflex. It contains a significant amount of glucosamine, which is capable of restoring the cartilage matrix.
But taking this medicine for a long period is not recommended.
To the analogues of Russian-made Diaflex is the following list of drugs:
- Nimesulide, 100 mg tablets;
- Glucosamine, tablets 300 mg;
- Structum, capsules 250 mg;
- Chondroitin-ACOS, capsules 250 mg.
