Droperidol - instructions for use, reviews of doctors and patients, drugs analogues

Droperidol( Droperidol), powdered, light cream colored. Manufacturer of Gedeon Richter.

Droperidol belongs to the group of medicines( antipsychotic) - butyrophenones .

When reacted with water and alcohol solutions, it dissolves in small doses.

When interacting with air and light, it has the property of changing the color to a yellow tint.

Pharmacological action

The drug ispsychotropic( neuroleptic), prescribed for mental disorders:

• enhances the effect of anesthesia, hypnotics, analgesics;
• has a positive effect in case of shock and antipsychotic state, vomiting;
• lowers blood pressure and arrhythmia.

Pharmacokinetics of the drug

After taking the drug, its components are observed in the patient's body after 3-15 minutes for 12 hours( the peak of a calming effect on the nervous system is observed for 2-4 hours after drug administration) and make up about 90%( fromthe main dose of admission).

Excretion from the body of occurs:

• mainly by the kidneys;
• partially feces;
• a small percentage of urine( unchanged).

Indications for use

The drug Droperidol is used in:

• psychiatry for hallucinations and psychomotor agitation;
• in anesthetic practice( in combination with other drugs analgesics) for muscle relaxation and insertion into a drowsy state, preventing a shock situation in the patient, for eliminating vomiting and its symptoms;
• application of the drug, based on studies, gives an easy way out of the anesthetic state of the patient;
• is used for surgical interventions and in the postoperative period, including local anesthesia;
• for various types of poisoning, in combination with other drugs, as part of complex therapy;
• narcology for alcoholic delirium( "protein").

Contraindications

Drug administration instructions Droperidol indicates such contraindications:

• various motor disorders caused by the use of medications( extrapyramidal disorders);
• for children under the age of three;
• with long-term use of drugs aimed at lowering blood pressure;
• depressive state, accompanied by constant fear;Caesarean section of the
• ;
• hypersensitivity to the constituents of the drug and morphine;
• coma.

Mechanism of Action

The drug has a calming effect on the receptors of the brain and the cortex of the hemispheres, the hypothalamus and dilates the peripheral vessels, reducing blood pressure.

Why does the stop or what is Morton's neuroma? Symptoms and treatment of the syndrome in modern conditions. The syndrome caused by damage to the sympathetic nervous system of the body or Bernard Horner's syndrome is the cause of development, the characteristic symptoms and treatment of the disease.

Instruction for use

Let's study the instruction to the preparation of Droperidol. The drug is used in such cases:

• anesthesia( in combination with fentanyl or opioid group drugs);
• preparation for surgical and endoscopic operations;
• is a psychomotor agitation;
• pain shock;
• myocardial infarction;
• poisoning( as part of complex therapy).

The drug is slowly administered intravenously.

Form

Produced in cardboard packages, as a solution for injection, in ampoules of 5 and 10 ml.

Ampoule 1 ml contains 2.5 mg of droperidol.

Dosage and methods of application of the preparation

Administration of the drug in a dose of 1-2 ml is possible every 6 hours.

The drug is administered intravenously:

1. In anesthesia. Adults 6-8 ml of the drug. Children 200-400 μg per kg of body weight. If the operation time takes a long time, the repeated administration of
2. is possible. Myocardial infarction, pulmonary drainage. 1-2 ml of the drug intramuscularly.
3. Premedication .15-45 minutes prior to surgery at a dose of 2,5-5 mg of droperidol. Children dose is calculated based on body weight( 100 μg per kg of body weight).
4. With anesthesia .Children 300-600 mcg per kg of body weight.
5. After the operating period. Adults 1-2 ml of the drug.

Overdose and additional indications

In case of an overdose, the following symptoms are observed:

• a sharp drop in blood pressure;
• breathing disorder;
• extrapyramidal disorders.

What happens with an overdose of

An overdose of the drug Droperidol-use of a dose of 25 mL and more:

• cardiac arrhythmia occurs with a fatal outcome;
• may be an extension of the peripheral vessels;
• development of the blockade of the nerves( intercostals).

Side effects of

On the part of different systems of the body:

1. Cardiovascular system: lowering of arterial pressure, tachycardia, arterial hypertension( in rare cases).
2. Nervous system: drowsiness( in the postoperative period), dysphoria, restlessness, motor excitability.
3. Digestive system: loss of appetite, nausea, jaundice( in rare cases).
4. Allergic reactions: trembling( rarely), dizziness( rarely), bronchospasm( rarely).

Special instructions

The initial dose should be reduced( from the dose needed for treatment) to the elderly and physically weakened( depleted).

The drug affects the ability to drive a vehicle.

During the day( after the last dose of the drug) avoid actions requiring increased attention and concentration.

Drug and alcohol

Use of the drug with alcohol under the supervision of a doctor. The drug potentiates the effect of alcohol.

Preparation for liver and kidney disorders

Use with extreme caution and under the supervision of a specialist.

Interactions with other

preparations It is worth highlighting such moments:

• is enhanced by the action of Droperidol with benzodiazepine derivatives;
• Droperidol enhances the action of drugs necessary for anesthesia;
• Droperidol enhances the action of hypnotics;
• decreases the effect when used with dopamine receptor agonists.

Pregnancy and lactation

Under the supervision of a physician. The last semester is contraindicated. There are no data on the effect of the drug on the fetus.

Not recommended for use during lactation.

Admission of children

The drug is contraindicated in children under two years of age. In the period from 2 to 3 years only under the supervision of a specialist. The dose is prescribed based on body weight.

Reviews of patients and doctors about the medicine. Droperidol

Reviews of patients and doctors are mostly positive.

The only condition for is the task and purpose of the preparation.

Until recently, in medical practice, the specialists tried to prescribe newer drugs, but their increased negative effect on the heart and nervous system of the patients made it necessary to return to the drug Droperidol.

Reviews physicians:

1. Vasiliev RO, cardiologist .With hypertensive crisis in complex therapy, Droperidol is the best drug.
2. Nikiforova PR, neurologist .Droperidol can cause a strong arousal in the patient, on the basis of this, special attention should be paid to the clinical picture of the patient's behavior and to prescribe it only in inpatient treatment.

Reviews of patients:

1. Michael.27 years. I was coded of alcohol addiction. Called the doctor at home. Diced various preparations of Disol, Pyridoxine. Droperidol helped. Although before that the results were equal to zero.
2. E is listed.21 year. I have a 1.5 month period of pregnancy. Severe toxicosis. Appointed Droperidol. After a week of use, the gag reflexes went away. Analyzes showed that the fetus is all right.

Tips for receiving patients from

In the hospital, I was prescribed Droperidol. Treatment with the drug was excellent. There were no side effects.

At home, without calculating with the dose, I injected a neighbor drug. Dyspnoea started violently, and her heart beat fast. As a result, I again( after calling an ambulance) got for 2 weeks in the hospital.

Advantages and disadvantages of

The above mentioned positive aspects also include the fact that preparation:

• can be used for veterinary purposes;
• preparation is available on prescription.

Form release and cost

Price for Droperidol:

• Droperidol 2.5 mg - 5 pcs ampoule 55 rubles;
• Droperidol 2.5 mg - 10 pcs ampoules of 135 rubles.

Storage conditions and storage conditions

Keep out of reach of children, dry and dark places at a temperature of no more than 5 degrees. It is released on prescription.

Analogues of the medicine

Next on the list are 3 drugs - the analogue of Droperidol.

In practice, there are many. Choose and note in what is better or worse this or that drug is not possible.

All of them belong to the group of neuroleptics and are prescribed based on the disease and practical application.

Be cautiously appointed or excluded at all in the appointment of children and women during pregnancy and lactation.

Haloperidol

Haloperidol tablets cost 22-55 rubles. Ampoules 69 rubles.

Pros and cons:

• is a potent antipsychotic agent;
• quick action;
• accumulates in the tissues;
• is not used as the primary and first drug for treatment.

Aminazine

The cost of 50-140 rubles, depending on the dosage, form of release and manufacturer.

Pros and cons:

• is available as a dragee( avoid injection);
• administration of the drug intramuscular and intravenous is often accompanied by pain.

Moditen

The cost of the drug is 65-83 rubles.

The drug is withdrawn gradually

Anyway, along with general recommendations, there is individual tolerance of the drug.

Therefore, should remember that any self-medication and self-prescription can harm your health. The prices indicated in the article may vary depending on the location of the pharmacy and its mark-up.