Metypred. Reviews of people taking the drug, instructions for use, side effects, analogues, price

Judging by the feedback from people, taking the drug Metipred, has an effective effect in cases when painful inflammatory processes occur in the body. The effect of the drug on the metabolic processes of the human body, namely on protein, lipid, calcium and carbohydrate, as well as their regulation, makes the drug 5 times more powerful than hydrocortisone.

Composition, release form and price

Metipred is produced by pharmaceutical companies in carton packs, the number of tablets can be 30 or 100 pieces per pack. The plates contain white tablets that are flat and round in appearance. On one side there is a strip along which the tablet can be divided into 2 equal parts. Also, Metypred is available in the form of a powder, from which a solution for intravenous injection is prepared.

The composition of the drug differs depending on the amount of methylprednisolone - a stronger and weaker drug is obtained, at 16 and 4 mg.

Each drug has auxiliary components:

• lactose monohydrate;
• gelatin;
• magnesium stearate;
• corn starch;
• talc.

The glucocorticosteroid is administered orally by the patient. For 1 package of 30 tablets, you will have to pay, on average, 200 rubles. Powder for injections is more expensive - 300-400 rubles.

Even in the presence of many positive properties, Metypred should be used with caution, because an overdose or prolonged use can cause serious illness in a patient. The action of the drug begins after 8 hours after taking, based on this, the best option would be to take it at breakfast.

Mechanism of action

Metipred (reviews of people taking the drug are based on the powerful effect that the drug has) has mechanism of action, which is designed for the interaction of tablets and steroid receptors located in cytoplasm.

Methylprednisolone, which is part of, directly affects proteins and enzymes that have a destabilizing effect on the body, cause immune and inflammatory reactions in the body. Taking the drug orally, the patient creates the necessary conditions for the activation of up to 80% of the active substance, which is perfectly absorbed in the stomach and intestines.

The drug has a complex effect on various processes in the human body:

• on his account, influencing various foci of inflammation, maintaining immunity and reducing depressive conditions;
• the drug increases the sensitivity of adrenergic receptors;
• the synthesis of albumin improves in the liver;
• helps to absorb carbohydrates in the digestive tract;
• reduces mineralization in human bone tissue;
• inhibits the connective tissue reactions of the body, which prevents scarring.

  

The antiallergic properties of the drug are due to a decrease in the synthesis and secretion of allergic mediators, a decrease in general sensitivity to allergens, adjustment of immunity and its changes, suppression of inflammatory process.

Indications for use

The drug is prescribed in cases of therapy for patients suffering from various diseases that require regular intake of glucocorticosteroid drugs.

Metipred is used in the following situations:

• in cases of poor functioning of the adrenal glands, when a small amount of hormones is produced;
• with severe allergic and inflammatory processes - aggressive forms of eczema, dermatitis or psoriasis;
• with hyperplasia - genetic proliferation of adrenal tissues;
• in the treatment of severe forms of arthritis, asthma, respiratory diseases, rheumatism;
• it is prescribed for patients undergoing chemotherapy as a remedy against chronic inflammatory processes;
• with an inflamed thyroid gland;
• in the case of the treatment of autoimmune diseases - leukemia or anemia;
• use by patients undergoing rehabilitation after operations that were associated with intracranial pressure - cerebral edema, various tumors;
• as an antiemetic in the treatment of cancer;
• reception after organ transplant surgeries - used as a preventive measure to reduce the risk of organ rejection;
• with nephrotic syndrome;
• hepatitis;
• lung cancer;
• in case of multiple myeloma;
• used in the treatment of multiple sclerosis - in the initial and acute stages.

As a medicine, Metypred has earned a lot of praise from both doctors and patients. All thanks to the powerful effect that the agent has on the human body. Tablets are used in the treatment of various diseases, they are actively prescribed by doctors.

Contraindications and side effects

Metipred, based on the reviews of people taking the drug as prescribed by a doctor, has many side effects. They are mainly associated with long-term use, overdose or individual intolerance to the components. The development of the following side effects is noted, mainly from the liver, gastrointestinal tract or the cardiovascular system of the body.

Immune, skin changes are frequent, the drug can affect the musculoskeletal system, the central nervous system and affect the development of other diseases.

The main side effects of pills include:

• vomiting, feeling of nausea;
• metabolic disorders, deterioration of the digestive system;
• the occurrence of ulcers on the intestinal or stomach mucosa;
• the occurrence of pancreatitis, bulimia in patients;
• there are individual cases of the development of gallbladder perforation;
• damage to the gallbladder - the appearance of candidal lesions;
• the development of heart failure;
• thromboembolism;
• constant jumps in blood pressure - it often rises;
• leukocytosis;
• can cause water retention in the body, lower the level of potassium in the patient's blood;
• the occurrence of osteoporosis;
• increased skin sensitivity, change in reaction to any skin tests;
• the appearance on the skin of various redness, rashes, constant itching in certain places, acne, the manifestation of urticaria or deterioration of regeneration;
• from the side of the tendons, a problem can also arise - they lose their elasticity and can rupture;
• the occurrence of Cushing's syndrome;
• relapse of tuberculosis;
• the appearance of pain throughout the body, an increase in body temperature, problems with the adrenal glands are not uncommon in situations of abrupt termination of the course of therapy.

The use of Metypred can contribute to the development of secondary insufficiency of corticoadrenal response or complicate the diagnosis of gastrointestinal diseases when they are just developing and are in latent period.

The drug also has a number of contraindications, which the patient should carefully read before taking the pills.

These include:

• individual intolerance to the components in the composition - this is especially true for the active active substance methylprednisolone;
• it is also not recommended to use the drug for those patients who have lactose intolerance;
• pills are not prescribed for patients with chronic diseases - viral, bacterial;
• with a latent or active form of tuberculosis - pills can provoke an acceleration of the development of the disease. Application is possible only in the case of active therapy of tuberculosis, to relieve inflammatory processes and reduce the gag reflex;
• extremely rarely, pills are prescribed to people suffering from diseases of the heart or circulatory system - arterial hypertension, heart failure;
• the drug can affect the patient's psyche, therefore it is not recommended for admission to persons with mental disorders;
• taking medication should be treated with caution by people suffering from diseases of the gastrointestinal tract.

Any physician deciding to prescribe Metypred should ask the patient for his family history. If there is a tendency to the development of diabetes mellitus, osteoporosis, glaucoma, if problems with blood coagulation are found, it is recommended to prescribe the tablets carefully.

If the patient suffers from liver disease or hypothyroidism, then the attending physician may prescribe the drug, but careful monitoring of the patient's condition will be required.

special instructions

The drug is prescribed to patients for many reasons, because it is suitable for the treatment of various diseases. Metipred is prescribed to patients by the attending physician - independent use of the drug is fraught with complications and can cause various side effects.

It is necessary to start taking it after consultation, the end of the course should also take place under the strict supervision of a doctor. You should also carefully combine drugs, because Metypred has the ability to enhance and suppress other drugs.

When planning a pregnancy

Metipred (reviews of people taking the drug are based on the use of tablets in their own therapy of various diseases) should be taken with caution by women who plan to have child. They use pills as one of their fertility treatments.

Often, changes leading to infertility are caused by diseases that negatively affect reproductive function. When planning a pregnancy, a woman consults with a doctor, while Metypred may be prescribed as a way to get rid of some disorders.

Pills can help in other cases as well:

• has a stabilizing effect on hormones;
• affects the foci of inflammation in the body;
• enhances the effect of other drugs;
• helps in eliminating the consequences of non-developing pregnancies, if any;
• affects fibroids in a woman's uterus - reduces them.

Basically, the drug affects the production of a large amount of male hormones in a woman's body - it slows down and normalizes this process.

With IVF

The appointment of Metypred to women with IVF occurs in cases where there have been miscarriages in the past or previous attempts to get pregnant with IVF have failed. At an early stage of pregnancy, using the IVF method, the fetus can be rejected by the immune system of the adult woman's body.

It is in this case that the drug has an effective effect - it stabilizes the immune system., reduces its aggressiveness and stabilizes the process of fertilization, bearing the fetus. Also, the drug is used in situations when the production of male hormones in a woman's body is increased.

During pregnancy and breastfeeding

The drug is actively used by women during gestation - it has a positive effect on a woman's immunity, also has a preventive effect, which makes it possible to successfully endure child.

Prescribing tablets during pregnancy is possible to stabilize and maintain normal hormones in a woman's body. According to research by scientists, Metypred does not affect the fetus, does not cause the development of intrauterine anomalies.

If possible, in the early stages of pregnancy, it is recommended to refuse to take any medications, but if a woman has serious illnesses, it is not prohibited to take it.

Taking Metypred in small doses when breastfeeding does not have any effect on a child, that is, it is considered a safe drug.

Can children be taken?

The drug can be administered to children from infancy. The appointment is appointed by the pediatrician, after the tests and examination of the baby. Treatment without prior consultation with a doctor is prohibited.

It is also necessary to strictly follow the directions and monitor the dosage. It is necessary to constantly monitor the growth and development of the baby by the pediatrician if a long course of the drug has been prescribed.

Application for impaired renal function

In case of impaired renal function, Metypred is prescribed only after consultation with the attending physician. Usually, tablets or injections are prescribed in cases of thermal insufficiency in Wegener's disease. In such situations, hormonal pulse therapy or immunosuppressive treatment is performed.

Overdose

Metipred (reviews of people taking the drug report that even in the case of an increase in the dosage of the drug, no there is no acute intoxication in the body) in case of an overdose it becomes the cause of chronic complications - work worsens adrenal glands.

If you find out that an excessive amount of the drug has been taken, it is necessary:

• Seek the advice of your doctor.
• If necessary, perform gastric lavage.
• Drink activated charcoal.

There are no special symptoms or consequences following an overdose. The active substance is excreted from the body on its own, during dialysis.

Instructions for use

Therapy with Metypred is prescribed to patients on an individual basis, after a complete examination and consultation with a doctor. For adults, the starting dosage of the drug starts at 4 mg and can go up to 48 mg. The dosage is set individually - it is based on an assessment of the course of the disease, its nature, clinical effect, and the presence of other diseases in the patient.

The use of tablets for serious diseases such as multiple sclerosis, brain edema, recovery after organ transplantation requires an increased starting dosage. The number of pills taken depends on how strong the substance was purchased and on the degree of therapy.

The completion of taking the drug should be carried out gradually - the dose is reduced, the use of tablets begins a day every other day.

Drug interactions

Often, the simultaneous administration of different drugs carries negative consequences - some drugs can enhance others or, on the contrary, completely suppress them.

Name, group of drugs	Interaction with Metypred
Non-steroidal drugs aimed at the treatment of inflammatory processes.	The ulcerogenic effect is enhanced.
Anticoagulants	There is a risk that bleeding will develop in the patient's body. The drugs are incompatible - the effectiveness decreases.
Anticholinesterase drugs	Patients with myasthenia gravis have an increased chance of developing muscle weakness.
Hypoglycemic drugs, insulin	Metipred has a strong effect and reduces the effect of taking other pills.
Enzyme inducing tablets	When taken simultaneously, the effectiveness of Metipred decreases.
Estrogens	The interaction of these drugs gives a reinforcing effect to the active substance of Metipred.
Tablets for vomiting, depression, which are used in chemotherapy.	The therapeutic properties are enhanced.
Cyclosporine	The patient is more likely to develop convulsions.
Vaccination use	If a patient undergoes a course of Metypred therapy and goes for vaccination, then he runs the risk of catching a viral disease.
Laxatives, diuretics	The excretion of potassium in large quantities begins from the body.

Before taking Metypred, you need to check which medications the patient is taking interact with the pills.

Storage conditions and periods

The shelf life of the tablets is 5 years from the date of their release, but only if stored correctly. If the drug is purchased in the form of a solution, then it is strictly forbidden to freeze it. Other forms of the drug should be stored in a dry place with temperatures up to 25 degrees.

The solution prepared for injection can be stored for a maximum of 1 day, under conditions of temperature from 2 to 8 degrees.

Analogs

Metipred (reviews of people taking the drug are shared) is taken purely individually - maybe there is an intolerance to the additional component or interaction with other discharged medicines.

Among the analogues, the following means can be distinguished:

• Betamethasone - the active active ingredient completely coincides, as well as the indications for use. The cost is 170 rubles. per tube.
• Methylprednisolone - a hormonal preparation, the active active substance also coincides, is included in the group of hormonal preparations. The cost of packaging is 300-500 rubles.
• Depo-mendrol - a drug with methylprednisolone in the composition, it is prescribed most often for endocrine diseases, it is included in the group of hormonal drugs. Price in pharmacies 260-400 rubles.
• Advantan - sold in the form of an emulsion or cream, it contains methylprednisolone, it is used to treat dermitis, eczema of varying severity. The price starts from 600 rubles. and goes up to 1000.

Judging by the reviews of people taking the drug, Metypred is used in the treatment of various diseases. Its action depends on the individual susceptibility of the organism.

The drug is prescribed and sold only by prescription, since self-treatment can lead to the development of dangerous diseases. Each specific case requires careful research and further medical supervision, based on the tests performed, the dosage of the drug is prescribed.

Video about the drug Metipred

Experience of using Metypred: