The preparation Hyalurum is manufactured by the Romanian company "Rompharm Company".The agent is an aseptic, viscoelastic fluid intended for insertion into the joint.
The active substance is sodium hyaluronate, which is obtained as a result of fermentation and does not contain animal proteins, which reduces the likelihood of allergies to a minimum. Produce a synovial fluid prosthesis in 2 ml disposable syringes.
Contents of the article
- Mechanism of exposure
- When is the drug prescribed?
- When to refuse injections
- Assignments to specific categories of patients
- Possible unwanted reactions
- Treatment Scheme
- Things to remember!
- Precautions
- Storage Conditions and Leave
- Integrated Opinion
- What can replace the synovial prosthesis?
Mechanism of exposure
Sodium hyaluronate is a glycan that is distributed in the human body everywhere, it is abundant in the vitreous humor, synovia, 
umbilical cord and dermis.
In synovia, sodium hyaluronate performs the function of lubrication, it is she who helps a person to move normally without feeling pain.
In such pathologies as arthritis, viscoelasticity of synovia decreases, as a result, the mechanical stress on the joint increases significantly and the resorption of cartilaginous tissue intensifies, which is manifested by a decrease in the amplitude of movement in the joints and the appearance of pain during walking.
Sodium hyaluronate restores visco-elastic, lubricating and damping qualities of synovia, activates the production of hyaluronic acid and complex proteins of extracellular matrix of cartilaginous tissue.
In addition, sodium hyaluronate covers the entire internal surface of the joint and protects the synovial membrane and cartilage from trauma, free radicals and mediators of inflammation.
Intra-articular injections of the drug Hyalur have an antioxidant, analgesic, anti-inflammatory and chondroprotective effect. Therefore, it is also called an "implant joint" or "liquid prosthesis."
The result after one course of therapy persists up to six months.
When is the drug prescribed?
The preparation of Hyalurum is injected into the joint:
- with pain and with a decrease in the amplitude of motion in the joints of , which is associated with degenerative-
dystrophic pathologies such as osteoarthritis and osteoarthritis, as well as injuries to the knee, hip and other mobile joints; - for the replacement and replacement of synovial deficiency ;
- as an additional lubricant for during arthroscopic manipulations and other surgical procedures;
- for the prevention of the onset of and joint wear in patients with active lifestyles and constantly loading the affected joint.
When to stop injecting
You can not do hyaluria injections if the patient has:
- hypersensitivity to the active ingredient and auxiliary components;
- infectious skin diseases at the site of drug administration;
- infection of the joints;
- complete destruction of cartilaginous tissue;
- problems with blood clotting;
- pregnancy;
- lactation period;
- child and adolescence.
Assignments to specific categories of patients
Hyaluron should not be used during pregnancy, as there is no evidence to prove the safety of injections for such patients. It is known that sodium hyaluronate can provoke stress for the body, leading to premature birth.
Sodium hyaluronate penetrates into the mother's milk and can adversely affect the health of the child, so during lactation it is better to refuse injections of the drug.
Currently, there are no facts confirming the safety of the drug treatment in patients younger than 18 years of age. Therefore, in pediatrics, the drug is not prescribed.
Elderly patients do not need to adjust the dosage regimen of the drug.
Persons suffering from liver and kidney disease, the solution is administered in normal doses.
Possible adverse reactions
Sodium hyaluronate is well tolerated by patients. Only occasionally at the site of the injection can be observed:
- painful sensations;
- hyperemia;
- local body temperature increase;
- swelling.
All these symptoms take place within 1-3 days. You can impose a cold for 5-10 minutes, then these phenomena will pass faster. Local anesthetics and anti-inflammatory drugs are allowed.
Treatment Scheme
Hyaluron can only be administered intra-articularly. The injection should be done by a doctor who has permission to do so. Before the introduction of the 
liquid implant, it should be maintained at room temperature for half an hour.
In large joints, for example, 2 ml of the drug are allowed to enter the knee, in small - 1 ml. It is inadmissible to inject more than 2 ml into the joint at a time.
Injection is done in one damaged joint 1 time in 7 days. The course of 3 pricks. Repeated treatment for the same joint is allowed after six months. At the same time, several joints can be treated.
Before injection of the drug, it is necessary to remove the effusion from the joint with a syringe, if available. The joint needs complete rest, the purpose of cold therapy or intra-articular administration of glucocorticosteroids is indicated. And only after 48-72 hours after that it is allowed to introduce a synovial prosthesis.
It is not necessary to dilute the solution with Hyalur before injection, it is already ready for use.
The solution is intended for single use only. Its repeated sterilization is forbidden. Unused remnants of the drug must be destroyed with a syringe.
The drug should be administered in accordance with the rules of asepsis. The site of the injection should be disinfected with an alcoholic napkin, wait until it dries and inject the drug.
For this, the prepared syringe is taken from a sterile case, the protective cap is removed, a sterile needle is put on, which is fixed with a slight turn.
Before blowing a syringe, it is necessary to remove air bubbles.
If painful sensations increase during the injection, then injects the drug further is prohibited. The needle must enter easily and without resistance - this indicates that all manipulations are performed correctly.
No cases of overdose with Hyaluron solution have been recorded at present. Since it refers to drugs of strict accountability, and only the health worker is allowed to do the injection.
Things to remember!
The following points should be considered:
- solution should be administered only by a certified specialist, in compliance with aseptic rules;
- is inadmissible to freeze and sterilize a "liquid implant";
- use it after the expiry date;
- exceed the permissible dosage;
- engage in self-medication, as this can be dangerous to health.
Precautions
Before starting treatment, you need to examine the patient and if symptoms of an acute inflammatory process are detected, you must first stop them and then start therapy.
After the injection it is forbidden to overload the joint for the first time, it is advisable to observe a gentle regime for several days.
If after the administration of the drug pain syndrome is observed, then it is necessary to consult the attending physician without delay.
It is unacceptable to simultaneously inject the solution with Hyalur with other intraarticular preparations, and also mix it with any medicines in one syringe.
Hyalur solution does not affect the ability to drive.
Storage conditions and leave
The drug is prepared as a ready-made injection for 1 or 3 injections per package. Each syringe contains 15 mg of sodium hyaluronate diluted with saline solution.
Store the solution at a temperature of not more than 25 degrees, not allowing it to freeze. In a place protected from children, moisture and light. The shelf life of the solution is 36 months, after which it is subject to destruction.
It is released strictly according to the prescription of the doctor, as only the specialist who has undergone special training should introduce the drug.
Comprehensive opinion of
Reviews of patients and doctors who practice the appointment and application of Hyaluron in their practice.
I suffer from arthrosis of the knee. The doctor prescribed injections of the solution with Hyalur. I've done them already more than 6 months ago. The injections themselves are quite painful and unpleasant. But the effect of them persists for a long time. The doctor said that a second injection would be needed in a year.
Maria
Has done more than once the injection of the drug. Until the last time everything was fine, but after the last injection the knee was swollen, it hurt to walk, the fever started. I called an ambulance, and went to the hospital.
It turns out that the last time an injection was made, they did not hit the joint. It's good that I asked for help at the time.
Maxim
Hyaluron is well tolerated by most patients and shows good results in the treatment of degenerative-dystrophic diseases, when the cartilage is deformed and depleted, but not completely destroyed. Therefore, before the start of therapy, it is necessary to make the X-ray of the damaged joint in two projections. And only if arthrosis of 2 and 3 degrees is observed, it is necessary to start treatment. There is no point in administering the drug if arthrosis of 1 degree is detected, but there are no clinical manifestations of pathology.
Also, before you do the injections, you need to give a general blood and urine test.
Sergey Mikhailovich, rheumatologist
How can I replace the synovial prosthesis?
Today, there are many solutions for intra-articular injection containing sodium hyaluronate. 
- Fermatron;
- Ostenil.
The Russian substitute for Hyaluron is the drug Hyastat.
