Equator (Ekvator) tablets from pressure. Instructions for use, reviews, price

Since hypertension can be caused by many causes, monotherapy of the disease is ineffective. In 75% of cases, pills that eliminate one of the provoking factors - increased blood pressure, at the same time enhances the action of the other, reducing the positive effect to zero and harming the body. Complex drugs are devoid of these disadvantages, one of which is Equator. However, before purchasing it, you must carefully study the instructions for use.

Composition, release form

A hypothetical drug from the largest pharmaceutical concern Gedeon Richter, known in Russia as Equator, was recognized in 2006. in Hungary "Medicine of the Year".

This is due to the advantages of the product:

• efficiency;
• long term of action;
• the minimum of therapeutic doses.

The action of the drug is aimed at expanding the coronary vessels and maintaining them in this state for a long time.

Equator tablets from pressure (instructions for use should be studied in advance) have a therapeutic effect due to the presence of the following ingredients:

Component	Description
Amlodipine	Biologically active substance belonging to the group of AK (calcium antagonists). By reducing the activity of calcium channels, the pathways by which calcium ions (Ca2+) enter the cardiomyocytes, amlodipine eliminates excess calcium in the muscle fibers of the walls of the coronary vessels, causing them to relax and expand. The component provides: hypotensive effect: a decrease in blood pressure on the walls of the coronary and peripheral vessels, or blood pressure (BP); antianginal effect: due to vasodilation, the load on the heart is reduced and, accordingly, the need for oxygen decreases. Expansion of the coronary vessels helps to improve the supply of oxygen to the heart muscle.
Lisinopril	The active substance belongs to the class of ACE inhibitors. It has the ability to block the angiotensin-converting enzyme (ACE), without which the synthesis of angiotensin II, a substance with a pronounced vasoconstrictor effect, is impossible. By reducing the amount of angiotensin II, lisinopril maintains the dilated vessels, providing a long-term effect of the drug. In addition, lisinopril has a beneficial effect on the heart muscle: prevents a pathological increase in its volume (hypertrophy); strengthens; restores damaged tissues; reduces the risk of complications after a heart attack.
Excipients	Sodium carboxymethyl starch and microcrystalline cellulose, which ensure the bioavailability of the tablets and give them certain parameters: shape; weight; strength; the ability to collapse under the influence of liquid.

The therapeutic effect is noticeable 1 hour after taking the drug, reaches a maximum after 6 hours and lasts for 24 hours. After, Amlodipine, entering into a biochemical reaction with liver enzymes, forms metabolites that do not have medicinal properties, and is excreted through the kidneys (approximately 60%) and through the intestines. The half-life is from 30 to 50 hours. Lisonopril, not having the ability to biotransformation, is excreted unchanged from the body by the kidneys, with urine. The half-life is 12 hours.

Due to the combined action of amlodipine and lisinopril, mutually reinforcing and complementing each other, the Equator is not only effectively reduces blood pressure, but also maintains its normal values ​​for a long time, reducing the daily dose to 1 pills.

When using the combination "amlodipine + lisinopril", the risk of developing undesirable effects is minimized, which may occur when these drugs are taken separately.

Equator is produced in the form of white tablets with a chamfer on one of the surfaces and a relief inscription "A + L" on the other.

The tablets are packaged in blisters and packed in a cardboard box, which indicates:

• name of the drug;
• the amount (in mg) of the 1st and 2nd active ingredients;
• number of tablets.

In pharmacies "Equator" is offered in several versions:

Amlodipine amount (mg)	Amount of lisinopril (mg)	Number of tablets in a package (pcs.)
5	10	30
10	20	30
5	10	10
10	20	10
10	20	60
10	10	30

Terms of dispensing from pharmacies, drug price

Equator tablets from pressure (instructions for use contain detailed information on the nuances of use, indications and contraindications), if taken uncontrolled, can be dangerous. In pharmacies, the drug is dispensed strictly according to the doctor's prescription. Depending on the amount and percentage of active substances in the 1st tablet, as well as the number of tablets in the package, the price of one pack varies from 500 to 650 rubles.

Indications and contraindications

The main and only indication for the use of the Equator is essential (primary) hypertension. Equator can also be prescribed as part of substitution therapy for patients who have previously taken drugs based on ambolodipine and based on lisinopril, in order to reduce the drug load on organism.

Among the contraindications:

• pathological reaction to the drug, expressed in the development of extensive Quincke's edema, covering the skin, subcutaneous layer, mucous membranes of internal organs;
• large defects in the structure of the heart muscle, manifested by a narrowing of the aorta or mitral valve, which can affect the movement of blood through the vessels;
• thickening (hypertrophy) of the walls of the ventricles;
• hypotension (severe);
• a state of cardiogenic shock, in which the force of contractions of the heart muscle sharply decreases, as a result of which the process of supplying blood to organs and tissues is disrupted;
• pregnancy and lactation period;
• children's age (up to 18 years old);
• intolerance to any ingredients of the drug, allergies.

Instructions for use

Equator tablets from pressure (instructions for use contain clear information on the rules of admission) is taken daily, 1 tablet, regardless of the meal. The concentration of active ingredients is indicated by the doctor and is determined by the optimal initial or maintenance dose. If necessary, the dose is adjusted in the direction of decreasing or increasing.

In the first days after the start of treatment, there is an improvement in the patient's condition with increased blood pressure, but to obtain stable normal values, a course of 1-2 months is required. The drug is not addictive, and there have been no cases of the development of "withdrawal syndrome" (a sharp jump in pressure after stopping the intake).

special instructions

Self-treatment with Equator or a violation of the admission regimen can lead to a number of complications.

There are also certain restrictions on taking this drug in the presence of the following pathologies:

Pathology	Description
Low pressure	Typical for patients with low circulating blood volume, taking diuretics, or for other reasons experiencing fluid deficiency. Treatment with Equator is possible after elimination of the symptoms of dehydration, constant monitoring of blood pressure is required.
Stenosis of the aorta and / or mitral valve	For patients with these pathologies, the drug is prescribed in the lowest possible doses and under constant medical supervision.
Kidney pathology	In order to select the smallest, therapeutic effect, doses, separate administration of amlodipine and lisinopril is first practiced, accompanied by the control of kidney function. Based on the information received, a conclusion is made about the possibility or impossibility of using the Equator.
Quincke's edema	When edema appears that is localized on the face or extremities, the Equator is stopped, the patient is prescribed antihistamines. If there is no effect or an increase in symptoms (laryngeal edema), injections of epinephrine and antihistamines are performed.
Liver failure	In diseases associated with defective liver function, the half-life of amlodipine is lengthened. To date, there are no official recommendations regarding dosing methods for such cases. The drug is prescribed to the patient only after evaluating the appropriateness of its use.
Neutropenia	In rare cases, it occurs as a result of taking ACE inhibitors (including lisinopril). As a rule, after discontinuation of the drug, the blood composition is normalized.
Cough (dry, unproductive)	Sometimes it occurs as a reaction to the effects of lisinopril and disappears when the drug is discontinued.
Hyperkalemia	When treated with Equator, it can develop in patients suffering from diabetes mellitus, kidney disease, acidosis. It is also possible while taking potassium-containing drugs with the Equator. In order to prevent complications, constant monitoring of potassium levels is recommended.
Heart failure	In patients with heart disease, taking amlodipine may increase the risk of complications. For this reason, it is recommended to replace Equator with a preparation that does not contain calcium antagonists.
Poison desensitization	Desansibilization is a method of treating an allergy to wasp and bee stings by introducing gradually increasing doses of poison into the body. The simultaneous administration of poisonous drugs and ACE inhibitors can cause the development of anaphylactic reactions, for this reason it is advisable to separate these procedures in time.
Hemodialysis	In some cases, associated with the use of membranes based on polyacryl, this procedure, in combination with the administration of lisinopril, can cause anaphylactic reactions. It is recommended to use a different type of membrane or use antihypertensive drugs that do not contain ACE inhibitors.

At the first receptions of the Equator, which causes a sharp decrease in pressure, you may experience:

• dizziness;
• slow response;
• feeling tired.

At the initial stages of treatment, it is recommended to abandon driving a car and engaging in activities associated with a danger to others, requiring extreme attention and concentration.

For patients of small stature or underweight, a dose adjustment downward may be required. In the process of treatment with Equator, control of body weight and regular visits to the dentist are desirable in order to prevent various diseases of the oral cavity.

Elderly patients (over 65 years of age) should be prescribed Equator under the condition of constant medical supervision and after determining the minimum dose. As a rule, for this purpose, at the beginning of treatment, lisinopril and amlodipine are prescribed separately.

During pregnancy and lactation

Equator tablets for pressure (instructions for use contain information on contraindications of the drug to pregnant and lactating women), during pregnancy and lactation are prohibited. No studies have been conducted to confirm its safety. If a woman has previously taken Equator, then she should stop taking it.

In the case when a pregnant or lactating woman needs to take antihypertensive drugs, she is transferred to drugs whose safety has been confirmed by clinical and laboratory tests.

Terms and conditions of storage

The equator is suitable for 3 years from the date of manufacture, provided that it is stored correctly: temperature - no higher than 25^O C, without access to light.

After the expiration date, the drug must be disposed of.

Analogs

To date, to normalize (lower) blood pressure, several groups of drugs are used that give antihypertensive effect, but differing in the mechanism of action, as well as complex preparations, the ingredients of which belong to different groups.

When choosing a specific remedy, the cause of hypertension is taken into account; its type (primary, secondary), other features.

Tablets from pressure as analogues of the Equator (instructions for their use may differ from the original) the following can be prescribed:

Type of drugs	Description
Diuretics	These are diuretic drugs. Their mechanism of action is based on the ability to accelerate the excretion of sodium from the body, a substance that contributes to the narrowing of the coronary vessels. This group of drugs includes: Indapamide, Indap, Arifon - preparations with the active substance indopamide, which has the properties of a diuretic and a calcium channel blocker. The price for a package (30 tablets) varies from 87 to 265 rubles; Hydrochlorothiazide, Hypothiazide - diuretics based on hydrochlorothiazide (a diuretic with hypotensive properties). They are used to lower blood pressure, as a decongestant, as a prophylaxis of urolithiasis. The price of a package for 20 tablets is 60-76 rubles. Diuretics, if taken carelessly, can cause: seizures; paresthesia (feeling of "creeping creeps"); numbness of the fingers; heart rhythm disturbances.
Beta blockers	Drugs that reduce the frequency of myocardial contractions and normalize blood pressure due to partial blockage β1-adrenergic receptors, sensitive to adrenaline and "working" to accelerate the heart rate and increase HELL. Beta blockers are: Atenolol and Atenolol-Ozone are products with the main active ingredient atenolol, which has β-blocker properties. Applications: hypertension; various conditions requiring a decrease in the load on the heart: heart attack, angina pectoris, tachycardia. Package price (ranges from 23 to 43 rubles; Metoprolol, Betalok, Metocard, Egilok - drugs with the active substance metoprolol (beta-blocker), which are used for hypertension, arrhythmias, angina pectoris, as well as for the prevention of migraines. Price for 1 package - 125-300 rubles; Bisoprolol, Bidol, Biol, Bisomor - antihypertensive drugs based on the beta-blocker bisoprolol. They are used for hypertension, chronic heart failure, as a prophylaxis for angina pectoris. Bisoprolol packing price - 90 rubles; Nebivolol, Nebilet, Nebilong, Nebikor are drugs with the active substance nebivolol (β-blocker). The price for a pack of Nebivalol is 370 rubles. Beta blockers are often the cause of: allergic rashes; weakness; ailments.
Calcium channel blockers (CCBs)	Drugs that reduce the amount of calcium in cardiomyocytes, promote relaxation of muscle fibers and vasodilation. The drugs that have the properties of CCBs include: Verapamil, Verogolid, Isoptin are antihypertensive drugs that can normalize the heart rate and increase the flow of oxygen to it. The active ingredient in them is verapamil. Verapamil packaging cost - 110 rubles; Amlodipine, Amlotop, Cardiolopin, Amlorus are drugs that lower blood pressure by blocking amlodipine, calcium flow into cardiomyocytes and expansion of coronary vessels. They also have an antianginal effect. The price of 1 package of Amlodipine is 156 rubles; Nifedipine, Cardafles are drugs based on nifedipine, a calcium antagonist that reduces the muscle tone of the coronary vessels, contributes to their expansion and increases the flow of oxygen to the heart. The price of 1 package of Nifedipine is 30 rubles; Felodipine, Felodil, Felotens are antihypertensive drugs with the active substance filodipine, which reduces the supply of calcium to the cells of the heart muscle. The price of 1 package of Felodipine is 300 rubles. CCBs can cause heart palpitations and mild dizziness attacks.
Alpha blockers	They directly affect the blood vessels, causing them to dilate, due to the blockade of the receptors responsible for their narrowing (α1-adrenergic receptors). This group includes drugs: Doxosazin, Zoxon, Kamiren - antihypertensive drugs based on α blocker1 adrenergic receptors doxosazin. Price per package - 270 rubles; Urapidil, Ebrantil - preparations with the active substance urapidil. The price of one pack is 1490 rubles.
Combined drugs	Preparations that contain 2 active substances belonging to different groups. Due to their complex composition, they have a more pronounced effect, give fewer side effects and require 1 dose per day. The most commonly used combinations are: diuretic + β-blocker. These include, for example, Bisangil, a drug that contains hydrochlorothiazide (diuretic) and bisoprolol (β-blocker). The remedy is used for mild to moderate manifestations of hypertension. Price per package - 256 rubles; diuretic + ACE inhibitor. EXAMPLE Accuzid containing hydrochlorothiazide (a diuretic) and quinapril (an ACE inhibitor). The tool is used to eliminate hypertension. Packing cost - 450 rubles; diuretic + angiotensin II receptor blocker. A representative of this group of drugs is Vasotens, which contains a diuretic hydrochlorothiazide and an Angiotensin blocker losortan. You can buy Vasotez at the price of 355 rubles; CCB + ACE inhibitor. This group includes the Equator, its other representative is Enanorm, which contains enalapril (an ACE inhibitor) and nitroneedipine (CCB). The drug is used for essential hypertension, its cost is 500 rubles.

Equator tablets belong to a combination drug, which is not without its drawbacks. However, it has high efficiency, prolonged action and minimal drug burden on the body. If you take it in accordance with the doctor's prescriptions and instructions, then the result in the form of ideal indicators "120/80" will not keep you waiting.

Video about the drug Equator

Description and instructions for Equator tablets: