Azidrop (Azitrop) drops in the eye. Instruction, price, reviews

Azidrop is a drug antimicrobial action, which is produced by the French pharmaceutical company "Laboratoire Unither". Drops are designed to be instilled into the eyes with signs of an infectious and inflammatory process. The medication is used as the main or auxiliary agent, depending on the severity and severity of the ophthalmic disease.

Release form

Azidrop comes in the form of a clear drip solution for the eyes, which has an oily consistency. The drug is completely colorless, or has a light yellowish tint. The filling of the drug is carried out in polyethylene bottles that contain a single dose of the drug. All bubbles of the drug Azidrop are soldered together in a continuous tape. One row contains 6 single doses in sealed bags of combination material. The main packaging of drops is a cardboard box.

Composition of the preparation

Azidrop - eye drops, which belong to the pharmacological group of ophthalmic solutions with antibacterial action. This drug is designed for topical use. The table below shows the constituent substances of this medication.

Compound	Chemical dosage and description
Azithromycin dihydrate	The active ingredient in eye drops is Azidrop, which is presented at a concentration of 15 mg per 1 g of the drug. By its nature of origin, it is an antibiotic azalide, belonging to the 2nd generation of drugs in this group. The indicated dosage corresponds to the content of pure azithromycin in the range of 14.3 mg.
Medium chain triglycerides	An excipient, which is presented in the composition of ophthalmic drops at a dosage of up to 1 g.

Many people misspell and pronounce the name of this drug. For example, "Azitrop". Although the correct spelling of the drug should be performed through the letter "d" - "Azidrop".

Pharmacological properties

The action of Azidrop eye drops is due to the biochemical activity of their constituent components.

This drug has the following pharmacological properties:

• has an antimicrobial effect, reducing the number of bacterial microorganisms;
• relieves the inflammatory process in the structure of the eyeball;
• reduces the severity of the edematous process caused by infectious inflammation;
• accelerates the restoration of vision, which was reduced due to infection of the eyeball with bacterial microorganisms.

Pharmacological drops Azidrop appear in relation to infectious strains with individual sensitivity to the antibiotic azalide - azithromycin. The therapeutic properties of the drug are realized in the first 24 hours from the beginning of the course use of the ophthalmic solution.

Pharmacodynamics and pharmacokinetics

Azidrop - eye drops that have passed multiple clinical trials for safety for the body of patients of different age categories. The manifestation of the pharmacodynamic properties of this medication occurs by inhibiting protein synthesis in the cell of a bacterial infection. Azithromycin binds to ribosomes of pathogenic microorganisms, preventing further translocation of their peptides. The principle of action of this type of eye drops is to destroy the cellular structure of the bacterium, which is deprived of the ability to reproduce daughter cells.

Infectious microorganisms of the following types are sensitive to the active component of Azidrop eye drops:

• Staphylococcus aureus;
• streptococcal infection;
• enterococcus;
• chlamydia;
• gonococcus;
• enterobacterial infection.

The constituent components of the drug Azidrop have positive pharmacodynamic activity in relation to most bacterial microorganisms of the anaerobic and aerobic type, which are capable of causing purulent-inflammatory processes in the organ vision.

The pharmacokinetics of this medication is manifested locally. The constituents of the eye drops do not saturate the composition of the general bloodstream and lymphatic fluid. Azidrop is evenly distributed over the tissues of the diseased organ of vision, showing therapeutic properties exclusively in the area of ​​solution application. According to clinical trials, the detection limit of azithromycin in human blood is a single application of a dosage of 0.0002 μg of active substance per ml. Pharmacokinetic studies were carried out on patients of the adult age group.

Indications for use

Azidrop - drops in the eyes, which have indications for their use as the main or auxiliary therapy:

• trachomatous conjunctivitis, the causative agent of which is the bacterial microorganism Chlamydia trachomatis;
• uncomplicated forms of conjunctivitis caused by infectious strains that are sensitive to azithromycin;
• bacterial conjunctivitis, accompanied by abundant accumulation and discharge of purulent contents (this form ophthalmic disease is most often caused by Staphylococcus aureus and streptococcal infection, which requires systemic therapy).

The decision on the advisability of using Azidrop drops in a specific clinical case should be made by an ophthalmologist after a preliminary examination of the patient. In medical practice, there are situations when monotherapy with this drug is sufficient to restore the tissues of the eyeball. Complicated cases of bacterial infection of the eyes require combined treatment with the simultaneous use of not only Azidrop, but also additional antimicrobial agents.

Contraindications

Eye drops Azidrop have a minimum number of restrictions on their use. This is due to the local action of the constituent substances of the drug. This drug is contraindicated in adults and children who have been diagnosed with individual intolerance to azithromycin or other chemical compounds that make up the medicinal solution.

Treatment with Azidrop drops should also be abandoned by patients who have previously experienced the manifestation an allergic reaction in response to taking antibacterial agents from the pharmacological group macrolides. There is a high likelihood of a recurrence of similar symptoms.

Clinical studies have shown that due to the local action of azithromycin in the form of a drop solution for the eye does not overcome the placental barrier, and also enters the composition of breast milk in minimal quantities. This amount of antibacterial agent is not able to have a negative effect on the child's body. In this regard, the drug Azidrop is approved for use in relation to women who are in a state of pregnancy, as well as breastfeeding a newborn baby. The constituents of the medication do not affect the fertility level of men and women.

At what age can the drug be used?

Azidrop - drops in the eyes, which are considered safe for the body of adults and children. This medication is approved for use in patients of newborn age from the first days after their birth. Elderly people do not need to adjust the therapeutic dosage or establish a special regimen for the use of this agent.

Instructions for use, dosage

Adults and children are prescribed the use of the ophthalmic drug Azidrop 2 times a day (morning and evening). The medication is introduced into the conjunctival sac of the diseased eye 1 drop at a time. The standard duration of a therapeutic course is 3 days. In the absence of signs of positive dynamics to improve the general condition of the organ of vision, disappearance of signs inflammatory process, it is necessary to re-examine by an ophthalmologist with further adjustment of the regimen therapy.

A prerequisite for successful treatment with Azidrop is a preliminary examination of the eyeballs for bacterial microflora. Purulent exudate and lacrimal fluid separated from the organ of vision are subjected to microbiological examination to establish a strain of pathogenic bacteria. This will allow Azidrop drops to be used against infectious agents that are indeed sensitive to azithromycin.

The table below provides step-by-step instructions for using the ophthalmic agent Azidrop:

Step-by-step algorithm of actions	Description of therapeutic manipulations
Step 1. Performing hygiene procedures.	Before proceeding with the introduction of the medicinal solution into the tissues of the diseased eyeball, you must thoroughly wash your hands, and then wipe them dry with a clean towel. Do not open the disposable dropper bottle with dirty hands. Such actions are fraught with infection of the organ of vision with a secondary infection.
Step 2. Autopsy of the medication.	Open the lid of the single dose vial of this drug. Make sure that the mouth of the dispenser is free for the drug solution to pass.
Step 3. The introduction of the drug.	The bottle with drops must be brought to the surface of the eyeball at a distance of 1 cm. By pressing on the walls of the vial with the medicine, 1 drop of the solution should be squeezed onto the surface of the conjunctival sac.
Step 4. Distribution of the drug.	After the medication has got on the mucous membrane of the organ of vision, it is necessary for 3-5 minutes. close the sore eye so that a uniform distribution of the medicinal solution occurs. At this stage of the therapeutic process, a slight burning sensation and a painful sensation may be felt, which is normal reaction of inflamed tissues in response to exposure to chemical components of the ophthalmic funds. The patient's head at this moment should be thrown back to prevent spontaneous leakage of the drug from the conjunctiva of the eye.
Step 5. Skin surface cleaning.	After 3-5 minutes. after applying drops of Azidrop to the surface of the eyeball, it is necessary to take a sterile cotton tampon, and then remove from the surface of the skin around the eye the remnants of the drug and lacrimal liquids. Then it is recommended to wash your hands again with soap and water.

During the introduction of the ophthalmic agent on the surface of the conjunctival sac, it is necessary to ensure that the tip of the dispenser of the bottle does not come into contact with the eyelid. Upon completion of the therapeutic procedure, the vial with the remains of the medication is disposed of together with household waste. The contents of each bottle can only be used once. Storage of drops with further repeated use of the ophthalmic agent, which remained in a disposable dropper, is fraught with infection of the eye with microorganisms of other strains.

Side effects

Most of the side effects associated with the use of Azidrop are manifested in the form of a local allergic reaction.

During drug therapy, symptoms may occur:

• sensation of a foreign body in the structure of the eye;
• a feeling of cutting and burning, which appears immediately after the introduction of the medicinal solution to the surface of the conjunctival sac;
• adhesion of the upper and lower eyelids (the oil solution of this medication can cause an uncomfortable sticking sensation in the eye, which immediately disappears after rinsing it with water);
• the appearance of fog before the eyes and a decrease in visual acuity (this symptom is of a short-term nature, but its presence is the basis for an immediate appeal to the attending physician);
• active lacrimation;
• redness of the mucous membrane of the diseased eye with increased edema of epithelial tissues located in the circumference of the organ of vision;
• erythema of the surface of the eyelids;
• tingling sensation in the structure of the eyeball.

The appearance of the above side effects indicates that the patient's body shows an individual intolerance to the constituent components of the drug. Immediately after the detection of this symptomatology, it is necessary to stop further use of Azidrop drops, and then immediately visit an ophthalmologist. In the presence of acute signs of an allergic reaction, you will need to undergo a course of antihistamine therapy.

Overdose

1 disposable vial with a medicinal solution of Azidrop contains the optimal concentration of the active substance in the form of azithromycin, which is sufficient for the therapy of 2 eyeballs. Taking the medication by mouth or accidentally administering it intravenously will not cause symptoms of an antibiotic overdose. Deliberate violation of the prescribed dosage regimen with Azidrop drops can lead to side effects in the form of a local allergic reaction. These symptoms are described in the section above.

special instructions

During therapy with Azidrop, the following recommendations must be observed, which are prescribed by the manufacturer of these drops:

• The ophthalmic solution cannot be administered into the body in the form of intramuscular, intravenous injections or ingested.

  

• The appearance of the slightest signs of an allergic reaction is the basis for discontinuing treatment with Azidrop.
• The maximum duration of the therapeutic course with this medication is 3 days. The drug should not be used longer than the specified time, even if signs of a bacterial infection persist in the organ of vision. In such a situation, it is necessary to switch to eye treatment with more potent medicines based on other active substances.
• Patients diagnosed with conjunctivitis of bacterial etiology should refuse to wear contact lenses.
• Systemic use of drugs based on azithromycin can cause the development of a fulminant form of hepatitis with the threat of acute liver failure. Therapy with Azidrop drops with a local action of the active substance avoids such consequences.
• In newborn infants and children under the age of 3 years, dangerous diseases of the body in the form of bacteremia and infectious pneumonia can be accompanied by the manifestation of conjunctivitis. In this case, patients need systemic treatment with combined drugs.

There are no clinically confirmed data on the effect of the constituent substances of the drug Azidrop on the reaction rate and the level of concentration. If signs of blurred vision, active lacrimation appear, it is necessary to refrain from control vehicles, mechanisms, technological equipment, and also do not perform work with increased danger.

Drug interactions

Laboratory studies on the drug interaction of Azidrop drops with medicines of other pharmacological groups have not been carried out. The introduction of this drug is recommended to be performed last, but not earlier than after 15 minutes. after instillation of drip solutions based on other biochemical components.

The use of this approach will minimize the risk of undesirable side effects in the form of local allergic reactions. In the process of searching for the drug Azidrop, it is necessary to pay attention to the fact that the name of the drug is written with the letter "d", and not through the "t". Many people prescribe this drug called Azitrop, which is misleading.

Azidrop's analogs

The table below shows ophthalmic preparations that are analogs of Azidrop drops.

Name of the medication	Characteristics of the medicinal product
Tobrex	A medicinal solution that is effective against most ophthalmic diseases of an infectious nature. This medication is prescribed in 1-2 drops to be applied to each eye. The duration of treatment is determined by the doctor. Contraindicated for use in pregnant women and breastfeeding women. The average cost of the drug is 240 rubles.
Sulfacil	This agent has a different active substance in the form of sodium sulfacyl, but it has a similar antimicrobial effect. The drug is applied in 1-2 drops to each sore eye. The price of the medication is from 20 to 60 rubles. for a bottle of 5 ml.
Futsitalmik	Ophthalmic agent from the category of fusidins. Differs in effectiveness in the treatment of eye diseases caused by Staphylococcus aureus. This remedy is used in 1-2 drops in each eye 2 to 3 times a day. The cost of the medicinal solution is 480 rubles. for a bottle of 5 ml.

The appointment of the above drugs with similar properties should be performed only by an ophthalmologist after a preliminary examination of the patient.

Terms, conditions of sale and storage

The purchase of Azidrop eye drops is possible only on the basis of a prescription from an ophthalmologist. The storage of the medication should be carried out away from children in a room or container where the air temperature is in the range from +2 to +8 degrees Celsius. The medicinal solution must be left in its original packaging. It is impossible that during the storage of drops on the surface of the bottle, direct sunlight should not be affected.

Price

The average cost of this drug is from 286 to 383 rubles. per pack of 6 disposable dropper bottles. Azidrop is an antibacterial drops based on the active substance azithromycin. This component has antimicrobial, antiseptic and anti-inflammatory properties.

The advantage of using this drug is that the effect of the antibiotic extends exclusively to the tissues of the eyeball. Azithromycin does not saturate the composition of the bloodstream, does not overcome the placental barrier, does not go through the complex process of metabolism in the patient's liver. Drops of Azidrop are applied to the sore eye 1 drop 2 times a day for 3 days. Longer use of the medication is contraindicated.

Video about the active substance of Azidrop drops

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