Clopidogrel (Clopidogrelum) analogues and substitutes for the drug. Price

Clopidogrel is effective antiplatelet drug, used to prevent the formation of blood clots in patients with a tendency to blood clots. Analogues and some drug substitutes have similar properties, therefore they are used in case of intolerance to the components of Clopidogrel.

Since the agent belongs to the group of antiplatelet agents, it is often prescribed to patients with cerebrovascular accidents, heart and blood pathologies in various forms. The medicine helps to reduce the likelihood of impaired circulation as a result of blood thickening and the formation of clots on the walls of blood vessels. Today, the remedy is considered effective, it is prescribed as the main treatment or as part of an auxiliary therapy.

Domestic and imported analogues

Despite the effectiveness of the remedy, it cannot always be used in the therapy of patients. In this case, experts select substitutes with similar properties. Some of them may have a different composition, but have a similar effect on the patient's body. When choosing, the doctor does not take into account the cost of the medicine, but pays attention to the composition and effectiveness.

Today, domestic imported analogues with antiaggregate properties are used.

Curantil

Clopidogrel (analogues and substitutes of the drug may have another active ingredient in the composition) contains in as an active ingredient, the active substance of the same name, which slows down the gluing process platelets. Its analogue Curantil has an effect due to the presence of dipyridamole. The substance, like the component in the original, inhibits the adhesion of platelets. The main difference between the product and the original is the action of its main substance, which is not only affects the adhesion of blood cells, but also stimulates the immune forces, improves the state of the vascular walls.

The drug, like Clopidogrel, is available in tablet form with different dosages of the active ingredient. The tablets are taken orally according to the scheme determined by the doctor during the examination.

Unlike the original, the substitute has a larger list of indications:

• Encephalopathy.
• Cerebral circulation disorders in various forms.
• Weakening of immunity, frequent colds and viral pathologies.
• Thromboembolism, a condition preceding this disorder.
• Varicose veins complicated by thrombophlebitis.
• Coronary heart disease. The drug is used as the main treatment or to prevent the development of complications.

Unlike Clopidogrel, Curantil often provokes complications, has more contraindications. It is used in short and long courses, depending on the symptoms of the disease.

In the acute period of myocardial infarction, exacerbation of angina pectoris, the drug is not prescribed, since the aggravation of symptoms and the development of concomitant complications is possible. When using the original, patients may experience systemic disorders in the form of fever, nausea and vomiting. When prescribing an analogue, disorders affect the work of internal organs and systems, and may require the prescription of medications to eliminate them.

Unlike Clopidogrel, Curantil is allowed to be used for patients over 12 years old. The original is for adult patients only. The original and the substitute can provoke an overdose, but only Curantil has a specific antidote. In case of an overdose as a result of taking Clopidogrel, symptomatic therapy is prescribed, since there is no specific antidote.

The efficacy of the substitute is high, as with the original, but it may differ when taken by different patients.

Cardiomagnet

Clopidogrel contains only 1 active ingredient. Many analogues and substitutes can contain several components. For example, the drug Cardiomagnyl contains acetylsalicylic acid, which has antiaggregate properties, prevents the formation of blood clots and facilitates the movement of blood through the vessels. Additionally, the product contains magnesium hydroxide. The substance has a beneficial effect on the work of the heart, improves the condition of the myocardium.

Unlike the original, the substitute not only reduces the risk of blood clots, but also helps to improve the functioning of the entire cardiovascular system.

If Clopidogrel is used mainly for disorders of the vessels and the brain, then its substitute is indicated for arterial hypertension, heart pathologies of varying severity. It is often used prophylactically to prevent the development of complications in patients with hypertensive crisis.

Like the original, the analogue is available in tablet form, the dosage of active substances may differ. Pills are taken orally according to a certain scheme, and the duration of the therapeutic course depends on the disease and the degree of its neglect.

Like the original, the drug is used only for adult therapy. Unlike Clopidogrel, which is not prescribed during pregnancy and lactation, the analog can be used in the 1st and 2nd trimester, if necessary.

The peculiarity and difference of the substitute is considered to be a negative effect on the gastric mucosa, especially in patients who have pathologies of the digestive tract of inflammatory origin in anamnesis. That is why the analogue is not prescribed for exacerbation of such diseases, peptic ulcer and internal bleeding. The original remedy can provoke complications from the groans of the organs of the digestive system, like a substitute.

When using Cardiomagnyl, the following are more often observed:

• heartburn;
• indigestion;
• repeated vomiting during the day.

The mechanism of action of the drugs is somewhat different, which does not make the analogue less effective. But in the acute course of any disease, the best result can be obtained if the original remedy is prescribed.

Brilinta

Clopidogrel (analogues and substitutes for the drug may be more effective) is considered effective drug, but some of its analogues have more pronounced properties, especially in the acute period diseases. Brilint's drug is considered more effective, if you believe the research of specialists in the treatment of patients with various forms of pathologies.

The analogue contains another active ingredient, ticagrelor, which provides the main effect on the body. The principle of action of the drug almost does not differ from the original, that is, the main substance blocks adhesion of platelets and clotting factors that are involved in the formation of blood clot. The effect of the substitute manifests itself earlier than when the patient receives the original, which is considered an advantage if immediate assistance is needed.

One of the differences is considered to be an increased risk of bleeding after discontinuation of the medication before surgery. Unlike Clopidogrel. Brilinta often provokes such complications. Like the original, the substitute is allowed to be taken in long courses to achieve a pronounced result, it does not accumulate in the blood and tissues. An analogue is produced in tablet form, which allows you to take it at home as prescribed by a doctor.

In most cases, the original medicine is used as the main treatment or in combination with medicines from other groups. The substitute is often combined with drugs based on acetylsalicylic acid, which increases the effectiveness of treatment, especially in severe disease.

Brilinta has contraindications, like the original:

• Intolerance to the ingredients of the composition.
• Bleeding tendency.
• Internal bleeding of various origins, bleeding against the background of a violation of the integrity of the skin during injuries.
• The period of lactation and bearing of the child.
• Children and adolescents.

Experts note that the analogue rarely provokes complications from the digestive organs, but often leads to the appearance of hematomas on the skin, even with a slight effect on it. Unlike a substitute, Clopidogrel can provoke a severe overdose, which threatens not only the health, but also the patient's life.

Warfarin

Clopidogrel (analogues and substitutes of the drug can often provoke complications) belongs to the group of antiaggregative drugs, but not all analogues belong to the same group of medicines. For example, Warfarin is an indirect anticoagulant from the group of coumarin derivatives. As the main ingredient in its composition, there is a substance warfarin, which helps prevent the formation of blood clots and the development of pathologies against the background of thickening of the blood.

The principle of action of the drug is somewhat different from the effect on the body of the original remedy. This is due to the fact that when warfarin enters the body, it blocks the synthesis of enzymes in the liver that take part in blood clotting. If the original acts directly on the adhesion of platelets, then the analog has an indirect effect.

The drug is indicated for the following indications:

• Venous thrombosis.
• Violation of cerebral circulation, stroke of various forms and severity.
• Embolism of various origins.
• The recovery period after undergoing surgery.
• The need for a prophylactic course in order to prevent the development of complications.

The drug is available in the form of tablets for oral administration, like the original. The medicine is usually prescribed in short courses, while the original can be used over a long period of time. The dosage and duration of use depends on the severity of the symptoms, as well as the presence of concomitant abnormalities in the patient's internal organs.

The original is not prescribed during pregnancy, but the substitute is allowed to be used in the 2nd trimester of gestation, if the need arises. The analogue has many contraindications, it is especially important to take into account the impossibility of using it in case of exacerbation of pathologies of the digestive tract. The original for such violations can be used with caution, since it does not have a pronounced aggressive effect on the mucous membrane of the digestive system.

Like the original, the substitute can provoke negative reactions in the form of bleeding and malfunction of internal organs, allergic reactions. An analogue in some cases leads to the development of an overdose, which worsens the general condition. Despite this, the action of Warfarin develops quickly, which is important if the patient needs immediate assistance.

Plavix

One of the most popular analogs of the drug, containing clopidogrel as the main active ingredient, like the original medication. The principle of action of the drug does not differ from the effect of the original on the patient's body. A medication is produced in the form of tablets for oral administration.

The medicine slows down the adhesion of platelets, which leads to a slight thinning of the blood and facilitates its movement through the vessels. With its use, an improvement in the condition is observed, the likelihood of complications decreases. The medication has the same indications as the original, that is, it is prescribed for thrombosis, pathologies of the heart and brain.

Unlike the original, the analog can be used to diagnose acute coronary syndrome. The scheme of therapy with a remedy may differ depending on the severity of the manifestations of pathology. Some substitutes are used only in short courses, but Plavix can be prescribed in long courses if the need arises.

Like Clopidogrel, Plavix is ​​not used in the treatment of children, nursing and pregnant women, as well as patients with intolerance to the ingredients of the composition. Despite the similar composition, the substitute often provokes allergic reactions in the form of irritation on the skin, itching and severe burning sensation. If such complications appear, it is recommended to immediately stop using the medication and consult a doctor.

Magnikore

Clopidogrel (analogues and substitutes for the drug have their own contraindications, which should be considered before prescribing) is considered effective at different stages of the pathological condition, but the one-component composition sometimes does not allow to achieve a pronounced result. The analogue of the drug Magnikor contains magnesium and acetylsalicylic acid. The first ingredient has general tonic properties, helps to improve the condition of the myocardium, stimulates the functioning of the cardiovascular system.

Acetylsalicylic acid:

• has antithrombotic properties;
• prevents blood clots;
• reduces the load on the walls of blood vessels.

Unlike the original, the analogue acts aggressively on the walls of the digestive tract, especially on the mucous membranes of the stomach. That is why it is not recommended to use it in the therapy of patients with a history of stomach and intestinal diseases in an acute form.

The substitute therapy regimen differs from that used when the original was prescribed. This is due to the presence of another ingredient in the composition and a slightly different mechanism of action. The drug directly affects platelets and the process of their adhesion, which makes it effective in various forms of diseases, accompanied by blood clots and thrombus formation.

The original less often leads to the development of complications from the digestive system, but the analog, if used incorrectly, can provoke such reactions. Patients report stomach pain, severe heartburn and nausea.

For pregnant women, medication can be prescribed only if necessary, while the original is strictly prohibited for use at this time. The dosage form is considered to be the similarity of the funds, since both medicines are available in the form of tablets.

Prices

The cost of the original is quite high, but many analogs cost a little more. When prescribing, the doctor takes into account not the price of the drug, but its effectiveness for a particular patient.

Product name	Price
Clopidogrel	You can buy the product for 700-1800 rubles.
Curantil	The price of the medicine ranges from 800-1500 rubles.
Cardiomagnet	The cost of the funds is approximately 120-180 rubles.
Brilinta	A medicine in pharmacies costs about 2,800-5,000 rubles.
Warfarin	The price of the tool is 110-250 rubles.
Plavix	The medicine costs about 800-1300 rubles.
Magnikore	The cost of the drug is 1300-1800 rubles.

The price depends on the amount of medicine in the package and the dosage of the active ingredient.

Clopidogrel is considered a popular and effective drug for preventing blood clots. Analogues and many drug substitutes may have the same composition, but often contain different ingredients. Depending on the characteristics of the patient's body, the doctor in each case selects the medicine individually.

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