Proserin injections. Indications for use, instructions, price

Proserin is a drug that in most cases is prescribed for various disorders of the nervous system and the work of the brain. The injections have a wide range of applications and an affordable price.

Release form and composition

The drug is produced in Russia in the form of an injection solution. The product is contained in ampoules and packed in cardboard boxes.

The active substance is neostigmine methyl sulfate.

Pharmacological properties

The cholinomimetic effect of the drug is due to its ability to suppress cholinesterase and acetylcholine. The components of the drug help to improve the transmission of nerve and muscle impulses, have a restorative effect on the motor function of the gastrointestinal tract and increase the tone of the bladder.

The medication also allows the passage and formation of mucus in the bronchi, lowers blood pressure, causes pupil constriction, and reduces pressure inside the eye. In this case, there is an increase in spasms in the eye area (nerve and muscle spasms).

Pharmacodynamics and pharmacokinetics

When administered, the drug undergoes metabolic transformation and breaks down into inactive forms of metabolites. The level of interaction with blood proteins is from 15 to 25%. The agent is excreted from the body mainly along with urine. For the first day, the body leaves about 80% of the components. The rest is excreted unchanged or as metabolites. The drug poorly penetrates the blood-brain barrier.

Indications for use

The tool has a wide range of applications. Before starting to use it, it is required to undergo preliminary studies.

Indications:

• myasthenic syndrome;
• violation of motor functions due to head injuries;
• rehabilitation after meningitis;
• various forms of neuritis;
• the presence of polio;
• inflammatory diseases of the brain;
• decreased tone of the gastrointestinal tract and bladder;
• labor activity (as an aid).

Also, the drug can be prescribed as an antidote after the use of various anesthetics. Injections can be used to treat children with established myasthenia gravis.

Contraindications

Proserin - injections (indications for the use of the solution and other dosage forms are identical), which are allowed to be prescribed to patients only after preliminary studies.

The tool has some restrictions on its use, which are associated with the influence of the active ingredient or special conditions of the patient.

Contraindications:

• intolerance to the composition;
• epileptic seizures;
• hyperkinetic states;
• ischemic disorders;
• various forms of arrhythmias;
• bronchial asthma;
• pregnancy;

  

• lactation period;
• atherosclerotic lesion (pronounced form);
• thyrotoxicosis;
• the presence of ulcers in the stomach and duodenum;
• acute infectious processes;
• obstructive disorders in the stomach or urinary tract;
• inflammation of the peritoneum;
• hyperplasia of the prostate;
• toxic damage to the body (for children).

In the presence of these restrictions, the agent should be replaced with another drug that is similar in indications or action.

At what age can the drug be used?

The medicine can be used in pediatric practice. There are no specific age restrictions for the solution. In this case, therapy should be carried out with the permission of a doctor and under his supervision.

Instructions for use, dosage

The product is intended for subcutaneous, intravenous or intramuscular administration. Dosage regimen: 0.5-2 mg 1-2 times a day. In this case, it is recommended to inject the drug subcutaneously.

The maximum daily dosage should not exceed 6 mg. The duration of therapy is individual, up to 1 month. After a break of 1 month, treatment can be repeated.

With a hernia

The medication can be used for a hernia of the spine. However, the dosage and duration of therapy in this case are determined by the attending physician on an individual basis.

If there are no special prescriptions and recommendations of the doctor, the treatment is carried out according to the general scheme.

With intestinal atony

Routes of administration: subcutaneously or intramuscularly.

Dosage: 0.5 ml every 4-6 hours. The course is individual and usually takes from 3 to 4 days.

With myasthenia gravis

Injections should be given under the skin or intramuscularly.

Dosage regimen: 1 ml per day.

The duration of the course is according to the doctor's recommendations.

With neuritis of the facial nerve

In this case, the dosage and duration of therapy is determined by a specialist. If there are no special recommendations and indications, the treatment is carried out according to the general scheme.

With paresis of the larynx

At the beginning of therapy, the solution is injected intravenously, after which they switch to subcutaneous injections.

Dosage: 0.5-1 ml per day.

The duration of therapy is individual.

With neuropathy

With the development of neuropathy, treatment is carried out according to the general scheme or individually according to the recommendations of a specialist.

The duration of the course is individual.

Side effects

Proserin - injections (indications for the use of the dosage form should be studied in advance), which, if used incorrectly, can lead to side effects.

Adverse reactions develop extremely rarely and are associated with the physiological characteristics of the patient and the influence of active substances.

Side effects:

• Gastrointestinal disorders: symptoms of dyspepsia, salivation, disturbance of intestinal motility.
• Malfunctions of the central nervous system: migraines, dizziness, malaise, drowsiness, visual dysfunction (pupillary constriction), tremors in the limbs. Convulsive states, problems with speech may also occur, spasms develop in the area of ​​\ u200b \ u200bthe muscles, and loss of consciousness may occur.
• Cardiovascular Disorders: violation of heart rhythms, lowering blood pressure, AV block, junctional rhythm, changes in the cardiogram, cardiac arrest.
• Dysfunction in the respiratory system: spasms in the bronchi, shortness of breath, increased secretion from the glands located in the bronchi. In rare cases, respiratory depression may occur.
• Allergic manifestations: rashes, itching, redness on the face, signs of anaphylaxis.
• Other reactions: hyperhidrosis, frequent toilet visits, joint pain.

With the development of the listed symptoms, as well as other reactions not noted in the instructions, you should stop using the solution and consult your doctor.

Overdose

If the indicated dosages are exceeded, undesirable reactions may develop.

Symptoms:

• salivation;
• soreness in the abdomen;
• increased sweating;
• diarrhea;
• breathing problems;
• decrease in heart rate (less than 60 per minute);
• constriction of the pupils;
• blue discoloration of the skin;
• weakness and twitching of the muscles.

If these signs occur, treatment should be discontinued and a doctor should be consulted for symptomatic therapy (administration of atropine).

In a convulsive state, sodium thiopental injections are prescribed.

special instructions

When using the solution in higher dosages, the introduction of atropine is required. If signs of myasthenia gravis or cholinergia develop, additional research is needed. It is necessary to exercise a high degree of caution when driving or during work that requires enhanced psychomotor reactions.

Drug interactions

Proserin injections can be used as an antidote after taking drugs belonging to the group of muscle relaxants. This is one of the indications for the appointment of the drug. However, such use should be previously agreed with the attending specialist.

The effect of the drug may be reduced when used simultaneously with the following drugs:

• m-anticholinergics;
• quinidine;
• local anesthetics;
• anti-Parkinson drugs;
• medicines for seizures;
• novocainamide;
• tricyclic antidepressants;
• ganglion blockers.

If necessary, the solution should be used in conjunction with ephedrine.

The combined use of the main drug with an agent from the group of β-blockers can lead to a more pronounced course of bradycardia.

For a patient with myasthenic syndrome, the drug is prescribed in conjunction with anabolic hormones and steroids.

M-cholinomimetic reactions decrease with the simultaneous use of a medication with atropine, methocinium iodide and drugs belonging to the class of m-cholinergic blockers.

With extreme caution, the agent can be prescribed to patients taking various antibacterial drugs (neomycin, streptomycin, kanamycin), local and general pain relievers, anti-arrhythmia medications, and other medications that cause the disorder cholinergic impulses.

The solution can react with muscle relaxants and lead to an increase in the effect of the second group of drugs.

The following agents are opposite in action to the main drug:

• m-anticholinergics;
• quinidine;
• novocainamide;
• ganglion blockers;
• local anesthetic drugs.

Less pronounced antagonists are tricyclic antidepressants, drugs for seizures, epilepsy, and drugs used to treat Parkinson's disease.

Reduces the action of the injection when used simultaneously with cyanocobalamin.

The activity of pyridoxine may decrease when combined with a solution.

The combined use of the main agent and strychnine can lead to an increase in the tone of the vagus nerve. When a solution is combined with laxatives, the effect of the second group of medicines is enhanced.

The use of injections in conjunction with β-blockers can worsen the course of bradycardia.

When using other means during the period of administration of the solution, you should inform the attending physician about this in advance, which will avoid drug incompatibility and, as a result, prevent the development of unwanted manifestations.

Analogs

Proserin - injections (indications for the use of analogs may differ), which in some cases can lead to the development of intolerance reactions. In the event of such manifestations, the drug should be followed by other remedies similar in indications and action.

It should be borne in mind that the selection of a generic is made only by the attending specialist. It is not recommended to prescribe and use analogs on your own. Since the wrong medication can lead to complications and worsen the course of the underlying disease.

Nivalin

This substitute is produced in Bulgaria in the form of a solution for injection. The active ingredient is galantamine hydrobromide. The drug belongs to the group of cholinesterase inhibitors and is used strictly as directed by the attending physician. The drug has a wide range of applications. It can be used in surgery, gastroenterology, pediatrics, as well as in various studies or physiotherapy.

Indications:

• Cerebral palsy (infantile cerebral palsy);
• various forms of neuritis;
• injury to the nervous system;
• urinary incontinence;
• toxic damage to the body by anticholinergics;
• atonic disorders;
• spinal cord injury;
• neuromuscular diseases (myopathy);
• physiotherapy (in the treatment of disorders associated with the work of the peripheral nervous system).

Dosage regimen: 10 mg once. The maximum daily dosage should not exceed 20 mg. The duration of the course is 1.5-2 months. Repeated doses of the medicine are possible after a break.

The drug has an extensive list of contraindications, which should be consulted in advance. The medication is not prescribed during pregnancy and during breastfeeding. Age restrictions - children under 1 year old. Dispensing conditions - prescription. The cost of the drug in regional and regional pharmacies in Russia varies from 100 to 1800 rubles.

Kalimin N

Proserin - injections (indications for the use of the drug should be previously clarified with a specialist), which can be replaced with other dosage forms only with the permission of the attending physician.

This tool is manufactured in Israel in the form of tablets for oral use, the active ingredient of which is pyridostigmine bromide. Pharmacological group - cholinesterase inhibitor. The drug is prescribed in the treatment of myasthenia gravis.

Dosing rules: 30-60 mg 1-2 times a day. In more severe cases, the dosage can be increased to 0.18 g. Moreover, the maximum daily rate should not exceed 0.72 g. Patients with impaired renal function may require dosage adjustment. The duration of treatment is individual, according to the indications of the attending physician. If necessary, re-therapy must be previously agreed with a specialist. At the same time, a break of at least 1 month should be taken between courses.

Restrictions on admission:

• intolerance to the components;
• bronchial asthma;
• obstructive damage to the bronchi, urinary and biliary tract;
• pregnancy;
• inflammation of the iris of the eye;
• Thomsen's disease;
• lactation period;
• minor age;
• intestinal obstruction;
• shock condition caused by surgical interventions;
• the presence of spasms in the gastrointestinal tract.

Terms of sale - prescription.

The price of a medicine in public and private pharmacies in Russia ranges from 640 to 825 rubles.

Axamon

This agent is manufactured in Russia in the form of an injection solution, the active ingredient of which is ipidacrine hydrochloride.

The drug belongs to the group of cholinesterase inhibitors and is used in the treatment of the following disorders:

• pathologies affecting the peripheral nervous system;
• diseases of the central nervous system;
• rehabilitation after the transferred diseases of the central nervous system, which have an organic nature of origin;
• atonic disorders in the intestines.

Dosing rules: the solution is injected subcutaneously or intramuscularly at 5-30 mg from 1 to 3 times a day, depending on the detected violation. The duration of therapy varies from 2 weeks to 2 months. In the future, treatment is carried out with other forms of the drug (tablets).

Contraindications:

• epileptic seizures;
• pain and discomfort in the chest area;
• the presence of ulcers in the region of the stomach and duodenum (aggravated course of the disorder);
• bronchial asthma;
• pregnancy;
• lactation period;
• age under 18;
• vestibular disorders;
• intolerance to the drug;
• decrease in heart rate (less than 60 beats per minute);
• extrapyramidal syndromes;
• obstruction of the intestine or urinary tract.

Terms of sale - prescription.

The price of a medicine in public and private pharmacies in Russia ranges from 700 to 1455 rubles.

Terms, conditions of sale and storage

• Store the injections in a clean and dry place at a temperature of 15-25 ⁰C.
• Shelf life is 3 years from the date of issue.
• Do not use after the expiration date printed on the package.
• Terms of sale - prescription.

Price

The cost of injections depends on the region and region of its sale. You can find out the exact price and purchase the drug at any pharmacy located in your place of residence.

Region, region	Volume / dosage	Price
Moscow, Moscow region	Solution, 1 ml	RUB 30-95
St. Petersburg	Solution, 1 ml	35-100 rub.
Saint Petersburg (suburbs)	Solution, 1 ml	40-80 rubles.
Leningrad region	Solution, 1 ml	35-90 rubles
Novgorod region	Solution, 1 ml	40-75 rubles.

Before using the injections, you should consult with a current specialist or pharmacist, and also carefully read the instructions for use of Proserin, especially the indications and contraindications. Additionally, it is recommended to study the reviews of patients and doctors.

Video about the drug Proserin

Test in Proserin: