Micoderil analogues are cheap for nails. Price

Micoderil is antifungal spectrum of action. The product is produced in the form of a cream and a solution for nails. It is widely used in dermatology for the treatment of candidiasis of the skin and nails, as well as pityriasis versicolor. There are several cheap analogs on the pharmaceutical market.

Basic instructions

Fungus on the skin or nails is not only a medical but also a social problem. This disease is manifested by a number of unpleasant symptoms and noticeable external changes. Today, about 1 million the world's population suffers from ailment. According to statistics, every fifth citizen of Russia has noticed a manifestation of a fungal infection.

In such patients, the quality of life is significantly reduced, because they try to avoid visiting public places, wearing open shoes and clothes. Correctly selected treatment tactics are the key to victory over the disease. There are many antifungal drugs on the pharmacy shelves. So, funds based on naftifine hydrochloride are presented in more than one dozen names. Therefore, there is always the problem of choosing the best drug.

The active ingredient of Mikoderil is naftifine hydrochloride in an amount of 10 mg per 1 ml of the finished product. When applied externally, the substance sinks well into the inner layers of the skin and nail plate, creating high concentrations there and destroying fungal cells.

The mechanism of action of naftifine is due to an obstacle to the synthesis of squalene-2,3-epoxidase, as a result of which the formation of ergosterol is disrupted (a component of the cellular walls). As a result, the cells of microorganisms are destroyed.

When using the drug, the following changes occur:

• inflammation and itching disappears;
• the healthy appearance of the skin and nails is restored;
• the risk of developing secondary bacterial infections is reduced, since naftifine has a detrimental effect on most microorganisms.

Despite local application, the active ingredient quickly penetrates inside and accumulates in the tissues. About 6% of the total amount of the product that was applied to the skin or nails enters the bloodstream, some of this is metabolized. Naftifine is excreted by the kidneys and the gastrointestinal tract.

Micoderil is widely used in dermatology in patients who have skin or nail lesions caused by Candida and many others.

In this regard, the list of indications for use includes:

• fungus of the skin and its folds;
• nail fungus;
• skin lesions between the toes;
• pityriasis versicolor;
• nail fungus.

Micoderil solution is intended for the treatment of lesions of the nail plate. The liquid formula effectively penetrates into the dense structure and accumulates in it.

With severe symptoms of a fungal infection, the doctor tries to prescribe a complex therapy (nail solution + skin cream). In such a combination, the drug acts as quickly and efficiently as possible.

Analogs

Micoderil analogs cheap for nails are presented on the pharmaceutical market with a wide range. These drugs have the same active ingredient and similar release forms.

These include:

• Naftoderil produced by OZON LLC.
• Fungoderil produced by JSC "Nizhpharm".
• Exoderil, which is produced at the pharmaceutical plant "MERCK KGaA & Co" in Austria.

The listed funds contain naftifine hydrochloride as an active component, have antifungal effect and can replace the use of Mikoderil.

Naftoderil

This tool has many characteristics in common with Mikoderil, namely:

• name and concentration of the active substance;
• pharmacodynamic and pharmacokinetic properties;

  

• mechanism of action;
• spectrum of antifungal activity;
• indications for use;
• release forms.

That is why they are complete analogues of each other. However, before deciding what to choose for the external treatment of the fungus, it is important to pay attention also to the difference between the drugs.

They differ in the following points:

• Manufacturer. The drug Mikoderil is produced by the Russian pharmaceutical company OTCPharm PJSC, St. Moscow. Naftoderil is produced by Ozone LLC, Samara region.
• Raw materials used. Despite the fact that the active composition of the preparations is the same, manufacturers can use different medicinal raw materials to create a cream. PJSC "OTCPharm" uses the substance of the Italian company "Sifavitor SRL" in the production of cream and Micoderil solution. This is done to ensure that the final product is of high quality.

Thus, Mikoderil is a Russian drug with an acceptable price (no heavy transportation costs) and European quality.

On the official website of the manufacturer, the following advantages of the molecule they use in production are indicated:

• strongly pronounced antimycotic effect;
• elimination of inflammation;
• rich history of use in medical practice;
• inclusion in Russian guidelines for the treatment of external fungal infections of any localization;
• FDA approval in the United States.

Thus, it is important to look not only at the active compound and the list of indications, but also at the quality of the raw materials used. The therapeutic effect of the drug, the severity of unwanted side reactions, and the likelihood of allergies directly depend on this.

Micoderil for nails should be replaced with cheap analogs only if a specialist (it may be a therapist or dermatologist) considers it necessary. Self-withdrawal of some drugs and replacing them with others is fraught with complications of the current disease.

Fungoderil

The drug is produced by the Russian pharmaceutical company AO Nizhpharm only in the form of a solution for external use.

Unlike Micoderil, which has 2 forms of release at once. The presence of only one treatment option in the lineup is not always convenient, since dermatologists with severe pronounced lesions of the skin and nails prefer to prescribe to patients a complex therapy of fungi.

It is desirable that both the solution and the skin cream be presented under the same trade name. This makes it easier to track the effectiveness and safety of the treatment.

In addition to the manufacturer and the form of release, these drugs are not significantly different.

By the way, none of the drugs compared above is an original remedy. All of them are analogs of a western drug for external use based on naftifine hydrochloride. It is an antifungal agent under the trade name Exoderil.

Exoderil

Micoderil (cheap analogs for nails are generics of the original Exoderil) practically does not differ from the original, since it is produced on the basis of the same compound. Exoderil is an original drug that has undergone many randomized controlled trials.

In the course of research, this tool has proven not only its effectiveness, but also safety. Micoderil, Naftoderil and Fungoderil are generics, in which manufacturers also use naftifine hydrochloride. However, these funds do not have their own evidence base. Although the manufacturer of Micoderil conducts tests of the quality and effectiveness of the drug.

When the original is created and released to the pharmaceutical market, the manufacturer becomes the owner of the patent. This document does not allow anyone to manufacture such drugs. However, a patent has an expiration date, and upon its expiration, companies begin to release products with a similar effect on the market.

Their differences from Exoderil are as follows:

• Production technology. Generics can change the creation algorithm. This is evidenced by the lists of auxiliary components, which are presented in the instructions for use. As a rule, they are very different from each other. This can greatly affect the quality of the product, because as a result, the rate of entry of the active component into the tissues changes, and its concentration decreases. The requirements in the Russian Federation on this issue are quite flexible. There is no need for manufacturers to completely repeat the clinical experience of the original creators. The main thing is that the biological equivalence of drugs is the same.
• Mode of application. The funds have the same lists of indications, contraindications and dosage regimen. The only difference is that the original Exoderil has a unique attachment for more convenient application to the affected area. Considering that the drug must be applied twice a day for a long time (at least 4 weeks), for many patients the issue of comfortable use of the drug can become significant.

Now you should pay attention to the fact that in many ways the original and generics are still similar.

Namely:

• Side effects. There was no expert comparison of funds under this item. Presumably, the frequency and severity of unwanted side reactions in drugs are the same. Burning, dry skin, redness usually occur at the site of application of funds and disappear on their own. The same applies to allergic manifestations. However, if the patient notes a severe allergic reaction, the drug should be discontinued.
• Contraindications. All topical agents based on naftifine hydrochloride are contraindicated in patients who are carrying a child at any time or are in the lactation period. They should also not be used on children under the age of 18.

Price of funds

Mikoderil, cheap analogs for nails, have a different cost. The exact amount that the buyer must pay for one package of the drug depends on the region, city and pricing policy of the pharmacy chain.

Name	Price
Micoderil. Solution 10 ml Solution 20 ml Cream 15 g Cream 30 g	RUB 500-550 RUB 870-920 400-450 rub. 620-670 rub.
Naftoderil Solution 15 ml Cream 15 g Cream 30 g	RUB 430-480 RUB 260-310 RUB 380-430
Fungoderil Solution 15 ml	RUB 450-500
Exoderil Solution 10 ml Solution 30 ml Cream 15 g Cream 30 g	590-640 rub. RUB 1350-1400 RUB 500-550 800-850 rub.

From the presented table it can be seen that the original drug Exoderil has the highest cost. At the same time, generics are in approximately the same price category.

The cheapest remedy is Naftoderil cream, because 1 g of this cream will cost the buyer about 14-19 rubles, and 1 ml of solution will cost about 30 rubles. The advantage of the tool is its relatively low cost. Among the disadvantages, the manufacturer's lack of its own clinical trials should be highlighted, which in some cases may not be the best evidence of the quality of the drug.

Fungoderil is available in the form of a solution, 1 ml of which will cost the patient about 31.5 rubles. Thus, the cost of this generic is the same as that of Naftoderil. The disadvantage of Fungoderil is the absence of other forms of release with the same trade name. Therefore, if a complex treatment is necessary, the doctor will have to turn to other pharmaceutical companies to prescribe naftifine in the form of a cream.

If we talk about using an Austrian antifungal agent called Exoderil, you should pay attention to its price category. It is the highest in the table. This is typical for original products, because the price includes not only the cost of transportation from Europe to Russia, but also the cost of conducting a number of randomized trials.

During them, the effect and safety of Exoderil was proven. Buying it, the patient gets a kind of guarantee that he is using the most proven remedy in this line. If the pharmaceutical company "MERCK KGaA & Co", which produces the drug, did not conduct this work and did not become the owner of a patent, no company could produce generics based on naftifina.

1 ml of Exoderil solution will cost about 60 rubles, which is almost 2 times higher than that of the funds described above. 1 g of cream costs about 32 rubles. As you can see, treatment with the original will cost the patient almost 2 times more.

Micoderil is in the middle price category. If you calculate the cost of 1 g and 1 ml of the finished drug, you get about 27 rubles. and 45 rubles. respectively. Considering that the manufacturer of Micoderil conducts its own research, it uses the substance of the European production, perhaps, it is the highest quality and safest generic among all presented in article. The cost of Micoderil is significantly lower than Exoderil, but higher than other analogues.

Mikoderil, cheap analogs for nails and Exoderil have the following pattern. The larger the volume of the package, the more profitable it is to purchase. Indeed, when creating any form of release, the manufacturer spends approximately the same amount on advertising, packaging and selling the finished product through pharmacy organizations.

Remember that preventing the development of fungus is easier than dealing with long-term treatment. Whichever remedy is chosen, antifungal therapy is not cheap. Observing basic hygiene rules (do not use someone else's shoes, do not walk barefoot in public places, watch out for condition of the skin and nails), you can not only maintain your health, but also save energy, time and money funds.

All compared drugs are theoretically capable of effectively fighting fungal infections of the skin and nails, because they all contain naftifine hydrochloride in their composition. The compound is an effective agent for the destruction of not only the fungus, but also a number of other pathogenic microorganisms. However, in practice, the drugs have different severity of therapeutic action.

Micoderil for nails has many analogues. Some of them are quite cheap. At the same time, Micoderil is a generic version of the original Exoderil. By purchasing the original, the patient can be sure of the effectiveness and safety of the treatment. As it became clear from the article, Micoderil represents the best value for money. If you do not want to overpay for the original, but you want to feel the effect, you should give preference to Micoderil. At an average cost, the drug has its own evidence base and is made from high-quality raw materials.

Author: Olga Orlova

Video about the analogue of Mikoderil

A short video instruction for Exoderil: