Famotidine (Famotidine). Indications, instructions for use, price, reviews

Famotidine - antiulcer medication with pronounced properties, which is often prescribed to patients with an exacerbation of the symptoms of the disease and the appearance of complications. Indications for the use of the drug are described in the official instructions, as well as possible complications during therapy, obstacles to its implementation. The drug is recommended to be used only when certain symptoms appear, but not to prevent their occurrence.

Composition and form of release

The medicine is available to patients in different pharmacies in the form of tablets intended for oral administration use and covered with a special film coating that dissolves in the digestive path.

The tablets are round and small for ease of use. They are placed in plates, each of which can contain 7, 14, 28 tablets. There are packages with a large number of tablets. A description is attached to the plates with the medicine, which indicates the nuances of use, possible complications and contraindications for treatment.

The main ingredient in the composition of the drug is famotidine, which provides antiulcer action.

The tablets contain inactive ingredients:

• Talc.
• Starch.
• Croscarmellose.
• Silicon dioxide.
• Magnesium stearate.
• Macrogol.
• Iron oxide.

These ingredients have no medicinal properties. The amount of the main substance in 1 tablet can be 20 or 40 mg.

On pharmacy shelves, you can find a product in the form of a lyophilisate, packaged in small glass containers. The dosage of the ingredient in 1 bottle is 20 mg. A description is also attached to the product in the form of a lyophilisate. The lyophilisate is intended for the preparation of a solution that is administered intravenously.

Terms of sale, price

Famotidine (indications for the use of the drug are described in the official instructions) is dispensed in different pharmacies after presenting a certified form from a doctor. The cost of a medicine depends on its quantity in the package, as well as the specific region of distribution. On average, the price is approximately 120-200 rubles. You can buy 1 bottle of lyophilisate for 50-60 rubles. The price varies depending on the batch and pharmacy.

Action

The drug has antiulcer properties, which makes it effective in the treatment of pathologies of the mucous membrane of the stomach and duodenum. The medication helps to eliminate the symptoms of pathologies and reduces the likelihood of complications with the progression of the disease.

The medicine acts on the production of hydrochloric acid, reduces its amount, which has a beneficial effect on the mucous membranes and protects against the aggressive effects of products, some medicines.

The tool has other properties:

• Improves the patient's digestion, especially in the presence of disorders, frequent indigestion and other complications.
• Coats the walls of the stomach, which reduces the aggressive effect of hydrochloric acid on the mucous membranes. The intense production of acid causes tissue damage, resulting in ulceration and ulceration.
• The drug reduces the acidity level of gastric juice. This is especially important for patients who suffer from gastritis with increased acidity of gastric juice.
• The medication has an effect on histamine receptors of the 3rd generation, which makes it possible to improve the condition of patients in the acute period of inflammatory diseases.
• The use of the drug allows not only to reduce the aggressive effect of the drug on the mucous membranes, but also stimulates their recovery in the presence of any damage. As a result of the acceleration of regeneration processes, the recovery period is shortened.
• If ulcerative lesions are not associated with high acidity, but arise as a result of other reasons, the patient's condition improves, the area of ​​the focus decreases. Often, the ulcer completely disappears after completing the full course.
• Normalization of acidity leads to an improvement in the functioning of the entire digestive tract, elimination of stool disorders, flatulence and related manifestations.
• Patients note the analgesic effect of the drug when taken. Experts explain this effect by the fact that the active substance envelops the walls of the stomach, while simultaneously reducing the production of hydrochloric acid. This leads to the elimination of pain, relief of the general condition.
• The tool prevents the development of gastrointestinal bleeding with severe damage to the mucous membranes.

If the patient suffers from severe pain, the remedy does not help to completely eliminate them, but facilitates the course of the disease. Additionally, patients talk about accelerating the movement of food through the intestines when taking medication in courses.

Famotidine (indications for use indicate the possibility of prescribing in the detection of acute and chronic forms of the disease) is well absorbed in the body of patients. After oral administration, binding to plasma proteins occurs by only 20%, which reduces the effectiveness of therapy. The maximum concentration of the main ingredient in the blood is reached 1 hour after taking a single therapeutic dosage. When using a parenteral dosage form, this period may be shortened.

The bioavailability of the drug reaches 45%. This is an average indicator, but it does not lead to a decrease in the effectiveness of therapy. After 3-4 hours, the concentration of ingredients in the patient's blood decreases. When using a parenteral dosage form, the bioavailability of the basic substance does not change, as does the time of maintaining a high concentration in the blood. Despite this, the therapeutic effect occurs somewhat faster when using the drug in the form of a lyophilisate.

The processing of the ingredient is carried out in the liver. Metabolites are evacuated by the kidneys, a small amount of components are excreted in the feces. The period of cleansing the body lasts up to 24 hours, but in the presence of kidney pathologies, it can be extended.

Drug substances do not accumulate in the blood and tissues. This avoids the development of an overdose with prolonged use. The components penetrate the placental barrier and pass into breast milk.

Indications and contraindications for use

The tabletted agent and the drug in the form of a lyophilisate is used to diagnose pathologies of the digestive system at different stages.

The main indications for the appointment:

• Peptic ulcer of the stomach and duodenum. The medicine can be used in the acute stage or in the chronic course of the disease. If complications are present, it can also be used.
• Acute and chronic pancreatitis. The drug does not affect the course of the inflammatory process in the pancreas, but in most cases, patients have complications from the stomach, therefore it is prescribed as part of a complex treatment.
• Reflux esophagitis at different stages. With increased acidity, the drug helps to alleviate the condition, it is used even in the absence of ulcerative lesions.
• Gastritis with increased acidity of gastric juice.
• Dyspeptic disorders that are associated with the intense production of hydrochloric acid.
• Erosive gastroduodenitis. The drug is prescribed in the acute stage and in the presence of complications in patients.

The drug can be used in the absence of acute manifestations of peptic ulcer disease in patients, but the presence of such disorders in the anamnesis. Despite the fact that the agent does not have prophylactic properties, its use helps to somewhat reduce the likelihood of bleeding as a result of the progression of the disease.

Famotidine is not always allowed to be used in patient therapy.

The official instruction describes not only indications, nor contraindications for use:

• Allergy to any of the ingredients in the composition. If in the past the patient was prescribed such medications and he had negative reactions, it is important to first carry out a test for the body's sensitivity to substances.
• Encephalopathy in severe form, accompanied by acute disorders.
• The period of lactation and bearing of the child. This condition does not apply to absolute contraindications for treatment, since the medicine can be taken individually if necessary. When prescribing, doctors take into account the woman's condition, the ability of the main substance to penetrate the placental barrier and enter breast milk.
• Acute cerebrovascular accident, acute stage in myocardial infarction.
• Hepatic failure in severe form, accompanied by a violation of the functioning of the organ.
• Kidney pathology of inflammatory or infectious origin.
• Liver cirrhosis and acute viral diseases of the organ.
• Swallowing disorder in patients.

The drug is prescribed with caution to patients with diseases of the brain, heart and blood vessels. Individual contraindications are determined during examination and questioning.

Like many drugs, Famotidine provokes complications if used incorrectly. Compliance with the recommendations does not guarantee the absence of negative symptoms affecting the work of internal organs.

Damage area	Frequent negative reactions
Nervous system	On the part of the nervous system, disorders are manifested in the form of headache and dizziness, sleep disturbances and deterioration in concentration.
Digestive tract	On the part of the digestive system, complications do not appear so often. Sometimes the patient's body reacts negatively to therapy, which leads to flatulence, upset stools, and pain in the abdomen.
Respiratory system	The respiratory system is not affected so often during therapy. Sometimes patients talk about coughing and shortness of breath during exercise.
Skin and mucous membranes	During therapy, allergies appear quite often. Rash, irritation and peeling appear on the body of patients, severe itching is noted, which leads to scratching of the affected areas and aggravation of symptoms.

Negative reactions are considered a reason for refusing treatment and seeking medical attention. Depending on the severity of the manifestations, the doctor may prescribe special treatment to normalize the condition.

Methods of administration and dosage

Famotidine (indications for the use of the drug should be studied before starting treatment) in tablet form is intended for oral administration. Depending on the disease and the severity of its symptoms, different therapy regimens can be used. There are also standard treatments that can be used in the absence of other indications.

Tablets are consumed at 20 mg 3 times a day for 30 days. Usually, doctors recommend taking them 30 minutes before eating food, which will prevent the development of complications after some foods. the duration of therapy is determined individually, and may vary depending on the manifestations.

The lyophilisate is used only to obtain a solution that is administered intravenously using a dropper or syringe. In the first case, 100-200 ml of physiological solution accounts for 1 bottle of the drug, the resulting medication is injected intravenously using a dropper.

When injected with a syringe, the lyophilisate is preliminarily dissolved in 10-20 ml of sodium chloride, injected slowly in a stream. The manipulation is repeated 1-2 times a day, and the duration of parenteral administration is 10-14 days. Typically, this dosage form is used in a hospital setting.

With peptic ulcer

If a patient is diagnosed with gastric ulcer and duodenal ulcer, the use of the drug continues for 3-5 weeks, which is determined during examination and diagnosis.

The tablets are taken 3 times a day, and a single dosage depends on the severity of the symptoms of the disease. The standard dose for 1 dose is 20 mg, but in severe peptic ulcer disease, it can be increased to 40 mg.

With repeated vomiting during the day, nausea and stool disorders, the patient is prescribed a lyophilisate in courses of 14 days. Every day, the introduction of the drug is repeated 1 or 2 times, the dosage for 1 time is 1-2 bottles.

For dyspeptic disorders

The drug is often prescribed for dyspepsia, provoked by increased acidity of gastric juice. Treatment continues for 2 weeks. The dosage for such disorders does not exceed 20 mg per dose, and it is repeated no more than 2 times a day.

In the absence of effect, the dose and duration of therapy may be increased. If symptoms arise in the form of complications of certain diseases, the drug is prescribed as an auxiliary method of treatment.

With reflux esophagitis

Reflux esophagitis is treated for 6-12 weeks, depending on the severity of the manifestations and the presence of concomitant symptoms in patients. A single dosage for the patient is 20 mg.

The application is repeated 2 times a day. The rate can be increased to 40 mg per dose, if the doctor considers it appropriate. Lyophilisate for such a violation is usually not prescribed. If necessary, a standard scheme is used, involving the intravenous administration of a solution prepared from 1 or 2 vials of lyophilisate, 1-2 times a day.

The duration of the course when applied and parenteral dosage form does not exceed 2 weeks.

For the prevention of complications

Famotidine (indications for the use of the drug indicate the possibility of prophylactic administration in some cases) is not so often used for prophylactic purposes. In this case, tablets are prescribed in courses of 4-6 weeks.

A single dosage of the drug is 20 mg, it is consumed 1 time per day. Sometimes you need to take it 2 times a day, but this scheme is used less often. Changes in dosage and duration of treatment should be agreed with your doctor. It is forbidden to independently adjust the rates and duration of the course.

Some analogues

The drug has analogues with the same properties. They can contain a similar ingredient in the composition, or they have an effect due to another substance.

The following substitutes are most often used:

• Kvamatel also contains the substance famotidine, which has an anti-ulcer effect. The medication helps to reduce the production of hydrochloric acid, inhibits the activity of pepsin and other enzymes, protects the walls of the stomach and duodenum from the aggressive effects of food, drinks. Like the original, the medicine is available in the form of tablets and a lyophilisate for parenteral administration. The scheme of using the analogue may differ, it is determined individually for each patient.
• Famosan also has an effect due to the presence of famotidine in the composition. The drug has antiulcer properties, helps to improve the condition in the acute stage and prevent the development of complications in the chronic course of the disease.
• Omeprazole has an antiulcer effect due to the presence of the same active ingredient in the composition. The medicine is available in the form of tablets and lyophilisate, it is used in short and long courses, depending on the severity of the manifestations. Like the original, the medicine reduces the amount of hydrochloric acid and protects the walls of the organs from the negative effects of enzymes.

The choice of a substitute is made only by the doctor after examining and interviewing the patient. Despite the similar composition of many drugs, some of them are more aggressive, others are not considered less effective.

Famotidine is an effective antiulcer agent used to treat patients with diseases of the mucous membrane of the digestive tract. The indications for its use are described in the official instructions, they should be studied before starting treatment, which will avoid the development of complications.

Video about the drug Famotidine

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