Napilept 500-1000 mg. Price, instructions for use, reviews

Napilept is a drug, used for disorders of the brain. The drug is available in 2 dosage dosages (500 and 1000 mg) and has an acceptable cost.

Release form

The medicine is made in the form of a solution for injection. It is a colorless transparent liquid, odorless.

The drug is contained in glass ampoules, packaged in contour cells, and packed in cardboard boxes.

Chemical composition

The active ingredient is sodium citicoline.

Additional composition:

• hydrochloric acid or sodium hydroxide;
• injection water.

Thanks to the complex action of all ingredients, a therapeutic effect is achieved.

Pharmacological properties

The medicine belongs to the group of nootropic drugs. Its main substance is a structural ingredient of cell membranes.

The drug has a wide spectrum of activity:

• regeneration of damaged cells located in membranes;
• suppression of the activity of certain enzymes (phospholipases);
• prevention of free radicals;
• impact on the mechanisms of cell death.

In ischemic strokes, the medication helps to reduce the affected area and restore cholinergic activity. The solution shortens the period of post-traumatic stress syndrome caused by brain damage (trauma), and also reduces the clinical manifestations and symptoms of disorders.

With insufficient oxygen supply to the brain cells, the drug has a therapeutic effect on cognitive impairment and helps to cope with the following symptoms:

• decreased or impaired memory;
• lack of initiative;
• Difficulty communicating or performing daily tasks.

The drug helps to increase memory, attention and consciousness, fights the symptoms of amnesia. The tool has proven itself well in relation to neurological disorders that have a vascular or degenerative nature of origin.

Pharmacodynamics and pharmacokinetics

The active substance of the agent quickly and well penetrates and is distributed throughout the tissues of the brain. It is actively absorbed into cytidine groups and phospholipid complexes.

In this case, the component is embedded in the following membranes located in the cells of the brain:

• cytoplasmic;
• cellular;
• membranes located in the mitochondrial region.

The drug undergoes metabolic transformation and breaks down into 2 active metabolites. At the same time, after intravenous or intramuscular administration, the level of choline in the blood increases.

About 15% of the applied dosage leaves the body (3% - by the renal system, 12% - with exhaled carbon dioxide), the rest is distributed to the tissues and cells of the brain.

Renal excretion of components occurs in 2 stages. At the first stage, the ingredients of the product leave the body within 36 hours. In this case, the elimination rate decreases rapidly.

At the second stage, the rate of excretion of metabolites decreases much more slowly.

The rate of elimination of components by means of exhaled carbon dioxide is also divided into 2 stages. In the first stage, the speed decreases rapidly after about 15 hours. In the future, it decreases significantly.

Indications for use

Neipilept 1000 mg (the price of a drug with a lower dosage may differ significantly) is recommended for use in more pronounced and severe forms of pathologies. The medication is prescribed for functional and cognitive disorders of the brain.

Indications:

• ischemic stroke (acute course of the disease) - as a complex treatment;
• rehabilitation after a previous ischemic or hemorrhagic stroke;
• TBI (traumatic brain injury) - acute course or rehabilitation;
• cognitive and behavioral disorders due to the development of degenerative and vascular pathologies of the brain.

The solution should be used only after passing all the necessary studies and making a diagnosis.

Contraindications

The medicine has some restrictions, in the presence of which it is necessary to refuse it use, as this can complicate existing diseases or lead to the development of additional violations.

Contraindications:

• allergy to ingredients;
• minor age.
• vagotonia (pronounced form of disorder) - hyperfunction of the parasympathetic part of the nervous system.

In these conditions, you should choose a different medication.

Before using injections, you need to make sure that there are no allergies to them. To do this, you must enter a single dose and monitor the reaction. In the event of the formation of any negative signs, it is necessary to abandon the further use of the product.

At what age can the drug be used?

The medicine is not intended for use in pediatric practice, since there are no data on the safety of the solution for this group of patients.

Instructions for use, dosage

The solution is recommended to be administered intravenously. Intramuscular use of injections is also allowed (as indicated by the attending physician).

Napilept 500 mg

The agent in a dosage of 0.5 g is prescribed for rehabilitation after a stroke, as well as for behavioral and cognitive disorders.

The duration of therapy is individual, according to the indications of the attending specialist.

Napilept 1000 mg

In acute ischemic stroke or TBI, 1 g is prescribed every 12 hours. Moreover, the maximum daily rate should not exceed 2 g.

The duration of the course is at least 1.5 months.

During the rehabilitation period after suffering strokes, as well as with cognitive dysfunctions, 0.5-2 g per day is prescribed. In this case, the drug should be administered intramuscularly or intravenously.

The duration of treatment is individual, based on the severity of the disorder.

Side effects

Napilept 500 mg (the price of the drug is affordable for most of the population) has a lower degree of side effects, since this dosage is more preferable.

Adverse reactions are extremely rare and are associated with the individual characteristics of the patient's body and the influence of the main ingredients.

Side effects:

• dizziness;
• migraine;
• feeling of heat;
• allergic manifestations;
• trembling in the body;
• nausea and vomiting;
• diarrhea;
• the formation of puffiness;
• dyspnea;
• sleep disorders;
• hallucinations;
• increased excitability;
• loss of appetite;
• overstimulation of the nervous system;
• drops in blood pressure;
• violation of the activity of liver enzymes;
• in persons with paralyzed limbs, a feeling of numbness.

In the event of the formation of these signs, as well as other symptoms not described in the instructions, it is recommended to interrupt further use of the drug and seek the advice of a specialist.

Overdose

The drug has minimal toxicity, so overdose cases have not been reported or provided. However, if the dosages prescribed by a specialist are significantly exceeded, a negative effect may develop in the form of allergic reactions or symptoms from the gastrointestinal tract.

If any negative signs occur, further use of the medication should be discontinued and a doctor should be consulted. If necessary, symptomatic therapy is carried out.

special instructions

With intravenous jet administration of the agent, the infusion rate should be low - from 3 to 5 minutes, based on the dosage used. When using a drop solution (jet), the rate of administration should be no more than 40-60 drops per minute. In case of hemorrhagic processes inside the brain, the established dosages should be strictly adhered to - no more than 1 g per day. In this case, the rate of administration should not exceed 30 drops per minute.

For intravenous injections, the solution is not injected into the same place. With each new infusion, the medicine should be injected into a different area. During pregnancy, the agent is prescribed only taking into account the potential risks and expected benefits. However, according to animal studies, the solution does not affect the course of pregnancy and fetal development. When breastfeeding, it is recommended to refuse feeding for the entire period of therapy. Elderly patients do not adjust the dosage. The medication is used immediately after opening the ampoule.

Occasionally, injections can lead to the formation of dizziness, so you should refuse or show high the degree of caution while driving or when performing work that requires increased psychomotor functions.

Drug interactions

The drug can potentiate all the effects of levodopa. It is recommended to refrain from the combined use of the solution and products that contain meclofenoxate.

When using other medications during the period of administration of the solution, you should inform the treating person about this in advance. doctor, which will avoid drug incompatibility and, as a result, prevent the development of negative reactions.

Analogs

Neipilept (1000 or 500 mg) in exceptional cases can lead to the formation of hypersensitivity reactions. With the development of such symptoms, it is recommended to replace the drug with another remedy similar in purpose and action. In this case, the cost of medicines is not taken into account.

The selection of analogs should be carried out by a specialist. It is forbidden to prescribe and use substitutes on your own, since an incorrectly selected agent can lead to an aggravation of the condition and cause additional complications.

Recognan

This analogue is manufactured in Russia in the form of an injection solution, the active ingredient of which is sodium citicoline. The drug belongs to the group of nootropics and is widely used for various brain disorders.

Application area:

• ischemic stroke (acute course of pathology);
• hemorrhagic and ischemic stroke (as a complex therapy during the rehabilitation period);
• TBI (acute course of disorders or rehabilitation);
• cognitive and behavioral disorders of degenerative or vascular origin.

Dosing regimen (intravenously): 1000-2000 mg per day according to the established form and severity of the disorder. Apply, thus, for 3-7 days. Then they switch to intramuscular use of the solution. Dosing regimen (intramuscularly): 500-1000 mg per day. The duration of use is individual, according to the doctor's indications.

Contraindications:

• allergy to ingredients;
• vagotonia;
• minor age.

During pregnancy, the use of injections is possible only with the permission of a doctor, taking into account the possible risks and expected benefits. During lactation, it is required to stop feeding for the entire duration of treatment. Dispensing conditions - prescription. The price of injections in state and commercial pharmacies in Russia is 340-1130 rubles.

Proneiro

Neipilept 500 mg (the price of similar drugs can largely be from the original drug) and 1000 mg have identical indications and dosage regimen with the drug. However, some of the generics can have completely different dosages and usage patterns. The Proneiro substitute is produced in Ukraine in the form of a solution for intravenous or intramuscular administration. The active ingredient is sodium citicoline. The drug belongs to the class of nootropic medicines and is used in the treatment of various brain disorders.

Indications:

• ischemic and hemorrhagic stroke (acute course of the disorder or rehabilitation period);
• head damage (aggravated course or rehabilitation period);
• behavioral disorders and cognitive dysfunctions caused by degenerative or vascular factors.

Dosing rules: 1-2 g per day intravenously. Injections are given for 3-7 days, then they switch to intramuscular infusion - 0.5-1 g per day. The duration of therapy is individual, according to the doctor's instructions.

Restrictions on the appointment:

• allergy to ingredients;
• children under 18 years of age (there are no data on the safety of the drug in this group of patients);
• the presence of vagotonia.

During pregnancy, the solution is prescribed only by the attending physician, taking into account the expected benefits and perceived risks.

During lactation, you should stop feeding for the entire duration of therapy. You can start feeding only after 3 days after stopping treatment. Dispensing conditions - prescription. The cost of the drug in regional and regional pharmacies in Russia is 380-945 rubles.

Nootsil

Napilept 1000 mg (the price of analogues and the main medication is not a criterion for their therapeutic action) or 500 mg can be replaced by other drugs produced in other dosage forms. Such funds are prescribed in the absence of the possibility of another route of administration. Nootsil is produced by a domestic manufacturer of medicines in the form of a solution for oral use. The active ingredient is sodium citicoline. The medication is a representative of nootropics and is prescribed for the development of disorders associated with the functions of the brain.

Application area:

• ischemic stroke (exacerbation stage);
• hemorrhagic and ischemic stroke (acute course of the disorder or rehabilitation period);
• TBI (complex treatment);
• oppression of cognitive and behavioral functions due to the presence of diseases with vascular or degenerative etiology.

Dosage regimen: orally during or after meals, 1 g every 12 hours. Before this, the solution should be diluted with water (half a glass). In severe violations, the dosage can be increased to 2 g per day. The duration of treatment is 1.5 months or as indicated by a doctor.

Contraindications:

• pronounced course of vagotonia;
• intolerance to the components;
• minor age.

Injections can be used while carrying a baby. However, it is necessary to take into account the possible risks and the expected effect. When prescribing a solution during lactation, it is required to stop feeding for a while. It is recommended to start feeding no earlier than 3 days after the end of therapy. The way of implementation is prescription. The cost of the solution in private and public pharmacies in Russia varies from 405 to 1010 rubles.

Terms, conditions of sale and storage

• The drug should be stored in a dark and dry place at temperatures up to 25 ° C.
• Shelf life is 4 years from the date of issue.
• Do not use after the expiration date stated on the package.
• Dispensing method - prescription.

Price

Solution prices may vary slightly depending on the region and area of ​​sale.

Region / region	Dosage form / dosage	Price
Moscow, Moscow region	Solution for injection (500 mg), 4 ml	RUB 250-555
St. Petersburg	Solution for injection (500 mg), 4 ml	255-570 rub.
Saint Petersburg (suburbs)	Solution for injection (1000 mg), 4 ml	RUB 520-940
Leningrad region	Solution for injection (500 mg), 4 ml	RUB 270-460
Novgorod region	Solution for injection (1000 mg), 4 ml	RUB 540-900

Before using Napilept (500 and 1000 mg), you should consult a specialist and carefully study the instructions for using the injections. You can clarify the cost and purchase the medicine at any private or state pharmacy located in your place of residence.

Video about the active substance of Napilept

Citicoline: