Ursodez 100 tablets 250-500 mg. Price, instructions for use, reviews

Ursodez - pharmacological agent, in demand in gastroenterology. Its price depends on the retail margins of the pharmacy chains. As part of the drug produced by a domestic manufacturer, the active substance is in a dosage of 250 mg, in a package of 100 tablets. With the help of Ursodez, it is possible to improve the well-being of patients with pathologies of the liver, gallbladder, cystic fibrosis. The drug is usually well tolerated, and with the correct dosage, its side effects are not noted.

Release form

The drug is produced by the Russian pharmaceutical company Severnaya Zvezda in the form of hard capsules. Under their gelatinous shells there is a fine-crystalline powder with an active substance and additional ingredients. The capsules are packaged in blister contour cells made of dense metallized foil. The secondary packaging of the pharmacological agent is a cardboard box, inside which there is still detailed instructions for use.

Chemical composition

The active composition of the drug is represented by only one component - ursodeoxycholic acid from the clinical and pharmacological group of hepatoprotective agents.

To form the contents of capsules and their shells, the manufacturer uses substances:

• croscarmellose sodium;
• hydroxypropyl methylcellulose;
• magnesium stearate;
• titanium dioxide;
• gelatin;
• dye.

Thanks to the combination of excipients, a metered release of ursodeoxycholic acid in the lumen of the gastrointestinal tract and prolonged (long-term) manifestation of its therapeutic effect.

Pharmacological properties

The therapeutic effects of the drug are due to the pharmacological properties of its active substance. It has a pronounced hepatoprotective effect, stimulates the secretion of bile. Regular intake of ursodeoxycholic acid in the body leads to a significant decrease in the biosynthesis of cholesterol in the hepatic structures, a decrease in its absorption into the systemic circulation. The fat-like substance dissolves faster, which leads to a decrease in its concentration in the bile ducts.

Under the influence of ursodeoxycholic acid, more bile is formed, and its discharge is accelerated. It increases the quantitative content of bile acids and at the same time decreases the concentration of fat-soluble organic compounds. After taking the drug, the production of digestive enzymes in the stomach and pancreas increases, their functional activity, which becomes the reason for better digestion of food and absorption of nutrients.

Against the background of treatment with ursodeoxycholic acid, stabilization of glucose levels in the systemic circulation is noted. Cholesterol stones are partially or completely dissolved, including due to a decrease in the saturation of bile with a fat-like substance.

The active substance of the drug has been found to have the properties of an immunomodulator. The course of immunological reactions in the hepatic structures is optimized, the expression of antigens is suppressed, the area of ​​localization of which is the membranes of hepatocytes. Ursodeoxycholic acid is capable of influencing the production of cells of the immune system that detect and neutralize proteins foreign to the body, including allergic agents. And also to reduce the concentration of eosinophils, weakening the course of the inflammatory process.

Pharmacodynamics and pharmacokinetics

After taking the capsules, the active substance is rapidly absorbed into the bloodstream from the small intestine. At the maximum therapeutic concentration, it accumulates in about an hour. Almost completely ursodeoxycholic acid forms high molecular weight complexes with plasma proteins that overcome physiological barriers. Against the background of the course of taking the drug, its share in the bloodstream is almost 50% of all acids that represent the composition of bile.

The active substance is biotransformed in the liver structures with the formation of taurine and glycine conjugates. Metabolites accumulate in bile, so most of them are evacuated from the body with feces. Ursodeoxycholic acid, not absorbed into the systemic circulation, reaches the large intestine. Here it becomes a breeding ground for microorganisms, breaking down by them to lithocholic acid. The substance is therapeutically insignificant, after biotransformation in the liver structures it leaves the body through the intestines.

Indications for use

The drug is intended for the complex therapy of diseases of varying severity, complicated by disorders of the formation of bile, its stagnation, disorders of assimilation and distribution.

Doctors include Ursodez in the therapeutic schemes of patients with the following pathological conditions:

• primary biliary cirrhosis, in which there are no signs of triggering compensatory mechanisms;
• biliary reflux gastritis;
• chronic hepatitis of various etiology;
• primary sclerosing cholangitis;
• cystic fibrosis (cystic fibrosis);
• steatohepatitis, unrelated to alcohol abuse;
• alcoholic liver damage;
• dyskinesia of the bile ducts.

The drug is also used for the symptomatic treatment of pathologies, the course of which is accompanied by the formation of calculi from cholesterol in the gallbladder cavity. After their dissolution and removal from the body, the capsules are taken for prophylactic purposes to prevent re-crystallization.

Contraindications

An absolute contraindication to taking capsules is hypersensitivity to components, including auxiliary ones.

The drug is not prescribed to patients with the following pathological conditions:

• X-ray-positive gallstones, the composition of which is represented not only by cholesterol, but also by calcium salts;
• non-functioning gallbladder;
• acute inflammatory pathologies affecting the gallbladder, bile ducts, intestines;
• decompensated stage of cirrhosis;
• a pronounced decrease in the functional activity of the liver, renal structures, pancreas;
• pancreatitis.

During gestation, the drug is not used, as well as during breastfeeding. It did not show teratogenic and mutagenic effects, but it has not yet been possible to fully trace the pharmacokinetics of the components. Therefore, breastfeeding is recommended to be interrupted, to resume a few days after the completion of treatment.

The drug is not intended for the treatment of patients weighing less than 34 kg. It should be used with caution in patients with a predisposition to the development of allergic reactions, suffering from cholelithiasis or cholestatic hepatic pathologies.

At what age can the drug be used?

In pediatric practice, the drug is used from 3 years old. In the treatment of children, the drug is used in individual doses. They are calculated by the doctor taking into account the weight and age of the child, as well as the diagnosed pathology. Treatment usually starts with minimal doses, and then they are gradually increased to therapeutically significant.

Instructions for use, dosage

If the doctor did not recommend the use of the drug in individual doses, then it is necessary to adhere to the recommendations of the annotation. The drug must be taken orally. The optimal time is during or after meals. The capsule should not be chewed, since the shell protects the active substance from gastric juice. It is swallowed whole with plenty of water. Single and daily dosages depend on the type of disease, the severity and nature of the symptoms.

Purpose of taking capsules	Dosage regimen
Loosening and removal of calculi	10.0 mg per kg of body weight after dinner. The duration of the therapeutic course varies from six months to 2 years with regular X-ray control of the size of calculi.
Prevention of calculus formation	10.0 mg per kg of body weight in the evening hours. The duration of therapy is several months.
Biliary reflux gastritis	0.25 g after dinner. The duration of treatment can vary from. 10 days to 2 years.
Elimination of symptoms of primary biliary cirrhosis	10.0-15.0 mg per kg of body weight twice a day or in the morning, at lunchtime and in the evening for 3 months. When you feel better, the daily dose is taken once after dinner.
Hepatic pathology therapy	12.0-15.0 mg per 1 kg of body weight three times or twice a day with the same time intervals. The duration of treatment is from six months to two years.
Treatment of primary sclerosing cholangitis	10.0-15.0 mg per kg of body weight in the morning and evening or in the morning, at lunchtime and in the evening. The duration of the treatment course is from six months.
Cystic fibrosis therapy	20.0-30.0 mg per kg of body weight twice a day or in the morning, lunchtime and evening hours. The duration of the therapeutic course is from six months or more.
Treatment of biliary dyskinesia	10.0 mg per kg of body weight twice a day. The duration of treatment is from half a month to 2 months.

If the discomfort does not disappear or subside slightly after 2 weeks of treatment, you should consult your doctor. It may be necessary to replace the drug with an analogue with another active substance. Changing the dosage regimen often allows you to improve your well-being.

Ursodez, 250 mg

The drug in a low dosage is convenient to use in the complex therapy of children. They do not need to take large amounts of ursodeoxycholic acid. The drug in this dosage is also recommended for patients who are prescribed 1 capsule daily for prophylactic purposes.

Ursodez, 500 mg

Ursodez in a dosage of 250 mg No. 100 tablets is intended primarily for the treatment of adults. Its price is more favorable than the drug in a low dose. If the appointment of 1.0 g of ursodeoxycholic acid per day is prescribed, then it is more convenient to swallow 2 capsules, and not 4.

Side effects

Ursodez (100 tablets, 250 mg), the price of which varies depending on the dosage, penetrates into the bloodstream, so the occurrence of systemic and local negative effects is possible. They are observed mainly with excessively prolonged use of the drug or due to a timely undetected hypersensitivity to one of the components.

Systemic negative reactions are manifested:

• diarrhea;
• bouts of nausea;
• epigastric pain, uncomfortable pulling sensations in the right hypochondrium;
• an increase in the concentration of calcium in gallstones;
• increased activity of liver enzymes.

Allergic local reactions from the skin are possible in the form of itching, redness, and rashes.

You must immediately notify the supervising doctor about the deteriorated state of health, after stopping the treatment. They will be prescribed drugs to eliminate side effects, a safer analogue will be recommended. Patients with primary biliary cirrhosis, in whom taking capsules provoked transient decompensation, do not require symptomatic therapy. After their cancellation, all uncomfortable sensations disappear on their own.

Overdose

Ursodez (100 tablets, 250 mg), the price of which differs in different pharmacy chains, could theoretically cause an overdose. But in clinical practice, such cases have not yet been noted. If, after a single intake of capsules in large quantities, the state of health has worsened, then to eliminate the pathological condition, it is necessary to rinse the stomach, take activated charcoal. And then see a doctor for symptomatic treatment.

special instructions

During treatment, alcohol should not be consumed, as this will weaken the therapeutic effects of the drug. Under the influence of ethanol, the work of all vital systems, including the digestive system, deteriorates. The likelihood of exacerbation of chronic pathologies, the development of side and allergic reactions increases. Avoiding alcohol will speed up your recovery.

The medicinal product is approved for use when driving vehicles. Refusal to perform work requiring increased concentration of attention, special speed of psychomotor reactions is not required. But provided that there are no side effects.

It is forbidden to use the drug without the consent of the doctor, carrying out preliminary diagnostics. Patients with severe renal pathologies do not need to calculate individual doses. But their subsequent correction is possible, depending on the response of the patient's body to the therapy. Constant monitoring of the patient's condition is required to assess the functional activity of the kidneys.

Drug interactions

Ursodez (100 tablets, 250 mg), the price of which depends on the number of tablets in the package, is able to change the pharmacokinetics and pharmacodynamics of simultaneously used drugs. When taken in combination with Kolestiramine, Colestipol, antacids, the composition of which is represented by aluminum hydroxide or oxide, ursodeoxycholic acid is absorbed from the intestine into the blood in a smaller concentration. This significantly reduces the therapeutic effects of the drug. Therefore, it is recommended to use such funds at least 2 hours in advance.

In turn, ursodeoxycholic acid stimulates the increased absorption of Cyclosporin, provoking an overdose. It requires constant monitoring of its content in the systemic circulation, if necessary, recalculating doses downward.

The drug in combination with lipid-lowering agents, including Clofibrate, as well as estrogens, neomycin, progestogens, increases the quantitative content of cholesterol in bile. This significantly impairs the dissolution of cholesterol gallstones.

Analogs

If a patient is found to be hypersensitive to an active substance, an auxiliary component, or due to the lack of a drug in pharmacies, the use of analogues is required.

Medicines have similar therapeutic properties:

• Urdoksy;
• Livedex;
• Ursofalk;
• Urso;
• Ursodex;
• Ursoroma from Rompharm;
• Ursoliva;
• Ursolita;
• Ursoroma C;
• Choludexan;
• Ursosana;
• Exhola.

Ursodez (100 tablets, 250 mg), the price of which may be higher or lower than analogs, is replaced only by a doctor, taking into account anamnestic data and contraindications. The chosen drug should be just as effective. He usually has a narrower list of possible side effects.

Terms, conditions of sale and storage

The shelf life of the drug is 5 years. It must be stored at room temperature in a dark place. Keep out of the reach of children. When buying a choleretic agent, you do not need to show a doctor's prescription to a pharmacy employee. It is forbidden to use capsules when the surface of the shells cracks, changes in color.

Price

The price of the drug varies depending on the number of capsules in the package and the dosage. The average cost of a drug in various pharmacy chains is 1000-1100 rubles.

Ursodez (100 tablets, 250 mg) increases the functional activity of the liver and gallbladder. Its price for 100 tablets with a dosage of an active ingredient of 250 mg is low, and its therapeutic efficacy has been confirmed by clinical trials. The drug is prescribed by gastroenterologists to normalize the outflow of bile, restore damaged liver cells. Subject to the dosage regimen determined by the doctor, the likelihood of side effects is minimal. This is one of the safest remedies used in gastroenterological practice.

Video about the drug Ursodez

Instructions for using Ursodez: