Plavix 75-300 mg 100 tablets. Price, instructions, reviews

Plavix is ​​an antiaggregatory medication, which is often used for patients with a tendency to form blood clots. Tablets can have a dosage of the active ingredient of 75 or 300 mg, therefore, if necessary, the most appropriate option for the patient can be selected depending on the symptomatology. The price of the drug for 100 tablets is high, but it is justified by the effectiveness and rapid achievement of the therapeutic effect.

Composition and form of release

The drug is available for purchase in the form of tablets for oral administration. The tablets are small, oblong, pink in color. The appearance of the tablets does not differ depending on the dosage of the active substance.

The drug with an increased dosage of the active substance is packaged in blisters of 10 pieces. The drug with a dose of 75 mg is placed in plates of 7, 10 or 14 pieces. The plates are in a cardboard box, in each of which you can find 1-3 pieces. A description of the use of the tablet preparation is attached to the plates.

The tablets contain the main ingredient clopidogrel, which has therapeutic properties.

The medication contains excipients:

• Pink dye.
• Macrogol.
• Mannitol.
• Wax.
• Microcrystalline cellulose.
• Castor oil.

Additional substances in tablets with a dosage of 75 and 300 mg do not differ.

Terms of sale, prices

Plavix 75 mg (100 tablets, the price of which is high, is enough for a therapeutic course) and a remedy on the other dosage of the main ingredient is dispensed in different pharmacies after presentation of a certified prescription form from a doctor. This prevents self-administration without a doctor's prescription.

The cost of the product ranges from 900-3200 rubles, which depends on the number of tablets in the package. In different pharmacies and regions, the price may differ.

The maximum shelf life of the drug is 3 years. At the same time, it is important to exclude moisture and direct sunlight from getting on the tablets for a long period. After the expiration date, the use of the medication is prohibited. The production date can be seen on the packaging.

Action, efficiency

The drug is highly effective, despite the fact that it is a prodrug. This means that the active ingredient does not directly affect the coagulation processes. blood, but its metabolites block platelet adhesion, which provides antiaggregatory the effect.

Due to this, blood thinning occurs.

The tool has additional properties:

• Reduces blood pressure on the walls of blood vessels, which prevents them from stretching and reducing elasticity.
• It thins the blood, prevents a critical increase in blood pressure and improves the general condition of patients with a tendency to thrombosis.
• Weakens the manifestations of cerebrovascular accident, which often develops in patients with hypertension and a tendency to thrombus formation.
• Improves the condition in the malignant course of arterial hypertension. Often, thickening of the blood leads to a critical increase in blood pressure, but taking the medication somewhat weakens the manifestations and prevents the development of complications.
• The drug improves blood circulation by facilitating the movement of blood through the vessels. As a result, a better saturation of tissues with oxygen occurs, the development of oxygen starvation is prevented.

Plavix 300 mg (100 tablets, the price of which differs in different regions, are most often purchased by patients) and a medicine with a lower dosage of the active ingredient is rapidly absorbed in the body after oral administration use. The main substance is absorbed through the walls of the small intestine and enters the bloodstream.

The processing of clopidogrel leads to the formation of metabolites, which affect the process of blood coagulation. Within 2 hours after use, the first therapeutic effect can be noted with the help of a laboratory blood test.

The maximum concentration of ingredients in the blood is reached 1 hour after taking a single therapeutic dosage. For several hours, it remains at the same level, after which it gradually decreases. The main substance binds to plasma proteins by 95-96%, which is considered a high indicator and explains the effectiveness.

The processing of components is carried out in the patient's liver, therefore, if the functioning of the organ is disrupted, a slowdown of this process is noted, which can affect the time of the onset of the therapeutic effect. The period of elimination of the ingredients of the composition from the body can take up to 7 days, since the substances accumulate in a small amount in the body. Within 5 days, approximately 50% of clopidogrel metabolites are evacuated with the help of the kidneys. The rest of the components are excreted in the feces.

In some patients, the period of cleansing the body takes up to 2 weeks, especially in the presence of chronic kidney pathologies. A slight delay in the evacuation of ingredients does not always affect the therapeutic effect.

Indications and contraindications for use

The drug in tablet form is used in the diagnosis of various diseases accompanied by blood clots.

The main indications for the appointment:

• Acute coronary syndrome, in which the condition of patients worsens against the background of thickening of the blood and an increased risk of blood clots.
• Violation of cerebral circulation with a wound of the form and degree of severity. The drug can be used in low dosages for the prevention of complications or in an increased dose in the case of a severe course of the pathological condition.
• The need for a prophylactic course when diagnosing atrial fibrillation in patients. In this case, the medication is taken in the minimum dosage.
• The patient's tendency to thrombosis, revealed by laboratory blood tests.

The drug can also be used for other diseases, if the examination determines the risk of thrombosis and other complications. Often it is prescribed as part of the complex treatment of arterial hypertension, if the condition is aggravated by intense adhesion of platelets.

Plavix at a dosage of 75 mg and a drug at a different dose may not always be used. The high price of 100 tablets of the drug is considered one of the obstacles to use by some patients. But there are contraindications not related to the cost of the medicine. The main allergy is considered to be the components in the composition.

Other barriers to treatment include:

• The patient's tendency to bleed. The drug can aggravate the condition and provoke complications, especially when taken in high doses.
• Internal bleeding of various origins. They can be associated with damage to the walls of the digestive tract or trauma to internal organs. Taking the drug provokes blood loss, which only worsens the patient's condition.
• The period of childbearing and breastfeeding is considered an absolute contraindication. Even with the appearance of specific indications, patients at this time are selected other drugs with a safer effect.
• The patient's age is up to 18 years. The tool aggressively affects the body of children and adolescents, can lead to complications in an acute form.
• Exacerbation of gastritis and gastric ulcer, duodenal ulcer. For acute colitis and enteritis, the remedy is also not used. After the normalization of the condition, its appointment is allowed according to indications.
• Hemorrhagic stroke. In this condition, the use of anticoagulant medications only aggravates the manifestations.
• Hepatic and renal failure.
• Acute viral pathologies of the liver, infectious kidney diseases in the acute stage.
• The recovery period after undergoing surgery on the internal organs. At this time, patients may develop postoperative bleeding, therefore, it is better to postpone taking the pills until the condition normalizes.

With caution, the agent is prescribed to patients who have a history of allergy to non-steroidal anti-inflammatory drugs. The use of medicines based on clopidogrel can provoke complications, like NSAIDs. Relative contraindications include the period of therapy with other drugs with anticoagulant properties. Taking Plavix often worsens the condition.

Despite the effectiveness of the remedy, it often leads to the development of complications from the internal organs and systems.

Damage area	Frequent negative reactions
Nervous system	A change in the perception of taste is often observed with the use of the product. Patients are worried about headaches, dizziness, drowsiness and fatigue.
Blood system	An increase in bleeding time is considered the most common adverse reaction with pills. Often, the process of formation of blood cells is disrupted in patients, which leads to a decrease in their number.
Digestive tract	Gastrointestinal disorders manifest as heartburn, pain, indigestion, diarrhea, or persistent constipation. With prolonged use, the symptoms of chronic stomach diseases are aggravated, complications may appear.
Musculoskeletal system	Joint and muscle pains are often observed with the use of the remedy. If the patient additionally suffers from diseases of the musculoskeletal system, the symptoms appear in an acute form.
Respiratory system	Shortness of breath and coughing occurs less often during treatment. Against the background of prolonged use, symptoms of pneumonia may appear.

Allergy to the drug is often manifested, even in patients who have not previously suffered from similar disorders. It is accompanied by the appearance of rashes and areas of irritation on the skin, itching and flaking. As you continue to take the pills, the symptoms worsen, which can lead to the development of Quincke's edema, urticaria.

The drug can lead to the development of an overdose, which is associated with a cumulative effect. If complications or symptoms of this condition appear, you should immediately consult a doctor. The treatment regimen is selected individually, taking into account the symptoms.

Method of administration, doses

Plavix 300 mg (100 tablets, the price of which may be higher in some pharmacies, usually have a lower dose) and 75 mg are taken only by mouth as directed by a doctor. In each case, the dose and duration of use is determined individually, depending on the disease.

With atrial fibrillation

The dosage for patients with a diagnosis of such a disorder is 75 mg per day. This is usually sufficient to prevent complications from blood clots. The duration of therapy is 2-4 weeks, but according to individual indications, it can vary.

Often, the remedy is used in combination with other medicines, but the doctor must first study the compatibility in order to avoid the development of complications. The tablets are taken at approximately the same time, which will maintain the concentration of the ingredients in the blood.

In acute coronary syndrome

Diagnosing such a disorder requires a different treatment regimen. On the first day after the development of the pathology, the patient takes a loading dose of the drug, which is 300 mg. The next day, the dosage is reduced to 75 mg.

The duration of the therapeutic course ranges from 4-6 weeks, but the tablets can be used for a long time, if there is such a need.

With ischemic stroke

The tabletted agent is allowed to be used with varying degrees of severity of cerebrovascular accident. The dosage per day does not exceed 75 mg.

If necessary, a method can be used in which a loading dose of 300 mg is prescribed on the first day of therapy, but this is usually not required. The duration of the pill intake is different for different patients, there are no standard recommendations. As with other uses, it is recommended to use the medicine at the same time.

If the patient missed taking the pill, but less than 12 hours have passed, it is worth taking it as soon as possible. If more than 12 hours have passed, the next tablet is taken at the usual time. In this case, it is prohibited to increase the rate by 2 times.

Patients should carefully adhere to the rules of drug treatment. It is forbidden to increase the dose or prolong the course without a doctor's prescription. With prolonged use, the patient should regularly visit a doctor, who, if necessary, will prescribe a laboratory blood test to determine the body's response to the medication.

Some analogues

Plavix 75 mg (100 tablets, the price of which can reach 3200 rubles, the patient can take for 3 months continuous treatment) and the drug in a higher dose has analogues prescribed in case of impossibility of use original.

Effective substitutes with similar properties:

• Clopidogrel is considered the most popular substitute with pronounced antiaggregatory properties. It is available in tablet form with different dosages of the active substance. They take the medicine in long and short courses, depending on the condition. The drug is prescribed for thickening of the blood and the patient's tendency to thrombosis. The analogue has a more affordable cost, but the original is considered safer. Despite this, the drug is often prescribed in long courses for patients of different ages.
• Zylt has an effect due to the presence of clopidogrel in the composition, is available in tablet form, helps to reduce blood viscosity, prevents blood clots and the development of complications against this background violations. The medicine is available in only one dosage of 75 mg, therefore, if necessary, the patient uses more than 1 tablet per day. Like the original, the analogue should be taken at approximately the same time, the duration of the course is determined during the examination. The dose for the patient is adjusted taking into account the body's response to the drug. Sometimes the minimum rate is sufficient to achieve a therapeutic effect.
• Curantil available to patients in the form of tablets and dragees for oral use. The drug contains another active ingredient - dipyridamole. This substance also has antiaggregatory properties, additionally stimulates the immune forces and improves the condition of the vascular walls. The use of a medicine must be approved by a specialist, which is associated with a different composition. Usually, tablets or pills are taken 1-2 pieces per day, depending on the symptoms. Unlike the original, they can be used for patients over 18 years of age if necessary. An analogue is prescribed not only for blood thickening, but also for the prevention of viral pathologies.

The presence of other active ingredients in some substitutes makes it impossible to independently select a medicine if it is impossible to use the original. As with Plavix, treatment with analogs must be approved by a doctor and carried out under his supervision. Extension of therapy or exceeding the dose is prohibited without specific indications.

Plavix is ​​an effective antiaggregatory agent in tablet form that reduces blood viscosity and prevents blood clots. The price of the drug is high, especially when purchasing 100 tablets for a long course. Despite this, the drug at a dose of 75 and 300 mg is often used by patients due to its effectiveness and rapid achievement of a pronounced result.

Video about Plavix

Plavix tablets description and instructions: