Ursofalk (Ursofalk) suspension analogs for children. List

Ursofalk is a hepatoprotector, which is available in the form of capsules, film-coated tablets or suspension. This drug, like its counterparts for children, promotes the resorption of cholesterol stones - hardened deposits of digestive fluid that are most often formed in the gallbladder.

The tool has a cytoprotective effect and the ability to strengthen the body's immune system. The pronounced therapeutic effect of the drug in some pathological conditions allows you to avoid surgical intervention, then only on the condition that the treatment was started on time.

Characteristics of the drug

Distinctive features of Ursofalk suspension for oral administration is white color, homogeneous consistency, which contains small air bubbles. The aroma is dominated by pronounced notes of lemon.

In one measuring cup of the medicine, in addition to 250 mg of ursodeoxycholic acid, the following auxiliary components are contained:

• monobasic carboxylic acid E210 - 7.5 mg;
• xylitol or polyhydric alcohol pentanpentazole - 1,500 mg;
• microcrystalline cellulose - 100 mg;
• glycerol - 450 mg;
• sodium salt of hydrochloric acid - 3 mg;
• synthetically derived sweetener E952 - 30 mg;
• anhydrous citric acid - 13 mg.

In each carton, complete with a 250 ml dark glass bottle, there is a measuring cup. Its volume is 5 ml.

Since Ursofalk belongs to the group of hepatoprotectors, ursodeoxycholic acid (or epimer of chenodeoxycholic acid, which is a hydroyl, non-cytotoxic bile acid), reduces the cholesterol content in bile.

This happens by the dispersion of a waxy fat-like sterol substance and the formation of a liquid-crystalline phase. The active substance of the suspension affects the cyclic circulation of bile acids in digestive organs, reduces the reabsorption of hydrophobic and potentially toxic compounds in intestines.

Ursofalk suspension, analogs for children of which are as effective as the original drug, affects immunological reactions.

Due to oral administration of the drug, cholesterol gallstones are partially or completely dissolved, lithogenic index of bile, abnormal expression of class I HLA antigens in working cells of the parenchyma decreases liver. And also the production of low molecular weight regulatory proteins (cytokines) and interleukins synthesized by leukocytes is suppressed.

Doctors prescribe Ursofalk if the patient has the following pathologies of the liver or bile ducts in the patient's history:

• cirrhosis - a diffuse chronic process characterized by damage to normal liver cells, their replacement by scar tissue, the formation of excessive fibrosis and structural and anatomical regeneration units;
• cystic fibrosis - hereditary disease, which leads to a malfunction of the functions of the glands of external secretion;
• dyskinesia biliary tract, change in the tone of the gallbladder, tubular formations and their sphincters;
• cholangitis - nonspecific inflammatory lesion of the bile ducts of acute or chronic course;
• gastroduodenitis - inflammation of the mucous membrane of the duodenum and the pyloric zone of the stomach.

Hepatoprotector is also prescribed in complex therapy after liver or other organ transplantation, for prevention of cholestatic syndrome that occurs while taking contraceptives that change hormonal background.

The doctor draws up the recommended dosage regimen based on the indications, clinical situation, patient's age and body weight. As a rule, you need to drink the suspension once a day, before bedtime. But some diseases require two or three times a day with a gradual increase in the dose in the evening. Since infants cannot yet drink the medicine from a measuring container, it can be given from a syringe, after removing the needle from it.

Basic instructions

There are no age restrictions for the use of the epimer of chenodeoxycholic acid, which suppresses the synthesis in the liver and the secretion of Xc, and also inhibits its absorption in the intestine. This drug does not cause any harm to both the body of newborns and children from one year old.

But he has a number of contraindications, in the presence of which the use of Ursofalk is strictly prohibited:

• hypersensitivity to one or more active ingredients that make up the drug;
• Calcareous or X-ray-positive stones in the bladder / bile ducts, the removal of which is possible exclusively by surgical methods;
• non-functioning gallbladder with morphofunctional changes that contribute to trauma to the extrahepatic bile ducts;
• decompensated cirrhosis of the liver, in which the organ ceases to function fully;
• blockage of the bile ducts - mechanical obstacles to the movement of bile from the liver and gallbladder into the duodenum.

Ursofalk suspension, analogs for children of which will be discussed below, should not be taken with severe hepatic failure and gallbladder dyskinesia. The second disease is characterized by functional impairment of the contractility of the muscular layer of the biliary walls, which complicates the evacuation of bile, and is accompanied by biliary pain, icteric syndrome, dyspepsia.

With prolonged use of the medication, various side effects can sometimes occur, upon detection of which the dosage must be reduced or completely canceled.

For example, when taking a suspension, kidney stones can be calcified, and from the patient's digestive system disturbing symptoms such as impaired bowel movements (mushy stools), diarrhea, bouts of cramping pain in stomach. On the part of the skin and subcutaneous tissues, allergic reactions are not excluded, manifested in the form of itchy red blisters.

During the first 90 days of treatment with Ursofalk, the doctor is obliged to monitor the functional parameters of the liver. The patient needs to regularly take a biological blood test to monitor alkaline phosphatase, gamma-glutamyltransferase, transaminase.

If the medication is taken to dissolve cholesterol plaques, an ultrasound scan is performed six months after the start of treatment to assess progress in therapy. If it was not possible to visualize a complete organ on X-rays or if calcification of stones was found, Ursofalk does not need to be taken.

Analogs

Ursofalk suspension has many cheaper substitutes - the so-called generics, which today can be found in the assortment of any pharmacy. Analogs for children and adults are identical to the original in composition and therapeutic effect, but they are produced under the brand name of another manufacturer.

But when buying them, you need to pay attention to the ingredients, since some manufacturers use low quality components, neglect the rules of their storage, use outdated equipment. If after taking the generic you have complaints, you need to refuse it.

Livodex

The main active component of this drug is also ursodeoxycholic acid. It contains immunomodulatory, choleretic, cholelitholytic and lipid-lowering effects.

This hepatoprotector stabilizes parenchymal and epithelial phenotype cell membranes in humans. It successfully dissolves stones, the size of which ranges from 15 to 20 mm, thanks to hypocholesterolemic action reduces the absorption of natural polycyclic lipophilic alcohol in the intestines.

Livodex is prescribed for the treatment of cystic fibrosis, primary sclerosing cholangitis, non-alcoholic steatohepatitis. It is also effective for inflammatory liver diseases of viral origin, lesions of the inner lining of the esophagus, formed against the background of excessive release of acid from the stomach. But with lactose intolerance, a deficiency of milk sugar in the body or cirrhosis of the liver in the stage of decompensation, Livodex cannot be taken.

If Ursofalk is prescribed even to infants, then Livodex is strictly prohibited for children under 3 years old. Because this analog comes in pill form, it can be difficult for babies to swallow.

Ursosan

Ursofalk suspension, analogs for children of which are provided in the article, has another effective generic Ursosan. In addition to ursodeoxycholic acid, the capsules contain starch, titanium dioxide (food supplement E171) and gelatin, of which the capsule shell consists.

The drug has a choleretic effect, eliminates the imbalance of various parts of the immune system, regulates cholesterol levels.

Pathological conditions requiring treatment with Ursosan are presented:

• various types of hepatitis;
• gallstone disease;
• cystic fibrosis;
• cirrhosis of the liver.

The dosage of the medicine for children should be calculated by the doctor on an individual basis. As a rule, for 1 kg of body weight, the patient should receive 15-20 mg of the drug per day. The capsules do not need to be chewed; it is better to drink them whole with plenty of water. The duration of treatment with Ursosan can be from 3 months to six months.

If the skin and visible mucous membranes of the newborn have acquired an icteric tint, the Ursosan capsule is recommended divide into several small parts, then dilute each portion in water or add to mixtures / breast milk.

Choludexan

Each pink colored gelatin capsule contains 300 mg of ursodeoxycholic acid, granular corn starch, magnesium stearic acid, potassium sorbate. The degree of dissolution of the active substances of Choludexan is 70-80%, and after their resorption in the intestine, they are combined with glycine and taurine, and excreted together with bile.

This analogue of Ursofalk prevents the destruction of cell membranes, protects hepatocytes from the negative effects of damaging factors, and has a hepatoprotective effect.

Immunomodulatory activity helps to reduce the severity of pathological changes in the liver, the formation of non-toxic mixed micelles. Thanks to the intake of Choludexan, the bile lithogenicity index decreases, cholesterol calculi with a high proportion of calcium salts dissolve and the risk of the formation of new ones is minimized.

It is recommended to take this drug for the purpose of litholysis of stones (like those that formed against the background severe inflammation of the gallbladder or hereditary, and those that appeared after surgery on the biliary ducts). Contraindications are represented by an acute form of pancreatitis, frequent hepatic colic, pregnancy, disorder of the motor activity of the gallbladder.

Ursohol

According to clinical reports, long-term use of Ursochol, which, like its original the drug, includes ursodeoxycholic acid, is important for functional disorders in the hepatobiliary system.

They occur, as a rule, with cystic fibrosis. The neoplasm of cells and cellular structures in the bile ducts decreases, as well as the progression of histological and hepatobiliary changes stops. But only on condition that treatment was started at an early stage of the disease.

Ursochol also manifests its effective effect in gastritis with bile reflux (when the gastric mucosa becomes inflamed as a result of its damage by bile, retrogradely coming from the intestine). There are no age restrictions for the medication, and it should be taken in the evening, based on a dosage of ≈10 mg / kg of weight. The duration of treatment, depending on the diagnosis, can vary from 6 months to a year. If the gallstones have not decreased at the end of the course, the reception of Ursochol is discontinued.

Exhole

Ursofalk suspension, analogs for children of which are no less effective than the original, sometimes may not be available at the pharmacy. In such a situation, it can be replaced with Exhol, a drug whose action is aimed at improving the organs of the biliary system and the liver. It is produced in the form of capsules and tablets, and a distinctive feature is that side reactions during administration appear quite rarely.

One capsule / tablet contains 0.5 g of ursodeoxycholic acid, 0.4 g of calcium hydrogen phosphate dihydrate, 0.007 g of calcium and stearic acid salt and several other auxiliary elements. After the course of treatment with Exhol, the patients' immunity is strengthened, the amount of cholesterol decreases, and the secretion of bile is accelerated and increased. The stones that form in the gallbladder dissolve, and the components that make up the hepatoprotector perform protective functions.

The drug, which is used in the treatment of hepatobiliary pathologies, has a list of the following indications:

• dyskinesia of the biliary tract or impaired motility;
• reflux gastritis of the liver;
• inflammatory process of the liver against the background of its fatty degeneration, which occurs due to alcohol abuse;
• cystic fibrosis.

Restrictions on admission are represented by an inoperative gallbladder, hepatic or renal failure, the presence of stones with a high calcium content. Exceeding the daily dosage is fraught with nausea, allergies, exacerbation of psoriasis, if any, back pain. Sometimes patients complain of stool disturbance, hair loss. But, as mentioned earlier, side effects are rare.

Henofalk

The latest generic Ursofalk from the selection, which stops the formation of a waxy, fat-like sterol substance in the liver. Chenodeoxycholic acid, magnesium stearate, silicon dioxide and corn starch are completely absorbed in the body, interact in the liver with organic compounds, the molecule of which simultaneously contains carboxyl and amine groups. Partial reabsorption occurs in the intestine.

Henofalk is prescribed before contact lithotripsy - a method of treating urolithiasis, nephrolithiasis and gallstone disease, during which an endoscope is inserted inside to crush the kidneys, urinary or gallstones. The medication is contraindicated for calcification of stones, hepatitis, pregnancy, stomach ulcers. If the daily dose is exceeded, which is 1.5 g, indigestion, skin rash, biliary colic are possible.

Price of funds

Ursofalk and its analogues are in different price ranges. To make it easier to choose a medicine based on the budget, the cost of all the drugs listed in the article is collected in the table below.

Name	Price
Ursofalk	from 900 to 1,700 rubles.
Livodex	from 470 to 745 rubles.
Ursosan	1595 RUB
Choludexan	574 r
Ursohol	RUB 6700
Henofalk	RUB 1846-1902
Exhole	From 463 to 586 rub.

Each of these drugs is highly effective, and their popularity among patients is growing every day and has already reached 85% of buyers. The disadvantage in the form of the high cost of some medicines is compensated by the dissolution of gallstones, a rare manifestation or the complete absence of adverse reactions.

Ursofalk in the form of a suspension, tablets or capsules is prescribed only by a doctor and is dispensed with a doctor's prescription. Therefore, it is not recommended to self-medicate and try to buy a medicine or its analogues for children / adults without first consulting a specialist.

Video about Ursofalk analogs

Analysis of hepatoprotectors: