Flosteron injections. Price for 1 ampoule, instructions for use

Flosterone is a parenteral glucocorticosteroid medication that has anti-inflammatory properties and helps stop the symptoms of many chronic, acute pathologies. The cost of 1 ampoule of the drug is quite high, but it is justified by its effectiveness. For some patients, price is one of the barriers to use.

Composition and form of release

The drug has an effect due to the presence of betamethasone in the substance.

The composition of the medication also includes small amounts of auxiliary ingredients:

• Polysorbate.
• Sodium chloride.
• Sodium carmelose.
• Methylparaben.
• Hydrochloric acid.
• Benzyl alcohol.
• Purified water.

The medication is available as a suspension for injection. The composition has a whitish color, it is cloudy, and may have a slight sediment. The suspension is placed in a transparent glass ampoule in the amount of 1 ml. The ampoule is in the contour cell. A cardboard box contains a plate with 5 ampoules and a description indicating the nuances of use, possible complications and contraindications.

Terms of sale and prices

Flosterone is dispensed in different pharmacies after presentation of a certified prescription form from a doctor. The price of 1 ampoule of the drug is approximately 200-250 rubles.

The cost may differ depending on the region of distribution and the specific pharmacy.

Pharmacological properties

The pharmacological agent has anti-inflammatory and anti-allergic properties, which is associated with the presence of a glucocorticosteroid component in the composition. The substance is a synthetic analogue of hormones produced by the human adrenal glands.

The drug also has an immunosuppressive effect, helps to slow down the immune response in patients with autoimmune pathologies. As a result, the condition improves significantly, especially in the acute course of the disease.

The drug prevents the exacerbation of symptoms in the chronic course of the disease, has analgesic properties, despite the absence of an analgesic component in its composition.

Pharmacodynamics and pharmacokinetics

After the agent enters the body, its distribution over the affected tissues occurs quickly. The active substance from the group of glucocorticosteroids quickly eliminates signs of inflammation in case of damage to the articular joints, skin or internal organs.

The ability of betamethasone to influence the energy metabolism in tissues is noted, which has a positive effect on the course of the pathological condition.

The drug also has another effect on the body:

• Suppresses the inflammatory process in connective and other tissues. For example, when the joint capsule is damaged, the drug is highly effective. The drug blocks substances that provoke inflammation, which leads to the elimination of manifestations, even in the acute course of the pathological condition.
• The ability of the agent to act for a long time and prevent the recurrence of acute symptoms in the chronic course of the disease is noted.
• The drug additionally suppresses the process of tissue destruction under the influence of degenerative-dystrophic changes.
• The solution suppresses the progression of pathologies of the respiratory system, especially with exacerbation of chronic forms, accompanied by bronchospasm and other disorders.

Depending on the method of administration of the medicinal suspension, the effect of the active ingredient may differ. The drug acts systemically or locally if it is injected into a specific area to stop the inflammatory process in it.

Flosterone (the price of 1 ampoule is high for many patients) is absorbed in the body quickly, does not accumulate in the tissues, since it is usually used in short courses. The maximum concentration of the component is reached 20-30 minutes after the administration of a single therapeutic dose.

The processing of the ingredients is carried out in the patient's liver, after which the decay products of the active substance are excreted with the help of the kidneys. Disruption of the liver and kidneys leads to a slowdown in the processing and elimination of components from the body. This does not affect the therapeutic effect, but it may increase the level of the drug in the blood.

Indications for use

The drug is used for various pathological conditions, which is associated with its properties and the rapid provision of a therapeutic effect.

The main indications for use:

• Pathologies of the articular joints, accompanied by a pronounced inflammatory process. The medicine is prescribed for rheumatoid arthritis and the classical course of a pathological condition with severe pain, general signs of a disorder.
• Respiratory system diseases. The drug is indicated for acute bronchial asthma, when bronchospasm and associated symptoms develop. Some obstructive bronchial pathologies.
• Systemic lupus erythematosus. The drug is indicated as an auxiliary method of treatment.
• Synovitis in the acute stage. In a chronic course, the remedy is usually not used.
• Hepatic coma against the background of systemic diseases.
• Edema of the brain with various injuries, pathologies of toxic origin.
• Osteoarthritis, in which patients develop complications.
• Acute psoriasis affecting a large area of ​​the skin. Means for external use in this case do not help alleviate the condition, therefore, the use of systemic drugs is necessary.
• Insect bites, accompanied by the appearance of severe edema and redness on the skin. The drug is often used for the development of acute allergic reactions after a bite.
• Allergic reactions of various origins. The medicine is indicated in the case when the tablets do not help to stop the symptoms.
• Contact atopic dermatitis.
• Anaphylactic shock associated with the use of certain drugs, food or drink.
• Acute myositis.

The drug can be used as the only method of therapy or as an auxiliary method to alleviate the condition. During pregnancy, the medicine can only be used if the potential benefit is greater than the possible harm to the baby.

Contraindications

Flosterone (the price of 1 ampoule may differ depending on the batch supplied to the pharmacy by the manufacturer) has a long list of contraindications due to its pronounced action and hormonal origin composition.

The main contraindications:

• Breastfeeding period. If the appointment of a remedy is necessary, feeding should be discontinued.
• Intolerance to the components in the composition of the drug.
• Severe diseases in which the immune system is affected and immunodeficiency develops. The drug can aggravate the patient's condition.
• Thromboembolism, a tendency to thrombosis.
• Active tuberculosis.
• Glaucoma at an advanced stage.
• Osteoporosis. The course of the disease is aggravated by the use of the drug.
• Diagnosis of a viral, infectious or fungal disease in an acute form. After elimination of the manifestations, the use of the medicine is allowed.
• The patient's age is up to 3 years.
• Deformation of the articular joint against the background of degenerative-dystrophic changes.
• Joint instability.
• The period of preparation for vaccination, as well as recovery after it. It is usually not recommended to use hormonal agents for 2 weeks before the procedure and for 2 weeks after it.
• Congenital pathologies accompanied by blood clotting disorders.
• Malignant course of diabetes mellitus.
• Chronic severe renal and hepatic impairment.
• Cirrhosis of the liver.
• Obesity of 2-3 degrees.
• The period of rehabilitation after suffering an ischemic stroke and myocardial infarction.
• Hepatitis of viral origin.
• Polio.

The drug is used with caution in the treatment of elderly patients suffering from vascular and heart diseases.

Methods of administration and dosage

The medication is used for parenteral administration. Depending on the disease, the suspension is used for intra-articular or intramuscular infusion. In case of systemic diseases of internal organs or damage to the skin, the drug is administered intramuscularly, in case of damage to the articular joint, it is poured into the articular bag.

Infusion method	Dosage and manipulation features
Intramuscular injection	Depending on the patient's well-being and the presence of complications, the dosage of the drug ranges from 0.1-2 ml. The initial dose does not exceed 0.1 ml, but if there is no effect, it is increased according to indications. Intramuscular injection is carried out according to the standard scheme, it must be injected deep into the muscle, which will avoid the development of complications from the tissues in the infusion area. The duration of use is 3-7 days, a one-time rate is administered 1 time per day, preferably at the same time. The drug is not always administered daily, the intervals between injections can be 1-2 weeks.
Intra-articular infusion	Intra-articular administration is carried out only by a doctor in a hospital or clinic. For this, the patient takes a comfortable position, the specialist determines the necessary points for safe infusion. After that, the puncture area is treated with an antiseptic solution, the drug is injected at 1-2 points, depending on which joint is affected. The puncture areas are re-treated with an antiseptic solution and sealed with a plaster. The introduction into the joint is repeated no more than 1 time in 7 days. The course consists of 3-5 sessions, depending on the symptoms. Usually, therapy is carried out once every 6-12 months. The specific duration of the period is determined for each patient individually.

The dosage of the drug for intra-articular administration differs depending on the size of the compound. Up to 1 ml of solution is injected into the hip joint, from 0.5 to 1 ml into the knee joint, and up to 0.5 ml into the shoulder joint.

It is not recommended to use the medicine on your own at home, as well as to exceed the norm, the duration of the therapeutic course.

Side effects

Flosterone (the price of 1 ampoule of the drug depends on the region of its distribution) can provoke negative reactions, even if all the recommendations of a specialist are followed.

Complications affect the work of internal organs and systems:

• On the part of the nervous system, disorders are manifested in the form of headache, weakness and dizziness. Patients talk about drowsiness, decreased performance, irritability.
• When used in some patients, the risk of thrombosis increases, the symptoms of peripheral vascular disease are aggravated.
• Digestive disorders often bother patients with treatment. They talk about nausea and abdominal pain, upset stools, and lack of appetite. Over the course of several days, the condition worsens, there is intense thirst, dryness of the mucous membranes of the mouth and heartburn.
• The drug can lead to seizures and the development of manic-depressive states in patients who are prone to such reactions.
• Edema of tissues and an increase in blood pressure are observed in patients with a history of heart pathologies. The retention of fluid in the tissues only worsens the condition of the patients.
• Allergy to the drug manifests itself in the form of a skin rash, itching and flaking, irritation. Swelling of the mucous membranes, allergic rhinitis and conjunctivitis develops with continued use of the drug.
• Prolonged use can provoke a deterioration in the condition of the heart and even necrosis of some parts of the myocardium.

The appearance of negative symptoms is considered a reason for refusing to use the suspension.

Overdose

Like other hormonal medicines, Flosterone can provoke an overdose when used in high doses.

At the same time, the condition of the patients suddenly and greatly deteriorates, additional symptoms are added to the negative reactions:

• Hallucinations, impaired coordination of movements.
• Convulsions.
• Emotional Disorders.
• Repeated vomiting during the day, diarrhea.
• Dehydration.
• Depressive state. Some patients report euphoria followed by depression.
• Deterioration of bone tissue.

If symptoms of an overdose appear, it is important to immediately stop using the product. Treatment of the condition is carried out in a hospital, various means are used depending on the symptoms, since Flosteron does not have a specific antidote. Hemodialysis is ineffective in the treatment of overdose.

special instructions

Flosterone (the price of 1 ampoule in some pharmacies does not exceed 180 rubles, which is considered one of the most profitable options) should be injected into the joint cavity only if indicated and after a preliminary X-ray examination connections.

For intramuscular infusion, it is necessary to use a long needle, which will allow the agent to be injected as deeply as possible for better absorption. When negative reactions appear in a mild form, treatment is not always canceled, but only the doctor makes the decision.

Drug interactions

The drug is not prescribed concurrently with other glucocorticosteroids. Its use in combination with non-steroidal anti-inflammatory drugs increases the likelihood of gastrointestinal bleeding.

With caution, the drug is prescribed in combination with antipsychotic, antiparasitic agents, Paracetamol. If it is necessary to combine several medications, it is important to visit a doctor who will determine possible contraindications and risks for the patient.

Analogs

The medication has analogues that, if necessary, can be used for patients. Substitutes often contain different ingredients but have similar properties.

Effective counterparts of the remedy:

• Dexamethasone also refers to glucocorticosteroid medicines, contains the active ingredient of the same name in the composition, helps to stop inflammatory symptoms, can be administered intramuscularly, as well as inside the joint capsule in rheumatoid arthritis and other inflammatory joint pathologies. The medicine is available in the form of a solution for parenteral administration, tablets for oral administration.
• Diprospan is considered the most popular analogue, since it has the same composition, it is produced in the form of a suspension for intra-articular or intramuscular administration. The drug is highly effective, it helps to eliminate the symptoms of inflammation after the first use, and prevents the progression of the disease.
• Depo-Medrol contains methylprednisolone as the main substance, belongs to hormonal agents and is produced in the form of a suspension for parenteral administration. Like the original, the drug can be injected into the muscle and the articular joint if the doctor considers this method to be effective.

Substitutes are prescribed by a doctor if the original cannot be used for various reasons.

Storage conditions and periods

The drug may be stored in a dark and cool place, excluding access to sunlight. The maximum storage time is 3 years.

After the expiration date, the use of the suspension is prohibited.

Flosterone is a hormonal medication with anti-inflammatory and immunosuppressive properties, which is prescribed for diseases of the internal organs, the musculoskeletal system. The price of 1 ampoule of the drug is high, but it is justified by its effectiveness, provided it is used correctly. Treatment with the drug is prescribed only by a doctor; performing manipulations at home is prohibited.

Video about the drug Flosetron

Flosterone ampoules: