Pradaxa (Pradaxa) 75-110-150 mg. Price 60 tablets, instructions for

Pradaksa is anticoagulant medication with pronounced properties, which can be used to treat pathologies accompanied by the formation of blood clots. The drug can be prescribed at a dosage of 75 or 150 mg, depending on the symptomatology. The price of tablets is different, which is associated with a different dose and number of them in the package.

Composition and form of release

The drug is available to patients in the form of oral capsules, also called tablets. They are opaque, have an oblong standard shape and size, and are placed in polyethylene bottles of 60 pieces.

Pharmaceutical companies can put the tablets in blisters of 10. A small cardboard box contains 1, 3, 6 plates. A description is attached to the medicine in different packages, which indicates all the features of the application, possible contraindications, negative reactions that occur during therapy.

The composition of the drug includes dabigatran etexilate, which has the main therapeutic effect.

The capsules also contain auxiliary ingredients:

• Isopropanol.
• Talc.
• Hypromellose.
• Potassium chloride.
• Ethanol.
• Propylene glycol.

  

Additional substances do not have a therapeutic effect on the body. The amount of the main component per 1 capsule is 75, 110 or 150 mg.

Terms of sale, prices

Pradaxa 75 mg and the drug in a different dosage have different costs. The price of tablets (capsules) ranges from 2000-3500 rubles.

Dispensing of funds in pharmacies is carried out after presentation of a certified prescription form from a doctor. This eliminates the likelihood of complications developing on the background of independent use.

Pharmacological properties

The drug belongs to the group of direct-acting anticoagulants and thrombin inhibitors. When taken orally, the formation of blood clots is suppressed, the development of complications against the background of damage to the walls of blood vessels by blood clots is prevented.

The drug has a positive effect on blood circulation, reduces the load on blood vessels as a result of blood thickening. The effect on the body of patients who suffer from diseases of the heart and blood vessels is especially pronounced.

The drug does not act on the body in a complex way, but it is considered quite effective if it is used correctly during a period determined by the doctor.

Pharmacodynamics and pharmacokinetics

After taking the capsules inside, the components of the composition actively penetrate into the blood and spread through the vessels. The main substance acts on thrombin, reduces its amount. As a result, the likelihood of developing complications against the background of thrombosis of large vessels is significantly reduced.

The medication does not affect the number of platelets, but its action is directed directly at slowing down the processes of their adhesion. Not having enough thrombin makes it impossible for blood clots to form.

The medicine helps to alleviate the course of pathologies of the cardiovascular system, since increased blood clotting leads to an increase in the load on the myocardium and cerebral vessels.

Pradaxa 150 mg (the price of tablets is high for many patients) and the drug in a different dosage is well absorbed in the patient's body, but its bioavailability does not exceed 6%. A low bioavailability does not guarantee minimal efficacy; the drug is considered effective, even with a single use.

The processing of the active substance is carried out in the liver. The withdrawal time of the ingredients does not exceed 24-30 hours, it differs in different patients. After taking a single therapeutic dosage, the effect of therapy is noticeable after 1-3 hours. Maximum efficiency is achieved with course use, especially in severe pathological conditions.

Indications for use

The drug is prescribed to patients only for certain indications, which is associated with pronounced properties.

The main violations for which the medicine is used:

• Increased blood thrombin levels.
• Thromboembolism of systemic origin, accompanied by acute disorders from other organs.
• Acute venous thrombosis. In the chronic course of pathology, the drug is usually not used, since it has a pronounced effect over a short period of time.
• Atrial fibrillation. The medicine is not used as the only method of therapy, but is often included in the course of the main treatment to reduce the likelihood of complications.
• Ischemic stroke, in which thickening of the blood leads to the appearance of concomitant complications. The medication, as in other cases, is used as part of a complex treatment.
• Thickening of the blood against the background of dehydration and an increase in the likelihood of thrombus formation.

The drug can be used in short courses for certain diseases of the cardiovascular system, for example, for hypertension, severe heart failure with an increased level of thrombin. In each case, treatment is prescribed individually, depending on the patient's condition.

Contraindications

Pradaxa 75 mg (the price of tablets when purchasing a large package is higher than in the case of buying 1 plate) and medication in a higher dosage is not used when diagnosing the intolerance of its components, both basic and auxiliary.

Other contraindications for drug therapy include the following conditions:

• The patient's tendency to bleed. The drug only increases the risk of severe bleeding due to its effect on the platelet adhesion process.
• Gastrointestinal bleeding, developing against the background of damage to the mucous membranes of the stomach and intestines.
• Genetic pathologies in which there is a decrease in the number of coagulation factors.
• The presence of an artificial valve in the patient's heart. The medicine can negatively affect the course of the pathology and worsen the condition of the patients.
• Severe renal failure and infectious kidney disease, accompanied by an increase in body temperature and other systemic reactions.
• Liver pathologies of viral origin, liver failure in acute and chronic form. The drug can lead to an exacerbation of symptoms and the development of complications, therefore its use is not recommended.
• Acute cerebral circulation disorder of hemorrhagic type.
• Swallowing dysfunction.
• Exacerbation of gastric ulcer and duodenal ulcer. Only sometimes a medicine can be prescribed to patients with such disorders.
• Malignant neoplasms in the stomach or different parts of the intestine.
• Aneurysm of large vessels.

Individual contraindications can be determined for patients after a preliminary diagnostic examination.

Methods of administration and dosage

The medication is intended only for oral use in a dosage determined by a doctor and for a prescribed time. Depending on the severity of the symptoms, the dosage and duration of use differ. The standard regimen involves taking the medication for 2 weeks at a dosage of 100-300 mg.

The standard treatment regimen is not always applied, it is adjusted individually for each patient.

With thrombosis

Diagnosing thrombosis of large vessels requires complex treatment. Capsules are taken in courses of 10-14 days. In the acute stage, patients consume 150 mg 2 times a day, observing an approximately equal time interval.

For 3-5 days, the drug is consumed in an increased dosage, after which the doctor reduces it to 150 mg, that is, the patient uses 75 mg in the morning and in the evening. Sometimes longer use is required, but the patient alone cannot change the dose or duration of the course.

With ischemic stroke

Pradaxa 75 mg (the price of tablets with a minimum dosage is slightly lower) is prescribed for a mild form of violation cerebral circulation, when the patient is not impaired and a full swallowing function.

The medicine is taken for 2 weeks, 2 times a day, 75 mg. After the end of the therapeutic course, an examination is carried out, laboratory diagnostics of blood, which makes it possible to evaluate the effectiveness of treatment. If necessary, the treatment is extended up to 3 weeks.

With heart disease

If cardiac pathologies are accompanied by thickening of the blood and an increased risk of thrombus formation, patients are prescribed drugs to prevent such disorders. The medication helps to reduce the likelihood of developing complications such as myocardial infarction and thromboembolism.

The daily dosage for patients is 220 mg, that is, it is necessary to take 110 mg in the morning and evening. The duration of treatment depends on the degree of disease progression. Sometimes 2 weeks are enough, often the therapy is extended to 3-4 weeks.

Side effects

The medicine often provokes complications, even if all the rules and recommendations of the doctor are followed. Complications affect not only the blood system, but also the work of internal organs.

Damage area	Frequent negative reactions
Nervous system	Decreased performance and severe weakness often bother patients. They report headache, dizziness, and impaired motor coordination. Some people report sleep disturbance and increased irritability in the absence of a normal night's sleep.
Blood system	On the part of the blood system, there is a violation of the formation of new cells, which can provoke an imbalance and the development of concomitant deviations.
Vessels and heart	Tachycardia and heart rhythm disturbances often bother patients with prolonged therapy with capsules. In patients with chronic diseases, fluctuations in blood pressure indicators are possible, as well as aggravation of the manifestations of the underlying pathology.
Digestive tract	Stomach pain is considered the most common reaction from the digestive system. Patients also note heartburn, indigestion, upset stools, nausea. Against the background of these disorders, the patient's appetite worsens, flatulence and bloating are noted.
Respiratory system	Bronchospasm can develop in patients with chronic respiratory diseases. The condition is accompanied by coughing, shortness of breath during exertion and emotional stress, attacks of suffocation.

In patients with a tendency to allergic manifestations, there may be a rash on the skin, itching and burning, peeling of tissues. Over the course of several days, symptoms may worsen if the patient continues to take capsules.

Negative symptoms are considered a reason for refusing to use the medicine and visiting a doctor. Sometimes the specialist does not cancel the therapy, but adjusts the dose, which eliminates the manifestations. If the effect of changing the dosage is absent, doctors cancel the treatment.

Overdose

Like other drugs with anticoagulant properties, the drug can provoke an overdose if taken for a long time in high doses.

The most severe manifestation of this condition is gastrointestinal bleeding. Usually, a complication occurs in patients suffering from chronic diseases of the digestive system.

The condition is accompanied by a critical decrease in blood pressure, severe weakness and flashing of flies before the eyes. In the absence of therapy, the patient's life is threatened. Overdose can manifest itself in the form of indomitable vomiting and frequent loose stools, pain in the abdomen. Patients may experience intense thirst, accompanied by dryness of the mucous membranes in the mouth.

Overdose is not treated at home, as the patient's condition is usually severe. If symptoms appear, it is necessary to consult a doctor who places the patient in a hospital and prescribes treatment on an individual basis. There is no standard scheme for all patients, as overdose manifests itself in different ways in patients. After a few days in the hospital, the patient may be allowed to go home, but medications are prescribed for independent use.

Negative reactions or manifestations of an overdose cannot be ignored, as well as using any medication without the appointment of a specialist.

special instructions

Pradaxa 150 mg (the price of tablets for many patients is an obstacle to treatment) is prescribed only when severe course of the pathological condition, which is associated with the pronounced effect of such doses on the body sick.

If the patient has a history of bleeding, but treatment with a drug is necessary, constant monitoring of blood counts is required. At the first sign of internal or external bleeding, it is worth discontinuing therapy.

Patients need to take into account the impossibility of self-adjusting the dosage. This often leads to serious complications.

Drug interactions

The drug is not prescribed simultaneously with drugs that have the same properties or have the same active ingredient in their composition. Do not use the drug in combination with vitamin K antagonists, Ketoconazole and Clarithromycin. This can provoke serious complications.

With caution, the drug is prescribed simultaneously with Pantoprazole and its analogues with the same ingredients. Do not use the medicine in combination with acetylsalicylic acid, as this increases the likelihood of bleeding.

Analogs

The impossibility of prescribing a remedy forces specialists to select analogs for patients with similar therapeutic properties. Some substitutes contain the same ingredient, while others work due to the presence of other substances.

Popular analogues:

• Xarelto - a drug based on rivoroxaban with anticoagulant properties. The medicine is prescribed when diagnosing thrombosis and pathologies accompanied by an increased risk of thrombosis. The medication, like the original, belongs to direct-acting anticoagulants. It is produced in tablet form, it is prescribed in short and long courses. The mechanism of action of the agent is somewhat different from the effect on the body of the original, therefore, the appointment is made only by a doctor.
• Eliquis contains another active ingredient, but is a direct anticoagulant. It is prescribed for acute thrombosis, heart disease, increased blood viscosity against a background of various factors. The medicine has pronounced properties, but it can provoke bleeding if the instructions are violated.
• Warfarin has a different mechanism of action, but has anticoagulant properties. Unlike the original, the analogue is considered more dangerous for patients, as it can provoke severe complications. When using it, it is important to constantly monitor blood counts in order to exclude the likelihood of bleeding.

The choice of a substitute is made by the doctor based on the examination data. Many analogs are considered more dangerous for patients, especially when used alone.

Storage conditions and periods

The medicine is allowed to be stored for 3 years. The production date is indicated on the packaging, it is worthwhile to study the information before using.

If the patient uses capsules in a bottle, they can be used within 4 weeks after opening it. It is forbidden to use after the expiration date.

Pradaxa at a dosage of 75, 110 or 150 mg is prescribed to patients with thrombosis and some other diseases. The price of the product in the form of capsules (tablets) differs depending on the dose and quantity of the medicine in the package. The effectiveness of drug treatment has been proven, but if the instructions are violated, severe complications from the internal organs develop.

Video about the drug Pradax

Comparative review of Pradax, Xarleto and Eliquis: