Moxifloxacin tablets 400 mg. Price, instructions for use, reviews

Moxifloxacin is an antibiotic produced by Indian and Russian pharmaceutical companies in the form of eye drops with concentration of 0.5%, tablets with a dosage of 400 mg and a solution for injection containing 1.6 mg / ml of the main component. The drug is easy to use and has proven to be effective. At the same time, the drug has 2 significant disadvantages: a large list of side effects and an overpriced.

Composition and form of release

The tablet form of Moxifloxacin is presented in the form of biconvex oval and coated pink tablets. The contents of the tablets are light yellow in color. There is a medication in cellular blisters in the amount of 5 pieces. A cardboard box contains 1 or 2 blisters and instructions.

The composition of Moxifloxacin tablets is represented by the following elements:

List of components	Component characteristics
The main component
Moxifloxacin hydrochloride	The element is an antibiotic with a wide range of action, it prevents the growth of bacteria and provokes their death.
Minor components
Microcrystalline cellulose	The substance is a stabilizer and filler, it also makes the tablets strong and homogeneous. In addition, the component attracts and removes toxins from tissues, and then from the body.
Lactose monohydrate	It is a preservative, and the component prevents the tablets from absorbing excess liquid when stored in a humid place.
Magnesium stearate	The component is used as a filler and stabilizer.
Titanium dioxide	The substance is necessary to give the tablet the required white shade.
Talc	It is a thickener and filler, it also attracts water and has an antiseptic effect.
Hydroxypropyl cellulose	The component is used as a thickener and stabilizer.
Hypromellose	The component has a softening and moisturizing effect and eliminates irritation of the mucous membranes.
Polyethylene glycol	The substance is used as a solvent, stabilizer and moisture regulator for tablets.
Iron oxide red	The element gives the tablet shell a pink tint.

The active ingredient in 1 tablet contains a concentration of 400 mg.

Terms of sale, storage, prices

Moxifloxacin tablets 400 mg, the price of which is not considered budgetary, can be purchased at the pharmacy only after presenting a prescription with data on the dosage and duration of administration. At home, tablets should be stored in packaging, in a dark place and at temperatures up to 25 degrees with a plus sign.

Since the medication is dangerous in the development of severe side effects, it should be kept away from the reach of children. Subject to the listed recommendations, the shelf life of the antibiotic will be 3 years from the date of release.

The cost for a package of Moxifloxacin containing 5 tablets is approximately from 330-420 rubles. The difference in prices depends on the place of purchase and the region.

Pharmacological properties

Moxifloxacin tablets belong to the group of antibiotics with antimicrobial action.

Pharmacodynamics and pharmacokinetics

Moxifloxacin tablets 400 mg (their price is indicated later in the article) after oral use have the following effect on the body and pathogenic microflora:

• the main component disrupts the reproduction process, and also provokes the strongest changes in the cells, as a result, the bacterium dies;
• attracts and removes harmful substances and toxins produced by bacteria from the body;
• promotes faster removal of feces from the intestines, due to a mild laxative effect;
• violates the composition and activity of beneficial microflora in the intestine. But approximately 14 days after the end of the course of treatment, the composition of the microflora in the intestine is restored;
• the main element has a toxic effect on the reproductive organs, disrupting their functioning.

The therapeutic effect of the antibiotic is observed approximately within 30-60 minutes after taking the pill and lasts up to 12 hours. The active substance is excreted from the body with feces and urine.

The main substance penetrates (approximately 45%) into the blood, as well as into all organs and tissues, exerting a bactericidal effect in them.

Indications for use

Moxifloxacin tablets are prescribed by doctors only if the disease is caused by bacteria that are sensitive to the action of this antibiotic.

Indications for the use of the drug may include the following diseases:

• tuberculosis. At the same time, Moxifloxacin is used as an additional agent in conjunction with anti-tuberculosis drugs;
• runny nose, as well as nasal congestion due to the development of inflammation processes (without flow from the nose) provoked by bacteria;
• sinusitis. Pathology is expressed by the development of inflammatory processes in the paranasal sinuses, accompanied by pain in forehead, severe headaches when moving the head, as well as a thick runny nose and high temperature;
• tonsillitis. The disease is manifested by the development of the process of inflammation in the pharyngeal and palatine tonsils. Pathology proceeds with severe sore throat (possibly the appearance of purulent plaque on the tonsils) and high fever;
• pharyngitis. The disease is characterized by the development of inflammation of the mucous membranes of the lymphoid tissue in the pharynx. Pathology is accompanied by dry cough, runny nose and fever. A purulent plaque may form on the throat;
• bronchitis, including in the stage of exacerbation. The disease is expressed by the development of inflammation of the mucous membranes of the bronchi. The pathology is manifested by a strong cough (possibly a yellow-green sputum separation), shortness of breath and high fever;
• pneumonia. With this disease, the development of inflammation in the lungs is noted, which is accompanied by a severe cough, high fever, the appearance of purulent sputum;
• otitis. The disease is characterized by the development of inflammation in the ear tissues, manifests itself as pain in the ears, there may be discharge from the auricle, and there is also a high temperature;
• bacterial infection of the digestive tract. The disease is accompanied by inflammation of the affected organ, disruption of its activity, as well as frequent vomiting and loose stools;
• the presence of pathogenic bacteria in the organs of the genitourinary system. Infection with these diseases can affect the reproductive and urinary organs, as well as the kidneys;
• inflammation of the skin, as well as soft tissues as a result of the vital activity of bacteria.

In addition, Moxifloxacin is used to eliminate complications after diseases caused by bacteria.

Contraindications

It is forbidden to use moxifloxacin in tablet form if the patient has the following contraindications:

• hypersensitivity to the elements of the tablets or the presence of an allergy to the composition of the antibiotic;
• lactose intolerance or lactase deficiency;
• severe damage and impaired liver function;
• inflammation of the mucous membranes and tissues of the large intestine;
• the patient's age is less than 18 years;
• the patient's weight is below 33 kg;
• predisposition to the development of seizures and seizures;
• severe arrhythmia (violation of the rhythm of heart contractions);
• malnutrition of myocardial muscle (heart muscle) with oxygen in severe form;
• pathologically reduced number of heart contractions;
• severe heart failure;
• violation of the condition or activity of cells of the nervous system;
• identifying mental abnormalities in the patient;
• severe muscle weakness or rapid muscle fatigue;
• potassium deficiency in the body and other disorders of the water-salt balance;
• the patient has a viral or fungal infection. An antibiotic weakens the immune system, as a result, these infections begin to progress;
• change in the condition of the tendons due to the intake of antibiotics of the quinolone group;
• violation of the condition of articular and cartilaginous tissues in severe form;
• exacerbation of diseases of the digestive tract;
• the presence of internal bleeding;
• violation of the condition and work of the kidneys in severe form;
• carrying a child. The antibiotic provokes the development of pathologies (more often a violation of the state of development of the joints) and deformities in the fetus.

If necessary, use Moxifloxacin during lactation, the baby should be transferred to the mixture during the course of the course. It should also be borne in mind that patients over 65 years of age should take the antibiotic with extreme caution.

Method of administration and dosage

Moxifloxacin 400 mg tablets should only be used after the prescription of the attending physician, as before starting the use of an antibiotic, it is required to identify the sensitivity of the infection to the main component of the medication. In addition, the specialist will determine the course of treatment and can announce the approximate price of the drug for the entire period of therapy.

The antibiotic Moxifloxacin should be used only once in a single dose during the day, while the use of the medication does not depend on food intake. The tablet should not be bitten or chewed, but it should be taken with a liquid (preferably juices or water) in the amount of 150-200 ml. It is also required to take into account that it is forbidden to use the antibiotic if the patient's weight is less than 33 kg, as the likelihood of side effects increases.

Features of dosage of Moxifloxacin tablets, depending on the type and severity of the disease:

Type and severity of pathology	Single dosage	Duration of treatment	Notes (edit)
Tuberculosis	1 tablet, preferably taken in the morning.	2 weeks	Combined treatment with anti-tuberculosis drugs is required.
Rhinitis or inflammation of the tissues in the nose of a bacterial nature	1 tablet. The antibiotic should be taken during the daytime.	3-5 days	In the presence of a strong nasal flow, nasal agents are prescribed in addition to the antibiotic
Sinusitis	1 tablet. It is recommended to take the medication in the evening.	5-7 days	Additionally, the specialist prescribes antipyretic and analgesic drugs.
Tonsillitis	1 tablet. It is better to use the product in the morning.	5-10 days	Along with the antibiotic, antipyretics and disinfectants are prescribed for treating the tonsils.
Pharyngitis	1 tablet. It is advisable to take the drug in the morning or afternoon.	7-10 days	Along with Moxifloxacin, you need to use throat treatment and antipyretic medications.
Bronchitis	1 tablet used during the day.	5-10 days	The antibiotic is prescribed in combination with cough medicines and antipyretics.
Pneumonia	1 tablet. It is advisable to take the antibiotic in the morning.	7-10 days	The tablets are used in conjunction with medicines to facilitate the discharge of sputum and means to lower the temperature.
Otitis	1 tablet. You can take the remedy in the afternoon or evening.	Week 1	Moxifloxacin is prescribed in combination with ear drops and antipyretic drugs.
Bacterial infection of the gastrointestinal tract	1 tablet. It is necessary to use the medication during the day.	10-14 days	A combination therapy is needed together with anesthetic drugs, as well as drugs to normalize the functioning of the gastrointestinal tract.
Bacterial infection in the genitourinary system	1 tablet. The antibiotic should be taken in the afternoon or evening.	1-2 weeks	The antibiotic is used with pain relievers and antipyretic medications.
Bacterial skin and soft tissue infection	1 tablet. You can use the drug in the morning or in the evening.	7-20 days	Moxifloxacin is used in conjunction with external agents that eliminate itching and pain, as well as promote cell regeneration.
Complications after diseases caused by pathogenic bacteria	1 tablet, which can be taken at any time of the day, but better in the morning.	5-7 days	In addition to the antibiotic, it is necessary to take vitamin complexes and immunostimulants, for a faster recovery of the body and strengthening of immunity.

The information in the table is for guidance only. A more accurate dosage, as well as a course, can only be prescribed by a doctor who is observing the patient.

Patients with impaired renal or liver function need to adjust therapy.

Side effects

Moxifloxacin tablets are not safe, their use may be accompanied by the following negative reactions:

• pain throughout the abdomen;
• the accumulation of gases in the intestines and their discharge;
• vomit. It is more often noted after taking the pill;
• disruption of the digestive tract;
• changes in bowel function. May manifest as constipation or diarrhea;
• deterioration of the liver in both mild and severe forms;
• development of dryness in the oral cavity;
• decrease in body weight;
• the development of a fungal infection in the mucous membranes of the mouth or vagina;
• accession of viral pathology;
• violation of the swallowing reflex;
• change in the color of the tissues of the tongue;
• dizziness;
• the appearance of severe weakness and rapid fatigue;
• violation of the process of falling asleep and sleep;
• headache;
• a sudden and unreasonable feeling of anxiety;
• tingling or creeping sensation on the skin;
• speech impairment;
• vision of hallucinations;
• convulsive muscle contraction;
• confusion and impaired consciousness;
• deterioration or loss of taste;
• decreased sense of smell;
• an increase in the number of heart contractions;
• pain in the region of the heart;
• violation of the rhythm of heart contractions;
• worsening breathing, shortness of breath;
• exacerbation or appearance of attacks of bronchial asthma;
• the appearance of pain in the joints or back, both during exercise and at rest;
• deterioration in kidney function;
• urticaria, swelling (including swelling of the internal organs and respiratory tract) and other signs of allergies, including in a severe form;
• a decrease in the amount of iron, platelets and leukocytes in the blood;
• a decrease in the concentration of potassium in the body, manifested by a violation of the water-salt balance;
• an increase in the amount of uric acid in the body;
• pathological psychomotor activity;
• the development of depression, accompanied by suicidal thoughts;
• memory impairment;
• blurred vision, double vision, or retinal detachment;
• ringing or noise in your ears;
• the appearance of fainting;
• increase (or decrease) in the pressure value;
• dehydration of the body, in the presence of severe vomiting and diarrhea;
• necrosis of skin tissue;
• change in gait due to a violation of the condition of the tissues of the musculoskeletal system;
• a decrease (possibly a sharp increase) in the amount of glucose in the blood. The development of coma in patients with diabetes and taking insulin is not excluded.

  

If a patient has any (or several) side effects, it is necessary to immediately inform the attending specialist about this. The doctor can correct the therapy or replace the antibiotic with an analogue.

Overdose

Moxifloxacin tablets 400 mg (the price of an antibiotic may vary in different regions) should be taken strictly 1 tablet every 24 hours. The use of tablets more often or in larger quantities, as well as more than 3 weeks, can cause the development of drug poisoning.

List of symptoms for Moxifloxacin poisoning:

• severe vomiting may develop almost immediately, the presence of blood in the vomit is not excluded;
• severe and very painful bloating of the abdomen, due to the accumulation of gas in the intestines;
• intolerable pain throughout the abdomen;
• severe diarrhea, blood may also be present in the stool;
• yellowing of the epidermis and protein in the eyes as a result of liver dysfunction;
• complete absence of swallowing reflexes;
• loss of consciousness;
• complete lack of strength;
• intolerable headaches;
• pronounced aggression or complete detachment from the outside world;
• severe speech impairment;
• bright hallucinations;
• convulsions;
• lack of taste and smell;
• disorders of the heart and kidneys;
• loss of vision (or hearing), temporary or permanent;
• rapid increase in pressure;
• worsening or stopping breathing;
• a sharp decrease in the amount of basic blood elements;
• memory loss;
• severe joint pain;
• coma.

In cases where no more than ½ hour has passed after the poisoning, then gastric lavage is necessary, then sorbents are taken. If more time has passed, then the patient is only prescribed sorbents. Further treatment depends on the symptoms manifested and the severity of their severity.

special instructions

The antibiotic Moxifloxacin must be taken after reading the following special indications:

• if the listed symptoms of an adverse reaction appear in a severe form, then the reception of Moxifloxacin must be canceled immediately;
• in the presence of allergies, even in a mild form, the antibiotic is not used;
• women and elderly patients should use pills with caution, since this group of patients is more susceptible to the development of arrhythmias and tachycardia;
• you can not take the drug after suffering severe damage to the tissues of the heart, since the antibiotic can cause the organ to stop;
• the antibiotic increases the sensitivity of the skin to ultraviolet light, therefore it is necessary to avoid direct sunlight on the epidermis;
• tablets help to lower immunity, therefore, before starting therapy, it is important to exclude viral, parasitic and fungal infections, since otherwise the diseases will progress;
• patients with diabetes mellitus, impaired liver and kidney conditions should take an antibiotic under the supervision of a physician and according to an individual treatment regimen;
• the medication can cause serious damage to the skin tissue, therefore, with sensitive, dry and rash-prone skin, tablets should be used with extreme caution;
• in the presence of epilepsy or with a tendency to seizures, the drug should be used carefully, as it can provoke the development of seizures (convulsive or epileptic);
• an antibiotic can provoke an exacerbation of mental illness, therefore, for this group of patients, the medication is used with caution;
• Moxifloxacin can cause severe muscle weakness, visual impairment and dizziness, so you should not drive or perform hazardous work while taking it.

After completing the course of treatment (or simultaneously with taking an antibiotic), it is necessary to undergo a course of using probiotics in order to restore the microflora in the intestine.

Drug interactions

Moxifloxacin 400 mg tablets (the price of an antibiotic can be checked with a doctor) should not be taken simultaneously with the following medicines:

• hormonal drugs increase the manifestation of side effects;
• increase the effect of medications used to lengthen the period between heart contractions;
• multivitamin complexes impair antibiotic absorption. Therefore, between doses of drugs, an interval of at least 2 hours must be maintained;
• medicines to increase iron should be taken about 8 hours after using the antibiotic, since they impair the absorption of Moxifloxacin;
• increases the effectiveness of drugs used to thin the blood.

Quinol antibiotics and moxifloxacin increase the stress on the liver, heart and kidneys, resulting in severe side effects from both drugs.

Analogs

You can replace the antibiotic Moxifloxacin with the following analogs:

• Siflox. Pills. On prescription. The price is about 500 rubles;
• Factual. Pills. On prescription. The cost is approximately 1,700 rubles;
• Lefokcin. Pills. On prescription. The approximate price is 400 rubles;
• Lebel. Pills. On prescription. The approximate cost of 200 rubles.;
• Ofloxacin. Tablets, injection solution, ointment. On prescription. Depending on the form of release, the cost varies from 100 to 800 rubles.

A broader list of substitutes can be obtained from your doctor who will replace the Moxifloxacin tablets.

Moxifloxacin 400 mg tablets are recognized by patients and doctors as an effective broad-range antibiotic. The main component of the drug not only prevents the growth of pathogenic bacteria, but also causes their death. The disadvantages of antibiotics are side effects and overpriced.

Author: Kotlyachkova Svetlana

Video about the drug Moxifloxacin

Instructions for the use of Moxifloxacin: