Verospiron tablets. Dosage, instructions for use, price

Veroshpiron is a drug, which is widely used in medical practice. Tablets are prescribed for the treatment of disorders caused by insufficient production of potassium. Each disease has its own characteristics of intake and dosage.

Release form

The medicine is produced in Hungary in the form of oral tablets. The tablets are white, round and flat. There is a special marking on one side. The capsules are packed in blisters and packaged in cardboard containers.

Chemical composition

The main active ingredient is spironolactone.

Additional composition:

• magnesium stearic acid salt;
• milk sugar;
• colloidal silicon dioxide;
• corn starch.

Auxiliary components enhance the effect of the main substance and complement each other.

Pharmacological properties

The drug belongs to the group of potassium-sparing diuretics. When using it, there is a retention of water and sodium aldosterone in the body. Interacting with aldosterone receptors, the agent promotes the elimination of sodium, chlorine, water and urine ions from the body. In this case, there is a decrease in the excretion of potassium and urea ions, which, in turn, leads to a decrease in the acidity of urine.

The medicine leads to a decrease in pressure, which is due to its diuretic effect.

Pharmacodynamics and pharmacokinetics

The active substance is rapidly and completely absorbed from the gastrointestinal tract. It interacts with proteins (about 90%). The component lends itself to metabolic transformation in the liver and breaks down into several active metabolites. The half-life of the ingredients is 1.3 to 11.2 hours.

Most metabolites leave the body through the renal system. A small part is excreted through the intestines. The main component can pass into breast milk and through the placenta. The half-life of metabolites is significantly higher than that of the main substance.

The functional ability of the kidneys after taking a single dosage is restored after 7 hours and lasts for 1 day.

Indications for use

Veroshpiron tablets (the dosage of the drug may vary significantly depending on the form of the disorder) should be taken strictly in accordance with the instructions of the doctor.

The drug has a wide range of recommendations for admission:

• high blood pressure (essential form of the disorder) - as part of complex treatment;
• heart failure (congestive form of the disease) - in the absence of the effectiveness of previous therapy or in combination with other diuretic drugs;
• cirrhosis of the liver (in the presence of concomitant symptoms - edema, nephrotic syndrome);
• deficiency of potassium in the body (in the absence of the possibility of other treatment);
• Connes syndrome (when diagnosed or as the main treatment);
• insufficient production of potassium (as a prophylaxis in patients who take cardiac glycosides or in the absence of the possibility of other therapy).

The medication is prescribed only with an established diagnosis.

Contraindications

The tool has some limitations associated with the special conditions of the patient or the presence of certain diseases.

Contraindications:

• intolerance to the components;
• pregnancy;
• lactation period;
• Addison's syndrome;
• high concentration of potassium in the blood;
• low sodium content;
• kidney failure (severe or acute disorder);
• allergy to lactose, lactase deficiency, glucose-galactose malabsorption syndrome;
• anuria;
• heart failure.

With extreme caution, tablets can be used in the following cases:

• high blood calcium;
• heart block;
• kidney failure;
• metabolic acidosis;
• diabetes;
• porphyria;
• the use of anesthetic drugs;
• liver failure;
• elderly age;
• cirrhosis of the liver.

If there are contraindications, it is necessary to choose another treatment.

At what age can the drug be used?

The drug is intended for the treatment of adults and children from 3 years of age.

Instructions for use, dosage

Verospiron in tablets (the dosage is selected in each case separately) is intended for oral use.

With edema

With the development of edema, 25-200 mg of the drug is prescribed per day. In this case, the dosage can be divided into 2 equal doses. With a low level of potassium and sodium ions in the urine, the dosage can be from 0.2 to 0.4 g per day. The duration of therapy is according to the testimony of a specialist.

At high pressure

With increased pressure, the initial dosage is 25 mg per day. In the absence of a pronounced effect within a month, the dose can be increased to 50 mg per day. The duration of the course is individual, not less than 3 months.

With a hangover

With a hangover syndrome, take 0.1-0.4 g once or after dividing the dose into several equal doses.

For acne

For acne, it is recommended to take the medicine at the rate of 1-3 μg / kg of body weight. The resulting dosage should be divided into several identical doses (no more than 4 times).

The duration of therapy depends on the severity of the pathology and is set individually.

Side effects

Negative manifestations occur extremely rarely and in most cases go away on their own after the drug is canceled.

Side effects:

• Violations of hematopoietic functions: a decrease in the number of leukocytes and platelets, an increase in the level of eosinophils.
• Immune system: increased sensitivity.
• Endocrine Disorders: Excessive hair growth.
• Metabolic processes: an increase in the level of potassium in the blood, a decrease in sodium concentrations, porphyria, dehydration, an increase in the acid-base balance.
• Mental disorders: confusion.
• Cardiovascular disorders: arrhythmias, vasculitis, decreased blood pressure.
• Digestive organs: nausea and vomiting, gastritis, diarrhea. Pain in the stomach, ulceration and bleeding in the stomach.
• Respiratory system: change the tone of the voice.
• Liver and bile ducts: development of hepatitis.
• Skin and tissues: rashes, eczema, baldness, erythema, bullous rash.
• Bone and muscular system: softening of bones.
• Kidneys and urinary system: kidney failure (acute course of the disease).
• Reproductive system and mammary glands: decreased libido and potency, enlargement of the mammary glands in men according to the female type, pain in the area of ​​the mammary glands, soreness in the chest (in men). There is also an increase in the volume of the mammary glands, a change in menstruation, infertility (in rare cases).
• General disorders: fatigue, asthenic conditions.

Among laboratory parameters, there is an increase in the concentration of uric acid, hemoglobin and creatinine. In the event of the development of these symptoms or other signs, it is recommended to cancel the drug and consult a specialist.

Overdose

In case of exceeding single and daily dosages, Veroshpiron can lead to the development of undesirable symptoms, so the tablets must be taken strictly according to the instructions.

Overdose:

• nausea and vomiting;
• episodes of dizziness;
• increased sleepiness;
• confusion of consciousness;
• diarrhea;
• rashes;
• decrease in sodium concentration;
• increased potassium levels;
• renal coma.

With the development of these signs, gastric lavage is performed, the normal level of water and acid-base balance is restored.

If necessary, therapy is carried out aimed at normalizing the water-electrolyte balance. In this case, potassium-sparing diuretics are used and injections of a dextrose solution with insulin are injected.

In more difficult situations, extrahepatic blood cleansing is performed.

special instructions

With extreme caution, a medication is prescribed to patients with diseases that can lead to the development of acidosis or an increase in potassium.

In patients with diabetic nephropathy, the risks of an abnormal increase in potassium in the blood are significantly higher.

The drug can provoke an increase in AMK, especially in patients with functional renal disorders or pathologically elevated levels of potassium in the blood. In this connection, in this category of patients it is required to periodically conduct studies of the functions of the blood, kidneys and liver.

A critical increase in potassium in the blood can be fatal, therefore, in patients with heart failure, this indicator should be regularly monitored.

At values ​​of 3.5 mmol and above, the drug should be discarded.

The control of potassium in the blood must be carried out according to the following schedule:

• 1st study - 7 days after the start of therapy.
• 2nd stage - every month for the first 3 months.
• 3rd stage - every 3 months throughout the year
• Follow-up control - every six months.

It should be borne in mind that taking pills in patients with porphyria may exacerbate this disease.

During therapy, it is necessary to refuse to take alcoholic beverages.

At the initial stages of therapy, you should stop driving. Time limits are set on a case-by-case basis.

Drug interactions

Veroshpiron in tablets (the dosage of the drug can be adjusted throughout the entire course of treatment) in childhood is allowed to be preliminarily crushed to a mushy state.

The medication can react with other drugs and substances. Thus, the combined use of tablets and the following groups of drugs and components can provoke the development of a severe pathological increase in potassium in the blood:

• potassium-sparing diuretics;
• ACE inhibitors;
• aldosterone blockers;
• potassium preparations;
• angiotensin 2 receptor antagonists;
• a dietary menu that includes a high potassium content;
• salt substitutes containing potassium.

The simultaneous use of the main agent with cotrimoxazole can also provoke the development of signs of hyperkalemia.

With the combined use of tablets and other diuretics, an increase in urine output is possible.

The risks of a pathologically high potassium content can be triggered by the following drugs:

• cyclosporine;
• ammonium chloride;
• immunosuppressants;
• cholestyramine;
• tacrolimus.

The simultaneous use of antipsychotic pills and tricyclic antidepressants can lead to a decrease in blood pressure.

The pills can enhance the effect of medicines that lower blood pressure.

ACE inhibitors should not be taken for a long time in conjunction with the main agent, especially in patients with functional renal impairment.

The decrease in blood pressure caused by the intake of the main medication can be increased when it is used simultaneously with the following medications:

• nitroglycerine;
• nitrates;
• vasodilators.

The combined use of tablets and alcoholic beverages, barbiturates or narcotic drugs can lead to the development of hypotension.

It is necessary to use anesthetic drugs with caution in conjunction with the main medication.

Other groups of drugs and their interaction with tablets:

• NSAIDs - an increase in the risks of a pathological increase in potassium in the blood; strengthening the action of the main asset.
• Glucocorticosteroids and ACTH - decrease in potassium concentration.
• Digoxin - an increase in the elimination time of the drug, an increase in its toxicity (dosage adjustment is required).
• GnRH analogues, buserelin, gonadorelin triptorelin - increase the effect of this group of drugs.
• Antipyrine - an increase in the metabolism of this drug.
• Lithium preparations - it is possible to increase the toxicity of this agent.
• Carbenoxolone - decrease in the effectiveness of tablets.
• Carbamazepine - lowering sodium levels.
• Heparin - an increased risk of severe hyperkalemia.
• Coumarin derivatives - a decrease in the effectiveness of these medicines.

The main agent may affect laboratory digoxin and fluorescence readings.

Analogs

Similar drugs are prescribed if the main drug is poorly tolerated. In this case, the physiological characteristics of the patient and the severity of the disease should be taken into account.

The choice of replacement should only be dealt with by the attending physician.

Spironolactone (Russia)

Generic is available in capsule or pill form. The main component of the product is the substance of the same name (spironolactone).

The drug is used in the following cases:

• swelling caused by heart failure or pregnancy;
• chronically high blood pressure;
• pathologically low concentration of potassium in the blood;
• increased production of aldosterone and conditions associated with this disorder;
• premenstrual syndrome.

Dosing features: 0.1-0.2 g, divided into 2-3 equal doses. The duration of treatment is 2-3 weeks. The drug has a wide list of contraindications that you should familiarize yourself with in advance. Terms of sale - by prescription. Cost - 200-250 rubles.

Diuver (Croatia)

The medicine is produced in the form of tablets for oral administration. Its active component is torasemide. The medication belongs to the group of diuretic drugs and is used in the treatment of edema caused by internal diseases and other factors. Also, tablets can be used in the treatment of arterial hypertension.

Dosing regimen: 5 mg once a day. Then the dosage is gradually increased to 20-40 mg once a day. The maximum daily allowance should not exceed 0.2 g. The duration of therapy is individual. The medicine has numerous contraindications, so it is recommended that you familiarize yourself with their list in advance. The method of sale is prescription. Price - from 300 to 470 rubles.

Urakton (Italy)

Veroshpiron in tablets (the dosage of the drug in childhood is calculated based on the child's body weight) should not be taken in conjunction with similar drugs, as this may cause the development overdose. This medication is available in the form of tablets for internal use. The active substance of the agent is spironolactone.

The medicine belongs to the group of diuretic drugs and is used in the following conditions:

• increased production of aldosterone and disorders caused by this phenomenon;
• edema triggered by various diseases;
• hypertonic disease.

Dosing rules: 2 tablets per day. The duration of therapy is individual, according to the doctor's recommendations.

Contraindications:

• intolerance to the components;
• acute renal failure;
• anuria;
• pregnancy;
• lactation period;
• abnormally high levels of potassium in the blood.

Sales through pharmacies - prescription. Cost - from 50 rubles.

Terms, conditions of sale and storage

• The medicine should be stored in a dark and dry place at temperatures up to 30 ⁰C.
• Expiration date - 5 years from the date of issue.
• Do not use after the expiration date stated on the package.
• Dispensing method - by prescription.

Price

Prices for pills may vary slightly depending on the region of sale and the pharmacy trade network. You can clarify the availability of the drug on sale, as well as find out its cost, at any pharmacy located at the place of residence.

Region / region	Dosage form / dosage	Price
Moscow, Moscow region	Tablets, 25 mg, 20 pcs.	70-115 rub.
St. Petersburg	Tablets, 25 mg, 20 pcs.	RUB 75-95
Saint Petersburg (suburbs)	Tablets, 25 mg, 20 pcs.	80-105 rub.
Leningrad region	Tablets, 25 mg, 20 pcs.	75-90 rubles.
Novgorod region	Tablets, 25 mg, 20 pcs.	70-90 rubles.

Before using Veroshpiron, it is imperative that you read the instructions for using the tablets and consult your doctor. When taking the drug, you must strictly follow the dosage prescribed by a specialist.

Video about the drug Veroshpiron

Instructions for the use of Veroshpiron: