Groprinosin syrup for children. Instructions for use, reviews

Syrup Groprinosin is an anti-infectious and antiviral agentintended for systemic use. The medicine is suitable for both adults and children. They need to be used according to the instructions on the package. To prevent the risk of developing serious complications, it is required to consult a specialist before use. Otherwise, you can aggravate the situation, as well as cause significant harm to health.

Composition and form of release

Groprinosin is a syrup for children that has a clear liquid and a sweetish taste. Therefore, taking the medicine will be pleasant and comfortable.

5 ml of the product contains 250.00 mg of the active ingredient - inosine pranobex.

The following substances are considered additional components of the drug:

• purified water;
• sodium hydroxide;
• E216;
• E218;
• citric acid monohydrate;
• sucrose.

Terms of sale, prices

A dark glass container contains 150 ml of syrup. The contents of the bottle are hermetically sealed with a screw cap. The cardboard box contains 1 container with a medicine, instructions in Russian and Kazakh languages ​​for medical use, and a syringe dispenser with a scale from 0.5 to 5 ml. The medicine is dispensed at any pharmacy with a prescription. The cost of the drug varies within 500 rubles.

Pharmacological properties

Groprinosin is presented in the form of an immunostimulating drug, which is characterized by an antiviral effect. The tool is considered complex, since it contains inosine pranobex, as well as inosine with a salt of para-acetamidobenzoic acid in a painting ratio of 3: 1, respectively.

Pharmacodynamics and pharmacokinetics

The active ingredient is characterized by antiviral effect, since it binds to cellular ribosomes that are infected with a virus. As a result, the connection between pathogenic cells is suspended, which provokes the suppression of genomic viruses. Due to the strong transition of interferon formation, an indirect effect is manifested. The immunomodulatory effect is associated with the effect on lymphocytes, as well as an increase in the absorbed activity of macrophages.

Under the influence of the active component, lymphocytes strongly secrete interleukin-2, and also help prescription expression on lymphoid cells.

In the presence of herpes infection, the active ingredient contributes to the rapid formation of antibodies, a reduction in clinical signs and the regularity of relapses.

On the pharmacokinetic side, each pranobex inosine substance has individual pharmacological characteristics:

Process	Features of the course
Absorption	After ingestion, the active ingredient is rapidly and almost completely absorbed from the gastrointestinal tract and enters the bloodstream.
Metabolism	After ingestion of 1 g of the active ingredient after 120 minutes. in plasma, the DIP substance will be determined in an amount of 3.7 μg / ml, PAcBA - in a volume of 9.4 μg / ml after 60 minutes. The increase in the volume of uric acid has a non-linear type and over 180 minutes. varies in the range of 10%.
Withdrawal	With a regular intake of 4 g within 24 hours, the daily urinary output will reach about 85% of the dose taken. The half-life for DIP varies within 3 hours 30 minutes, for PAcBA - 50 minutes.

Indications for use

Groprinosin is a syrup for children whose age ranges from 12 months to 6 years.

The medicine is prescribed for the following problems:

• an auxiliary therapeutic course for those who have a weakened immune system due to recurrent respiratory infections;
• infections of the mucous membranes or skin, which have developed due to herpes viruses type 1 or 2;
• sclerosing panencephalitis of the subacute type.

For patients over 6 years old and weighing over 21 kg, it is recommended to use a tablet medicine, which can be crushed, chewed or stirred in a small volume of liquid before taking.

Clinical experiments that are associated with the impact on the formation of the fetus and conception have not been carried out. It is also not known about the methods of excretion of the active ingredient in breast milk.

In this regard, it is undesirable to prescribe the medicine at the stage of pregnancy and breastfeeding. However, the doctor can prescribe the drug if he is confident that the benefits will be greater than the potential risks.

Contraindications

Groprinosin syrup has a number of contraindications, in which the medicine cannot be used.

The remedy must not be prescribed to adults or children if the following factors are present:

• 3 degree of acute renal failure;
• children under 12 months old;
• urolithiasis pathology;
• hypersensitivity to the active ingredient or other substance from the auxiliary group;
• excess of uric acid in serum;
• gout attack.

With additional consumption of loop, thiazide diuretics, xanthine oxidase inhibitors or drugs, which increase the output of uric acid by the kidneys, Groprinosin syrup must be taken with a special caution.

Method of administration and dosage

Groprinosin is a syrup for children, the dosage of which will depend on the severity of the disease and the patient's weight. The daily intake must be divided into several identical single doses taken at the same time intervals throughout the day. 1 ml of the drug contains 50 mg of inosine pranobex.

For adults and the elderly, the syrup rate reaches 1 ml / kg of body weight per day. During the day, the patient must drink 60 ml of the medicine. The volume must be divided into 3 or 4 doses. The maximum amount of the product reaches 80 ml per day. The drug is not suitable for children under 12 months of age. For children over 12 months of age, the daily volume is 1 ml / kg of body weight.

The dose must be divided into 3 or 4 doses, taking into account the following:

Patient weight	Medicine volume
41-50 kg	3x17.5 ml
31-40 kg	3x15 ml
21-30 kg	3x10 ml
15-20 kg	3x7.5 ml

To correctly measure the required dose, it is recommended to use the syringe with a measuring scale that comes with the package.

The duration of treatment often varies between 5-14 days. After reducing the symptoms, the medicine must be used for 2 days. If after the course there is no visible effect, you need to consult a specialist.

Subacute sclerosing panencephalitis

In the acute course of the disease, the dosage can be increased to 2 ml / kg of body weight. With regular therapy, it is recommended to constantly examine the patient's condition.

Acute infections

A treatment course for adults and children often lasts from 5 to 14 days. Therapy must be adhered to until the clinical symptoms go away, as well as for 2 days after the symptoms disappear. If necessary, the duration of therapy can be increased individually and under the supervision of a doctor.

Chronic recurrent infections

For adults and children, therapy should take place in several courses, which last from 5 to 10 days with a break of 8 days. Carrying out supportive treatment, it is permissible to lower the dosage to 20 ml per day for a month.

Herpetic infections

Therapeutic therapy should last about 5-10 days until the symptoms disappear. To reduce the volume of asymptomatic relapses, the drug must be taken at 20 ml per day for a month.

Human papillomavirus infections

For monotherapy, the drug must be taken within 14-28 days. For adults, the daily dosage will be 60 ml, for children - 1 ml / kg per day.

Recurrent genital warts

For monotherapy or for joint surgical treatment, the drug should be consumed by adults in an amount of 60 ml per day, for children - 1 ml / kg for 24 hours.

The therapeutic course should consist of 3 receptions lasting 2 or 4 weeks and with a break of 30 days.

Dysplasia of the cervix

For treatment, 60 ml per day is prescribed for 10 days with a break of 2 weeks. The therapy consists of 2 or 3 courses.

Side effects

To classify the frequency of side effects, the following terms are used: quite rare, rare, not too frequent, frequent, too frequent, and the frequency is unknown.

An increase in uric acid in urine and serum is considered one of the regularly monitored side effects, which is directly related to the consumption of syrup. At the end of the medication, the uric acid level will return to its original values ​​after several days.

Too frequent unwanted effects:

• excess volume of uric acid in the urine;
• an increase in the level of uric acid in the blood.

Frequent side effects:

• arthralgia;
• headaches, malaise, fatigue and dizziness;
• high activity of blood serum components;
• discomfort in the stomach, nausea with a gag reflex, lack of appetite;
• rash and itching of the skin;
• an increase in blood urea.

Infrequent symptoms:

• high urine volume;
• diarrhea;
• constipation;
• nervousness with insomnia or drowsiness.

Symptoms with unknown frequency:

• anaphylactic shock;
• angioedema;
• pain in the stomach;
• high sensitivity;
• dizziness;
• hives;
• erythema.

  

If side effects appear, you need to immediately seek help from the attending doctor so that he can adjust the therapeutic therapy.

Overdose

There is no information on drug overdose. Considering the results of the study of the level of toxicity in animals, the appearance of dangerous negative phenomena, with the exception of an increase in the level of uric acid in the serum, is practically impossible.

If an overdose of syrup occurs, therapeutic treatment should be formulated at a supportive and symptomatic level.

special instructions

Groprinosin is a syrup for children and adults, which is recommended to be used with caution if a history of gout, renal dysfunction, gallstone or urolithiasis, as well as an increase in the volume of uric acid in blood. With such pathologies, during the course of the treatment course, patients need to regularly check its indicator.

If the therapeutic treatment lasts more than 3 months, each patient is obliged to take a general blood test, as well as an analysis for the content of uric acid in urine and blood serum. In this case, the doctor is obliged to monitor the renal and hepatic functions.

When the drug is consumed, there is a short increase in the level of uric acid in urine and serum, particularly in the elderly and in men. However, the excess is often within the permissible limits. The increase in concentration is due to the catabolic metabolism of the inosine component, which occurs in the body. However, this process is not associated with renal clearance or a change in the main functions of the enzyme.

With the development of complicated hypersensitivity in the form of anaphylactic shock, anaphylaxis, angioedema or urticaria, the drug must be abandoned.

In patients who are prescribed a long therapeutic course, stones may form in the kidneys. The syrup contains special substances that provoke the development of an allergic reaction. 650 mg of sucrose is present in 1 ml of syrup. This feature should be taken into account for those who have diabetes mellitus.

The medicine is not suitable for those who have rare hereditary pathologies:

• insufficiency of sucrase, isomaltose;
• intolerance to fructose;
• failure in the absorption of galactose and glucose.

The composition contains sucrose, which adversely affects the condition of the teeth. 80 ml of syrup contains about 23 mg of sodium. This volume is considered very low.

The effects of inosine on fetal formation have not been evaluated. At the same time, there is no information about the entry of the component into breast milk. In this regard, the doctor can prescribe this type of medicine only if the positive effect of the syrup is significantly higher than the likelihood of developing negative consequences. In other cases, at the stage of pregnancy and breastfeeding, such a remedy is not suitable.

The medicine does not affect the ability to control mechanisms or drive vehicles.

Drug interactions

Groprinosin syrup is required to be used with extreme caution if additionally have been prescribed:

• xanthine oxidase inhibitors;
• loop diuretics (ethacrynic acid, Torasemide, Furosemide);
• compounds that enhance the release of uric acid through the kidneys;
• thiazide diuretics (in the form of Indapamide, Chlorthalidone, Hydrochlorothiazide).

The medicine must be used at the end of the treatment course with immunosuppressants. This is due to the fact that pharmacokinetic interactions may occur that affect the expected therapeutic result. As a result, the effectiveness of the active ingredient may decrease.

If Zidovudine is additionally used, it provokes an increase in the formation of nucleotides through various mechanisms. As a result, the serum bioavailability of zidovudine increases, and intracellular phosphorylation is also enhanced in monocytes. Under the influence of the syrup, the Zidovudine values ​​are exceeded.

Analogs

If Groprinosin syrup is not available at the pharmacy, it is permissible to use its analogues, which are characterized by high efficiency:

• drops Groprinosin-Richter, intended for internal use;
• syrup Normomed;
• Groprinosin tablets;
• Isoprinosine tablets;
• Inosine pranobex tablets;
• Normomed tablets;
• Pronaber tablets.

Any analogue has a number of contraindications, therefore, before using it, it is recommended to consult with a medical specialist so as not to harm the body and health in general. Otherwise, the condition can be aggravated, so it is undesirable to self-medicate.

Storage conditions

For storage, it is recommended to choose a place that will be inaccessible to small children. In the room, the temperature indicator should not exceed +25 ℃. Do not refrigerate and freeze the medicine.

The shelf life of the drug is 24 months from the date of manufacture. When the bottle is opened, the contents of the container must be used within 6 months. When the expiration date has expired, the use of the drug is prohibited.

The antiviral agent Groprinosin can be prescribed for both adults and children, since the syrup has a sweet taste. The medication must be taken in accordance with the instructions on the package. Before use, it is recommended to consult with a specialist in order to exclude the presence of contraindications.

Video about the drug Groprinosin

Treatment of ARVI with Groprinosin: