Cortexinum for children. Reviews, instructions for use, what is prescribed, dosage, price

Cortexin is a nootropic drug, the active components of which have high biological activity. The medication was developed by specialists of the Military Medical Academy in St. St. Petersburg.

The drug is intended for the treatment of adults and children who suffer from neurological diseases and brain pathologies. According to the reviews of patients and doctors who used Cortexin for therapeutic purposes, the drug has an excellent therapeutic effect.

Forms of release and composition of the drug

Cortexin is produced in the form of a lyophilisate, which is used for the further preparation of intramuscular injections. Outwardly, the drug resembles a white powder, consisting of many small crystals.

It can also appear as a porous mass of light or yellowish tint. The drug is packaged in sterile glass vials, which contain 5 or 10 mg of the drug. The main package of the medicinal product is a box made of thick cardboard.

The table below shows the active and auxiliary components of Cortexin, the action of which provides the therapeutic efficacy of the drug.

Cortexin composition	Purpose of the constituent substance
Cortexin	This is the main component of the drug, which is a polypeptide fraction isolated from the cerebral cortex of cattle and pigs. 1 glass bottle of the drug contains at least 5 or 10 mg of this biochemical substance (depending on the dosage), and its total molecular weight cannot exceed 10,000 Da. Purified polypeptide compounds have a positive effect on the functioning of the central and peripheral nervous systems, protecting the cortex and subcortical region of the brain from the negative effects of external and internal factors.
Glycine	This is an excipient of the drug Cortexin. The main purpose of glycine is to stabilize the biochemical composition of the lyophilisate, to prevent its premature breakdown into metabolites. An indirect property of glycine is to stimulate the work of the cerebral cortex, as well as enhance the healing properties of Cortexin.

To use the drug as intramuscular injections, it is necessary to dissolve the lyophilisate with novocaine, sodium chloride or sterile injection water. In this case, these substances also become auxiliary components of Cortexin.

Pharmacological properties

Cortexin is a potent drug with nootropic properties. The medication is used for children of all age groups suffering from brain diseases, neurological pathologies, mental and physical development disorders. Reviews of patients and doctors who used this remedy indicate its high therapeutic efficacy.

Cortexin has the following pharmacological properties:

• improves the functionality of memory, which is very important for improving the performance of a school-age child;
• protects neurons from the negative effects of endogenous factors with neurotoxic effects (calcium ions, glutamate sodium, free radicals, mutated cells, chemicals in drugs, food, drinks);
• helps to stabilize the psychoemotional state in a stressful situation;
• prevents the development of concomitant diseases of the body, the occurrence of which is associated with nervous overstrain and neurological disorders;
• stimulates the performance of all centers of the brain, increasing their functional activity;
• acts as a natural and safe antioxidant, inhibiting physiological lipid oxidation inside nerve cells system (under stressful conditions, hypoxia or peroxidation, a greater amount of neurons);
• activates metabolic processes in the neurons of the peripheral and central nervous system, providing high-quality and nutritious nutrition to the brain tissues;
• has the ability to accelerate the adaptation processes of the body after changing the main place of residence, labor collective, daily living environment, type of activity;
• reduces the severity of the manifestation of painful symptoms in children, adult men and women suffering from neurological diseases, the consequences and complications of traumatic brain injury;
• prevents the development of cerebral ischemia, which makes it possible to use the drug for the prevention of cerebral stroke;
• maintains a stable tone of nerve endings, improving the functions of the musculature of the musculoskeletal system, the performance of internal organs, blood vessels;
• accelerates the recovery of the central nervous system after prolonged mental and physical exertion.

Cortexin acts on the cerebral cortex, stimulates the central and peripheral nervous system, but at the same time indirectly affects the functional activity of the whole organism.

The pharmacological properties of the drug are most clearly manifested in the complex treatment of diseases of the central nervous system or neurological pathologies. For children, Cortexin is prescribed by a neuropathologist based on the results of a comprehensive examination of the body.

Pharmacodynamics and pharmacokinetics

Cortexin for children, reviews of which are 95% positive, is a completely safe drug. Pharmacodynamics of the drug is due to the activation of peptide bonds of neurons, as well as neurotropic factors of the brain.

The active substances of the drug optimize the balance of the metabolism of amino acids, which stimulate and inhibit the functions of the central nervous system. The bioelectrical activity of the brain improves, the risk of paroxysmal seizures and other disorders in the functioning of the organ decreases.

The pharmacodynamic feature of the drug is that Cortexin acts directly on the cerebral cortex, which contributes to the restoration of its neurons. According to the developers of the nootropic drug, the drug is capable of repairing DNA inside brain cells.

Water-soluble polypeptide compounds of the drug are characterized by extremely low molecular weight.

This property of the active component of Cortexin ensures its unhindered penetration through the blood-brain barrier. The constituents of the drug get directly to the cells of the central and peripheral nervous system, where they show their main therapeutic properties.

The biochemical composition of the drug Cortexin, which is based on complex polypeptide fractions, obtained from the cerebral cortex of pigs and cattle, does not allow for a full analysis medication.

There are no data on the pharmacokinetic properties of the drug. This information is displayed in the instructions for use of Cortexin, and is also confirmed by the developers and manufacturers of the drug.

Indications for use for children

Cortexin for children, reviews of which indicate the high therapeutic efficacy of the drug, is a safe drug.

The medication is indicated for use in the presence of the following diseases and pathological conditions of the body:

• previous closed or open craniocerebral trauma, as well as its complications and negative consequences;
• violation of the stable process of cerebral circulation associated with diseases of the great vessels, cerebral ischemia, hereditary predisposition;
• viral or bacterial meningitis, encephalitis, myelitis (in this case, Cortexin should be used as part of complex therapy, aimed not only at restoring the functions of the central nervous system, but also at suppressing the activity of pathogens microorganisms);
• all types of mnestic and intellectual disorders;
• acquired or congenital epilepsy (the drug is not able to completely cure this disease, but its active substances allow to achieve stable remission and a significant reduction in frequency attacks);
• severe neuroinfections of bacterial or viral origin that affect the peripheral and central nervous system;
• chronic fatigue syndrome, accompanied by a changeable mood, manifestation of apathy, depression, indifference to processes occurring in the environment (in this case, the drug becomes effective for adolescent children age);
• cerebral palsy and complications associated with its presence (Cortexin is used as the main or auxiliary agent for improving neural conduction of nerve endings, stimulating the centers of the cerebral cortex, increasing the functional activity of the musculoskeletal apparatus);
• all types of birth trauma, the consequence of which is the critical condition of a newborn child;
• delay in speech or psychomotor development of children, which does not have a pathological nature of origin;
• congenital hydrocephalus of the brain (the medication supports the functions of the organ, but does not allow to achieve complete restoration of its tissues);
• perinatal damage to cells of the nervous system, received at the time of birth;
• decreased cognitive functions of the brain, memory problems that are not associated with the presence of concomitant diseases.

Cortexin can be used as a complex agent during the treatment of other neurological disorders. The medication is used to restore the stable functioning of the central nervous system in children who have experienced prolonged psycho-emotional stress, a severe stressful situation, and a state of depression.

Contraindications

Cortexin for children, reviews of which are mostly positive, is used for therapeutic and prophylactic purposes. The medication is well tolerated by most patients of all age groups.

The main contraindication to the use of Cortexin is individual intolerance to the main or auxiliary components of the drug.

In most cases, it is expressed in the form of an acute or moderate allergic reaction. The presence of redness of the skin, itching, the appearance of a rash, hyperemia, urticaria, the formation of edema and other signs of irritation in the area of ​​drug administration, indicates an intolerance to Cortexin. This is a direct contraindication to the further use of the medication.

At what age can the drug be used for children?

Cortexin is prescribed by a pediatric neurologist only if there are direct indications for the use of the drug. The medication can be used to treat a newborn child in the first days of his independent life.

Before prescribing a drug, the doctor weighs all the potential risks and consequences that may occur after using intramuscular injections. The dosage regimen intended for patients of the corresponding age category and body weight is mandatory.

Instructions for use, dosage

Cortexin is intended exclusively for intramuscular administration without mixing with other injectable drugs. To prepare the finished dose of the medication, you will need to dissolve the powdery contents of the glass a vial in 2 ml of sterile water for injection or a similar amount of sodium chloride with a concentration 0,9%.

After this, the medicine bottle must be shaken thoroughly. During the preparation of the solution, a large amount of foam forms inside the bottle. Therefore, while taking the drug, the syringe needle should be directed closer to the glass wall of the vial.

For infants, as well as children of the younger age group, whose weight does not exceed 20 kg, Cortexin is prescribed for intramuscular administration at 0.5 mg of the drug per 1 kg of body weight. The dosage is calculated individually by a neuropathologist or a doctor of another specialization who treats the child.

The drug is administered once a day. The duration of therapy depends on the type of disease and the general condition of the infant. Children weighing more than 20 kg receive intramuscular injections of Cortexin with a dosage of 10 mg of the drug once a day. The course of treatment is at least 10 days, and it can be repeated no earlier than 3 months later.

Side effects

Cortexin for children, reviews of which indicate its positive properties, is a safe drug.

Despite this, doctors do not exclude the possible occurrence of the following side effects:

• a local allergic reaction, which is expressed in reddening of the skin in the area of ​​drug administration, the appearance of itching, rash, signs of hyperemia;
• angioedema of the larynx with instant spasm of the upper respiratory tract (this is the most dangerous side effect that can lead to death);
• heart palpitations;
• anxiety, anxiety;
• sleep disturbance, which is most often accompanied by insomnia;
• disorders of psychomotor reactions (lethargy, increased agitation, sudden mood swings, unreasonable laughter);
• dizziness and lack of coordination of movements.

In case of manifestation of side effects of Cortexin, it is necessary to stop further taking the drug, and also inform the attending physician about this, who prescribed the administration of this medication.

Overdose

Currently, there is no informational data on cases of overdose with Cortexin.

In the case of intramuscular administration of higher doses that are not provided for by the rules of the instructions for use, symptoms may appear that resemble the side properties of the medication. A patient with signs of Cortexin overdose should be immediately taken to the inpatient department of the hospital.

special instructions

During treatment with Cortexin, the following rules must be observed, which will allow avoid the occurrence of side effects and other negative reactions of the body:

• use the medication only as directed by the attending physician;
• in the case of using Novocaine as an aid for dissolving Cortexin powder, the side properties of this substance should be studied in detail;
• it is not recommended to use the anesthetic Lidocaine for the preparation of intramuscular injections of Cortexin;
• a bottle with an already prepared preparation should be used within 10-15 minutes. (further storage and use of the ready-made solution is prohibited);
• the medication is contraindicated to be mixed with other injectables;
• the drug is capable of influencing psychomotor reactions, which requires more careful monitoring and monitoring of the child's health.

Cortexin solution, which is not completely used after its preparation, does not require special rules for its disposal. In case of skipping the injection of the medication, it is forbidden to use a double dose. It is necessary to wait until the next day and continue therapy as usual.

Drug interactions

Laboratory tests of drug interactions of Cortexin with other drugs have not been carried out. The manufacturer of the medication emphasizes that intramuscular injections of the solution should not be mixed with other means of general therapy.

The use of the anesthetic Lidocaine as the main solvent can provoke the development of a local allergic reaction. This feature must be taken into account for people who have an individual intolerance to this drug. Also, Cortexin is not recommended for simultaneous use with other medicines of the peptide group.

Analogs

The biochemical composition of Cortexin is unique. Currently, there are no similar medications for intramuscular administration that would contain a complex of purified polypeptide compounds obtained from the cerebral cortex of pigs and bovine livestock.

At the same time, they would have therapeutic and biostimulating properties in relation to the central and peripheral nervous system.

Terms, conditions of sale and storage

The drug must be stored in a dark and cool place, out of direct sunlight, and the ambient temperature does not exceed +25 degrees Celsius. The medication must be out of reach of children of all age groups.

The drug can be purchased at retail pharmacy chains, but only on the basis of a prescription from the attending physician. If all of the above conditions are met, the maximum duration of storage of the medication is 3 years. After opening the bottle with the medicine and preparing the finished solution, the drug must be used and the rest discarded.

Price in pharmacies in Moscow, St. Petersburg, regions

The average cost of Cortexin in Moscow, St. Petersburg and other regions of the Russian Federation is 1215 rubles. per pack of 10 vials, each containing 10 mg of active substance. A medication with a dosage of 5 mg of the main component and a complete set of 10 vials costs from 720 to 750 rubles. per packing. The final cost of the drug depends on the pricing policy of the pharmacy management.

Cortexin is a nootropic drug that is a natural biological stimulator of the functions of the central and peripheral nervous system.

The drug contains complex polypeptide compounds, which are obtained from the cerebral cortex of cattle and pigs. The drug is used to treat children with neurological diseases, impaired cognitive function, retardation of psychomotor and physical development, suffering from cerebral palsy, surviving craniocerebral or birth injury.

According to reviews of patients and neuropathologists who used Cortexin for medicinal purposes, the medication has excellent therapeutic properties, is completely safe and has practically no contraindications.

Video about Cortexin

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