Phezam. Reviews of patients who took the drug, instructions for use, side effects, analogues, price

Phezam - this drug, used in the treatment of various disorders of cerebral circulation. According to reviews of patients who took the drug, the drug has a high therapeutic effect.

Indications for use

The drug belongs to the group of neurometabolic and antihypoxic drugs.

Indications:

• toxic brain damage;
• impaired blood circulation in the brain, characterized by insufficient blood flow - rehabilitation after hemorrhagic and ischemic diseases, atherosclerotic brain damage, damage to the head, the presence of various forms encephalopathy;
• pathologies of the central nervous system, which are accompanied by a decrease in intellectual abilities - changes in mood, impaired concentration;
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• the period after suffering head injuries;
• organic psychosyndrome;
• asthenic condition, which has a psychogenic nature of origin;
• various forms of labyrinthopathies - the development of dizziness, tinnitus;
• prevention of the development of migraine pains and motion sickness;
• Miniere's disease.

The agent can also be prescribed as part of a comprehensive treatment for the development of organic psychosyndrome due to a decrease in learning in children.

Compound

The active ingredients of the drug are 2 substances - piracetam and cinnarazine.

Additional composition:

• 0.55 g of lactose monohydrate;
• 15 mg food supplement E551;
• 5 mg magnesium stearate.

The shell contains a gelatinous filler and titanium dioxide.

In what form is it produced

Phezam (reviews of patients who took the medication report one dosage form) is produced in the form of enteric capsules that have a cylindrical shape. The color of the tablets is white. Inside the capsule contains a powdery mass of white or almost white color. The cost of packaging (60 pcs.) Is from 266 to 273 rubles.

Pharmacodynamics

This drug belongs to the category of combined drugs with antihypoxic action. In this case, the drug exhibits high vasoconstrictor and nootropic properties. The main ingredients help to improve blood flow in the brain by decreasing vascular resistance.

The active ingredient (piracetam) helps to restore and improve metabolic processes in the brain.

This process is due to the strengthening of energy and protein processes, which greatly increases the resistance to the development of hypoxic syndrome. At the same time, there is an improvement in the transmission of nerve impulses emanating from neurons to the central nervous system.

The second active ingredient (cinnarizine) is a calcium channel blocker. This substance has a pronounced antihistamine effect, blocks the production and negative effects of calcium ions on brain cells.

The component leads to the expansion of blood vessels located in the region of the brain. However, it does not have a negative effect on blood pressure levels. The substance reduces the activity of the vestibular system and blood viscosity.

Pharmacokinetics

The drug has a good absorbing ability, therefore it is rapidly absorbed into the gastrointestinal tract.

The maximum level of the first active element (piracetam) is reached after 2-6 hours after its application. The concentration of the substance in the cerebrospinal fluid is reached after 2-8 hours. Bioavailability is 100%.

The active ingredient does not interact with proteins. The substance is able to penetrate into all tissues and organs, including the placental barrier. It tends to accumulate in the brain regions. The ingredient is not metabolized and leaves the body unchanged through the renal system. Its half-life from lymph is about 4-5 hours.

The time for removing the component from the cerebrospinal fluid is from 8 to 9 hours. In this case, the half-life of the substance may increase if the patient has kidney failure. However, the pharmacokinetic properties of the drug in the presence of this pathology remain the same.

The second active ingredient (cinnarizine) has a low absorption capacity. Its maximum level of accumulation in plasma is reached after 1-4 hours. The level of interaction with proteins is up to 91%. The substance undergoes isozyme metabolism. The half-life of the component is about 4 hours. More than 30% is excreted by the kidneys in the form of metabolites. Less than 70% of the components leave the body through the intestines.

Application

Phezam (reviews of patients who took capsules, in most cases positive) is intended for oral administration.

The dosage and other features of the capsule treatment depend on the patient's age and the presence of concomitant diseases.

For children under 18

The drug is approved for use in children over 5 years of age. In this case, the dosage is 1-2 capsules from 1 to 2 times a day. The duration of the course may vary and on average ranges from 40 days to 3 months.

For adults

Adult patients are prescribed 1-2 pills 3 times a day. The course of therapy is established by the attending specialist and on average should be from 1 to 3 months. There should be at least 2-3 such courses per year.

For pregnant

It is not recommended to use the drug while carrying a child. However, the agent can be prescribed by the treating specialist, taking into account the possible risks / benefits. In this case, the dosage will be calculated only on the basis of the condition of the pregnant woman.

For the elderly

Elderly patients are prescribed a standard dosage - 1-2 capsules at least 3 times a day. In the presence of functional disorders of the kidneys, the daily rate can be adjusted.

The duration of treatment is from 1 to 3 months.

Contraindications

Fezam has an extensive list of contraindications associated with the effect of the components on the patient's body. Based on the reviews and recommendations of experts, before you start taking the pills, you should carefully read this list of restrictions.

Contraindications:

• intolerance to the components that make up the medication;
• severe course of kidney or liver failure;
• increased agitated state of the patient during the period of prescribing the medication;
• hemorrhagic stroke;
• the period of bearing or feeding the child;
• Huntington's syndrome;
• galactose intolerance, lactase deficiency, glucose-galactose malabsorption syndrome;
• children under 5 years of age.

With high caution, capsules can be used in the presence of the following disorders and conditions:

• Parkinson's syndrome;
• any pathologies characterized by the risk of developing intraocular pressure;
• functional disorders of the kidneys or liver;
• severe bleeding;
• hemostatic disorders.

With these signs, drug treatment is carried out only under the supervision of a specialist.

Overdose

If dosages are exceeded, negative symptoms may develop, which, however, does not require drug withdrawal.

Overdose signs:

• sleep disturbance - insomnia;
• restless behavior;
• euphoric state;
• increased irritability;
• trembling in the body;
• nightmares;
• convulsive state;
• hallucinations.

With the development of negative signs, it is necessary to wash the stomach and use sorbing agents. In severe cases, hemodialysis is prescribed.

There is no specific antidote.

Side effects

Phezam (reviews of patients who took the drug indicate the possible formation of reactions intolerance) can lead to the development of side effects due to the action of the main substances means.

Side effects:

• Central and peripheral nervous system: nervous irritability, hyperkinetic psychosis, increased drowsiness, depression. In extremely rare cases, it is possible to develop dizziness, disturbances in sleep rhythms, increased excitability, anxiety, and hallucinations.
• Gastrointestinal tract: it is extremely rare to develop increased salivation, dyspeptic disorders - diarrhea, vomiting or nausea, pain in the epigastric region.
• Allergic manifestations: reactions of intolerance - rashes, itching symptoms, dermatitis, swelling, increased sensitivity to light.
• Other reactions: increased sex drive. In elderly patients, tremors (tremors) may occur.

With the development of side effects, including reactions not noted in the instructions, it is recommended to seek the advice of a treating specialist.

Drug interactions

The combined use of the drug with alcoholic beverages, tricyclic antidepressants, as well as drugs that have a depressing effect on the central nervous system, can lead to the development sedative effect.

The simultaneous use of capsules and vasodilators can cause an enhanced effect of the first drug. A similar effect is observed with the combined use of tablets and oral anticoagulants.

The main drug helps to increase the tolerance of antidepressants belonging to the tricyclic group, as well as drugs that exhibit antipsychotic effects.

Precautionary measures

Extremely careful prescription of the drug is required for persons with severe functional disorders of the kidneys or liver. With mild to moderate severity, it is necessary to reduce the daily dosage.

Patients with functional disorders of the liver need to undergo systematic studies aimed at determining the level of liver enzymes.

It should be borne in mind that the use of capsules can lead to false positive results for doping.

It should also be borne in mind that the drug has a stimulating effect on the thyroid gland, which can lead to tremors or restless behavior.

If the patient has ulcers or erosions in the gastrointestinal tract, capsules should be taken no earlier than 30 minutes later. after eating. The medicine can have a negative effect on hemodialysis procedures, therefore, before prescribing the capsules, it is necessary to inform the attending specialist about this.

When taking the medicine, great care should be taken while driving or when carrying out work that requires high psychomotor functions.

Storage conditions and periods

• The medicinal product must be stored in a clean and dry place at temperatures up to 25 C.
• The shelf life of capsules is 3 years from the date of manufacture.
• It is not allowed to use the product after the expiration date indicated on the package.

Conditions of dispensing from pharmacies

The drug is dispensed only with a doctor's prescription.

Analogs

Phezam (reviews of patients who took capsules report rare episodes of intolerance) can be replaced with similar drugs that exhibit identical therapeutic effects.

Name of the drug	Composition (active substance)	Features / characteristics	Price
Omaron	Piracetam and Cinnarizine	The manufacturer of this drug is a Russian pharmaceutical company. The medicine is produced in the form of tablets and belongs to the category of nootropic psychostimulants. The capsules have a vasodilating and antihypoxic effect. Indications for their use: encephalopathy, toxic brain damage, organic psychosyndrome, the period after head injuries, functional disorders of blood circulation in the brain. Patients over 18 years old are prescribed 1-3 tablets 3 times a day, for patients from 5 to 18 years old the recommended daily rate is 1-2 capsules 1-2 times a day. The therapy is carried out for 1-3 months. The medication is limited for use in functional disorders of the kidneys / liver, in hemorrhagic stroke, as well as during feeding or carrying a child. It is forbidden to use pills with lactose intolerance, psychomotor agitation and with the development of Huntington's syndrome. Prescription medicine is dispensed.	RUB 106-298
Olatropil	Gamma Aminobutyric Acid and Piracetam	This drug is a Latvian-made nootropic psychostimulant. It is manufactured in the form of oral capsules. They exhibit high vasodilating and neurometabolic properties. Indications for use: organic psychosyndrome, rehabilitation after injuries and ischemic stroke. As a treatment, 1 tablet is prescribed from 3 to 4 times a day. The therapy continues for 2 months. If necessary, the course can be repeated after a break (1.5-2 months). Before using the tablets, you should consult your doctor, as they have numerous restrictions on their prescription, including the period of pregnancy and children under 5 years of age. A medication is dispensed according to a specialist's prescription.	RUB 235-459
Kombitropil	Piracetam and Cinnarizine	This combination drug is produced by a Russian pharmaceutical company in the form of oral tablets. Capsules exhibit nootropic and psychostimulating effects and are prescribed in the presence of the following pathologies and conditions: blood circulation, organic psychosyndrome, toxic damage to parts of the brain, coma, depressive disorders, asthenic syndrome, prevention of migraine-type headaches, impaired cognitive abilities, and decreased learning ability in children. Before taking the medication, consultation with your doctor is required, as it has numerous contraindications and limitations, including childhood and Parkinson's syndrome. Adult patients are prescribed 1 tablet 3 times per day. The treatment is carried out within 1-3 months. In children over 5 years of age, 1-2 tablets are prescribed 1-2 times a day. The therapy is carried out for 1-3 months. If necessary, repeated courses can be carried out after a 2-month break. The product is subject to prescription.	64-69 rubles.

Before taking the tablets, you should carefully read the annotation for the use of Phezam and consult a specialist / pharmacist. In addition, it is recommended to read the reviews of doctors and patients who used the drug as a nootropic and neurometabolic agent.

Video about the drug Phezam

Review of the doctor about the drug Phezam: