Irifrin eye drops. Reviews, instructions for use, analogues, price

Irifrin eye drops is a medicine that is used in the field of ophthalmology. The drug is intended for the treatment of eye diseasesas well as performing diagnostic procedures. According to the reviews of patients and doctors who use the drug for therapeutic purposes, Irifrin is an effective and safe remedy.

Forms of release and composition of the drug

Eye drops Irifrin is an ophthalmic drug that comes in the form of a slightly yellowish liquid solution. The medication is poured into white plastic bottles with a capacity of 5 ml. The main packaging is a box made of high density paper.

Most of the reviews about Irifrin drops are positive and indicate the high effectiveness of the drug. The table below describes in detail the auxiliary and main substances of the medication.

Main and auxiliary components	Pharmacological properties of chemicals
Phenylephrine hydrochloride	This is the main substance of Irifrin eye drops. 1 ml of the drug contains 25 mg of phenylephrine hydrochloride. It is a synthetic substance that belongs to the category of adrenergic agonists. Acts as a stimulant for alpha-adrenergic receptors. Once in the human body, it causes a sharp narrowing of the walls of the arterioles. Phenylephrine hydrochloride can increase blood pressure, which should be taken into account in patients prone to arterial hypertension.
Benzalkonium chloride	This is an auxiliary substance that has pronounced antiseptic properties. Benzalkonium hydrochloride is effective against bacterial, fungal and viral microorganisms. Benzalkonium chloride was first synthesized in 1935. By its chemical etiology, it is a complex of chloride compounds. In drops, Irifrin acts as an antimicrobial agent.
Disodium edetat	This is an auxiliary substance that is obtained from edetic acid and sodium hydroxide. In the composition of eye drops Irifrin disodium edetate acts as a stabilizer of the chemical composition of the drug.
Hypromelose	It is an excipient that is an artificial replacement for tear fluid. Hypromelose softens the chemical properties of Irifrin and has an anti-inflammatory effect.
Sodium metabisulfate	It is an excipient that is used as an anti-inflammatory and disinfectant. Sodium metabisulfate has antioxidant properties.
Sodium citrate	In the composition of eye drops, Irifrin sodium citrate acts as an excipient. Sodium citrate is a preservative that stabilizes the chemical composition of the drug, prevents premature decomposition of its constituent components.
Lemon acid	Citric acid is an auxiliary substance in Irifrin drops. Used as a safe and cheap preservative.
Water for injections	Purified water for injection is the basis of the drug, in which the active and auxiliary substances of Irifrin are dissolved.

Irifrin - eye drops, reviews of which are 97% positive. They are an ophthalmic medication belonging to the pharmacological group of mydriatic and cycloplegic drugs.

Pharmacological properties

The main pharmacological property of the ophthalmic drug Irifrin is the dilation of the pupil of the eyeball. Achievement of this effect is necessary for high-quality diagnostics of the organ of vision. The medication has anti-inflammatory and bactericidal effects.

The main component of the drug is able to suppress the pathogenic activity of viruses and fungal microorganisms, which minimizes the risk of infection of the eye tissues during the examination. Irifrin drops have a pronounced antispasmodic effect, helping to relax the muscles of the eye and dilate the blood vessels.

Pharmacodynamics and pharmacokinetics

Irifrin - eye drops, reviews of which indicate their high therapeutic efficacy. They have a pronounced stimulating effect on postsynaptic alpha-adrenergic receptors. At the same time, the active component of the drug practically does not affect the work of the beta-adrenergic receptors of the heart.

The drug has vasoconstrictor properties. According to their mechanism of action, Irifrin drops resemble norepinephrine, but at the same time there is no chronotropic and inotropic effect on the heart muscle.

The vasopressor effect of the drug is less noticeable than that of norepinephrine. The use of moderate doses of Irifrin does not have an exciting and stimulating effect on the centers of the brain and nerve endings. After the medicinal drops fall on the surface of the eyeball, the dilator of the pupil, the smooth muscles of the arterioles and the conjunctiva contract.

There is no pharmacodynamic effect on the ciliary muscles at all. Therefore, mydriasis occurs without the manifestation of signs of cycloplegia. Due to these properties of Irifrin and reactions of the organ of vision, it is possible to achieve a stable expansion of the pupil with a prolonged effect.

The pharmacokinetic properties of the drug are due to the high chemical activity of the main component of phenylephrine. After contact with the surface of the organ of vision, this substance quickly saturates the deep tissues of the eye, and the maximum expansion of the pupil diameter occurs after 10-60 minutes. based on the results of the first instillation.

A pronounced mydriasis persists over the next 4-6 hours. Due to significant compression of the pupil dilator inside the anterior chamber of the eye, particles of coloring components that get there from the surface of the pigment sheet of the rainbow shell.

A similar reaction of the organ of vision occurs after 30 minutes. from the moment of instillation of the medicine. This physiological phenomenon must be distinguished from the symptom of such an ophthalmic disease. like anterior uveitis, the development of which is accompanied by local hemorrhages in the anterior chamber eyes.

The main pharmacokinetic properties of Irifrin are manifested locally. The active and auxiliary substances of the drug penetrate into the bloodstream, but in small quantities. The half-life of the constituent components of the drug occurs in the liver tissues, and most of the metabolites are excreted along with the urine.

Indications for use

Irifrin - eye drops, reviews of which are mostly positive. They are appointed by an ophthalmologist for the purpose of treating and diagnosing diseases of the eyeball.

The medication is indicated for use in the following cases:

• anterior uveitis, as well as iridocyclitis (the drug is used to prevent and treat the formation of posterior synechiae and reduce blood exudation from the iris);
• artificial expansion of the pupil of the eye for high-quality diagnostics (an examination of the posterior chamber of the organ of vision is carried out);
• carrying out a diagnostic test in patients who have a narrow angle of the anterior chamber of the eyeball with the presence of signs of closed-angle glaucoma that has not been detected by other methods diagnostics;
• forced dilation of the pupil before surgery on the fundus using laser equipment;
• inflammation or symptoms of irritation of the mucous membrane of the eye caused by an allergic reaction, the consequences of mechanical damage, trauma and operations;
• complex treatment of accommodation spasm in children of middle and older age groups.

Irifrin drops can be used for the prevention and treatment of asthenopia. The prescription of a medicinal product is carried out exclusively by an ophthalmologist. Unauthorized use of a medication can lead to a decrease in visual acuity and deterioration of eye health.

Contraindications

Irifrin drops cannot be used to treat patients who have the following diseases, but also pathological conditions of internal organs and systems:

• closed-angle or narrow-angle glaucoma (the prohibition on the use of the drug is justified by the fact that the dilation of the pupil of the eye can aggravate the course of the disease and lead to irreversible consequences);
• severe diseases of the cardiovascular system associated with arrhythmia, the presence of arterial hypertension, tachycardia, aortic aneurysm (it is for these reasons that Irifrin is often contraindicated in elderly patients age);
• diabetes mellitus with dependence on injection of insulin;
• thyrotoxicosis or hyperthyroidism of the thyroid gland tissues;
• diseases of the arteriosclerotic and cerebrovascular type;
• acute liver failure or porphyria;
• individual intolerance to the main or auxiliary components of the drug;
• violation of the integrity of the eyeball, the restoration of which is possible only through surgical intervention;
• congenital deficiency of glucose-phosphate hydrogenase.

Irifrin - eye drops, reviews of which indicate their excellent therapeutic efficacy. They are contraindicated for simultaneous use with tricyclic antidepressants, antihypertensive drugs, and monoamine oxidase inhibitors. The drug is strictly prohibited for use in infants with low body weight.

At what age can eye drops be used?

In pediatric practice, Irifrin eye drops are used for newborns. The medication is used as an aid for performing a diagnostic examination of the fundus, retinography and ophthalmoscopy.

The drug is not recommended for use in premature infants who have a low body weight. The ophthalmologist conducts a risk assessment for the possible development of adverse reactions.

Premature babies can be prescribed the use of the drug in a dosage of no more than 1 drop in 1 eye. In this case, the child must be under the supervision of a pediatric ophthalmologist and medical workers of other specialties.

Instructions for use, dosage

The dosage of the medicinal product is determined individually, depending on the type of disease or the diagnostic method that should be used in a specific clinical situation. To perform ophthalmoscopy, you will need to drip 1 drop of Irifrin solution with 2.5% concentration.

The drug is applied to the surface of the conjunctival sac. The maximum dilation of the pupil is observed after 15-30 minutes. and lasts for the next 3 hours. if there is a need to maintain a stable mydriasis, then after 1 hour, the drug is reapplied with a dose of 1 drop in each eye.

A similar dosage of a medicinal solution with a concentration of 2.5% is used for provocative diagnostics in patients with signs of closed-angle glaucoma.

If the difference between the indicators of intraocular pressure before the introduction of the drug and after its instillation is from 3 to 5 mm Hg. Art., then the survey results are considered positive. In the presence of iridocyclitis, anterior uveitis, Irifrin is used for therapeutic purposes, prescribing the drug 1 drop per conjunctiva of the diseased eye 2 to 3 times a day.

For the complex therapy of accommodation spasm, asthenopia in schoolchildren, as well as mild myopia, 1 drop of Irifrin is prescribed for 5-10 minutes. before going to bed. The drug is used exclusively on those days when an increased load is created on the organ of vision.

Treatment of moderate myopia requires applying the solution 3 times a week just before bedtime. Patients with farsightedness who have signs of pupil spasm are prescribed 1 drop of the drug in combination with the same amount of cyclopentolate 1% concentration. The medication is applied 3 times a day for 5 minutes. before sleep.

Side effects

Irifrin eye drops are considered a safe drug that is well tolerated by patients of all age groups.

Despite this, the manufacturer of the ophthalmic solution does not exclude the risk of developing the following side effects:

• an allergic reaction, which can be expressed in the form of conjunctivitis, redness of the eye, itching;
• decreased vision clarity;
• involuntary lacrimation;
• increased intraocular pressure;
• painful perception of sunlight;
• discomfort in the eye area;
• tachycardia;
• reflex bradycardia;
• pulmonary embolism;
• arterial hypertension;
• various heart rhythm disturbances;
• myocardial infarction;
• pallor of the skin.

In the event of the above adverse reactions, it is necessary to stop further taking the drug, and then report the incident to the attending physician. Pathologies of the cardiovascular system require urgent medical attention.

Overdose

The main substance of Irifrin eye drops - phenylephrine has a high degree of chemical activity.

Improper use of the drug in violation of the dosage can cause an overdose and the development of the following complications:

• reflex bradycardia;
• a significant increase in blood pressure with signs of a hypertensive crisis;
• acute allergic reactions, accompanied by redness of the mucous membrane of the eyes, tears, itching, the formation of edema;
• visual dysfunctions.

In the event of an overdose and the development of signs of reflex bradycardia, it is necessary to use drugs that belong to the pharmacological group of alpha-blockers. Atropine is used to stabilize the heart rate. For children, the medication is prescribed at the rate of dosage - 0.01 mg of the drug per 1 kg of body weight.

special instructions

In elderly patients, Irifrin eye drops can provoke the onset of reactive miosis. A similar reaction of the body is observed 24 hours after the application of the medication. Repeated administration of the drug leads to a decrease in the effect of pupil dilation.

The drug is prescribed with caution to patients suffering from cerebral atherosclerosis, bronchial asthma, hypertension, diabetes mellitus. Due to the rapidly developing effect of pupil dilation, floating spots of a red or pink tint may appear in front of the eyes.

Patients who wear contact lenses may experience eye irritation. Before introducing the drug into the conjunctiva of the eye, it is necessary to remove the lenses, drip the drug, wait at least 15 minutes, and then put them on again.

Women who are in a state of pregnancy can use Irifrin drops, but only if there is an urgent need to use them.

During lactation, the medication is not used. Before starting to drive a car or other means of transport, you must make sure that the organ of vision is fully functional.

Drug interactions

The table below details the drug interaction of Irifrin eye drops with medicines of other pharmacological groups.

Types of drugs	Drug interactions
Antihypertensive drugs	Contraindicated for use during the period of use of Irifrin, since the development of arterial hypertension with the onset of death is not excluded.
MAO inhibitors	Drugs in this group are not taken in combination with eye drops in order to prevent the occurrence of adrenergic effects.
Tricyclic antidepressants	With the combined use of antidepressants and Irifrin, attacks of cardiac arrhythmias occur.
Inhalation anesthesia	Simultaneous therapy with eye drops and the use of inhalation anesthesia leads to suppression of the functions of the cardiovascular system.
Quinidine as well as cardiac glycosides	The parallel use of drugs of this group is prohibited, since the patient may experience arrhythmia attacks.

All restrictions on the joint use of the above drugs with Irifrin drops explained to the patient by an ophthalmologist who treats or diagnoses him eye diseases.

Analogs

The following drugs are on sale, which are analogs of Irifrin eye drops:

• Phenephrine - a solution with 10% concentration in a 5 ml bottle, the cost of which is 570 rubles;
• Mezaton - eye drops with an active substance concentration of 2.5% in a 5 ml vial, the average price of which is 180 rubles;
• Mesanext - eye drops based on phenylephrine with a concentration of 2.5%, the cost of which is 210 rubles.

The above drugs are used for the diagnosis and treatment of ophthalmic diseases. Medicines have the pharmacological properties of Irifrin.

Terms, conditions of sale and storage

The drug must be stored in a dark and protected from light place at an air temperature not higher than +25 degrees Celsius. The general shelf life of drops is 2 years. After opening the bottle, the medication can be stored for no more than 1 month. The release of Irifrin is carried out only on the basis of a doctor's prescription.

Price in pharmacies in Moscow, St. Petersburg, regions

The average cost of eye drops in Moscow, St. Petersburg and other regions of the Russian Federation varies from 420 to 500 rubles. for a bottle with a capacity of 5 ml and an active substance concentration of 2.5%.

Eye drops Irifrin is an effective drug, the pharmacological action of which is to dilate the pupil of the eye. The drug is used for the diagnosis and treatment of ophthalmic diseases.

The dosage and duration of use of the drug depends on the type of pathology. According to the reviews of patients and ophthalmologists, Irifrin drops have an excellent therapeutic effect. The medication is approved for use in relation to newborn children.

Video about the drug Irifrin

Irifrin for myopia: