Antiglaucoma remedy Azarga is intended for the treatment of patients with vision problems in adulthood and old age. The active components of the ophthalmic preparation reinforce each other, making the drops even more effective. The price of a medicine in pharmacies usually does not exceed 1000 rubles.
Record content:
- 1 Composition, form of release, where to buy and price
- 2 Mechanism of action
- 3 Indications for use
- 4 Contraindications and side effects
- 5 Overdose
- 6 Method of administration and dosage
- 7 special instructions
- 8 Precautionary measures
- 9 Drug interactions
- 10 Storage conditions and periods
- 11 Analogs
- 12 Video about drops for glaucoma
Composition, form of release, where to buy and price
The ophthalmic preparation Azarga contains:
- brinzolamide;
- timolol maleate;
- carbomer;
- sodium hydroxide;
- mannitol;
- sodium chloride;
- tyloxapol;
- edetate disodium;
- distilled water;
- benzalkonium chloride.
The minor constituents maintain the required acid level and also help the major constituents, timolol and brinzolamide, to be rapidly absorbed inside the eyes.
The auxiliary parts of Azarga are also at the same time:
- solvents;
- preservatives;
- stabilizers.
Azarga eye drops in the form of a homogeneous suspension, produced in a dropper bottle with a volume of 5 ml, are sold both online and in city or regional pharmacy chains.
Their cost, respectively, varies between 860-930 rubles. and 1060-1200 rubles. The product, together with the instructions for use, is placed in a cardboard package before distribution.
Mechanism of action
A carbonic anhydrase inhibitor, brinzolamide, reduces the production of fluid within the eye. This is due to the slow movement of sodium particles and the weakening of the synthesis of bicarbonate ions. An indiscriminate beta-adrenergic blocker, timolol, along with decreased fluid secretion, also accelerates fluid withdrawal.
Topically used timolol and brinzolamide are absorbed through the cornea and enter the systemic circulation. The second component of Azarga is 60% bound to plasma proteins and deposited in erythrocytes, thereby binding to the first carbonic anhydrase.
Due to this distribution, brinzolamide has an ultra-low concentration in the blood. Timolol after instillation with Azargoi continues to be in plasma for 12 hours.
Indications for use
Ophthalmologists prescribe combined Azarga for intraocular hypertension and acute-angle glaucoma for those patients who are not helped by monotherapy drugs.
The use of the described drops contribute to the rapid elimination of:
- painful sensations;
- burning sensation;
- visual impairment.
Azarga can also be prescribed for:
- change in visual angle and acuity;
- narrowed ophthalmic fields;
- congested blood vessels, due to which there is a change in the color of the conjunctiva.
Contraindications and side effects
Contraindications to taking eye drops include:
- pregnancy;
- lactation;
- children and adolescents (up to 18 years old);
- closed glaucoma with internal blockage in the eye drainage section;
- renal and severe heart failure;
- allergic rhinitis;
- atrioventricular block;
- chronic pulmonary obstruction;
- sinus bradycardia;
- predisposition to bronchospasm;
- bronchial asthma;
- impaired metabolism;
- cardiac pathology;
- high sensitivity to components;
- rejection by the body of sulfonamides;
- renal dysfunction.
Azarga is recommended for increased intraocular pressure. The innovative drops also prevent the further development of acute glaucoma. Eye remedy for up to 1000 rubles. applied topically by injecting it into the conjunctival sac.
The side effects of a highly concentrated ophthalmic drug are attributed to:
- allergies;
- the development of depressive conditions from long-term therapy;
- shortness of breath;
- sore throat and dry cough;
- hearing or vision impairment;
- pressure surges;
- heart palpitations;
- dizziness and migraines;
- fear of light;
- lacrimation;
- soreness and swelling of the eyelids;
- deterioration of visual acuity;
- lack of appetite;
- hypoglycemia;
- tremor;
- fainting;
- sneezing;
- flatulence;
- muscle pain and cramps;
- anxiety;
- a feeling of an unusual or bitter taste in your mouth;
- constricted pupils;
- fog in the eyes;
- sore throat and coughing fits.
Uncommon and rare side effects are:
- sinusitis;
- pharyngitis;
- hyperchloremia;
- anemia;
- leukopenia;
- angioedema;
- anaphylaxis;
- decreased libido;
- apathy;
- insomnia;
- amnesia;
- dysgeusia;
- hypotension;
- vertigo;
- alopecia;
- lichen planus;
- blood in the urine;
- itching;
- the appearance of crusts on the eyelids;
- conjunctivitis of an allergic nature;
- corneal erosion;
- redness and swelling of the eyelids.
Azarga eye drops (their price starts from 800 rubles) help to reduce pressure inside the visual organs. The complex medicine reduces fluid formation and improves fluid drainage. It also stabilizes membranes, thus exerting a positive effect on the myocardium.
Overdose
With increased doses of an ophthalmic drug or with its accidental If swallowed, the following symptoms of poisoning may occur:
- disruptions in the central nervous system;
- acidosis;
- disorganization of electrolyte balance;
- bronchospasm;
- heart failure;
- lowering pressure;
- bradycardia.
For any signs of an overdose, seek urgent medical attention. After that, the doctor must prescribe tests, as well as prescribe the restoration of the electrolyte balance and the acid level of the blood.
Method of administration and dosage
Azarga is taken locally, by instilling it twice a day, drop by drop in both eyes, for the conjunctiva. It is recommended to shake the bottle first. After the introduction of drops, the area near the inner edge of the eye is thoroughly massaged with a finger for about 2 minutes. This technique will significantly reduce the absorption of the drug into the bloodstream, preventing side effects.
With a missed dose, Azarga is buried the next time, according to the schedule. It is strictly forbidden to increase the portions of the drug prescribed in the instructions. Shake the bottle well before instillation, and after each use, be sure to close it tightly.
Method of using Azarga step by step:
- They wash their hands well beforehand.
- The head is thrown back.
- They begin to look up, pulling the lower eyelid down.
- 1 drop of the agent is injected into the opened area, without touching anything with the end of the bottle.
- Next, the eye is closed and blotted with a dry cotton swab.
- The inner corner of the eye, without opening it, is slightly pressed and held for 2 minutes.
special instructions
Before driving, remember that Azargo instillation reduces eye acuity and attention. If there is work ahead, for which visual clarity is required, then they begin to work half an hour after the application of the drops, since they immediately cloud the eyes.
Before using Azarga, lenses are removed from the eyes. Their re-installation is possible only after 20 minutes. after that. Take 10-minute breaks between doses of several ophthalmic medications. This approach is necessary to prevent flushing of the previous product.
Azarga eye drops (the price of the drug does not differ much from the cost of similar funds) delivers its main components directly to the systemic circulation. The withdrawal of the drug in an unchanged state occurs through the kidneys.
When using an ophthalmic drug, care must be taken that the dropper does not touch anything. Azarga is prohibited during pregnancy and lactation. Nursing mothers with an urgent need to use the drug should temporarily transfer the child to artificial nutrition. After the drops are canceled, lactation is resumed.
People with cardiovascular problems need to remember that Azarga almost always leads to complications when:
- low blood pressure;
- angina pectoris;
- ischemic disease;
- heart failure.
Azarga should be used very carefully for patients with low sugar levels and impaired peripheral circulation. And with myasthenia gravis, the drug aggravates muscle weakness. Azarga hides hyperthyroidism and can also lead to a more pronounced allergy to something.
Precautionary measures
Combined eye drops should be used with caution in those patients who, in addition to acute-angle glaucoma, also have:
- renal failure;
- elderly age;
- atopy;
- bronchial asthma;
- the consequences of filtering operations;
- prescriptions for surgical intervention;
- simultaneous treatment with systemic beta-blockers;
- a small number of endothelial cells in the cornea;
- diabetes;
- corneal dystrophy;
- severe liver failure.
Drug interactions
It is undesirable to use Azarga simultaneously with:
- epinephrine;
- parasympathomimetics;
- glycosides;
- amiodarone;
- other beta-blockers;
- guanethidine;
- paroxetine;
- fluoxetine;
- quinidine.
With an ophthalmic preparation, it is also unacceptable to use funds based on:
- itraconazole;
- ritonavir;
- clotrimazole;
- troleandomycin;
- ketoconazole.
Storage conditions and periods
Eye drops must be stored for 3 years, away from children, at a temperature of 2 to 30 degrees. When the expiration date has expired, it is prohibited to use Azarga. The opened bottle with the product is stored for no more than a month.
Analogs
The table below will familiarize you with drugs like Azarga:
| Analog name | Compound | Cost, in rub. |
| Timolol | Timolol | From 20 |
| Arutimol | Timolol | From 40 |
| Cosopt | Timolol and dorzolamide | From 690 |
| Betaxolol | Betaxolol hydrochloride | From 70 |
| Duotrav | Travoprost and timolol | From 650 |
| Xalak | Timolol and latanoprost | From 480 |
| Combigan | Timolol and brimonidine | From 650 |
| Gunforth | Timolol and bimatoprost | From 600 |
| Betalmik | Betaxolol | From 55 |
| Okumol | Timolol maleate | From 60 |
| Proxopheline | Clonidine and proxodolol | From 220 |
| Dorzopt + | Timolol and dorzolamide | From 500 |
| Taflotan | Tafluprost | From 730 |
| Grass press | Travoprost | From 370 |
| Travatan | Travoprost | From 390 |
| Lumigan | Bimatoprost | From 2500 |
| Trilactan | Latanoprost | From 370 |
| Prolatan | Latanoprost | From 400 |
| Glaumax | Latanoprost | From 360 |
| Lanotan | Latanoprost | From 400 |
| Xalatan | Latanoprost | From 500 |
| Brinzopt | Brinzolamide | From 240 |
| Azopt | Brinzolamide | From 590 |
| Acetazolamide | Acetazolamide | From 190 |
| Diakarb | Acetazolamide | From 200 |
| Fotil | Timolol and pilocarpine | From 130 |
| Pilocarpine | Pilocarpine | From 30 |
| Luxfen | Brimonidine | From 340 |
Azarga eye drops (the price may vary, depending on the location of the pharmacy) are effective only for open-angle glaucoma. For other types of this disease, other drugs are usually used.
Cheaper eye drops Timolol are not prescribed for:
- bronchospasm;
- bronchial asthma;
- tachycardia.
Combined Cosopt is prohibited for patients with:
- a tendency to spontaneous hypoglycemia;
- weak sinus syndrome;
- corneal dystrophy;
- renal failure.
The cheaper Arutimol does not affect the clarity of vision and the pupil in any way.
And from the use of Duotrav, the following side effects may occur:
- swelling of the macular;
- nervous irritability;
- dyspnea;
- hypertension;
- bronchial asthma;
- chromaturia.
Azarga eye drops (their price is not the same in different places of sale) can lead to the appearance of undesirable reactions and effects. Therefore, independent use of the drug, without medical supervision, is strictly prohibited. But even if there are prescriptions for the medicine, one should not neglect to read its instructions for use.
Betaxalol often causes:
- pain and itching in the eyes;
- loss of sensation and fogging;
- change in the size of the pupils;
- fear of sun rays;
- the appearance of spots on the cornea;
- increased tear production;
- dryness of the mucous membrane of the eye.
From the use of Xalacom you may experience:
- corneal calcification;
- swelling;
- asthenia;
- Peyronie's syndrome;
- skin problems;
- diarrhea;
- difficulty breathing;
- arrhythmia;
- eye irritation;
- keratitis;
- anaphylaxis;
- conjunctivitis.
Combigan drops are contraindicated in the presence of:
- asthma;
- cardiogenic shock;
- therapy for depression;
- pulmonary or cardiac pathology;
- bronchial obstruction.
In the treatment of acute glaucoma with Gunforth drops, the following are sometimes observed:
- change in visual acuity;
- swelling;
- blepharitis;
- irritability in the eye area;
- increased body hair growth;
- systematic migraines;
- runny nose.
Betalmik eye drops are prohibited:
- pregnant women;
- breastfeeding;
- having problems with the heart and sinus node;
- suffering from asthma;
- with corneal dystrophy;
- those who have a high sensitivity to the components of the drug.
Contraindications to the instillation of Okumol are:
- sinus bradycardia;
- asthma;
- hypotension;
- atrophic rhinitis;
- thyrotoxicosis;
- newborn age;
- chronic muscle weakness;
- pulmonary or renal pathology;
- diabetes;
- lactation period;
- pregnancy;
- allergy.
If ophthalmological recommendations are not followed from therapy with Okumol, the following may appear:
- corneal opacity;
- increased tearing;
- eye itching and burning;
- split vision;
- drooping of the eyelid;
- keratitis;
- blepharitis;
- change in visual acuity;
- skin hyperemia on the eyelids;
- conjunctivitis.
Proxophelin is suitable for the effective treatment of early acute glaucoma.
The combination of drug components:
- maintains the hydration of the mucous membrane of the eye;
- fights pathogens;
- relieves pressure inside the visual organs.
Proxopheline can lead to:
- thirst;
- constant weakness;
- dizziness;
- slowing down and violation of the pulse;
- hypotension.
The drug Proxofelin is contraindicated:
- in childhood;
- in the 1st trimester of pregnancy and lactation;
- with allergies to medicines;
- with bronchial and pulmonary obstruction;
- with cardiovascular complications.
Pathological reactions arising from the use of Taflotan:
- cough and runny nose;
- headaches;
- photophobia;
- eye infections;
- corneal problems;
- violation of ciliary growth;
- swelling of the eyelids;
- redness of the eyes.
Taflotan should be used with caution in patients with:
- complex asthma;
- ocular amyloidosis;
- congenital and closed glaucoma;
- impaired integrity of the lens;
- missing or artificial lens.
Tableted Acetazolamide is not recommended for use with:
- hypoglycemia and uremia;
- breastfeeding;
- chronic form of closed glaucoma;
- acidosis;
- stones in the bladder;
- cirrhosis;
- kidney problems;
- allergies to sulfonamides.
Adverse reactions after using acetazolamide:
- the appearance of glucose or blood in the urine;
- fear of light;
- polyuria;
- allergy;
- nausea and vomiting;
- stomach bleeding;
- liver problems;
- lack of appetite;
- diarrhea;
- acidosis;
- hypokalemia;
- paresis;
- hearing and vision problems;
- the occurrence of seizures;
- violation of taste;
- drowsiness.
Negative effects of instillation with Fotilum:
- allergy and hypersensitivity to the drug;
- myopia;
- corneal cyst or detachment;
- violation of the color of the lens;
- heart problems;
- asthma attacks;
- lowering blood pressure;
- increased salivation;
- nausea;
- dryness of the mucous membrane of the eye;
- dermatosis;
- migraine;
- burning.
Due to the presence of an extensive list of contraindications and adverse reactions for all Azarga analogues, only the attending ophthalmologist has the right to replace therapeutic drops.
He should do this after a complete examination of the patient and familiarization with his anamnesis. It will not be possible to independently purchase the above antiglaucoma drugs without a medical prescription.
The most effective anti-glaucoma remedy, Azarga, is not entirely safe. The eye drug, along with a decent price, also has a fairly wide list of contraindications. Self-use of drops, without ophthalmic prescriptions, can lead to unpleasant side effects.
Author: tanyda
Video about drops for glaucoma
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