Brinzolamide eye drops. Price, instructions for use, analogues, reviews

Popular eye drops Brinzolamide is actively used to treat patients of different ages. The price of the medication is high, but the effectiveness fully justifies it, therefore, the medication is often prescribed to patients with various disorders of the visual apparatus.

Composition, release form

The medication is available to patients in the form of a topical solution for administration to the conjunctival sac.

The solution is a clear, colorless liquid with no specific aroma. It is packaged in 5 ml bottles. Each polyethylene bottle is in an individual cardboard box; instructions for the correct use of the drug are always attached to it.

The composition of the medication contains the main active ingredient in brinzolamide, which has a therapeutic effect.

The solution also contains auxiliary ingredients:

• Carbomer.
• Benzalkonium chloride.
• Tyloxapol.
• Sodium chloride.
• Edetate disodium.
• Hydrochloric acid.
• Purified water.

Excipients do not have a therapeutic effect, but are present in the composition to maintain the correct chemical formula throughout the shelf life.

Terms of dispensing from pharmacies, drug price

The drug can be purchased at different pharmacies, but upon presentation of a doctor's prescription. The cost of the medication ranges from 600-800 rubles. The price may depend on the region of distribution and the specific pharmacy.

Principle of operation and efficiency

Brinzolamide - eye drops (the price depends on the region of distribution of the drug), which have pronounced medicinal properties. The principle of action of the drug is based on the ability of the active ingredient to influence the production of substances that stimulate the production of intraocular fluid. As a result, its amount decreases, which leads to a decrease in intraocular pressure.

The effect is especially important for patients suffering from pathologies accompanied by an increase in intraocular pressure, for example, glaucoma. The tool also improves the condition of the mucous membrane of the eyes, normalizes the general condition of the visual apparatus, prevents the progression of the disease and the development of severe complications.

It should be noted that after a decrease in intraocular pressure indicators, an improvement in ocular blood circulation occurs. apples, the load on the visual apparatus decreases, the elimination of discomfort associated with the progression is noted diseases.

Additionally, the medication has a mild anti-inflammatory and antiseptic effect, protects the mucous membranes, which has a beneficial effect on the patient's condition.

After application for the purpose of instilling the eyes, a rather rapid absorption of the medicinal solution is observed. A significant amount of it accumulates in the blood, namely in the erythrocytes, due to which it provides the suppression of ingredients that stimulate the production of fluid.

The drug remains in the blood for a long period, binds well to plasma proteins, but its main amount is concentrated in erythrocytes.

Its bioavailability is approximately 60%. Active ingredients can pass into breast milk or cross the placental barrier. In the body, the main substance breaks down into metabolites, which are stored in the body for a long period and have a therapeutic effect.

The processing of active substances is carried out in the liver, therefore, when an organ is damaged, a slowdown in this process is observed. If the disease is severe, there is no decrease in the effectiveness of the agent, since it acts locally.

Despite this, there is a slowdown in the period of kidney-assisted evacuation of components. Normally, the process takes up to 3 days, but with pathologies of the urinary system, the time is extended by 1-2 days, which can provoke complications.

The drug is highly effective, has an advantage over other drugs, which is associated with direct penetration into the systemic circulation and providing a therapeutic effect.

Experts have carried out many studies that have proven the absence of carcinogenic and mutagenic effect with prolonged use of the drug by patients suffering from chronic forms of glaucoma.

It is also considered to be an advantage over other medications. The complex effect of the solution on the visual apparatus allows it to be used as an independent therapy or in combination with other medications to increase their effectiveness.

Indications for use

Brinzolamide is used for patients with various disorders.

Eye drops (the price depends on the manufacturer of the product) are most often prescribed in the presence of the following indications:

• Increased intraocular pressure against the background of pathologies of the nervous system. With damage to the brain or blood vessels, such violations occur quite often. The tool in this case can be used as part of the complex treatment of the underlying disease.
• Diagnosis of retinal opacity against the background of age-related changes or inflammatory pathologies of the eyeball.
• Glaucoma in acute and chronic form with or without severe manifestations. The drug is equally effective at any stage. With severe disorders, longer use is prescribed.
• Open-angle glaucoma in acute and advanced form.

It should be noted that the greatest efficiency is achieved when using the solution at the initial stages of the pathological process. Despite this, the drug can be prescribed for an advanced or chronic form of the disease, but the result from use can be noticed after a while.

Contraindications and side effects

The drug is absorbed in large quantities into the systemic circulation. Therefore, it can provoke complications. It is not prescribed for children and adolescents under 18 years of age, due to the lack of data on the effect of the active ingredient on the child.

There are other contraindications for eye drop therapy:

• Intolerance to the components of the composition or a tendency to allergic manifestations in the patient's history. It is especially important to observe this rule in the case when the patient has had negative reactions to products containing the same active ingredient in the past.
• Lactation and pregnancy period. The instruction indicates that these periods are not considered an absolute contraindication for therapy, but for today there is not enough data on the effect of the active ingredient on the development of the fetus and the body mother.
• Angle-closure glaucoma is considered a reason for refusing to use the medication. This is associated with an increased risk of complications with the use of drops.
• Pigmentary glaucoma, in which there is a discoloration of the cornea and some other disorders.
• Dryness of the cornea against the background of exposure to negative external factors or internal diseases, accompanied by its drying out.
• Corneal damage, the presence of a foreign body in the eye that damages tissue and increases the risk of infection.
• Infectious eye pathologies in the acute stage.
• Herpetic conjunctivitis of a neglected form with severe disorders of the visual apparatus.
• Pseudoexfoliative glaucoma.

With pathologies of the digestive tract of a severe form, the agent is not prescribed. It is not used for blood diseases accompanied by impaired production of red blood cells. Severe renal and hepatic impairment is also considered an obstacle to prescribing medication, which is associated with an increased risk of complications.

Elderly patients who suffer from heart failure, angina pectoris, ischemic heart disease, the drug is prescribed with caution and only after a preliminary examination.

Brinzolamide - eye drops (the price of the product is quite high), which can provoke complications if the rules for their use are violated. But it is worth noting that negative manifestations can occur if all recommendations are followed. In most cases, they are associated with the fact that the patient did not familiarize himself with all the contraindications or did not tell the doctor about them.

Adverse reactions affect internal organs and systems, which is associated with their significant absorption into the systemic circulation during use.

Organs and systems	Common adverse reactions
Nervous system	From the side of the nervous system, complications occur quite often, accompanied by headache and dizziness. In addition, patients may be worried about insomnia, a deterioration in general well-being. There is a decrease in mental performance, as well as impairment of memory and concentration. Patients may notice the development of a depressive state, increased irritability and lack of interest in life.
Respiratory system	When using the drug, complications from the respiratory system are not observed so often. They are accompanied by respiratory failure, shortness of breath on exertion. In advanced cases, patients speak of shortness of breath, up to choking.
Heart and blood vessels	When using drops, a decrease or increase in blood pressure is possible. That depends on the individual characteristics of the patient's body. In addition, patients with chronic pathologies of the cardiovascular system will be able to note tachycardia and arrhythmia.
Digestive tract	On the part of the digestive system, symptoms occur quite rarely, accompanied by pain in the stomach, nausea and impaired appetite. In some cases, the manifestations are aggravated by intense thirst and dryness of the mucous membranes of the mouth.
Musculoskeletal system	Pain in muscles and joints in most cases occurs in patients who suffer from diseases of the musculoskeletal system. After refusal of treatment, the symptoms disappear.
Skin	An allergic reaction to the drug manifests itself quite often, accompanied by a rash on the body, limbs, even the face. Patients report severe itching, burning of the skin and irritation. The condition can be aggravated by the spread of the rash over large areas of the skin.

The severity of negative reactions depends on the patient's body. With prolonged use of the drug in high doses, an overdose may develop. At the same time, a large amount of ingredients accumulates in the blood, which leads to an aggravation of the condition.

In case of an overdose, all negative reactions are acutely expressed, the condition is aggravated by frequent vomiting and stool disorder. In this case, the allergic reaction is also aggravated, the development of rhinitis and conjunctivitis is observed. With repeated vomiting, the risk of dehydration increases, which threatens not only the health, but also the patient's life.

If negative reactions or symptoms of an overdose appear, you should immediately stop using the medication. In many patients, the manifestations disappear within a few days, but special treatment is often required depending on the symptoms.

In case of an overdose, the patient receives help in a hospital setting, and the therapy regimen depends on the manifestations and their severity. The agent does not have a specific antidote, therefore, different drugs are used to eliminate negative reactions.

Instructions for use

Brinzolamide - eye drops (the price of the medication justifies its effectiveness), which are used only as directed by a doctor. The duration of the therapeutic course in each case may differ, but most often 7-14 days are enough to obtain a pronounced therapeutic effect.

When applying, it is important to follow all the rules. No more than 1 drop is injected into each eye, after which the eye is closed and the upper eyelid is carefully massaged with a finger in order to improve the distribution of the components along the cornea. It is recommended to inject the product into the eye at the same time in the morning or in the evening. The standard therapeutic regimen involves instilling the eyes 1 time per day.

The time of day does not matter. If the most pronounced disorders are observed in the morning, the agent is administered at this time. If the patient feels worse in the evening, evening administration is allowed. In advanced cases, the doctor may increase the dosage up to 3 drops per day in each eye. In this case, there should be approximately the same time interval between injections.

When burying, you can be in a horizontal position, but it is also allowed to sit. Throwing my head back. If the patient is not able to independently administer the medicine, it is worth contacting relatives or undergoing treatment in a hospital. It is strictly contraindicated to exceed the daily dosage or prolong the course, even if there is no effect from the use of the solution.

special instructions

When using drops, it is important not to touch the tip of the bottle to the cornea. This can provoke the transfer of microbes from one eye to another, the development of an inflammatory process.

In the first few minutes after instillation, patients may notice the appearance of a veil before their eyes. It usually disappears quickly and does not require special treatment. Do not bury the product if you have contact lenses in your eyes. They must be removed, after which the procedure must be carried out. After that, it is allowed to use the lenses again no earlier than 15 minutes later.

Since the drug is absorbed in large quantities into the systemic circulation, it is not necessary during the treatment period. drive vehicles or perform manipulations that require increased concentration attention.

When used in patients with liver disease, it should be borne in mind that the active ingredient can provoke complications. That is why the decision on the appointment of a solution to such patients is made by the doctor in each case individually.

Interaction with other drugs

Brinzolamide - eye drops (the price is considered one of the disadvantages of the medication), which should not be prescribed in combination with products containing a similar active ingredient. This can provoke complications.

It is not allowed to use the drug in combination with salicylates, which can provoke a violation of the acid-base balance in the body. Significant absorption into the systemic circulation is considered a reason for refusing to combine the drug with some hormonal, antibacterial and non-steroidal anti-inflammatory drugs.

If it is necessary to use other eye drops, it is worth keeping at least 15 minutes between instillations, which will prevent negative reactions. In each case, before using any medication, a doctor's consultation is required, especially in the case when the patient is taking funds on an ongoing basis.

Storage conditions and periods

Store drops in a cool and dry place, away from children and direct sunlight. In this case, it is important not to allow exposure to sunlight directly on the bottle without a cardboard box.

The production date is indicated on the packaging. The use of the medication after the expiration date is not allowed. The solution can be stored for a maximum of 2 years.

Analogs

In the absence of an original medication, it is allowed to use a substitute with similar therapeutic properties.

The most popular analogues:

• Brinzopt - popular eye drops based on brinzolamide as an active ingredient. The remedy is prescribed when the intraocular pressure increases as a result of various factors, it is considered very effective and helps prevent the progression of the condition. The drug is used for the treatment of adults, the course of treatment lasts up to 2 weeks.
• Trusopt - means in the form of eye drops based on dorzolamide. The ingredient has similar therapeutic properties, helps to reduce intraocular pressure and improves the condition of the visual apparatus. The course of treatment lasts up to 2 weeks, the daily dosage is determined depending on the degree of neglect of the condition.
• Azopt - a product based on brinzolamide, which has pronounced therapeutic properties. Helps to cope with acute manifestations of open-angle glaucoma. Prevents its progression and development of complications. It is prescribed in short and long courses, depending on the patient's condition.

Any of the analogues is highly effective, but the use is allowed only after examination by a specialist.

The effective and popular Brinzolamide eye drops, which have pronounced therapeutic properties, can eliminate acute manifestations of glaucoma of varying severity. The price of the drug is high, but its effectiveness and speed justifies it. Application is permitted only as directed by a physician.

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