Zinc pyrithion (Zinci Pyrithionum) cream. Price, instructions, where to buy, analogs, reviews

On the territory of Russia, only 2 creams containing zinc pyrithione are allowed to be produced. The substance is an active component in the composition of funds that are developed for the treatment and prevention of dermatological diseases.

Pharmacology includes effective use in gram-positive and gram-negative bacteria. Prices for creams containing this active substance in the composition vary from 335 to 3900 rubles. per packing.

Release form, where to buy and price

Zinc pyrithione (ZPT) is an active material that has been used for over 50 years to effectively treat dandruff and seborrheic dermatitis (D / SD). The active substance has become the most common for this purpose.

Its use has also expanded for other skin benefits such as hygiene and dermatological reactions. The active supplement was developed under unnatural conditions. The resulting molecule, which was modeled after the naturally occurring antimicrobial aspergillic acid, caused many negative side effects.

The effectiveness of ZPT comes from two attributes:

• First, it has a very broad antimicrobial spectrum of action, including fungi, gram-positive and negative bacteria.
• Second, the material has very low solubility, resulting in particulate formulation and delivery of the material, which has clear operational advantages.
• Particles are deposited and retained on targeted skin surfaces even when supplied from rinsing products. These particles slowly release the molecular active material to interact with surface fungal and bacterial cells, to control their reproduction by functioning as slow release reservoirs to provide long lasting and permanent advantages.
• This dispersed nature, however, leads to sophisticated pharmaceuticals to realize the full benefits of efficacy; There are often products with the same ZPT level that have different levels of clinical efficacy.

Several factors, determined by the product matrix, directly affect the final benefits:

• The molecules must be retained on the surface of the skin, achieving a uniform spatial distribution in the lateral direction, as well as in the hair follicles (especially on the scalp).
• Zinc pyrithione must be maintained as a physically stable dispersion in the product.
• It must exist in a chemically active form, as many chemical reactions can occur that can harm the biological activity of the ZPT.
• The benefits achieved with ZPT require significant pharmaceutical expertise to fully realize the benefits of this active material.

In this regard, zinc pyrithione should be produced in the form of a suspension to 1% solvent, which would contain the active substance. This applies to liquid and gel bases such as shampoos. Creams may contain powders and solid particles that contain zinc pyrithione.

The following types of creams are presented on the pharmacological market, which contain zinc pyrithione:

• The Hemigroup brand produces Skin-Cap cream. The cream is intended for external use, which contains 0.2% of the active substance. The plastic tube has 15 or 50 g. The cardboard box has the serial number No. 12231/02.
• The same Skin-cap cream can be produced in the form of a sachet, the weight of which is 5 g. The product is sealed in laminated foil.
• Pharmstandard has introduced a cream called Tsinocap on the market. The cream also has 0.2% active ingredient, and the shelf life is unlimited. The serial number of the registered component with WHO is LSR-010496/08. The cream is supplied in tubes of 25 and 50 g.

  

Alcohol-containing drinks or food, caffeine and broad-spectrum drugs should not be taken together with zinc pyrithione. They can reduce the effect of zinc pyrithione in the treatment of disease.

Zinc pyrithione (a cream, the price of which varies from 350 to 4000 rubles, can be purchased without a prescription) is part of 2 main creams that are allowed for sale in the Russian Federation.

In the EU and the USA, such formulations are prohibited in production, and zinc pyrithione is used only for the manufacture of drugs dispensed with the permission of a higher authority to hospitals and hospitals for the treatment of dermatovenerological diseases.

Compound

If we consider the composition of 2 different creams, it is worth noting that the composition contains identical active substances:

Skin-cap cream	Zinocap cream
Molecules for 0.2% zinc pyrithione cream are contained in the amount of 3 parts per 100 g of product.	Zinc pyrithione also constitutes 2 g of the active substance that is part of the cream.
The composition includes active additives in the form of isopropyl myristate. The substance is used in cosmetics and medicinal products to solve dermatological problems and improve skin absorption. Isopropyl myristate has been used as a skin permeation enhancer. Currently, the main use for which isopropyl myristate is formally indicated is as an active ingredient in an OTC pediculicidal rinse.	Macrogol cytostearate is intended for the treatment of seborrheic formations and dermatological diseases.
Polysorbate is a substance formulated by reacting a sorbitol fatty acid ester (nonionic surfactant) with ethylene oxide.	Cetostearyl alcohol is a chemical found in cosmetic products. It is a white waxy compound made from cetyl, stearyl and fatty alcohols. They are used in personal care products, mainly in skin lotions, hair products, and creams. The ingredients help create smoother textures, thicker lotions and more resistant foam products.
Polysorbate 80 is a hydrophilic nonionic surfactant. It is used as a surfactant in soaps and cosmetics, and as a lubricant for eye drops. In food or pharmaceutical products, it can act as an emulsifier. Polysorbate 80 is an excipient that is used to stabilize aqueous formulations of drugs for parenteral administration or vaccination.	Propylene glycol is used to preserve texture, which is more than 60% of liquid products. In cosmetics and beauty products, it allows you to retain moisture inside all components, preventing them from freezing or leaking at temperature differences.
Tegin M, Tegosoft EE, Tegosoft R, Tego Car 450 and the like are designed to eliminate rashes in case of seborrheic herpesvirus infection. Substances block symptoms, but do not eliminate them in the form of medicinal components.	D-panthenol or dexapanthenol is used as an emollient, soothing, and anti-inflammatory agent. It helps to create a barrier in the skin against irritation and water loss.

In the composition of Zinocap, you can also find such components as sodium dihydrogen phosphate dihydrate, sodium hydrogen phosphate dodecahydrate and purified water. These substances help to cleanse the scalp after using medicated creams. It is worth noting that the effectiveness of zinc pyrithione is significantly reduced in combination with these components, although the cost of Zinocap cream is much higher.

Indications for use

Zinc pyrithione (cream, the price of which may depend on the composition, volume and form of release, should contain 1-3% of the active substance, which are used in analogues in a concentration of up to 0.5%) is part of dermatological creams created for the treatment of external diseases.

As an independent ingredient, zinc pyrithione is used in the following spectra of action:

• anti-inflammatory and antibacterial effects;
• antifungal action;
• decrease in intracellular ATP levels;
• the ability to depolarize cell membranes;
• destruction of fungi and bacteria;
• reducing dandruff levels;
• reduction of symptoms of seboric dermatitis;
• psoriasis treatment;
• impact on the signs and symptoms of skin diseases.

As part of creams, zinc pyrithione is intended for the following functions:

• absorption of systemic skin rashes;
• fight against psoriasis;
• reduction of symptoms of atopic dermatitis with eczema and neurodermatitis;
• neutralization of itching with dry skin.

Creams help to reduce all inflammatory processes that occur with relapse and active disease. Pharmacological actions and pharmacodynamics of some signs of action of substances have not been studied. Also, zinc pyrithione in the composition of the cream can be used to treat pediatric dermatitis at the age of a child from 1 year old.

Contraindications

Creams with an active substance in the form of zinc pyrithione are not recommended for use on the skin by those who have individual intolerance to the components.

General rules of use:

• The composition should be applied to the skin in a thin layer.
• Scope - external, on the affected skin.
• The cream can be used 2-3 times a day.
• The course of treatment is 1-1.5 months. If there are repeated signs of skin lesions, the cream should be used within 3-4 weeks until the symptoms disappear. This applies to seborrheic dermatitis when the re-use period is 2 weeks.
• At the first signs of exacerbation in atopic dermatitis, the course period is 4-5 weeks.

It is not recommended to apply the cream to children if the child has an allergic reaction in the form of a rash and itching.

Side effects

Zinc pyrithione in creams, as a potent substance, can cause side effects. They are equated to the symptoms of the disease, therefore they do not require separate treatment. In case of a short-term manifestation, the course of treatment should not be discontinued. The price of the cream does not affect the effectiveness of the treatment, so you should not buy analogues.

Among the side reactions:

• itching and irritation;
• redness of the skin;
• short-term burning sensation;
• small red eruptions.

If the side effects persist within 24 hours, you need to stop using the drug or replace it with another one that does not contain the active substance in the form of zinc pyrithione.

Instructions for use

Creams based on zinc pyrithione should be used according to the instructions or as prescribed by a dermatologist in a whole course:

• The cream supplied in a tube must be opened, a small amount of the substance should be applied in a thin layer to the affected area of ​​the skin.
• It is important to respect the distance between the areas of application - it should be 10-15 cm.
• With psoriasis, the doctor may prescribe a course of admission in the form of 2 times a day in the morning and in the evening for 4-7 weeks.
• With atopic dermatitis, a dermatologist prescribes a course of treatment in the form of applying a cream 2-3 times a day for 1 month.
• Taking a break is not recommended for recurring symptoms. A dermatologist prescribes a course of treatment for a repeated clinical picture in the form of 2-4 times a day for 2 weeks.

For children, a second course of treatment can be prescribed only by a specialist in this field. Repeated application of the cream cannot be as long. 2 or 3 times, the cream should be used in a course within 1-1.5 months.

special instructions

Zinocap and Skin-cap creams can be used during pregnancy and lactation, but no longer than within 3-4 weeks even with a second course.

Children under 12 months should not be applied such formulations, therefore it is better to use more gentle components. or those in which the active substance will be another, similar in formula and action substance.

Zinc pyrithione (cream, the price of which should not exceed 4000 rubles. for 50 g in the form of a plastic tube, can be used repeatedly throughout the shelf life) the composition of creams does not cause side effects in case of an overdose, as well as an improvement in the condition during treatment.

It is not necessary to use the composition more times than the doctor prescribed.

To increase the effect and improve the general condition, it makes no sense to use such drugs. They do not improve the condition of the skin, do not contribute to a faster recovery.

Precautionary measures

If the composition of the creams must be applied to a child over one year old on the area covered hair follicles, it is worth considering the possible consequences:

• After applying the composition, the cream may cause slight itching for the first 1-2 hours.
• The child should not touch the head, try to comb the treated areas.
• It is advisable not to wash off the cream until it is completely absorbed, not to wash your hair with fluoride cosmetic products.
• To make it easier for the child to endure the first symptoms after applying the cream, it is better to carry out the skin treatment procedure on dirty hair.

To remove excess cream and dandruff, you need to use environmentally friendly shampoos. It is recommended to rinse the baby's head many times so that traces of cleaning and washing cosmetics do not remain on the head and hair.

Efficiency

Clinical studies confirm the effectiveness of the drug when used appropriately - daily for 3-7 weeks. After this, there is an improvement in symptoms.

Storage conditions and periods

After opening, the vial of the tube must be stored at a temperature of 4 to 25 degrees. Zinocap cream has an unlimited shelf life only after opening. In a sealed container, the cream is good for 2 g. The skin cap has a shelf life of 2 g. in the form of a cream, and in the form of a sachet - 12 months.

Analogs

Zinc pyrithione (cream, the price of which may depend on the manufacturer and the composition of similar products, is also produced by other companies, where other active ingredients may be contained) can also be included in similar creams, but not as an active component.

Below are analogs that are designed to solve the same dermatological diseases, but with different ingredients in the list active substances:

• Belosalik cream - comes in the form of a cream and ointment. Manufacturer - Croatia, Belupo brand. The tube has a volume of 15 and 35 g. The active ingredient is betamethasan and salicylic acid. The cost of the bottle is 180-190 rubles.
• Powercourt 0.05%. The cream is designed to treat dermatitis of various origins. Manufacturer - Iceland, Glenmark brand. The composition contains the active substance clobetasol. The bottle has a volume of 15 ml, and the price is 300 rubles. and higher.
• Xamiol for external use from the brand Leo Pharma from Ireland supplies gel creams for the treatment of atopic dermatitis. The composition contains an active ingredient in the form of a combination of betamethasone and calcipotriol. The cost of the cream is 2335 rubles. for 60 g.
• Akriderm cream is a hormonal agent that acts on any form of dermatological damage. The composition contains zinc oxide and salicylic acid. A bottle of 15 g can be bought for 480 rubles.
• Beloderm domestic production can be purchased for 115 rubles. The composition contains active substances based on iron and zinc, so it should be used with extreme caution for children. The cream has a volume of 50 g, and is sold only with a doctor's prescription.
• Fucinar is a gel-cream based on hormonal components - fluocinolone acetonide, which is duplicated in Sinaflan. The composition is designed to combat various skin pathologies of atypical origin. The bottle is designed for 35 ml / g, and its cost reaches 1050 rubles.
• Momat is considered an available imported analogue that contains synthetic glucocorticosteroid components. The active ingredient is mometasone furoate. The cream is intended for the treatment of atopic and seborrheic dermatitis and psoriasis, which are amenable to hormone therapy. The bottle has a volume of 15 and 60 g, and its price is 1000 rubles. and higher.
• Locoid available in the form of a cream and ointment. The drug is a synthetic analogue, which is included in the group of glucocorticosteroids. The active substance is based on hydrocortisone, a hormone that is produced in the human body. Therefore, the use of such an analogue is available after passing tests for adrenal hormones. The cream can be used in the acute and subacute phase of dermatitis, psoriasis and skin pathologies from 6 months.
• Tsindol is a prototype that contains zinc oxide. The preparation in the form of a cream has a drying and antimicrobial effect. With dermatitis, ulcers and diaper rash of the skin, you need to apply the cream several times a day, in a course prescribed by your doctor. A cosmetic product can be purchased for 48 rubles, but in Russia the drug is found in the form of suspensions and solutions.
• Desitin is also considered an analogue preparation that contains zinc oxide. The product is designed for the treatment of erythematous diaper rash, superficial trauma and contact dermatitis. The bottle can be bought for 110 rubles. for 35 g of volume.
• Psoricap is considered a "twin" of the above creams, which contains 2 g of zinc pyrithione in the form of an active substance. Cream of 2% concentration is used for the treatment of dermatitis, psoriasis and other specified skin diseases. The tube has a volume of 30 g, and the price of the cream is 190 rubles.

The analog component in the composition of Psoricap can be contained in the cream together with other active additives that are contraindicated in children under 1 year old. To choose the course of treatment and the dosage of the drug, you cannot do without consulting a doctor.

You can buy an analogue at a pharmacy only with a prescription form. For the treatment of atypical forms of dermatitis, it is necessary to use auxiliary drugs or ointments that will enhance the action and effectiveness of zinc pyrithione.

In Russia, on the free market, you can find analogues that do not contain active substances based on zinc pyrithione. Imported creams at a higher price may be introduced. To find the most suitable composition, it is important to take into account the characteristics of the diseases and the individual intolerance of the components.

The price of creams may differ not only because of the composition, form of release and volume. Ancillary additives also contribute to value formation.

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