Lidocaine patch. Price, instructions for use for joints, back, analogs, where to buy, reviews

To relieve pain, protect open wounds, scratches and cracks in the skin from the external environment, use lidocaine patch. It is a transdermal system for external use with local anesthetic and anti-inflammatory properties. The price of foreign drugs is quite high for a medicine.

Composition of lidocaine patches

In addition to the main active ingredient, such pain relievers contain a number of excipients that do not have significant pharmacological value, but increase the effectiveness of the drug and ensure its reliable attachment to the surface the skin.

The composition of the patch depends on its type and manufacturer. The list of such drugs is small. They differ only in auxiliary components and physical dimensions.

Additional substances of sterile dressings:

Name	Supporting components
Versatis	Glycerol, sodium polyacrylate, carbamide, polyvinyl alcohol, aluminum glycinate, sodium carmellose, gelatin
Emla	Sodium hydroxide, nitroglycerin
ParaPran	Paraffin

A plaster with lidocaine, the price of which depends on the component composition and the name of the manufacturer, necessarily contains an adhesive (sticky) substance on the inner surface.

It allows you to reliably fix the atraumatic dressing on the damaged area of ​​the epidermis. The basis of such a tool is a non-woven material of increased strength with resistance to abrasion.

The patches contain 5% lidocaine. The excipients of sterile dressings do not have pronounced pharmacological properties, but they perform important functions in the transdermal system.

Glycerol in Versatis dries the skin, absorbs pathological exudate, and has a moderate anti-inflammatory effect. Paraffin softens the skin, and carbamide cleans the wound from necrotic masses and accelerates healing.

Pharmacological properties

The local anesthetic effect of pain-relieving applicators is due to the ability of lidocaine to stabilize the membranes of epidermal cells. The main active component of the drug blocks the transmission of nerve impulses through sodium channels.

It expands the subcutaneous capillaries, stabilizing the pressure in them and improving blood microcirculation. The anesthetic effect is influenced by the ability of lidocaine to increase the parameters of the permeability of cell membranes for potassium ions.

The auxiliary components of the transdermal system simultaneously cleanse the wound, reduce pathological exudation, and relieve inflammation of the skin tissues. Plasters with lidocaine relieve the pain syndrome of traumatic etiology for a long time.

They also suppress dermatological irritations, relieve neurological pain and alleviate the manifestations of myalgia. An important pharmacological property of anesthetic applicators is to ensure the sterility of the wound surface.

This prevents the contact of the damaged area with the external environment, pollution, thermal irritation, bacterial-fungal and viral infection. Such funds not only block the current pain syndrome, but also prevent the emergence of new ones.

Pharmacodynamics and pharmacokinetics

Lidocaine belongs to the category of fast acting local anesthetics. It is an acetanilide derivative. When applied externally on an undamaged area of ​​the skin, it has an analgesic effect without a noticeable systemic effect on the body.

Lidocaine inhibits the synthesis of neurotransmitters and slows down the passage of nerve impulses through the sodium channels of synapses. No more than 3% of the substance penetrates into the systemic circulation. This amount is not enough for the overall effect.

Lidocaine is adsorbed and metabolized in liver tissues. Achieving a plasma concentration of 0.13 μg / ml is possible only with the simultaneous application of 3 atraumatic dressings for 12 hours.

Lidocaine binds to epidermal proteins and protein fragments of the blood of subcutaneous capillaries by 50-80%. The pharmacologically active local anesthetic substance is rapidly distributed in the tissues of the overlapping zone. The phase of therapeutic action occurs in 6-9 minutes. after transdermal application.

A plaster with lidocaine (the price of domestic ParaPran is acceptable, therefore many patients prefer it over expensive foreign counterparts) is first absorbed into tissues well supplied with blood, then into adipose tissue and deep-lying muscle fibers.

The ability of a local anesthetic to overcome the blood-brain and placental barriers has been established. In breast milk, it is recorded at a concentration of approximately 40% of the plasma content.

Hepatic metabolism is 90-95%. This process takes place under the influence of microsomal oxidation enzymes - a set of biochemical reactions in the 1st phase of transformation and decay of xenobiotic (foreign) agents and endogenous substances.

The latter should include lidocaine and auxiliary components of the transdermal application. As a result of catalysis by enzymatic systems of the membranes of the endoplasmic reticulum of hepatocytic cells with the participation of cytochrome P450, physiologically active metabolites are formed.

Elimination of lidocaine that has penetrated into the central circulation by 5-10% is carried out unchanged through the urinary ducts and choleretic canals. The volume of distribution is not associated with age and physiological state of the body.

Indications for use

Pain-relieving applicators with lidocaine have a wide range of anesthetic and anti-inflammatory effects. They are used for peripheral neuralgia, traumatic, burns and chemical damage to the skin.

Such funds are able to stop pain after minor surgical intervention - removal of warts, all kinds of growths.

The main indications for use include:

• tunnel syndrome, a neuropathic disorder that causes prolonged aching wrist pain and numbness fingers due to compression of the median conduction channel between bone fibers, transverse ligament and muscle tendons;

  

• convulsive seizures in the limbs and back;
• spasmodic conditions of various etiologies;
• peripheral polyneuralgia - multiple lesions of nerve endings, leading to sluggish paresis and limited tactile perception;

Transdermal applicators with lidocaine have proven effective in treating hyperpathy, a sensory disorder with distortion and radiating pain. Such patches are used to eliminate dysestnia, a pathological condition associated with the destruction of nerve fibers, accompanied by itching and burning sensations.

A typical indication for the use of applicators with lidocaine is considered to be a state of hyperestias - an increase in the threshold sensitivity, which leads to a strong increase in the susceptibility of organs and skin tissues to the effects of conventional external irritants.

Such patches are prescribed for inflammatory joint pathologies and back pain. With the help of anesthetic applicators, they suppress the symptoms of polyarthritis, osteochondrosis and spondylosis.

They are prescribed for myositis of any genesis - muscle disorders that are often found in clinical practice, which occur due to pathological accumulation of lactic acid in muscle fibers due to constant strong overvoltage.

The lidocaine patch can be used for herpes infection of nerve tissues, which is accompanied by itching pain. The high price of imported drugs is offset by their anesthetic efficiency. Atraumatic dressings are used in long-term complex treatment of such viral diseases.

The applicator is installed in the area with the most pronounced painful sensations. Such transdermal systems are widely used in vertebro-neurological practice, in pathological conditions, associated with pinching of the radicular elements of the spinal column and with functional disorders of the spinal brain.

These include:

• osteochondrosis - a degenerative-dystrophic multifactorial disorder of the musculoskeletal system;
• herniated disc - protrusion of the nucleus due to damage to the annulus fibrosus;
• protrusive disorders;
• compression of the radicular elements by a tumor neoplasm.

Plasters with lidocaine are prescribed for myositis, an inflammatory process in striated muscles that develops due to bacterial-viral infection or severe hypothermia.

With the help of such funds, pain syndrome is stopped in case of rheumatoid arthritis of the knee joints, which occurs due to erosive-destructive lesions of the connective tissue. This is a severe autoimmune pathology for which no radical treatment has been developed.

The lidocaine applicator is used to suppress painful symptoms and in the maintenance therapy of this osteoarticular disease. Anesthetics are used for inflammation of the sciatic and trigeminal nerves.

They are indicated after cosmetic procedures associated with prolonged and disturbing painful sensations:

• epilation;
• surgical skin tightening;
• rhinoplasty.

Some lidocaine dressings are intended for attachment to open wounds, ulcerative destruction of the epidermis, burn lesions of the epidermal cover. Such pain relievers have no therapeutic value, but they are used to suppress symptoms in dermatological pathologies.

Contraindications

Lidocaine patches are not prescribed in case of established hypersensitivity to excipients of the drug composition and allergy to a substituted amide derivative of acetanilide.

Some applicators cannot be used if the integrity of the skin in the area of ​​application is violated, others, on the contrary, are intended for this. Due to the ability of lidocaine to penetrate the systemic circulation, it is contraindicated to use the patch for heart block and congenital organ dysfunctions.

Do not prescribe such drugs for cardiogenic shock - an extreme degree of left ventricular failure, coupled with a sharp suppression of myocardial contractility, a decrease in shock and minute emissions.

Do not use lidocaine applicators for myasthenia gravis, a neuromuscular disease characterized by suppressed tone of the adductor fibers and pathologically rapid fatigue of the striated muscles.

It is recommended to refrain from using the product during the period of bearing a child and while breastfeeding. The main pharmacologically active component is able to penetrate the placental barrier, having a negative effect on intrauterine development and causing allergic reactions in the newborn.

The lidocaine patch, the price of which depends on the brand and country of manufacture, is not recommended for patients over 60 years of age. This is due to the stress on the cardiovascular system that the local anesthetic creates when it enters the central circulation.

At what age can the patch be used?

The effect on the body of children and adolescents of the pharmacologically active components of the chemical formula of the pain reliever has not been carried out. The use of lidocaine applicators is not recommended for persons under the age of majority.

Instructions for use

The application does not have a prolonged effect. The pain syndrome is stopped only during the period when the patch is on the surface of the body.

Rules for using the anesthetic applicator:

• The adhesive bandage can be applied for up to 10 hours.
• Avoid getting moisture on the surface of the product. Replace it if it gets wet.
• If the lidocaine applicator is intended to be applied to an intact skin area, care should be taken to ensure that so that in the installation area there are no open wounds, ulcers, cracks, abrasions, scratches and other violations of the integrity of the surface layer epidermis.
• There should be no hairs in the place of application. They must first be removed without using a razor - with nail scissors or a hair clipper.
• After removing the patch, it is undesirable to touch the adhesive layer of the medical device. In case of accidental contact, you should immediately wash your hands thoroughly with warm water and toilet soap. Before that, you can not touch the mucous membrane of the nose, mouth and eyes.
• After removing the lidocaine patch, it is recommended to apply the next one no earlier than 12 hours later.

Do not take a bath or shower, or visit the pool or bathhouse with the pain reliever applicator on the body. Exposure to high humidity will cause the product to peel off and lose its anesthetic properties.

Do not apply more than 3 plasters for 12 hours. Some applicators provide a 3 hour interval. between installations. It depends on the brand and composition of the drug.

There are adhesive dressings with anesthetic properties designed to be applied to mucous membranes. They are used in gynecological and dental practices.

Side effects

When using lidocaine-based anesthetic applicators in recommended doses and in compliance with safety rules, negative consequences are not recorded.

Local anaphylactic reactions to acetanilide derivatives occur in 16% of patients.

They are expressed in:

• hyperemia;
• itching;
• small rash on the skin;
• allergic contact dermatitis.

Such side effects usually disappear on their own and do not require termination of applications or symptomatic treatment. Due to the penetration of lidocaine into the central circulation in small volumes, systemic negative reactions are unlikely.

special instructions

The plaster with lidocaine (the price of imported medical products is much higher than the domestic analogue) is intended for single use. Do not reapply.

The analgesic product contains biologically active substances. Therefore, it must be disposed of in accordance with the established rules immediately after removal from the skin surface. The patch must be folded in half with an adhesive layer inside. Make sure that the discarded product is out of the reach of children and pets.

Caution should be exercised when using the pain reliever applicator to patients with infectious infections and traumatic skin lesions at the site of application. A preliminary consultation with a doctor is necessary in case of exacerbation of chronic dermatological diseases and with a weakened state of the body.

Drug interactions

Due to the ability of lidocaine to cross the blood-brain barrier it is undesirable to use an anesthetic adhesive bandage during the course of treatment with class I antiarrhythmic drugs.

The transdermal application system does not enter into a biochemical relationship with the pharmacologically active components of oral medications. It should not be combined with other local anesthetics such as gels or ointments.

Theoretically, there is a possibility of developing side symptoms when combining some lidocaine transdermal patches with drugs to increase the tone of the vagus nerve, ultra-short-acting anesthetics, curariform substances and polymyxin antibiotics.

Terms, conditions of sale and storage

Anesthetic applicators can be purchased at any pharmacy. No prescription is required to purchase them. Manufacturers set different expiration dates for such products. They are usually 36 months.

The opened patch must be used within 14 days. After this period of time, the product loses its pharmacological properties. The recommended storage temperature is not higher than + 25 ° С.

Band-aids trade marks, their cost, comparison

The most famous lidocaine applicators are Versatis. These are effective anesthetic drugs produced in Germany and Japan. In pharmacies in Moscow and St. Petersburg, a pack of 5 such plasters will cost 480-560 rubles.

The Emla pain-relieving applicator, produced by the Swedish pharmaceutical concern Recipharm Karlskoga AB, is popular. In addition to lidocaine, the drug contains another acetanilide derivative - prilocaine. Such an applicator costs about 615 rubles. a package of 2 plasters.

The available Russian analogue is ParaPran, based on lidocaine and containing medical paraffin as an auxiliary component. It's not really a patch as it doesn't have a sticky layer. For installation, a gauze or bandage is required. The average price of such an anesthetic is 50 rubles. for 1 pc.

Patch video

About the plaster Versatis with lidocaine: