Bactroban (Bactroban) nasal ointment. Price, instructions for use, analogs, where to buy, reviews

Otolaryngological medicine Bactroban is a nasal broad-spectrum antimicrobial ointment. The price of an English-made drug is high, but it is offset by its exceptional pharmacological characteristics, clinical efficacy and safety of use.

Forms of release and composition of the drug

Bactroban is a white gel-like substance with a slight medicinal odor. It is delivered to pharmacies in aluminum tubes with a plastic tip for easy insertion and a plastic screw cap.

Secondary packaging is made of laminated lightweight cardboard with a clear and easily readable print. Each aluminum tube contains 3 g of nasal medication. The drug is manufactured by the pharmaceutical concern SmithKline Beecham PLC (Great Britain).

Another dosage form is an external ointment for suppressing skin infections and treating dermatological diseases provoked by them. Such a preparation is packaged in hermetically sealed aluminum tubes with a volume of 15 g. A special opening tool is included in the scope of delivery.

Bactroban is a nasal ointment, the price of which is much higher than domestic medicines of a similar purpose. The main pharmacologically active component of the English drug is calcium mupirocin.

It is a chemical compound with pronounced antimicrobial and bacteriostatic properties. It is obtained by laboratory action on organic enzymes secreted by gram-positive microorganisms of the genus of fluorescent Trichomonas.

As a result, the waste products of rod-shaped bacteria are transformed into hydroxyphenylacetic acid that inhibits methicillin-resistant pathogenic antibiotics resistant to beta-lactam antibiotics agents. The auxiliary components of the nasal ointment are purified paraffin, macrogol and softizan.

Pharmacological properties

Bactroban is a bacteriostatic and antimicrobial antibiotic. In small concentrations, when applied externally, it temporarily inhibits the ability of cellular pathogens to multiply. Has no cross-resistance with other antimicrobial drugs.

In high doses, Bactroban causes the death of the entire population of the pathogenic flora. The active component of the drug mupirocin calcium blocks protein synthesis in microbial cells and inhibits the production of the enzyme isoleucyl-transfer-RNA-synthetase, which plays a key role in life microorganisms.

Special pharmacological properties, specific mechanism of action and unique molecular structure make it effective against a wide range of pathogenic bacteria.

Range of antimicrobial activity of nasal ointment:

Genotype of a pathogenic strain	Description and characteristics
Citrobacter	Gram-negative rod-shaped anaerobic optional class. As a carbon source, it uses cleavable citric acid salts. Causes otitis media, inflammation of the respiratory tract, anemia of the mucous membranes.
Pasterella	Coccobacillus, sensitive to antibiotics of the penicillin series. The causative agent of some common diseases of the respiratory system. Releases toxic substances and endotoxins. It provokes purulent processes, swelling of the tissues of the nasal sinuses, capillary thrombosis.
Haemophilus influenzae	A gram-negative bacterium that affects the respiratory system and the central nervous system. A common cause of the formation of purulent foci. It is localized in the upper respiratory tract, from where it can spread throughout the body.
Meningococcus	Gram-negative pathogen of the diplococcus category. It affects the mucous membrane of the nasopharyngeal cavity, causing pharyngitis. It spreads by airborne droplets and attacks the epithelial tissues of the cerebral zone.
Gonococcus	Severe anthroposic infection of the genitourinary system. It is often part of the mixed pathogenic microflora of the mucous membranes of various organs.
Branhamella	Gram-negative parasite of epithelial tissues. Causes otitis media, sinusitis, acute respiratory diseases.
Proteus mirabilis	A representative of the natural microflora of the human body, which, under favorable conditions, actively multiplies and acquires pathogenic properties. Belongs to the category of enterobacteriaceae. Provokes a disorder of the functions of the gastrointestinal tract and urinary system. Participates in the development of cystitis, pyelonephritis, urethritis. It provokes the pathology of the ENT organs - frontal sinusitis and purulent sinusitis.
Bordatella	A typical causative agent of whooping cough, classified as immobile non-spore-forming gram-negative anaerobes. Attacks the epithelium of the bronchi, causing an inflammatory and purulent process.
Staphylococcus aureus	Globular bacteria of the gram-positive class. It provokes numerous pathological processes, can cause pneumonia, sepsis, a state of infectious-toxic shock. Some strains are resistant to methicillin antibiotics but susceptible to mupirocin calcium.

Bactroban is a nasal ointment (the price of the drug is justified by a wide range of antimicrobial effects), which is effective against all strains producing beta-lactamases - special enzymes designed to combat antibiotic substances.

Only some types of enterobacteria are insensitive to mupirocin - Salmonella, Escherichia coli and Plague bacillus.

Resistance to Bactroban are possessed by:

• micrococci;
• non-fermenting gram-negative pathogens;
• corynebacteria;
• escheheria;
• klebsiella;
• morganella and other enterrobacteria, for the suppression of which the drug is not intended.

Pseudomonas aeruginosa is resistant to mupirocin calcium. With the correct use of the drug, resistance is not developed in sensitive strains.

Pharmacodynamics and pharmacokinetics

As a result of suppression of protein synthesis in bacterial cells by temporary binding of the isoleucyl-synthetase RNA enzyme, a break in the nucleotide chain is observed, which ensures the multiplication and vital activity of the microorganism.

The drug has a moderate anti-inflammatory effect. Bactroban in the form of an intranasal ointment is slightly absorbed into the systemic circulation and does not have a noticeable generalized effect.

No more than 1% of the applied dose is fixed in the urinary sediment. The active substance of the drug is metabolized in the kidneys and excreted in the process of deurination, without showing pharmacological activity.

Indications for use

Bactroban is used to inhibit mupirocin-sensitive pathogens.

It is used to treat acute and chronic rhinitis, including the following forms:

• catarrhal, accompanied by diffuse edema of the mucous membrane, rhinorrhea, oppression of the olfactory function;
• hypertrophic - inflammation of the nasal sinuses, characterized by the proliferation of the lining epithelial covering and involvement of the bone frame in the pathological process;
• atrophic - a degenerative condition of the mucous membrane with blood vessels and nerve endings located in it;
• vasomotor, caused by a decrease in capillary tone due to exposure to allergic irritants or bacterial agents and manifested by constant nasal congestion, abundant secretion of mucous secret;
• ozenic - a rare type of rhinitis with unexplained etiological factors, which more often affects women and children than men;

Bactroban is used to treat various forms of sinusitis. The ointment demonstrates good effectiveness in sinusitis - acute or chronic inflammation of the epithelial layer of the maxillary sinuses.

Otolaryngologists use a medicine to suppress the symptoms of frontal sinusitis, an infectious disease of the frontal region of the olfactory organ. The drug eliminates pathogenic microflora localized in the area of ​​the ethmoid labyrinth of the sinuses and causing ethmoiditis.

Bactroban is prescribed for sphenoiditis, an inflammatory process of the wedge-shaped segment of the olfactory organ. Nasal ointment is equally effective for unilateral and bilateral diseases. The price of a medicine can hardly be called democratic, but this is due to the country of manufacture and the pharmacological properties of the medicine.

Contraindications

Bactroban is not prescribed to patients with hypersensitivity to the constituents of the chemical formula of the drug. Mupirocin calcium can provoke allergic reactions in people with a congenital predisposition to them.

Preparations in the form of intranasal ointments and external agents have a different list of absolute contraindications and temporary situational restrictions. Medicines containing macrogol should not be used on large areas of the skin surface in patients with renal insufficiency.

Polyethylene glycol and its derivatives cross the transdermal barrier in a small but sufficient amount to hinder metabolization and elimination.

During the lactation period, the ointment should not be used to prevent and treat bacterial infection of nipple cracks. Due to the systemic absorption of polyethylene glycol, special care should be taken in elderly patients.

At what age can the drug be used?

Bactroban in the form of a nasal ointment is indicated for the treatment of children over 12 years of age. Dermatological medicine for external use can be used in moderation from the 1st year.

Instructions for use, dosage

Intranasal medicine is placed in both nostrils 2-3 times a day. After laying the ointment in order to ensure uniform distribution and maximum absorption in mucous membranes need to close the nasal passages with a finger and massage the side surfaces a little olfactory organ.

The average course of therapy is 5-7 days. Bactroban for external use should be applied to a previously cleaned and fat-free area of ​​the skin with a thin layer.

The procedure is performed 2-3 times a day. A bandage can be applied over the ointment. The duration of treatment is determined by the dermatologist individually and is usually 7-10 days.

Side effects

The drug is well tolerated by most patients. Possible side effects are associated with individual intolerance to the components of the drug.

In rare cases, the following negative reactions are observed:

• itching in the area of ​​the medication installation;
• slight burning sensation in the nasal cavity when using an ointment of the appropriate purpose;
• excessive dryness of the skin for a dermatological agent.
• hyperemia due to overfilling of the epidermal capillaries with blood;
• signs of allergic reactions in the form of urticaria;
• swelling of tissues;
• contact dermatitis.

Such manifestations usually quickly disappear on their own and do not require a cancellation of the course of treatment. If the side effects persist, you should consult a doctor. He will help you choose a biologically compatible analogue.

Overdose

Bactroban is a nasal ointment, the price of which is also due to the established high safety profile. Signs of drug intoxication are not detected even when using large volumes of the drug composition and increasing the frequency of use.

In this case, the therapeutic effect does not improve. Therefore, it is necessary to use the drug in the dosage recommended by the doctor. A specific antidote to calcium mupirocin has not been developed. The insignificant degree of systemic absorption excludes the possibility of overdose.

If the ointment gets into the mouth and esophageal canals, it is recommended to rinse and wash the stomach. In emergency cases, symptomatic and supportive therapy can be prescribed with medical supervision of the patient's condition.

special instructions

In case of impaired functions of the renal organ and urinary system, correction of the applied volumes of the ointment downward is not required, given the insignificant degree of absorption of the drug.

Avoid getting the drug in the eyes and mouth. After the installation procedure, you must thoroughly wash your hands. Systemic absorption of the active substance and auxiliary components of Bactroban, in particular, macrogol, increases when the integrity of the epidermis is compromised.

Prolonged and uncontrolled use of antibacterial ointment can lead to the development of resistance in some pathogenic and opportunistic microorganisms.

During the period of gestation and breastfeeding, the drug can be used only after a preliminary assessment by the pediatrician of the ratio of the expected clinical effect and possible risks.

The teratogenic properties of the drug and its effect on intrauterine development have not been studied. In studies of the characteristics of Bactroban in laboratory animals, reproductive toxicity has not been identified.

When using an external drug for the prevention and treatment of bacterial contamination of nipple cracks it is strongly recommended to suspend lactation for the entire duration of treatment and resume it at least 3 days after completion of therapy.

Bactroban is a nasal ointment (the price of the drug largely depends on the region and the commercial policy of the pharmacy chain) with an unidentified safety profile for children under 12 years of age.

Drug interactions

Do not combine medication with other external antimicrobial agents. Cross-use reduces the antibacterial activity of both drugs.

It can lead to the loss of stability of the chemical formula and deterioration of pharmacological properties. This restriction does not apply to nasal ointment. Bactroban does not interact with the active ingredients of oral medications.

It can be combined with any oral or injectable medication. When combined with other medicines of similar use, it is recommended to maintain an interval of at least 30 minutes.

Analogs

In case of hypersensitivity to the constituents of the chemical formula of Bactroban, you can choose a remedy with identical or similar pharmacological characteristics. The list of such drugs is limited.

Analogs of external antibacterial ointment include:

• Altargo. Dermatological antibiotic of local action based on retapamulin. The active substance of the drug selectively blocks the synthesis of proteins of pathogenic microorganisms by acting on a specific site of the bacterial ribosome. It is used to treat dermatological diseases caused by strains sensitive to the active ingredient. The price of a 5 g tube is 2,100 rubles.
• Baneocin. Antimicrobial drug for external use on a synergistic 2-component basis. The active ingredients are neomycin and bacitracin. They enhance each other's pharmacological properties. It is used to treat contagious impetigo, furunculosis, ecthyma, and other dermatological diseases. Estimated price - 200 rubles.
• Bonderm. Popular antibacterial agent for external use. Prescribed to children from 3 years old. It is used to suppress streptococcal and staphylococcal infections. Bonderm is used to treat furunculosis of the auricles. The cost of a 15 g tube is 340 rubles.
• Chitosan-Genta. The drug is based on gentamicin - an aminoglycoside antibiotic with a broad spectrum of antimicrobial action. The gel-like consistency ensures good absorption and solubility of the drug. Has pronounced sorption properties and the ability to absorb wound exudate. Forms a protective film on the surface of the skin that prevents re-infection. Price - 155 rubles.
• Levomycetin. An antibacterial drug widely used in dermatology and pediatrics. It is active against most of the known gram-positive and gram-negative infectious agents. It is indicated for the suppression of Haemophilus influenzae, chlamydia, rickettsia and other pathogenic agents. The approximate cost of a 20 g tube is 110 rubles.

An analogue of nasal ointment is Supirocin, which has the same pharmacological properties and indications for use as Bactroban, but costs much less - 523 rubles.

Terms, conditions of sale and storage

Antibacterial medicine is a potent medicine, so it is only sold by prescription in pharmacies. The drug is suitable for use within 2 years from the date of production. Store the ointment at room temperature, out of the reach of children.

Price

The drug Bactroban in the form of a nasal ointment costs about 1,750 rubles in the capital's pharmacies. for a tube of 3 g. In the regions, the price of an antibacterial drug is slightly lower. The cost of a dermatological composition for external use is approximately the same.

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