Wipe off the pills. Reviews of the drug, instructions for use, price

For the treatment of complex forms of acne apply the drug Will erase. This is a drug of the pharmacological category of retinoids. Reviews of the medication note its effectiveness and rapid improvement in the condition of the skin. It enhances the regenerative processes in the epidermal tissues.

Terms of dispensing from pharmacies, drug price

It is produced by the Indian pharmaceutical concern Ranbaxy Laboratories Ltd. This is a prescription medicine that is dispensed in pharmacies only if there is a dermatologist's prescription filled out in accordance with all the rules. In the capital, acne capsules can be purchased for 1200 rubles.

Composition, release form

The medicinal product is intended for oral administration. Erase is supplied to pharmacies in the form of soft capsules in an enteric gelatinous shell. It is opaque and oval in shape, easy to swallow.

On the capsules in the lateral seam area there is a Latin bigram "RP". It indicates the manufacturer and is made with black food ink. Capsules, depending on the dosage, have a different color design.

The drug with an active ingredient concentration of 10 mg is colored in a light pink shade. Capsules containing a pharmacologically active component in a dosage of 20 mg are decorated in a rich burgundy color.

Inside the gelatinous shell is a yellowish-orange substance. The capsules are packaged in hermetically sealed blister blocks - each with 10 units of dermatological medicine.

Secondary packaging is made of medium density smooth laminated cardboard. Each pack contains 3 or 6 blisters and instructions for use. The active ingredient of the medication is isotretinoin.

Reviews of the drug Erase emphasize the good acceptability of the drug by the body thanks to the easy digestible and hypoallergenic auxiliary components, including:

• refined soybean oil, enriched with iron, vitamins of groups K and E, phytosterols;
• white beeswax containing essential components, lipid acids and carbohydrates;
• edetate butylhydroxyanisole - complex food supplement E320;
• disodium is a chelating agent that facilitates the elimination of heavy metal salts and toxins from the body.

The composition of the gelatinous shell includes glycerol, iron oxide, isopropanol and other safe elements.

Principle of operation and efficiency

The pharmacologically active component of the drug isotretinoin is a stereoisomer of polytransretinoic acid. The features of the biochemical effect of a substance have not been fully studied. It was found to be effective in the treatment of severe forms of acne by suppressing the activity of the sweat glands.

This is confirmed by histological studies, during which a decrease in the size of physiological elements was observed. Erase has an anti-inflammatory effect on the entire depth of the epidermal layers.

Under the influence of isotretinoin, hyperkeratosis of the cellular structures of the mucous membrane occurs. The process affects the hair follicles. With acne, corneocytes slough off into the flow channels of the sebaceous glands, causing them to become clogged with secretions and keratin fragments.

The pathological process is often aggravated by inflammation associated with the formation of comedones. The active ingredient Erase suppresses the proliferation of sebocyte cells, restoring the natural differentiation of cytological structures.

The main substrate for acne is excessive accumulation of subcutaneous fat. A decrease in its production reduces the colonization of excretory ducts of the sebaceous glands by pathogenic microorganisms.

Isotretinoin enters into biochemical interaction with protein fragments of the plasma part of the blood in the subcutaneous capillaries, slightly accumulates in serum and epidermal layers.

Pharmacokinetic properties

Isotretinoin and physiologically active metabolic products are linearly absorbed into the systemic circulation. This allows predicting the plasma concentration after a single dose.

The active substance of the drug does not affect the secretion and degree of activity of liver enzymes that are involved in the metabolism of exogenous substances, including the components of the drug formula.

Suction

The speed of overcoming the components Will erase the gastroenterological barrier by chemical compounds and penetrate into the bloodstream varies. The bioavailability index of pharmacological active ingredients has not been established.

In the treatment of acne in patients with normal metabolism, the maximum saturation of the plasma fraction of blood after oral administration of 80 mg of the drug on an empty stomach reaches 320 ng / ml and is observed after 3-4 h

This figure is 1.7 times higher than the serum saturation, which is explained by the weak introduction of isotretinoin into erythrocyte cells. The combination of the drug with food intake doubles the bioavailability.

Distribution

The pharmacologically active compound of the Indian medication for acne is 99.9% bound to the protein elements of the hematological fluid, forming stable biochemical complexes. The main molecular interaction is with albutamines.

The average saturation of blood plasma with isotretinoin when taking 40 mg of the drug 2 times a day is 120-200 ng / ml. Not enough scientific data has been collected on the ability of the active substance to accumulate in organs, tissue and bone structures.

Metabolism

Isotretinoin biotransformation products are characterized by increased physiological activity, which is confirmed by laboratory testing. They provide the clinical efficacy of the drug.

Approximately 20-30% of the taken dose of the drug is metabolized by the isomerization method. The pharmacokinetic properties of Erase are largely influenced by the parameters of enterohepatic circulation. Cytochrome P-450 plays an active role in the metabolism of isotretinoin.

Excretion

The elimination half-life is about 19 hours. Excretion is carried out equally by the urinary mechanism and by defecation. The endogenous concentration of the natural retinoid is fixed within 2 weeks after the completion of the therapeutic course.

Indications for use

Erase is intended for the treatment of severe forms of acne, which is difficult to eliminate with other medications, physiotherapeutic and cosmetic means.

It is prescribed for the following types of acne:

• cystic-nodular, in which comedones merge with papules and pustules into a single structure with painful sensations when pressed;
• comedonal, characterized by lipid blockage of the mouths of the sweat glands;
• papulopustular, which is characterized by epidermal destruction without purulent filling;
• deep acne with a high risk of scar formation;
• conglomerate with multiple accumulations of comedones.

Indian capsules are used to treat the inverse form of acne affecting the scalp and other difficult-to-treat similar dermatological diseases. They are used in the complex therapy of fulminant and tropical acne.

Reviews of the drug Erase note the effectiveness of the drug for excoriated acne caused by neurological disorders or endocrine disorders.

Capsules are used to treat an abscessed form of acne, after which atrophic scars remain on the surface of the skin. The drug is effective for phlegmonous acne with the formation of hyperemia and tissue edema around comedones.

Contraindications and side effects

The medication has an impressive list of absolute medical prohibitions on the use and relative clinical limitations associated with the current physiological state of the body or exacerbation of chronic diseases.

The first category includes:

• functional disorders of the hepatobiliary system;
• a pronounced state of hyperlipidemia - an abnormal concentration of fatty acids and lipoprotein compounds in the blood;
• oversaturation of the body with retinol and other vitamers of group A;
• individual intolerance to soybeans and peanuts;
• renal failure;
• chronic diseases of the heart apparatus;
• stomach ulcer.

Erase is not prescribed during the period of taking drugs on a tetracycline basis.

Relative contraindications include:

• violation of fat metabolism;
• depressive disorders;
• obesity;
• diabetes;
• alcohol addiction.

In such pathological conditions, the drug for acne should be taken under strict medical supervision. Most of the side effects of Erase are reversible and are regulated by dosage adjustment.

Some negative manifestations persist for a month after the cancellation of the course.

Established side effects will be erased:

Functional system	Negative impact
CNS	Migraine, dizziness, intracranial hypertension, edema of optic nerve-conducting fibers, fatigue, decreased muscle tone, convulsive readiness.
Urinary excretion	Proteinuria, hematuria, glomerulonephritic disorder.
Respiratory mechanism	Catarrhal inflammation of the larynx and sinuses, drying out of the mucous membranes of the dental cavity, epistaxis.
Digestion	A reversible increase in the concentration and activity of transient liver enzymes - transaminases, diarrhea, nausea, inflammatory pain in the epigastric zone.
Musculoskeletal system	Arthralgia, myalgia, calcium deposition in bones, ligaments and tendons, hyperostosis, arthritic manifestations.
Skin covering	Dermatitis, onychodystrophy, erythema, overgrowth of granulation tissues, excessive sweating, thinning hair shafts, hyperpigmentation.
Sensory apparatus	Photosensitization, blepharitis, conjunctivitis, tint perception abnormalities, hearing loss, edema of the optic discs.
Hemostasis	Thrombocytopenia, anemic conditions, increased ROE, lymphadenopathy.

While taking Erase, patients with chronic diseases of the respiratory system may experience short-term bronchospasm. Rarely, there is a change in the hematocrit number and the likelihood of infection with gram-positive bacterial pathogens increases.

Instructions for use

Erase is intended solely for oral administration. Reviews of the drug state that the best therapeutic effect is achieved when capsules are consumed simultaneously with food. This avoids pathological reactions of the gastrointestinal tract.

The dosage regimen and frequency of use are determined individually. The average therapeutic dose, suitable for most patients, is considered to be a volume of active substance of 0.5 mg / kg body weight.

According to the doctor's prescription, the dose can be increased to 1000 mcg. For acne of the trunk and difficult-to-treat types of acne, high doses of the drug with a volume of active ingredient of 2 mg are used.

An improvement in the clinical effect is observed up to a daily dose of 0.12-0.15 g. The duration of the course is determined by the nature of the pathological process and the daily amount of medication taken.

In most cases, sustained remission occurs after 16-24 weeks of schematic treatment. Patients who do not tolerate the components of the medicinal composition can take it away longer at a lower dosage.

Acne often disappears completely after a single course of the specified duration. In case of relapses, the medication is prescribed again, changing the dosage. The break between courses of admission should be at least 2 months.

Patients with chronic dysfunctions of the hepatobiliary system are advised to start treatment with a lower dosage under medical supervision. The amount of the drug is gradually increased to the tolerance limit.

In childhood

Erase is a potent drug that is prescribed only to adult patients. In exceptional cases, according to a doctor's prescription, the treatment of children from 12 years of age is allowed. They are prescribed a medication in a reduced dosage, which is chosen individually by a dermatologist.

During pregnancy and lactation

It is forbidden to take Indian capsules for acne during the period of gestation and breastfeeding. The drug is characterized by pronounced teratogenic properties. Its use by pregnant women causes severe intrauterine defects in the embryo.

Reviews of the drug Erase it is reported that after the conception of a child, gynecologists demand to immediately stop the course of treatment. Isotretinoin is characterized by increased lipophilic properties and the ability to be absorbed into breast milk. It is recommended to use reliable contraceptives during the treatment with Erase.

For fertile women, it is advisable to start drug therapy for acne on the 3rd day of menstruation in order to avoid the likelihood of conception and severe consequences for the child. It is recommended that you use a pregnancy test on a monthly basis throughout your treatment.

There is clinical confirmation of the following defects in embryonic development associated with the use of Erase:

• dysfunctions of cerebellar formation;
• hydrocephalus;
• cardiac and vascular anomalies - destruction of the septa, anatomical changes in the main arteries, ventricular stenosis and others;
• pathological condition of the parathyroid glands;
• microphthalmos;
• microcephaly;
• violations in the hearing aid.

Acne capsules increase the risk of spontaneous miscarriage. The exposure of isotretinoin concentrated in semen is insufficient for the onset of severe teratogenic effects.

Interaction with other drugs

The simultaneous use of retinol and capsules for acne leads to hypervitaminosis A.

Cannot be combined with such acne treatments:

• Adapalene - an ointment with anti-inflammatory and comedonolytic properties;
• Acitretin - a synthetic analogue of ritinoic acid;
• Tazarotene - an effective 3rd generation retinoid;

Reviews of the drug Erase argue that the drug weakens the pharmacological effect of hormonal contraceptives based on progesterone. Combination therapy with tetracycline antibiotics causes intracranial hypertension.

Cannot be combined with topical preparations with keratolytic and exofolative effect. The risk of developing anaphylactic reactions increases. Indian Acne Capsules should not be combined with sulfonamines and diuretic medications.

Storage conditions and periods

The shelf life of the drug is 24 months from the date of manufacture. Store it should be erased in a dry, dark place at temperatures up to + 25 ° C.

Avoid direct sunlight and contact with heating devices on the package with the medicinal product.

Analogs

Erase has a large number of side effects and absolute contraindications.

If necessary, the Indian medicine will be successfully replaced by the following analogs:

• Verocutane. Domestic medicine based on isotretinoin, showing good results in eliminating difficult-to-treat types of acne.
• Acnecutane. A medication for acne, inhibiting the secretion of sweat glands, destroying pathogenic bacteria and restoring the natural differentiation of epidermal cells.
• Roaccutane. Swiss acne medicine. It has anti-seborrheic and anti-inflammatory effects. Relieves tissue swelling.

All analogues of Erase have the same active ingredient, but different additional components that do not affect the pharmacological properties of the drug. Patient reviews note that all drugs have approximately identical efficacy, a list of contraindications and a regimen of use.

Video about the drug

The result will be erased for 4.5 months: