Milgamma or Combilipen. What is better, more effective, instructions for use, doctors' reviews, price

Milgamma and Combilipen - widely used drugsoften used in the treatment or prevention of many neurological diseases, the effectiveness of which has been confirmed in clinical trials.

Milgamma properties

Milgamma is a German medicinal product that is a source of vitamins B1, B6, B12. The tool is actively used in the treatment of diseases of the nervous and musculoskeletal activity. The medicine has an analgesic effect, helps to regulate the transmission of signals to nerve endings, and improves blood circulation.

Composition and form of release

Milgamma is sold in tablet form and a solution that is injected into the muscles. The liquid has a pink-red hue, which has a pungent and specific odor. Each ampoule contains 2 ml of the drug. Light-colored tablets, coated with a special coating. Available in 15 pcs. in one blister. Pharmaceutical production is located in Germany.

Each Milgamma container contains the following components:

• Main substances: thiamine hydrochloride (vitamin B1), pyridoxine hydrochloride (vitamin B6), which contains 100 mg of each component, cyanocobalamin (vitamin B12) - 1 mg, lidocaine - 20 mg.
• Additional components: benzyl alcohol - 40 mg; sodium polyphosphate and hydroxide (20 and 12 mg, respectively), potassium hexacyanoferrate - 0.2 mg; water for injection - up to 2 ml.

One tablet contains:

• Active ingredients: 100 mg of pyridoxine and benfotiamine each.
• Additional ingredients: silicon dioxide in the form of colloids, croscarmellose sodium, anti-caking agent - talc, cellulose in the form of microcrystals.

Indications and contraindications

Milgamma is best suited for the complex treatment of diseases of neurological origin.

These include:

• neuralgia, including intercostal;
• neuritis and polyneuritis;
• severe pain in the cervical and lumbosacral spine - lumbago, sciatica, radiculopathy, plexitis, muscle pain of a different nature;
• neuropathy of a different nature - diabetic, alcoholic, post-traumatic;
• convulsive twitching in the muscles, occurring in the adult population, due to a lack of thiamine and pyridoxine.

The drug has a number of contraindications:

• hypersensitivity or intolerance to certain components of the drug;
• high sensitivity of the body to certain sugars (fructose, glucose, galactose);
• periods of breastfeeding and pregnancy at all stages;
• persons under the age of 16.

Side effects and overdose

As a result of using Milgamma, an infrequent manifestation of negative symptoms is possible:

• allergies, which may be accompanied by skin rash and itching, Quincke's edema and even anaphylactic shock;
• dizziness, confusion, or loss of consciousness;
• reactions are manifested in the form of seizures, increased sweating, arrhythmias. Nausea and urticaria are extremely rare.

In most cases, malfunctions in the body occur as a result of exceeding the specified dosage or the rapid administration of the drug. To eliminate symptoms, doctors recommend special drug therapy.

Instructions for use, doses

In case of acute pain in the neck or lower back, Milgamma should be used in a complex manner. The drug is best used intramuscularly first. Most often, the doctor prescribes a 5-10 day course of one injection every day.

After reducing severe pain, it is possible to continue taking Milgamma tablets, or reducing the number of injections to 2-3 pcs. in Week. The duration of the course is no more than 3 weeks.

Kombilipen properties

Kombilipen is a domestic product used by therapists for the treatment and prevention of disorders of human nervous activity. It is a source of B vitamins.

Thiamin (vitamin B1) is a form of vitamin B1 that dissolves in water. Allow to transfer electrical impulses from sensitive endings to nerve centers, has analgesic effect, helps to synthesize vital biochemical compounds - amino acids, carbohydrates, fatty acid.

Benfotiamine is a fat-soluble form of thiamine, the main task of which is considered to be the transmission of nerve signals.

Pyridoxine (vitamin B₆) helps to produce carbohydrate and protein-fat metabolism to ensure the full functioning of the entire nervous system, as well as blood circulation.

This vitamin provides synaptic transmission between neurons, controls the processes of inhibition. Vitamin B6 participates in the formation of catecholamines, which activate the endocrine glands and stimulate the activity of the hypothalamus and pituitary gland.

Cyanocobalamin or cobalamin (vitamin B₁₂) is responsible for the normal growth and development of the body, the functioning of the blood and nervous system. It is necessary in the formation of nucleotides, it helps to synthesize myelin - a substance that forms the sheath of nerve fibers, and folic acid. It regulates the functioning of the circulatory and immune systems.

Lidocaine is a pain relieving drug. In production it is used in the form of hydrochloride. After the drug enters the body, vasodilation occurs, the conduction of sodium ions into the nerve endings is blocked, which prevents the penetration of painful impulses through the neurons.

Lidocaine begins to act in a few minutes after its introduction into the body.

Composition and form of release

Combilipen and Milgamma are found in the form of tablets and solutions suitable for administration into the muscle tissue. A medicinal solution of a light red hue with a specific odor. Each ampoule contains 2 ml of the product. Light-colored tablets in a special shell. Sold in 15 pieces. in one blister.

The mechanism of action of an intramuscular drug is determined by the following substances: thiamine and pyridoxine, cyanocobalamin, lidocaine (the content of active substances is the same as that of Milgamma).

The composition contains auxiliary components:

• aqueous solution for injection - about 2 ml;
• benzyl alcohol - 40 mg;
• sodium tripolyphosphate - 20 mg;
• potassium hescacyanoferrate - 0.2 mg.

The tablet contains active ingredients: benfotiamine and pyridoxine - 100 mg each, cyanocobalamin - about 2 μg. Additional substances include sodium carmellose, calcium stearate, polysorbate, talc, titanium dioxide.

Indications and contraindications

Kombilipen is best used in the treatment of the following neurological diseases:

• all types of neuralgia (it includes the intercostal, ternary and facial nerves);
• dorsalgia;
• muscle spasms;
• types of neuropathy (diabetic, toxic, post-traumatic);
• painful sensations associated with pinching of the nerve roots (lumbago, sciatica, cervical and shoulder syndrome and other manifestations of a similar nature);
• arthrosis and osteochondrosis.

What are the contraindications:

• intolerance to any substances in medicines;
• heart failure in acute or chronic form;
• pregnant and breastfeeding women;
• children and adolescents, since no clinical studies have been conducted for safety.

Side effects and overdose

In some cases, negative effects of the body are observed. These include the following symptoms:

1. allergy in the form of skin rash and itching, Quincke's edema, up to the onset of anaphylactic shock;
2. heart disorders - tachycardia, arrhythmia;
3. adverse reactions, which are accompanied by profuse sweating, seizures, nausea, urticaria.
4. dizziness, confusion, or loss of consciousness.

Instructions for use, doses

Kombilipen has a similar instruction to Milgamma. In the event of acute pain in the cervical or lumbosacral spine, Kombilipen is more effective to use in a complex manner. First, one injection is prescribed (dose - 2 ml) every day.

The application time is 5 to 10 days. When the pain becomes less severe, an additional course of Combilipen tablets is prescribed - 1 tablet 1-3 times a day. The doctor determines the time of appointment individually, but not more than 4 weeks. After the main use of the drug, it is possible to reduce the number of injections to 2 or 3 times a week.

What is common and different in drugs?

Milgamma or Kombilipen are better suited for the treatment of diseases of the nervous system.

In order to understand which of the drugs is most effective, a comparative analysis of the funds was carried out according to the main indicators.

Index	Milgamma	Kombilipen
Release form	Tablet form and intramuscular drug injections	Tablet form and intramuscular drug injections
Active ingredients in the composition of the drug	Thiamine hydrochloride, pyridoxine hydrochloride; cyanocobalamin; lidocaine (in liquid form). Pyridoxine; benfotiamine (tablets and capsules).	Thiamine hydrochloride, pyridoxine hydrochloride; cyanocobalamin; lidocaine (in liquid form). Pyridoxine; benfotiamine (tablets and capsules).
Prescribing a medicine	Neuralgia of various origins; acute pain in the neck, back, lower extremities (radiculopathy, lumbago, sciatica, myalgia, radicular syndrome, plexopathy); neuropathy of various nature - diabetic, alcoholic and post-traumatic; convulsive twitching due to lack of vitamins B1 and B6.	all types of neuralgia (such manifestations as intercostal, ternary and facial nerves); dorsalgia; muscle spasms; types of neuropathy; painful sensations accompanying pinched nerve roots (lumbago, sciatica, cervical and shoulder syndrome and other diseases of a similar nature); arthrosis and osteochondrosis.
Available contraindications	the presence of sensitivity or intolerance to individual components; intolerance to fructose, glucose or galactose; women who are at the stage of pregnancy and breastfeeding; persons under the age of 16.	intolerance to any components of the drug; the presence of heart disease in acute or chronic form; periods of pregnancy and lactation; children and adolescents.
Side effects, overdose	allergies, which may be accompanied by itching and redness, Quincke's edema and even anaphylactic shock; dizziness, confusion, or loss of consciousness; convulsive reactions, increased sweating, arrhythmias. Nausea and urticaria are extremely rare.	skin rash and itching, Quincke's edema, in rare cases anaphylactic shock occurs; disorders of the heart and blood vessels; side effects that are accompanied by profuse sweating, muscle cramps, nausea, hives; dizziness, confusion, or loss of consciousness.
Medication scheme	It is used as a complex therapy: injections are prescribed - one injection daily. The duration of the course is from 5 to 10 days. After reducing pain, an additional course of pills can be prescribed - 1 pc. 1-3 times a day. The course of admission is determined by the doctor individually for each person, but cannot exceed 4 weeks.	Assumes complex treatment: first, intramuscular injections are prescribed for 5-10 days, one ampoule (2 ml) of the drug daily. When strong pain sensations were removed, a course of tablets is prescribed - 1 pc. 1-3 times a day. The duration of the drug intake is no more than 4 weeks.
Opinions of doctors about taking the drug	Pros: suitable as a complex therapy, thereby accelerating the recovery of patients; the quality is fully consistent with its value; produced in various forms. Minuses: quite high price; in some situations, negative changes were recorded while taking the medication (allergies, irritation of the gastrointestinal tract).	Pros: eliminates pain symptoms in the neck, pelvis, spine, lower extremities. produced in various forms; affordable price; Excellent value for money and quality. Minuses: almost all experts note the painful administration of the drug, despite the presence of lidocaine; allergic reactions may appear.
Average cost of the drug	In ampoules for injections, the price ranges from 300 to 1200 rubles, in tablets - 680–1150 rubles. (based on the package contents).	Injections will cost 160–250 rubles, in tablet form - 240 to 450 rubles.

Milgamma or Kombilipen are best suited for complex use. These medicines are found in injections and tablets. Both drugs are prescribed for the treatment of many neurological diseases. Each of them has similar contraindications and adverse reactions to their use.

It is difficult to unequivocally assess which of the analyzed drugs is the most effective in the fight against nervous syndromes. Most experts believe that both drugs are beneficial in the treatment and prevention of a range of neurological symptoms. They differ from each other only in price. Kombilipen is significantly cheaper than Milgamma.

Combination of drugs with other medicines

Milgamma or Combilipen work better and more effectively if you do not take a number of drugs together. When their components interact with each other, neutralization and destruction can occur.

The chemical reaction of the interaction of sulfites with vitamin B1 leads to an accelerated decomposition of thiamine hydrochloride. Also, thiamine is incompatible with antiepileptic drugs, in particular with phenobarbital.

Long-term treatment with these agents can lead to vitamin B1 deficiency. Among chemical compounds, thiamine is not compatible with riboflavin, glucose, heavy metal salts (mercury chloride, copper salts). Copper promotes the rapid breakdown of thiamine.

Pyridoxine is not recommended to be taken together with levopod, since this drug interferes with the absorption of vitamin B6 into the blood, and levopoda itself loses its effectiveness.

Cyanocobalamin is not taken together with ascorbic acid, does not interact with heavy metal salts.

The use of lidocaine hydrochloride together with sedative and hypnotic drugs leads to disruption of the central nervous system, and a person may also have breathing problems. The use of anti-arrhythmia drugs, in particular amiodarone, together with lidocaine, causes muscle cramps.

The interaction of beta-adrenergic receptor blockers reduces the heart rate, and procainamide increases the excitability of the nervous system. The action of the same drug with lidocaine increases the likelihood of hallucinations. Also, the incompatibility of epinephrine with lidocaine hydrochloride has been noticed, the action of which negatively affects the activity of the cardiac system.

Milgamma or Combilipen work better and more effectively when combined with non-steroidal anti-inflammatory drugs (NSAIDs).

Medical practice shows successful results of the simultaneous use of Kombilipen and Diclofenac. They relieve acute pain and inflammation in the lumbar region and coccyx, the back of the thigh and other diseases of the nervous system in a short time.

Some clinical studies have revealed a positive trend in the combined use of diclofen and Milgamma. The patients' condition improved after the 1st use of these funds. Pain sensations became less pronounced.

As NSAIDs, together with Milgamma or Kombilipen, meloxicam, ibuprofen, nimesulide, actovegin, napraxen are often prescribed and some other medicines.

Milgammu and Kombilipen can be called effective agents in the fight against various diseases resulting from changes in nervous or motor activity. When choosing a drug, you should consider its cost.

Author: Ekaterina 2103-1

Video about the drug Combilipen

Instructions for use of Kombilipen: