Mesogel anti-adhesive gel. Price, instructions for use, where to buy, reviews

Anti-adhesion gel Mesogel has been used in the clinical practice of doctors since 2004. Since then, the drug has proved to be an effective remedy for prevent adhesion formation on damaged tissues in the postoperative period. As a result, complications are completely avoided for a relatively low price.

Indications for use

Anti-adhesion mesogel - a gel, the price of which depends on the method of purchase, it is recommended to buy it yourself after consulting your doctor.

Since the compulsory health insurance policy does not cover this level of costs, every patient should independently determine with the methods available to him in order to overcome the postoperative period.

Indications for using the gel:

• gynecology - after elimination of tumors, cysts, inflammatory processes in the endometrium, excision of adhesions, fibroids, ectopic pregnancy and chronic difficulties with conception, sterilization of both sexes;
• abdominal cavity - the drug is used for excision of adhesions in the peritoneum, resection of a part of the stomach, imposition, when connecting separate organs with common cavities and other operations of this type;
• urology - after surgical operations on the renal tissues, urinary tract, calyx-pelvic system, abdominal cavity, including manipulations to separate the synechiae of the foreskin;
• orthopedics and traumatology - the gel is used after restorative procedures on joints, cartilage formations and after the release of tendons from adhesions with surrounding tissues;
• rib cage - used for resection of lung tissue, removal of tumors and neoplasms, cystic masses and after surgical interventions on the esophagus;
• neurosurgery - after operations to isolate the nerves from the scars and other instrumental interventions on the patient's brain;
• otolaryngology - the gel is used for all types of surgical interventions in the area of ​​the nose, middle ear and during the treatment of adhesive otitis media.

In addition to serious indications for life-saving operations, the gel is used as a setting substance for surgical interventions in breast tissue.

Area of ​​use	Recommended volume
Gynecology	Up to 50 ml
Abdominal cavity	Up to 100 ml
Adhesive processes	Up to 200 ml
Pediatric surgery	Up to 50 ml
Neurosurgery	Up to 5 ml

Under normal conditions, it is usually not necessary to exceed the indicated amounts.

Compound

Mesogel is an anti-adhesion gel, the price of which usually fully justifies its purchase, consists of water-soluble derivatives of natural cellulose.

Depending on the needs of a particular patient, the assortment includes several packages in 1 syringe:

• 5 ml - 4855 rubles;
• 10 ml - 5675 rubles;
• 50 ml - 8475 rubles;
• 100 ml - 9890 rubles;
• 200 ml - 12,650 rubles.

You can use the drug only once, after which the syringe will become unsuitable for further use, especially for another patient. Such a condition is provided by safety measures to eliminate the risk of possible transmission of existing infections.

The active ingredient is a natural polymer, carboxymethyl cellulose, or CMC. Externally, after binding a sufficient amount of water, the mass becomes transparent and with a homogeneous structure.

The mesogel, completely ready for medical use, eliminates the risk of toxic, irritating or allergenic effects. In the presence of blood and other biological fluids, the drug does not become a breeding ground for the development and reproduction of bacteria and does not provoke the growth of connective tissues.

Pharmacodynamics

In terms of pharmacological activity, the drug has the following effects on living tissues:

• reduces the production of fibrins, which usually cause unwanted adhesions;
• forms a protective hydrophilic layer on healthy tissues during the operation;
• creates conditions for normal friction of internal organs in relation to each other;
• delimits damaged areas for the entire period of their recovery.

The result is healthy tissue healing in the shortest possible time.

Pharmacokinetics

Mesogel is an anti-adhesion gel, the price of which is due to the high purity of the components in strictly verified ratios; it dissolves inside the body on average about 2-6 days.

After the end of this period, its elements are displayed in several main ways. In most cases, some remains around the organs after a long time. At the same time, the composition does not have any negative effect on the tissues.

After the completion of the operation, the gel begins to slowly dissolve, attracting and absorbing additional volumes of water. In this case, carboxymethylcellulose molecules are split into shorter fragments. The particles subsequently become able to be absorbed into the capillary network of the peritoneal membrane and pass through the serous membranes into the lymphatic system.

CMC is excreted in the urine, the other part is decomposed to carbon dioxide, water and simple sugars. Therefore, gradually the entire volume injected without any pathological abnormalities is completely absorbed, having performed all the necessary functions in the acute period of the patient's recovery.

After analyzing the control results of ultrasound studies, it was revealed that by the 4th day, almost no gel residues were found. In 3% of people, traces of the gel were present for up to 9 days. The severity of intoxication and pain was significantly lower by 2 times than in the control group, in patients from which the gel was not used.

When treating adhesions with the capabilities of video laparoscopic devices against the background of Mesogel, it was possible to completely stop chronic abdominal syndrome in 84.6% of people within 3 years. Acute intestinal obstruction was compensated for in 99.3% of patients. Comparative analysis confirmed an improvement in the quality of life up to 14% 3 years after surgery.

Application

Mesogel - anti-adhesion gel, the price of which depends on the volume, can only be used by specialists directly in the process of performing surgical operations.

In this case, the gel is applied to the injured areas of organs and tissues, where there is a possibility of subsequent formation of adhesions. This happens by extrusion through a syringe and further distribution over the surrounding shells.

For children under 18

Children and adolescence are not contraindications. Therefore, the gel is approved for use if it is necessary to carry out surgical interventions.

For adults

In the absence of absolute contraindications, the gel is used in accordance with the manufacturer's recommendations.

For pregnant

Directly during pregnancy, Mesogel is not used in principle.

However, some conditions require it to be applied:

• undeveloped pregnancy;
• frozen fruit.

  

Its use in such cases is due to the need for early rehabilitation of the endometrium in the postoperative period. If you neglect such a condition for full recovery, in the future a woman may face difficulties. conception of a child, the introduction of the ovum into the endometrium and the inability to bear the fetus for a full period of healthy gestation.

For the elderly

Older people may require the use of the gel when performing surgery. Against the background of slowed metabolic processes in the body, Mesogel will contribute to the early recovery and return of the patient to the usual way of life.

Restrictions can arise directly from bans on the implementation of anesthesia and other risks associated with a high probability of death.

Contraindications

Relative contraindications:

• acute phase of purulent peritonitis;
• pathology of the kidneys and liver.

Absolute contraindications:

• intolerance to cellulose ethers (extremely rare cases);
• any deviations in the functions of organs in the stage of exacerbation;
• hypoxia, acidosis, tissue intoxication.

To assess the acceptability of the use of the drug, it is necessary to contact the practicing specialist directly.

Overdose

Cases of significant overdose have not been reported, since adequate, experienced surgeons always correlate the recommended consumption of such funds with the required amount in each specific case.

Side effects

The inert composition practically does not lead to clinically significant side effects.

Drug interactions

When used concomitantly with other anti-adhesion agents and hemostatic agents, standard caution should be exercised.

Storage conditions and periods

The drug Mesogel must be stored out of the reach of children, protected from moisture and direct sunlight at temperatures from 0 to 25 ° C. Shelf life - 3 years from the date of production, subject to storage conditions. The admissible temperature range during transportation is from -50 to + 50 ° С.

Conditions of dispensing from pharmacies

Mesogel is available without a prescription. Anti-adhesive gels for their intended purpose can only be used by specialists. Therefore, taking into account its price, the buyer does not expose himself to any risk.

Analogs

In addition to Mesogel, the pharmaceutical market offers other means for performing similar functions in body tissues. All of them are aimed at solving similar problems to eliminate the same type of symptoms. Each method has its own advantages and disadvantages. Therefore, the best option should be determined with an observing doctor.

Antiadgezin

The drug is a means for resorption of adhesions after laparoscopy and open surgery.

As active and auxiliary components, 1 ml of gel contains the following substances:

• carboxymethyl cellulose - 5 mg;
• sodium hyaluronate - 2.5 mg;
• sodium chloride - 8 mg;
• sodium hydrogen phosphate - 1.15 mg;
• potassium dihydrogen phosphate - 0.2 mg;
• potassium chloride - 0.2 mg;
• water for injection - up to 1 ml.

Packing options include several volumes in 1 syringe in the kit and an application catheter and instructions for medical use - 1.5, 3, 4, 5, 6 and 10 g.

The sodium salt of hyaluronic acid included in the composition is distinguished by the highest degree of purification and production without the use of genetically modified microorganisms. The drug is biologically compatible with living tissues, after which it decomposes without residues, absorbed and removed from all organs of the human body. Has no toxic effect.

Therapeutic activity lies in the ability to form a temporary layer between the injured areas. Thanks to this, the surfaces are completely separated from each other for the entire recovery period. The gel makes good contact with the treated areas without spreading.

As a result, a layer is formed in the form of a thick lubricating agent, which provides good sliding with adjacent organs and tissues within the body. The product also prevents them from sticking together.

The action of the gel lasts up to 7 days - the entire critical period of the initial stage of recovery after surgery. After this time has elapsed, the process of biological decomposition begins, gradual resorption and further excretion from the body.

Contraindications include the following conditions:

• allergy to hyaluronic acid;
• autoimmune pathologies;
• immunity disorders;
• tissue infection.

Care must be taken to use the product in the following cases:

• period of gestation and breastfeeding;
• diseases of the lymphatic system;
• liver or kidney pathology;
• malignant tumors;
• disorders of hemostasis.

Also, the drug should not be combined with drugs of a similar action.

ETHICON Intercoat Gel

The drug manufactured by Johnson & Johnson is intended for use as a softening barrier in abdominal cavity operations. Its use can reduce the prevalence and total number of adhesions after surgery. The duration of complete resorption does not exceed 1 month.

The composition of the tool includes the following components:

• carboxymethyl cellulose;
• polyethylene oxide.

The drug is produced in the form of a set of 2 sterile 20 ml syringes with an endoscopic channel, which are designed for uniform application of the gel.

The complex of active ingredients provides high efficiency against the formation of adhesions and other types of unwanted adhesions, including connective tissue.

Both substances undergo a complete disinfection procedure, which eliminates the infection of organs by microbes and bacterial agents. Only the surgeon can use the drug during the operation.

Adhesive barrier Interceed T7

The medicinal product is produced in the form of a sterile, woven material made by the method of controlled oxidation of reduced cellulose. The material retains its stability during storage up to 30 ° C.

The barrier is designed to physically separate surfaces that would otherwise be in contact with each other, in order to reduce the risk of adhesions and connective tissue strands. When applied correctly, the material is completely absorbed without leaving any traces behind.

The types of surgical interventions after which the use of a barrier is especially recommended:

• surgical separation of adhered fimbriae in the fallopian tubes;
• removal of myomatous nodes while preserving the cervix and body of the uterus;
• restoration of the function of the appendages;
• surgical separation of adhesions;
• removal of the body and cervix;
• ectopic pregnancy;
• endometriosis treatment;
• cesarean section.

Apart from the indicated indications, no studies have been conducted on the use of the barrier in other areas of the body. Therefore, due to the lack of data on efficacy and safety, similar drugs should be used, which have been successfully tested, and the results have been reliably confirmed by the results of therapy.

Mesogel, thus, provides the highest efficiency of surgical interventions, allows you to achieve anti-adhesion effect and in some cases creates a favorable ground for a successful and long-awaited conception child.

Against the background of general advances, the price of a gel in most cases practically ceases to matter. At the same time, the risk of reappearance of unwanted symptoms, which could require much more radical surgical interventions, is sharply reduced.

Anti-adhesion gels video

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