Erius (Aerius) tablets. Price, instructions for use from allergies, analogues are cheaper, reviews

Erius tablets are antihistamines (antiallergic) drugs, blockers of H1-histamine receptors of the 2nd generation, which are modern drugs of this group.

The active compound in the composition of this drug began to be introduced into practice in the second half of the 90s. XX century Compared to domestic counterparts, the price of the drug is in a high price range. Its prolonged action allows for a stable effect when taking 1 tablet per day.

Forms of release and composition of the drug

Erius is a pill that is overpriced in the opinion of many buyers. They come in a blue film coating that protects the drug from dissolution in the stomach. The medicine is produced by the largest international corporation in the field of pharmaceuticals Schering-Plow (Schering-Plow).

One of the convex surfaces is embossed with the manufacturer's abbreviation “SP”. Tablets (5 mg) 7 and 10 pcs. packed in foil-based blisters with transparent film. Secondary packaging is cardboard boxes.

1 tablet of the drug contains the following components:

• The main active ingredient - desloratadine (5 mg), which is an active metabolic product of its precursor, loratadine. Despite this, the pharmacological effect of desloratadine is 4-15 times higher. This compound belongs to antihistamines, third generation H1 receptor blockers.
• Auxiliary components:

1. calcium hydrogen phosphate dihydrate (crystalline hydrate of the acidic salt of calcium and phosphoric acid, 53 mg) - used in pharmaceuticals as a filler, acidity regulator, stabilizer, anti-caking agent;
2. microcrystalline cellulose (28 mg) - binder and carrier for the production of tablet forms of drugs;
3. corn starch (11 mg) - binder, carrier;
4. talc (3 mg) - a substance that reduces friction when pressing tablets.

• Components from the shell:

1. opadray (6.6 mg) - a composition of a polymer material to create a protective shell, with a blue dye (aluminum varnish);
2. carnauba and beeswax white (0.005 mg each) - binding compounds.

Pharmacological properties

Allergic inflammatory reactions in the human body are primarily associated with histamine, an organic substance that is naturally formed from amino acids. It accumulates most in mast cells and basophils, which are part of the immune system.

There are several types of receptors (or nerve fiber endings) that are sensitive to histamine - H1, H2, H3 and H4. The receptors of the first group are located in smooth muscle tissues, cells lining the internal cavities of blood and lymphatic vessels, as well as in the central nervous system.

Their excitement under the influence of histamine leads to the following types of processes:

• an increase in the space between cells, which, in turn, contributes to the accumulation of fluid and the occurrence of edema, including in the nasal mucosa and upper respiratory tract (allergic rhinitis);
• increased vascular permeability of the microvasculature - the appearance of hyperemia, blisters and itching (allergic urticaria);
• spasm of smooth muscles and bronchi (suffocation attack);
• activation of the production of hormones in the pituitary gland (sleep disturbance, increased aggression and anxiety, the development of tachycardia);
• blocking humoral immunity (reducing the production of antibodies).

Erius - tablets, the price of which is justified by the effectiveness. They contain an active ingredient that is able to block these receptors and suppress the body's allergic response in its acute phase.

The pharmacological effect is as follows:

• Stabilization of the cell walls of basophils and mast cells, thereby reducing the release of histamine and other biologically active substances from them that contribute to the development of an allergic reaction.
• Reducing the release of active molecules (RANTES chemokines) involved in the formation of inflammatory edema.
• Inhibition of the process of activation and movement of eosinophils to the inflammation focus - a type of leukocytes that contribute to the increased production of E class antibodies. An excessive amount of them leads to anaphylactic shock.
• Slowing down the formation of highly reactive superoxide radicals that cause tissue damage.

As a result, the drug has a complex anti-allergic and anti-inflammatory effect, reduces itching, spasms of smooth muscles lining blood vessels and internal organs, the severity of allergic edema, the permeability of blood capillaries.

The benefits of this drug include:

• the absence of a negative effect on the central nervous system (antiallergic drugs of the 1st generation have a hypnotic effect, the occurrence of drowsiness during treatment) and on the function of the heart;
• high therapeutic results, a small amount of negative effects;
• no worsening of psychomotor reactions (since the active ingredient is not able to enter the brain through the blood-brain barrier);
• independence from food intake;
• when used in a therapeutic dosage, there is no effect on acetylcholine - the most important mediator that carries out neuromuscular transmission;
• long-term action (the ability to take only 1 time per day);
• the active substance does not accumulate in the body, which makes it possible to prescribe prolonged courses of treatment.

Pharmacodynamics and pharmacokinetics

The process of absorption, distribution and excretion of the active substance occurs according to the following mechanism:

1. After taking the tablet inside, the main component is rapidly absorbed in the intestine. It is found in the blood after 10 minutes. The rate and extent of absorption does not depend on food intake and antacid (coating) drugs. The degree of bioavailability (the amount of active substance reaching the tissues) is proportional to the dose taken.
2. The maximum concentration in the blood is reached within 1-1.5 hours.
3. The drug is characterized by a fairly high degree of binding to blood proteins (up to 87%). It can cross the placental barrier and pass into breast milk.
4. The half-life (the time during which the concentration of the active substance is reduced by 2 times) is 21-24 hours.
5. The decomposition of the main component occurs in the liver by the addition of glucuronic acid and the hydroxyl group –OH. As a result, the active metabolite 3-hydroxydesloratadine is formed. When taking the drug in a dosage of up to 20 mg per day, the accumulation of the active substance in the body does not occur.
6. In unchanged form, <2% is excreted in the urine and <7% in the feces.

Indications for use

Erius - tablets, the main purpose of which is the treatment of allergies. The price for this drug is quite high, but there are cheaper drugs among domestic analogues.

The indications for its appointment are:

• Allergic rhinitis. The most common form of this disease is hay fever, a seasonal allergy to pollen and fungal spores. In addition, this condition can develop in patients as a result of a reaction to mite allergens in house and library dust, animal hair, bird feathers; to allergenic foods, drugs and hazardous occupational conditions. The active component of this remedy effectively relieves the manifestations of rhinitis - nasal congestion caused by swelling of the mucous membrane, sore throat, itching, sneezing, lacrimation, discharge of a large amount of nasal mucus. Since it is able to control the morning symptoms of rhinitis throughout the day, it significantly improves the quality of life of patients.
• Allergic rhinitis in combination with conjunctivitis and bronchial asthma. These diseases are often associated with each other, as they have a common pathogenetic basis. The inclusion of this drug in complex treatment allows not only to reduce the brightness of the symptoms of rhinitis, but also the clinical signs of conjunctivitis, asthma. The indicators of the function of external respiration improve, as well as the need for taking anti-asthma drugs and inhalation decreases, and the period of remission increases.
• Acute or recurrent urticaria including in combination with angioedema. At the same time, itchy rashes of a few millimeters to several centimeters in size appear on the patient's skin, and blisters form. Hives can appear under the influence of a wide variety of factors, from stress and vibration to exposure to drugs and chemicals. According to clinical studies, after the first intake of this drug, itching and skin rashes, the size and number of blisters are reduced. This improves the sleep of patients and their daily activities.
• Atopic dermatitis. In this case, the medicine is also prescribed as part of complex therapy and helps to reduce the skin manifestations of the disease.
• Contact dermatitis in combination with conjunctivitis.

Contraindications

The drug should not be used in the following cases:

• increased individual sensitivity to one or more components;
• pregnancy;
• lactation (since the active substance penetrates the placental barrier and into breast milk).

Restrictions for use - the presence of severe renal failure, as well as the patient's history of seizures.

At what age can the drug be used?

In the form of tablets, this remedy is allowed to be taken from the age of 12 years. The medicine is also available in the form of a syrup, prescribed for adults and children from 6 months. At an earlier age, the safety of the drug has not been clinically studied.

Instructions for use, dosage

The dosage for adults and children over 12 years old is the same - 1 tablet per day. It is recommended to take the drug at the same time every other day, which is associated with a decrease in the concentration of the active component in the blood and the half-life.

You can take pills both before and after meals. They must be swallowed whole without chewing, since absorption must take place in the intestine. The tablets should be taken with a little water.

Side effects

Erius - tablets, the price of which may seem high in comparison with analogues. They can cause side effects during treatment. Their features and frequency of occurrence are described in the table.

Body systems	Probability of occurrence
Unknown (prior data)	More than 0.01% but less than 0.1%	Less than 0.0001%
Nervous	—	Headache	Dizziness, sleep disturbances, agitation, involuntary muscle contractions
Gastrointestinal tract	—	Feeling of dryness in the mouth	Abdominal pain, nausea, vomiting, upset stools, increased appetite
Musculoskeletal system	—	—	Muscle pain
Mental	Behavior change, aggression	—	Hallucinations
Cardiovascular	Increased QT interval (symptom of ventricular tachycardia), slowed heart rate	—	Increased heart rate, palpitations
Other disorders	Increased sensitivity of the skin to light, neuropsychic weakness	Increased fatigue	Anaphylactic shock, Quincke's edema, shortness of breath, pruritus, rash, urticaria

In childhood, according to therapeutic practice, the most common side effect is headache. An increase in body weight is also possible. If the above and other negative effects occur, you must inform your doctor about them.

Overdose

As clinical studies show, taking the drug in nine times the recommended dose does not cause any significant disorders of the cardiovascular system. However, you need to adhere to the treatment rules outlined in the instructions.

If a patient accidentally takes a lot of pills, then you should immediately seek medical help. There is no specific antidote, general detoxification measures are carried out - gastric lavage, intake of enterosorbents, activated carbon. The method of extrarenal blood purification (hemodialysis) does not have the desired effect in this case.

special instructions

In the event of side effects from the nervous and mental systems, it is necessary for the duration of treatment to refrain from controlling mechanisms of increased danger, including vehicles.

Drug interactions

Since the drug does not affect the functioning of the cytochrome system (its enzymes play an important role in the metabolism of biologically active substances, bile and unsaturated fatty acids, phenolic metabolites, as well as in neutralizing poisons), then it can be used in joint therapy with antibacterial and antifungal agents (Azithromycin, Erythromycin, Ketoconazole).

Also, no interaction was found with the antidepressant Fluoxetine and the H2-histamine receptor blocker Cimetidine.

The incompatibility of this drug with grapefruit juice, which is characteristic of many other drugs, including anti-allergic drugs, has not been identified. Its effectiveness also does not decrease when consumed at the same time with food.

During post-registration studies (carried out after the registration of the drug with the health authorities), it was revealed that some patients develop intolerance to alcohol intoxication. Therefore, it is necessary to avoid drinking alcohol during treatment.

Analogs

Erius - tablets, the price of which does not exceed 700 rubles. They have analogues in composition (the main component is desloratadine). Their brief description is given in the table.

Name, form of issue	Dosage, per day	Peculiarities	Average price, rub.
Desloratadine, 5 mg tablets, syrup	1 tablet, single dose	In rare cases, it is possible to increase the activity of liver enzymes and the concentration of bilirubin, the occurrence of pharyngitis, a violation of the menstrual cycle	145 (10 pcs.)
Ezlor 2.5 and 5 mg tablets	Children: 1-5 years old - 1.25 mg, 6-11 years old - 2.5 mg, older age and adults - 1 tablet 5 mg, single dose	An additional contraindication is phenylketonuria.	230 (10 pcs.)
Elisey, 5 mg tablets, syrup	Children over 12 years old and adults - 1 tablet, single dose	200 (10 pcs.)
Blogir-3, 5 mg lozenge tablets, syrup	Children: 1-5 years old - 1.25 mg, 6-11 years old - 2.5 mg, older and adults - 1 tablet 5 mg, single dose	An additional contraindication is phenylketonuria.	300 (30 pcs.)
Lordestine, 5 mg tablets, syrup	1 tablet, single dose	As side effects, it is possible to increase the activity of liver enzymes and the concentration of bilirubin, hepatitis, jaundice.	335 (10 pcs.)
Desal, 5 mg tablets and oral solution	1 tablet each, solution: children 1-5 years old - 2.5 ml, 6-11 years old - 5 ml, over 12 years old and adults - 10 ml, single dose in all cases	In rare cases, diarrhea, fever, insomnia, and those symptoms described for the previous drug are possible	250 (10 pcs.)

Terms, conditions of sale and storage

The storage features of the drug include the following:

• keep away from children;
• optimal storage temperature - no more than + 30 ° С;
• general shelf life - 2 g.

The drug belongs to the over-the-counter category.

Price

The average price for pills in pharmacy chains is 600 rubles. (for 10 pcs.).

Erius tablets are a modern and safe medicine used for allergies. It is allowed for use in adolescents from the age of 12, but there is another form - in the form of a syrup, which can be prescribed to young children. The price for this product is quite high, since it is imported from abroad.

Its advantage is that it has fewer side effects compared to previous generations of antihistamines. The drug is also used for the complex treatment of allergies associated with bronchial asthma, dermatitis and conjunctivitis.

Erius tablets video

Review of Erius tablets: