Ursosan or Ursofalk. What is better, more effective than the difference, instructions for use, reviews, price

Ursofalk and Ursosan are effective drugs that have choleretic and hepatoprotective properties. These drugs of drug therapy are produced in the form of coated tablets, capsules or thick suspension.

To obtain the maximum therapeutic effect, hepatoprotectors Ursofalk and Ursosan are best used in in combination with other drugs that protect liver cells from the negative effects of external and internal factors.

Comparative characteristics of hepatoprotectors Ursosan and Ursofalk. Commonality and differences

Ursosan and Ursofalk are drugs, the pharmacological characteristics of which have more in common than distinctive features. In the treatment of acute or chronic liver diseases associated with the gradual death of hepatocytes, any of the above medications can be used.

For the treatment of newborns who suffer from jaundice, it is better to use the drug Ursofalk, since it is produced in the form of a thick suspension. Hepatoprotector Ursosan is available only in capsule form.

Compound

Medicines Ursosan and Ursofalk contain in their composition the main biochemical substance in the form of ursodeoxycholic acid. This is the main component that endows medicines with hepatoprotective properties.

The auxiliary substances of Ursosan are the following components:

• corn starch, which forms the protective coating of the drug;
• magnesium stearate;
• anhydrous silicon dioxide;
• pregelatinized starch.

The mass fraction of the main substance inside the Ursosan capsules is 250 mg. The drug Ursofalk is available in several pharmacological forms. These are tablets, capsules and suspensions intended for the treatment of patients under the age of 3 years.

The tablets of the drug Ursofalk contain the following components:

• microcrystalline cellulose;
• povidone;
• polysorbate 80;
• magnesium stearate;
• macrogol 6000;
• talc;
• silica;
• crospovidone;
• hypromellose.

The standard dosage of Ursofalk tablets is 500 mg of the active substance. Hepatoprotective agent, produced in the form of capsules contains the following auxiliary components:

• silicon dioxide - is an anti-caking agent;
• corn starch - is part of the drug shell;
• titanium dioxide - a chemical dye;
• gelatin - is part of the capsule shell;
• sodium lauryl sulfate - acts as a preservative;
• magnesium stearate - provides a stable powdery structure of the drug;
• water - used in the manufacturing process of the drug.

Each Ursofalk capsule contains at least 250 mg of ursodeoxycholic acid.

The same medication, which is produced in the form of a suspension, contains auxiliary substances in its composition in the form of:

• benzoic acid, which is a chemical stabilizer;
• lemon flavor identical to natural;
• purified water;
• sodium citrate;
• glycerin;
• propylene glycol;
• xylitol;
• sodium chloride;
• sodium cyclamate;
• avicela rc-591.

5 ml of a thick suspension of Ursofalk contains at least 250 mg of active substance. A measuring cup is included with the drug, which is necessary to determine the most accurate dosage. The chemical compositions of Ursosan and Ursofalk differ only in the list of additional components.

Pharmacological properties

It is better to take Ursosan or Ursofalk after a complete examination of the liver, gallbladder, pancreas, as well as the organs of the digestive system.

Due to the fact that these drugs have an identical active substance, they have the following pharmacological properties:

• protect liver cells from further death under the influence of alcoholic beverages, too fatty foods, chemicals, toxins, viral and bacterial microorganisms;
• reduce the general intoxication of the body in patients who have severe liver pathologies, and also undergo complex treatment with potent drugs;
• contribute to the active splitting of cholesterol-type stones formed in the cavity of the gallbladder;
• participate in the process of restoration of hepatocytes of the liver after their damage by the negative effects of external and internal factors (poor environmental conditions, toxins, poor diet, alcohol, sedentary lifestyle life);
• stimulate a more active outflow of bile, which helps to improve overall well-being and normalize the digestive function of all organs of the gastrointestinal tract;
• restore the functions of the pancreas (in the event that the organ's performance has been reduced due to chronic pathologies of the liver, the walls of the gallbladder and its ducts);
• take part in the regeneration of liver tissues that are damaged by cirrhosis, hepatitis of a viral or intoxication nature of origin;
• prevent the formation of extraneous calculi in the cavity of the gallbladder and its channels;
• reduce the severity of the harmful properties of bile in relation to liver tissue.

Ursosan or Ursofalk is best used at the initial stages of liver and gallbladder diseases, when only the first signs of a pathological state of organs appear. Severe forms of the disease require a longer and more complex treatment.

Indications

The drugs Ursofalk and Ursosan should be prescribed only by a hepatologist or a therapist who deals with the treatment of the liver, gallbladder and its ducts.

Medicines are indicated for use in the following cases:

• preparing the patient for a liver transplant operation or other organs involved in the digestion process;
• alcoholic and intoxication lesions of the liver tissue resulting from prolonged use of alcoholic beverages, as well as daily work with toxic substances;
• prevention and therapy of cholestatic syndrome caused by prolonged use of hormonal contraceptives;
• primary cirrhosis of the biliary type;
• hepatitis in an acute or chronic form of development (regardless of the nature of the disease);
• passing a course of crushing or dissolving calculi contained in the cavity of the gallbladder and its channels;
• gastritis, as well as reflux esophagitis, which is accompanied by frequent belching, heartburn, burning in the esophagus, sour taste in the mouth.

Ursosan or Ursofalk is best used for the prevention of the above diseases of the liver, the walls of the gallbladder and its channels. Therapy of hepatitis, intoxication and viral liver damage, gallstone disease, can be carried out in combination with other medicines with hepatoprotective properties.

Contraindications

Medicines Ursofalk and Ursosan do not differ in terms of contraindications to their use.

Medicines of these types are not used to treat patients who suffer from the following diseases:

• obstruction of the bile ducts, which is caused by the presence of extraneous stones or tumor neoplasms;
• individual intolerance to ursodeoxycholic acid or auxiliary components that are in the composition of drugs (expressed in the form of allergic reactions of the body);
• renal and hepatic failure (taking medications can lead to a deterioration in the functional activity of these organs);
• acute inflammatory processes in the gallbladder and its channels (before starting therapy, it is necessary stabilize the condition of the organ, relieve inflammation, and then prescribe a metered dose of Ursosan or Ursofalk);
• attacks of cutting or cramping pain caused by the presence of calcified stones inside the gallbladder;
• severe trauma and damage to the gallbladder and its channels, which require the use of surgical methods;
• the pathological condition of the muscles responsible for the synchronous contraction of the walls of the gallbladder, as well as the further outflow of bile (in in this case, the cause of the lack of muscle activity is determined, eliminated, and only then the administration of capsules is prescribed or suspension).

Ursofalk and Ursosan are potent medicines that are used only after preliminary examination of the liver, determining the performance of the gallbladder and its channels, and also of the digestive tract. In the process of diagnosis, other pathologies can be detected that exclude therapy with these drugs.

Instructions for use

The course of therapy with Ursosan and Ursofalk, which are available in the form of capsules and tablets, depends on the type of liver or gallbladder disease. For crushing cholesterol stones, one of the drugs is prescribed in a dosage of at least 10 mg of active substance per 1 kg of body weight.

The average duration of a therapeutic course is from 6 months. up to 2 years. If after 1 year the size of calculi in the gallbladder cavity has not decreased, then further administration of Ursosan or Ursofalk is not advisable. A different method of therapy should be selected for the patient.

During the first 3 months. treatment with Ursosan or Ursofalk, it is necessary to take an analysis for the level of hepatic transaminases every 30 days. Also, the patient must control the process of dissolution of cholesterol stones. At least once every 6 months. an ultrasound of the liver and gallbladder should be done, cholecystography should be performed in order to timely detect calculus calcification.

If, according to the results of diagnostics, calculi of this type have been identified in the gallbladder or its canals, then further taking Ursosan or Ursofalk capsules should be discontinued.

To get rid of acute gastritis with periodic reflux of bile, the patient is prescribed course therapy with Ursosan or Ursofalk, taking 1 capsule once a day. The average duration of a therapeutic course is from 10 to 14 days. In most cases, the timing of treatment depends on the severity and severity of the disease, as well as the possible presence of complications.

The attending physician can increase the duration of the therapeutic course. Especially if the patient has a positive trend towards the normalization of the functions of the gallbladder, as well as a decrease in inflammation of the stomach walls.

In the treatment of primary cirrhosis, as well as other liver diseases associated with premature death hepatocytes, Ursosan and Ursofalk are prescribed at a dosage of 14 mg of the main substance per 1 kg of total weight body.

The average daily dosage is from 3 to 7 capsules of the medication, which are divided into 3 doses. The hepatoprotective agent should be drunk during meals or after eating. The minimum duration of a therapeutic course is 3 months, but it can be extended indefinitely.

Ursosan and Ursofalk capsules must be swallowed whole with plain water. If necessary, the attending physician can adjust the dosage, reducing or increasing it to the amount of the active substance that is advisable to use at this stage of treatment.

With prolonged treatment of primary cirrhosis using large doses of Ursofalk and Ursosan, the risk of side effects of the drug increases. Most patients complain of skin irritation and itching.

Suspension Ursofalk is used to treat children of all age groups. The dosage of the drug is determined individually, taking into account that no more than 10 mg of the main component should fall on 1 kg of body weight. 1 measuring cup with a capacity of 5 ml contains 250 mg of ursodeoxycholic acid.

This dosage is used in the treatment of cholesterol stones localized in the gallbladder cavity. For the treatment of hepatitis and primary cirrhosis of the liver, it is advisable to use a dose of 14 mg of active substance per 1 kg of weight. In the first 6 months. treatment with Ursofalk suspension, the patient must be tested for the functional activity of hepatocytes every 30 days.

Application in special cases

Ursosan or Ursofalk is best used during a certain therapeutic course. This approach will provide a complete restoration of liver tissue and functions of the gallbladder, as well as its ducts. At the same time, drugs can be used for short-term therapy of pathological conditions of the liver.

These are special cases when, after abuse of alcoholic beverages, prolonged contact with chemicals, signs of intoxication of the body appear.

To maintain normal liver function, as well as to prevent the destruction of hepatocytes, Ursosan or Ursofalk are used. It is recommended to take 1 capsule of the drug 2 times a day (morning and evening) for 7-10 days, or until you feel better.

Side effects

The drugs Ursosan and Ursofalk are well tolerated by most patients of all age groups, regardless of whether the medication is taken in the form of capsules or liquid suspension.

At the same time, manufacturers of hepatoprotective agents do not exclude the following side effects:

• a feeling of a feeling of heaviness and spasmodic pain in the right hypochondrium;
• loose stools;
• urticaria, rashes and itching of the skin surface, edema of allergic etiology;
• nausea and vomiting;
• lack of appetite;
• calcification of cholesterol stones localized in the gallbladder;
• an increase in the level of activity of hepatic transaminases (this side effect is recorded in the first 3 months. from the start of treatment).

In case of manifestations of side effects of drugs, it is necessary to stop further taking Ursosan or Ursofalk, and also inform the attending physician about this, who prescribed therapy with hepatoprotective means.

Compatibility with other medications, with alcohol

It is not recommended to take Ursofalk and Ursosan simultaneously with the following drugs of drug therapy:

• antacids based on aluminum hydroxide, Colestipol, Colestyramine - reduce the degree of absorption ursodeoxycholic acid (it is advisable to take these drugs only 2 hours after taking Ursosan or Ursofalk);
• drugs based on cyclosporine - the concentration of the last substance increases;
• medicines with ciprofloxacin - ursodeoxycholic acid inhibits the absorption of this component;
• Nitrendipine - the active substance of Ursosan and Ursofalk reduces the absorption of this drug.

Doctors-hepatologists strongly recommend to refuse the simultaneous use of medications with hapolipidemic properties. These include the drugs Bezafibrate, Clofibrate, and Probucol. These drugs stimulate the secretion of bile and reduce the therapeutic effect.

Concomitant use of estrogen-based oral contraceptives, use of too oily food with a minimum fiber content, levels the pharmacological properties of Ursosan and Ursofalk. During the period of treatment with these drugs, alcohol is prohibited.

Ursosan or Ursofalk - which is better?

Ursosan and Ursofalk are hepatoprotectors that have similar properties, and also contain an active substance in the form of ursodeoxycholic acid. Therefore, these drugs have the same quality characteristics.

For newborns

For the treatment of diseases of the liver, gallbladder and its ducts, which have been diagnosed in a newborn child, it is necessary to use Ursofalk suspension.

This medicinal product has no age restrictions for its use. The syrup has a pleasant lemon aroma and a sweetish aftertaste.

For older children

For the treatment of older children who have already turned 5 years old, capsules of Ursosan and Ursofalk preparations, or a suspension, can be used.

The dosage of medicines is selected individually, taking into account the type of liver or gallbladder disease, as well as the severity of the pathological process.

For nursing and pregnant women

The drugs Ursosan and Ursofalk are strictly prohibited for women who are in the 1st trimester of pregnancy. In the later stages of gestation, the medication is used only in extreme cases, when the potential benefits of a hepatoprotective agent outweigh the risks to the child.

In general, during pregnancy, these medications are not recommended to be taken, since ursodeoxycholic acid is able to overcome the placental barrier. During lactation of a newborn with breast milk, taking hepatoprotective agents is contraindicated.

Comparative table on the parameters and price of Ursosan and Ursofalk

The table below shows the comparative characteristics of the drugs Ursosan and Ursofalk, which indicate the generality and distinctive features of the medicines.

Drug name	Cost by pharmacies and country of origin	Release form	Active substance	Pharmacological properties
Ursosan	This is an imported drug that is produced in the Czech Republic. It is an analogue of the drug Ursofalk. The average cost of a medicine in pharmacies is 510 rubles. per pack of 20 capsules.	It is produced in the form of capsules, which are allowed to be taken by children at least 5 years old.	Ursodeoxycholic acid with a concentration of 250 mg of active substance in 1 capsule.	Protection and restoration of liver tissue, gallbladder and its ducts from the negative effects of external and internal factors.
Ursofalk	This medicinal product is manufactured by the German pharmaceutical company Falk Pharma, which is located in St. Hamburg. The average cost of the drug in the form of capsules is 2300 rubles, tablets 2200 rubles, suspension 1350 rubles.	It is produced in the form of capsules, tablets, coated with a protective shell, and also in the form of a suspension.	The capsules contain 250 mg of ursodeoxycholic acid, 500 mg in tablets, and 250 mg of this active substance in 5 ml of suspension.	Protection and restoration of liver tissue, gallbladder and its ducts from the negative effects of external and internal factors.

Ursosan and Ursofalk are effective imported drugs that contain in their composition of a similar active substance, have the same pharmacological properties and differ only in the form release.

Hepatoprotective agents can successfully treat cirrhosis, alcoholic and intoxicated liver damage, dysfunctional disorders of the gallbladder, hepatitis. Ursosan and Ursofalk can be used as independent drugs or in combination with other medicines.

To achieve the maximum therapeutic effect, hepatoprotectors are best taken for 6-12 months.

Video about the drug Ursofalk

Overview of Ursofalk capsules: