Vitamin B9 in ampoules. Instructions for use, price

Vitamin B9 (folic acid) enters the human body along with fresh vegetables and fruits, and also a small part of it is synthesized by intestinal cells. With the development of an acute deficiency of this substance, medications are prescribed, which include a daily dose of vitamin B9.

In the pharmaceutical market, folic acid is presented in the form of white tablets with a dividing line in the center. In ampoules, vitamin B9 is contained only in one preparation called Medivitan.

This is a drug that consists of 2 chemical solutions. The package of this medication contains ampoules with vitamins B12 and B6, complete with a separate injection solution of vitamin B9.

Indications for use

Vitamin B9 in ampoules is indicated for admission to patients who have an acute deficiency of folic acid. At the same time, there is no possibility of replenishing the lack of this substance using other methods. For example, by using a tablet form of medicines based on folic acid.

Vitamin B9 in the form of an injection solution has the following properties:

• takes part in metabolic processes;
• is responsible for the stable growth of cellular material;
• ensures the integrity of the DNA structure;
• prevents the formation of benign and oncological tumors;
• helps to strengthen the immune system;
• improves the function of the heart and blood vessels;
• participates in the synthesis of vital amino acids;
• has a beneficial effect on the work of the central nervous system and peripheral nerves;
• increases the efficiency and endurance of the body during physical activity;
• plays an important role in the process of hematopoiesis, and also prevents the development of anemia.

For the first time, synthetic vitamin B9 was created back in 1947. Since that time, folic acid has been used for therapeutic purposes to treat pathological conditions in the body caused by a deficiency of this substance.

Compound

Vitamin B9 in the form of injections is presented as part of the Medivitan preparation. This is a combined product that has 2 different chemical solutions in ampoules, the components of which are listed in the tables.

Solution 1:

Composition of active ingredients	Dosage (per 4 ml)
Pyridoxine Hydrochloride (Vitamin B6)	5 mg
Cyanocobalamin (vitamin B12)	1 mg

Auxiliary substances of solution No. 1 are sterile water for injection and sodium chloride. The mixture of these vitamins is a transparent reddish liquid, and its filling is carried out in dark glass ampoules.

Solution 2:

Composition of active ingredients	Dosage (per 1 ml)
Folic acid (vitamin B9)	1.05 mg

Auxiliary components of synthetic vitamin B9 are sterile water for injection, as well as sodium chloride, which acts as a physical solution. The filling of this substance is carried out in dark glass ampoules, and outwardly the vitamin mixture looks like a transparent liquid with a pronounced yellow tint.

Depending on the individual needs of the patient's body, he may be prescribed an injection of only folic acid, or a complex therapy with the above 2 solutions. The simultaneous saturation of the blood with vitamins B6, B12 and B9 is indicated for patients who are in a state of acute deficiency of these substances.

In what form is it produced

Vitamin B9 in ampoules, which is part of the combined composition of Medivitan, is produced in the form of a solution. The average cost of a drug is from 975 rubles. per packing. The second form of folic acid release is white tablets, which are packed in plastic cell packs of 10, 25 and 50 pcs.

In this case, the concentration of the active substance in the form of folic acid is equal to 1 mg in 1 table. The main packaging of preparations containing vitamin B9 in tablets is a cardboard box or bottle made of dark glass. The average cost of medicines of this form of release is from 29 to 37 rubles. for 50 tab.

Pharmacodynamics

Vitamin B9 injectable solution has the same properties as the natural formula of folic acid found in food. After chemical decomposition, this substance forms a compound of tetrahydrofolic acid, which acts as a cofactor in fermentation systems.

The synthetic analogue of vitamin B9 carries out the transport of one-carbon particles, participating in metabolic processes for the exchange of nucleotides and amino acids. Folic acid plays a key role in the regulation of proliferation reactions, cell maturation and their further differentiation.

Vitamin B9 is vital for the stable intrauterine development of the fetus. The greatest need for a sufficient amount of folic acid is observed during the formation of the child's nervous system.

Pharmacokinetics

Vitamin B9 in ampoules is designed for intramuscular use. After the injection of folic acid at a dosage of 1.5 mg, the maximum concentration of this substance in the blood plasma is reached in the first 60 minutes. After that, there is a rapid decrease in the level of vitamin B9, which is due to its rapid metabolic breakdown.

The initial level of folic acid occurs 12 hours after the first injection. A distinctive feature of vitamin B9 is that it actively interacts with blood plasma proteins.

The accumulation and chemical breakdown of folic acid occurs in the liver tissue. According to the results of the metabolism of vitamin B9, tetrahydrofolic acid is formed, which is subsequently excreted from the body by the kidneys in the urine.

Folic acid injectable solution has the properties to overcome the blood-brain barrier, penetrate the placenta, and also saturates the composition of breast milk. These pharmacokinetic features of vitamin B9 must be taken into account by women who are pregnant and are also breastfeeding.

Application

The use of an injection solution based on folic acid is possible only as directed by a doctor. The introduction of the drug of this form of release is carried out in a medical institution.

For children under 18

Vitamin B9 in the form of an injection solution is used only for the treatment of patients of the adult age group. This medication is contraindicated in children.

For adults

The folic acid solution, which is part of the Medivitan combined product, is mixed with vitamins B6 and B12. The contents of the ampoule with solution No. 1 and No. 2 are drawn into a sterile disposable syringe. After that, the total dose of the multivitamin complex is obtained (5 ml).

A mixture of vitamins B9, B6 and B12 is injected into the patient's body intramuscularly or intravenously with a frequency of 2 times a week. The duration of the therapeutic course is 4 weeks.

In general, an adult patient should receive at least 8 injections of 5 ml each. To achieve the maximum therapeutic effect in the intervals between injections, it is recommended to take additional folic acid in the form of tablets.

For pregnant

Vitamin B9 in the form of injections is not recommended for women who are pregnant or breastfeeding. Restrictions on the use of the drug are associated with the lack of clinical data on its safety for patients in this category.

For the elderly

Elderly people who do not have direct medical contraindications for the use of the injection form vitamin B9, can be treated with this substance on a general basis, like all other adults the patients.

Contraindications

Folic acid injectable solution is contraindicated for use in the presence of the following circumstances:

• individual intolerance to the constituent components of Medivitan;
• the presence of skin rashes and other signs of a dermatological disease in the area of ​​injection solution;
• diagnosed with thrombosis or thromboembolism of blood vessels;
• found megaloblastic anemia.

Before prescribing vitaminizing therapy with injections of folic acid, the attending physician must perform a comprehensive examination of the patient, which will show the possible presence of other diseases that exclude the introduction of this substances.

Overdose

An overdose of vitamin B9 injections is manifested by the development of side effects, which are described in the section below. Patients who have received an excess dose of folic acid receive symptomatic therapy. On the part of doctors, measures should be taken to cleanse the patient's blood from this substance, to eliminate signs of general intoxication of the body.

For this, droppers with a saline solution are installed in the patient, and sorbent preparations are prescribed. In case of signs of an allergic reaction, drugs with antihistamine properties are used.

Side effects

Folic acid injectable solution, which is part of the multicomponent composition of Medivitan, can cause the following side effects:

• increased sweating;
• tachycardia attacks;
• the appearance of acne;
• anaphylactic shock;
• local allergic reactions in the form of urticaria, itching of the skin, rashes;
• feeling short of breath;
• dizziness;
• arrhythmia;
• cramps of the lower extremities;
• angioedema;
• Strong headache.

In the event of the appearance of the above symptoms that occur after the injection of vitamin B9, it is necessary to inform the attending physician about this. You should also make sure that the dosage regimen is not violated during folic acid therapy, since an overdose manifests itself with similar symptoms.

Special recommendations

Before prescribing vitamin B9, the doctor must perform a comprehensive examination of the patient, checking the concentration of folic acid in the blood plasma and directly in the cell structure erythrocytes. Re-analysis is given after passing the vitaminizing course.

The composition of 5 ml of the already prepared Medivitan solution contains at least 23 mg (less than 1 mmol) of the mineral component of sodium. The presence of this substance can affect the general condition of patients with concomitant kidney disease and chronic heart failure.

All the constituent components of the multivitamin preparation Medivitan, as well as vitamin B9 itself, do not have a depressing effect on the centers of the brain.

Folic acid injectable solution does not decrease the reaction rate and concentration of attention. Vitamin B9 is approved for use in relation to vehicle drivers, operators of machines, mechanisms, as well as persons performing work with increased danger.

Drug interactions

With the simultaneous use of an injection solution of folic acid with antibacterial agents based on tetracycline, neomycin, chloramphenicol, and polymyxin, vitamin absorption worsens AT 9.

Long-term therapy with analgesics, anticonvulsants, increases the patient's need for an additional amount of folic acid. It is not recommended to carry out the simultaneous use of oral contraceptives based on synthetic hormones with injections of vitamin B9.

The use of an injection solution of folic acid can lead to a decrease in blood plasma levels of phenobarbital, primidone and phenytoin. In this case, the occurrence of an epileptic seizure is not excluded. Medicines from the group of antacids, sulfonamides, containing cholestyramine, interfere with the absorption of folic acid.

You should not carry out simultaneous therapy with injections of vitamin B9 with the intake of the following drugs:

• Methotrexate;
• Trimethoprim;
• Triamteren;
• Pyrimethamine.

The above medications are folic acid antagonists and also inhibit tetrahydrofolate reductase. With drugs of other pharmacological groups, the injection solution of vitamin B9 does not enter into negative biochemical reactions.

Storage conditions and periods

Ampoules with injectable folic acid solution, which is included in the combined multivitamin complex Medivitan should be stored in a dark and cool place at temperatures not exceeding +25 degrees Celsius.

This drug should be left out of the reach of children. The general shelf life of vitamin B9 is 3 years, after which the solution must be disposed of.

Conditions of dispensing from pharmacies

Folic acid in the form of an injectable solution is dispensed with a doctor's prescription.

Analogs

The main analogs of vitamin B9 in ampoules are drugs in tablet form.

Folic acid

Folic acid in the form of tablets is an effective vitamin preparation, which is analogous to an injection solution of vitamin B9.

This medication is indicated for use in the following cases:

• anemia;
• chronic gastroenteritis;
• leukopenia;
• intestinal tuberculosis;
• treatment and prevention of acute folic acid deficiency.

Unlike the injectable form of vitamin B9, the tablet preparation is approved for use by pregnant women and women who are breastfeeding. For therapeutic purposes, folic acid tablets are prescribed to be taken at 5 mg per day.

Folacin

Folacin is a drug analogue of vitamin B9 injection solution, which is produced in the form of yellow tablets with a dividing line in the center. The medication does not have a specific medicinal odor. The composition of 1 tablet of Folacin contains 5 mg of the active substance in the form of folic acid.

This drug is indicated for use in the following cases:

• megaloblastic anemia;
• leukopenia;
• prevention of fetal neural tube anomalies during intrauterine development;
• vitamin B9 deficiency;
• long-term therapy with drugs that are folic acid antagonists.

Taking the drug Folacin is prescribed in a dosage of 1 to 3 tablets per day, depending on the total the patient's condition, as well as the type of disease, the presence of which became the reason for the therapy given medication.

Vitamin B9 in the form of an injection solution is produced in the combined composition of the Medivitan drug. The package of this drug contains ampoules with vitamins B6 and B12, as well as injections of folic acid.

The introduction of vitamin B9 using intravenous or intramuscular injections is performed if the patient is contraindicated taking folic acid in tablets, or due to concomitant diseases of the gastrointestinal tract, full absorption of this substances.

It is seen about vitamin B9

Why folic acid is tedious: