Biseptol (Biseptol). Indications for use, instructions for use, analogues, alcohol compatibility, reviews, price

Biseptol tablets are an antimicrobial combined agent that is indicated for use in cases of bacterial infectious processes in the body. It serves to disrupt the structure of cells of the pathogenic flora, as a result of which the causative agent of the disease is deprived of the ability to increase the population.

Release form, conditions of release from pharmacies, price

The drug is available in the form of tablets - compressed solid dosage forms and a suspension (liquid substance) intended for use by children.

The tablets are characterized by:

• a variety of dosages of 120 and 480 mg of active ingredients;
• flat round shape;
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• whitish-yellowish tint;
• the presence in the middle of the cut with the inscription "BS";
• form of release - in blisters of 20 and 14 pcs .;
• the presence of cardboard packaging.

Suspension for oral administration is made in a dosage of 240 mg of active ingredients in a volume of 5 mg in 80 ml vials, costing 130-150 rubles. The package includes a measuring cup, also a cardboard box.

The drug is dispensed from pharmacies with a prescription. Average prices for 120 mg tablets (20 pcs.) Are 80-90 rubles, 480 mg (28 pcs.) in 2 blisters of 14 pcs.) - 105-125 rubles.

Active ingredients

The formula of the drug includes 2 active components, in addition, a number of additional substances. Basic substances with quantitative values ​​are summarized in the table.

Compound	120 mg	480 mg	240 mg
Sulfamethoxazole (cotrimoxazole), mg	100	400	200
Trimethoprim, mg	20	80	40

A number of auxiliary ingredients include:

• potato starch - food product that serves to hold the substance together and give it the correct shape;
• polyvinyl alcohol - designed to create a film on the surface of drugs;
• monopropylene glycol - additive for binding moisture, preservative;
• talc - an additive used as an additional source of magnesium and silicon;
• magnesium stearic acid ester of paraoxybenzoic acid - a chemical compound added to preparations to maintain the consistency of the mass;
• para-hydroxybenzoic acid methyl ester - food additive with preservative properties.

Indications for use

The active components of the drug are characterized by rapid penetration into the cells and tissues of the respiratory system, urinary system, secretions and blood plasma. The drug is fully absorbed through the digestive system.

Biseptol (indications for the use of the drug imply the presence of a bacterial infection) refers to bactericidal substances with a wide range of action.

It provides an anti-inflammatory effect against the following pathogens:

• salmonella;
• enterococci;
• streptococci;
• listeria;
• klebsiella;
• escherichia;
• legionella;
• proteas;
• staphylococci;
• chlamydia;
• protists;
• gonococci;
• some pathogenic fungi.

With the help of the drug, you can reduce the normal course of life of pathogenic microflora in the intestine in case of digestive disorders. The duration of the therapeutic effect is on average 12 hours.

Antimicrobial medicine is used in the presence of the following pathologies:

• various infectious conditions in the respiratory organs (bronchi, lungs, pleural sheets, nasopharynx, ears);
• bacterial lesions in the urinary tract and reproductive system (diseases of the kidneys, urethra, reproductive organs, appendages);
• diseases of the digestive system (stomach, intestines, duodenum, liver, gallbladder);
• inflammation of the skin and soft tissues of bacterial origin.

Contraindications

Biseptol, the indications for the use of which are described in the instructions, has a list of restrictions.

It includes:

• allergic reactions to the components of the substance;
• during pregnancy and lactation;
• the existence of liver injury, fibrosis;
• acute syndrome of impairment of all kidney functions;
• with renal dysfunction, when the concentration of the active components of the drug in the blood is not determined, its intake is contraindicated;
• when in a plasma study, creatine is determined less than 15 ml / min;
• severe dysfunctions or structure of blood cells (leukocytes, platelets, erythrocytes) in the form of deficient anemias of various origins, hemoglobinopathies, coagulopathies, thrombocytopenias;
• deficiency of glucose-6-phosphate dehydrogenase.

With caution, doctors should prescribe a remedy for a lack of vitamin B9 (folic acid) in the body, when a history of bronchial asthma (chronic respiratory disease), thyroid (endocrine) pathology glands.

The tablet form of the drug is contraindicated for children under 3 years of age. In this case, a suspension should be used.

Side effects

Mostly the drug is well tolerated, no side reactions are observed.

However, the instructions for the use of the drug indicate a number of the following likely concomitant phenomena:

• headache;
• disorders of the vestibular apparatus (dizziness, loss of coordination of movements);
• depressive states with manifestation of apathy;
• the appearance of tremors and neuritis;
• aseptic meningitis is very rare;
• bronchospasm, cough;
• dysfunction of the digestive tract (gastroduodenitis with pain syndrome, stomatitis, cholestasis, inflammation of the pancreas, liver cell necrosis, intestinal dysfunction);
• blood pathologies associated with the structure and functioning of plasma;
• disorders of the urinary system (inflammatory kidney disease, renal failure, increased urination, urolithiasis, increased salt levels);
• defects in the musculoskeletal system in the form of myalgia (muscle pain), arthralgia (pain in the joints);
• the development of hypersensitivity to the composition of the substance in the form of allergies (skin rash, itching, burning, tearing, bronchospasm, nasal congestion, Lyell's syndrome);
• lowering blood glucose levels;
• increased concentration of potassium in plasma;
• a decrease in the concentration of sodium ions in the blood.

Instructions for use

The tablets or suspension are taken orally immediately after a meal. In this case, you need to consume a sufficient amount of liquid. The amount of the drug taken is set on an individual basis, it depends on the age of the patient and the disease. The data are summarized in the table (the dose is indicated for 1 dose).

Diseases / Age	3-5 years	6-12 years old	12 years and older
Infections of the respiratory system (upper and lower), urinary tract, digestive organs	2 x 120 mg	4 x 120 mg or 1 x 480 mg	2 x 480 mg
Gonorrhea	2 x 480 mg
Continuation of therapy after an acute period	1 for 120 mg	2 x 120 mg	1 x 480 mg

The drug is prescribed according to the rules:

1. The agent must be taken twice a day (morning and evening). The time period between use should be at least 6 hours, the optimal interval is 12 hours.
2. The duration of therapy should not be more than 2 weeks. The average course lasts from 5 days to 1 week.
3. When a severe course of pathology is observed or the presence of a disease in a chronic condition is determined from the anamnesis, then the daily dosage of the substance can be increased by 30-50%.
4. If the treatment period is extended by 5 days or more, or there is a need to increase the dosage, then control blood tests should be done every other day. When changes are determined in the results, then vitamin B9 should be added to the treatment regimen in an amount of 5-10 mg per day.
5. Patients who have kidney problems (failure) or a creatine synthesis rate in the range of 15-30 mg / min., Should halve the normal dose. However, if the creatine level drops below 15 ml / min, then the agent should not be used.

Overdose

Biseptol (indications for use imply a high frequency of prescribing the drug) has not been investigated by scientists to identify life-threatening dosages of active substances.

However, there are a number of signs that indicate an excess of the norm:

• loss of hunger;
• abdominal pain, headaches;
• gag reflex with nausea;
• loss of coordination of movements;
• depressive state, detachment;
• lethargy, weakness;
• fever;
• identification in the analyzes of symptoms of hematuria (blood in the urine), crystalluria (an increase in the concentration of salts in the urine), hyperbilirubinemia;
• deficiency in the production of blood cells.

If symptoms of an overdose appear, it is necessary to urgently stop using the drug and remove the contents from the stomach (no later than 2 hours after the last medicines).

It is possible to carry out the procedure for calling the gag reflex. After cleansing the stomach, you need to gradually take in a large amount of liquid. An injection of calcium folinate (5-10 mg once) can help you get out of the state.

Further, when you continue to use Biseptol, you will need to monitor the results of blood tests.

There is a low probability of the development of such a condition as a prolonged excess of the dose of co-trimoxazole, which develops when the substance is taken in excess of the norm for a long time.

Then there are signs:

• blood cell (bone marrow) deficiency syndrome;
• lowering platelet levels;
• reduction in leukocyte count;
• B12-deficiency anemia (malignant anemia).

Special recommendations

Biseptol, indications for the use of which imply the presence of a list of special recommendations, must be used with caution.

The list of prescriptions includes:

• Care must be taken to apply the medicine if the patient's history shows symptoms of a lack of vitamin B9, bronchial asthma, or there are allergic reactions.
• If treatment with Biseptol is carried out for a long time (over 2 weeks), then blood counts should be monitored, since it is able to change the formula.
• In order to prevent the transformation of blood parameters from going into an irreversible phase, experts prescribe an additional adjustment of the level of vitamin B9, taken at a dose of 3-6 mg per day.
• Caution doctors should prescribe the drug to older people or patients who have prerequisites for the initial lack of folate. The additional introduction of vitamin B9 into the therapy regimen is advisable when the dosage of the substance or the period of treatment is increased.
• As a preventive measure against an increase in the concentration of salts in the body, doctors recommend introducing control over the amount of urine excreted.
• During therapy, experts believe that it is advisable for patients to eat food containing green vegetables (all types of cabbage, greens, peas), as well as carrots and tomatoes.
• During the treatment period, it is necessary to refrain from sunbathing or going to the solarium.
• Most often, complications are observed in patients suffering from the immunodeficiency virus.
• Doctors do not recommend prescribing a remedy for the treatment of tonsillitis, pharyngitis caused by group A streptococci, since resistant strains of bacteria may appear.
• When interpreting test results, it should be borne in mind that trimethoprim changes the plasma formula only if the tests are processed by an enzymatic (enzymatic) method. When using the isotope immunological method, the distortion of the tests does not occur.

Alcohol compatibility

The prescription for medical use of the drug does not indicate the presence of interaction with alcohol.

However, based on the information that the agent has a negative effect on the liver, urinary and circulatory system (in the course of an overdose, symptoms of the appearance of blood or salts in the urine, disturbances in blood formation), then it is necessary to use the medicine with caution in conjunction with alcohol. It is advisable to refrain from it during the course of therapy.

How long does it take to start acting?

After consumption, all components of the drug are fully absorbed in the digestive system. The highest activity of chemical compounds occurs within 1-4 hours.

The withdrawal of the drug occurs mostly through the kidneys. The normal interval of activity of a substance is considered to be a period from 8 to 16 hours.

Drug interactions

The indications for the use of the anti-inflammatory drug Biseptol are checked by experts with concomitant pathologies.

The instructions for the drug indicate a list of possible conditions of the body that may appear when it reacts with other medications:

• Sulfamethoxazole is not recommended for use with antihypertensive diuretics, as in this case, thrombocytopenia (platelet deficiency) may occur.
• Co-trimoxazole inhibits blood clotting processes, and also slows down the adsorption of phenytoin and warfarin in the liver.
• After the use of pyrimethamine in dosages exceeding the norm, the likelihood of B12-deficiency anemia increases.
• There are a number of local anesthetics that reduce the effect of sulfamethoxazole treatment: lidocaine, novocaine, anesthesin.
• There is a possibility of overlapping allergies when taking sulfamethoxazole with diuretics and drugs to lower blood glucose (antidiabetic).
• Sedative medications related to phenytoin and barbiturates increase the lack of vitamin B9 in the body, and phenolic acid derivatives enhance the effect of co-trimoxazole.
• The simultaneous intake of a remedy with vitamin C increases the likelihood of salt formation in the body.
• Cholestyramine reduces the absorption of Biseptol, so it is better to use the drug one hour after taking it or 4-5 hours before it.
• The drug, when used synchronously with antidepressant neuroleptics, may not have an effect.
• Taking the drug reduces the possibilities of oral contraception, as it inhibits the intestinal microflora and binds the adsorption of hormones in the liver.

Storage conditions and periods

The drug retains its medicinal properties for 60 months from the date of manufacture. It is forbidden to use it after the expiration date of validity, which is always indicated on the packaging and additionally on the blister or bottle.

The bactericidal agent is stored at room temperature no more than + 25 ° C in a place inaccessible to children.

Analogs and prices

In places of sale of medicines, you can find on sale analogues of Biseptol of Russian and foreign production:

• Tablets Co-Trimoxazole No. 10 480 mg produced by Pharmstandard (Russian Federation) are sold at an average cost of 25 rubles. per packing.
• Bactrim syrup (Switzerland) 240 ml worth 160 rubles.

The medical product Biseptol, which has been on the pharmaceutical market for the last 30-50 years, has indications for use: inflammatory processes caused by bacteria and fungi. The tool is not the first generation that has proven its effectiveness.

Video about the drug Bispetol

Bispetol tablets. Review, instructions, indications: