Signicef ​​eye drops. Price, instructions for use, cheaper analogs, reviews

Signicef ​​is antimicrobial drug in the form of eye drops. It is prescribed for the occurrence of the most common infectious diseases of the organs of vision.

Effective against most pathogenic microorganisms. It is often used in combination with hormonal ointments and antiseptics in the form of eye drops. The price of the drug makes it widely available. When using, it is important to follow the individual recommendations and rules described in the instructions.

Forms of release and composition of the drug

It is produced in the form of drops for instillation into the eyes, has a light yellow color. The liquid is packed in a bottle with a dropper for ease of instillation. Volume - 5 ml.

1 ml of the drug accounts for the main active ingredient and auxiliary:

Group of substances	Specific substance	Features of the substance
Main component	Levofloxacin Hemihydrate	A bactericidal and antibacterial preparation of a wide range of effects
Supporting components	Benzalkonium chloride	An antiseptic drug capable of inactivating the herpes virus, has antifungal and antiprotozoal effects. Also serves as a natural preservative
Hypromellose	A preparation for softening and moisturizing the cornea of ​​the eye. Copies the optical properties of the tear film. It also has a regenerating and stabilizing effect. Accelerates epithelialization of eye tissues. Sometimes referred to as artificial tears
Sodium chloride	Relieves tissue swelling
Sodium hydroxide	Often performs the function of providing the desired pH level
Hydrochloric acid	Possesses antimicrobial and bactericidal properties
Water for injections	Is the main component of most ophthalmic solutions

Pharmacological properties

Levofloxacin hemihydrate belongs to the family of fluoroquinolone antimicrobial agents. Designed for use in ophthalmology.

When exposed to pathogenic microorganisms, levofloxacin performs several tasks:

• blocking of special bacterial enzymes - DNA gyrase and topoisomemrase;
• the processes of breaking and bonding of bacterial DNA chains will be disrupted;
• serious morphological changes are provoked in the cytoplasm, cell walls and bacterial membranes.

Similar effects are on the following microorganisms:

• all representatives of the Enterobacteriaceae family: cytobacteria, enterobacteria, Escherichia, Klesbiella, Shigella, Salmonella;
• gram-positive and gram-negative bacteria;
• other microorganisms - chlamydia.

The maximum concentration of levofloxacin when using the drug is 100 times higher than the indicators necessary for influencing microorganisms sensitive to the active substance.

Pharmacodynamics and pharmacokinetics

The maximum concentration of levofloxacin when using the drug is 100 times higher than the indicators necessary for influencing microorganisms sensitive to the active substance.

After instillation of 1 drop of levofloxacin, the maximum values ​​rapidly increase and remain in the tear film for a long time. For at least 6 hours at the maximum concentration required for treatment.

After applying the drug, the following values ​​are achieved:

• 1 hour after use, the average value of the drug is 0.86 ng / ml;
• on the first day - 2.05 ng / mg;
• the maximum values ​​during the entire treatment are reached on the 4th day - 2.25 ng / ml, provided that the drug is used every 2 hours a maximum of 8 times a day;
• the maximum values ​​reached by day 15 are lower than the concentrations that are formed when taking levofloxacin orally, almost 1000 times lower.

After instillation, the drug is actively absorbed into the bloodstream, providing a therapeutic effect and fighting pathogenic microorganisms. From the bloodstream, the active substances are metabolized in the liver cells, then the decay products are excreted from the body by the urinary system.

Indications for use

Signicef ​​- eye drops, the price of which allows you to have this drug in your home medicine cabinet.

They are assigned in the following situations:

• therapy of infections of the accessory apparatus of the organ of vision, as well as edema, provoked by the flora that reacts to levofloxacin;
• preventive measures after surgical and laser procedures to prevent the development of complications.

Contraindications

Here are the situations and conditions in which the use of the drug is prohibited:

• negative individual reactions to drug components that have already occurred in the past;
• the presence of negative individual reactions when using other antibacterial drugs of the fluoroquinolone group;
• waiting period for the child;
• period of breastfeeding;
• child's age up to 1 year.

For elderly patients, the drug is prescribed with caution, as there is a possibility of a decrease in renal function.

At what age can the drug be used?

Signicef ​​- eye drops, the price of which is low.

They can be used from the following age:

• use from the age of 1 year is permissible;
• in children under 18 years of age, it is used with caution.

Instructions for use, dosage

The drug is applied topically to the affected organ of vision. Instillation is performed from 1 to 2 drops, every 2 hours, no more than 8 times a day during the period of sleep absence. This scheme is valid for the first 2 days of treatment. Further, instillation is performed 4 times a day, at regular intervals.

This scheme is valid from 3 to 5 days of therapy. The course is prescribed by the doctor after examination, but not less than 5 days, since this is the minimum length of the course of treatment to obtain the maximum benefit from antibiotic therapy.

Side effects

Some side effects are possible when using the drug. Statistics show that they occur in no more than 10% of those undergoing treatment with the drug.

How often do negative reactions occur?	What reactions may occur
Often, it occurs in 1 to 10% of people undergoing treatment.	decrease in visual acuity; formation of mucous cords
Rarely, it occurs in 0.1 to 1% of people undergoing treatment.	inflammation of the mucous edges of the eyelids; swelling of the conjunctiva of the eye; papillary formations on the conjunctiva; swelling of the eyelids; a feeling of sand in the eyes and a burning sensation; redness of the conjunctiva; secretion of mucus; insufficient tears for permanent lubrication of the eye; redness of the non-mucous surface of the eyelid; rhinitis; fear of light; headache.

Overdose

Signicef ​​has such a low content of levofloxacin that even with accidental ingestion of eye drops, a toxic reaction does not develop. However, if a similar situation arises with a child, you should consult a doctor as soon as possible, the price of delay is the child's health.

If the dosage of the drug is exceeded, the symptoms will be signs of side effects and their intensification. If this happens, you should rinse your eyes with drinking water at room temperature. With a strong increase in the effects, you need to consult a doctor.

special instructions

If a person uses contact lenses, it is necessary to consult a doctor if the medication will damage the lenses. There are some chemicals that can disrupt the structure. For example, during therapy with Signicef, it is worth excluding the use of hydrophilic contact lenses, since sodium benzalkonium in the composition is able to penetrate into the structure of the lenses. This can cause irritation of the eye tissue and discoloration of the lenses themselves.

When instilling the drug, you must adhere to certain rules.

Instillation method - under the lower eyelid:

1. The drug is suitable only for instillation, it is forbidden to use it for injections.
2. Before the procedure, it is important to wash your hands with soap and wipe dry.
3. If the bottle with the medicine is stored in the refrigerator, then before instilling it is necessary to slightly warm the drug in your hands.
4. Ideal for instillation is a horizontal position of the body. This way the liquid is better distributed.
5. If the instillation is performed while sitting, then for the correct entry of the medicine, you need to tilt your head back.
6. It is necessary to look up, then pull the lower eyelid, thereby creating a gap between the eyelid and the eyeball.
7. Drop one drop of the medicine into the lumen. Wait until the substance is distributed in the formed cavity.
8. In the process of instillation, the pipette should not touch the tissues of the eye and eyelids itself, so that pathogenic organisms do not fall on the pipette and subsequently into the medicine. This rule also helps to avoid mechanical injury to the eye, which can be accidentally caused.
9. Next, you need to lower the eyelid and close the eye.
10. The lid of the vial with the drug should be tightly closed and placed in a place suitable for storage.
11. Gently press your finger on the inner corner of the palpebral fissure. Pressing is performed for 1-2 minutes.
12. If the treatment regimen involves the use of several drugs, then the next drug should be instilled in 10-20 minutes.
13. During treatment, the dosage recommended by the doctor must not be exceeded. An excess of the amount of medication can provoke an overdose and worsen the condition of the diseased organ of vision.
14. If after 3-4 days from the start of treatment there is no minimal improvement in the condition, you should consult a doctor. It may be necessary to change the treatment regimen.
15. It is also important to stop using the drug on time, taking into account the recommendations for the drug, since long-term the use of antibiotics can provoke the emergence of resistance of pathogens to the active substance.

In order for recovery to occur, it is worth following a few simple but important rules as soon as possible:

• after washing, use only your own towel, it must be changed every day, washing should be carried out at a high temperature, preferably ironing;
• exclude or minimize all touching the eye area and face, if contact is necessary, hands should be thoroughly washed with soap;
• it is also important to use your own pillow, change bed linen more often, do laundry at a high temperature, after drying, additionally iron the linen with an iron;
• at the time of treatment, women are advised to abandon the use of decorative cosmetics, when using moisturizers, cleansers and creams, carefully avoid the area around the eyes;
• for a while, it is worth abandoning the use of specialized products for the skin around the eyes and eyelids;
• if possible, an adult should take sick leave;
• children should stay at home during treatment not to attend children's educational institutions.

Application features when driving vehicles:

• the drug does not have an inhibitory effect on the central nervous system, does not cause drowsiness, does not reduce the speed of psychomotor reactions;
• after using the drug, a short-term decrease in visual acuity is possible, before getting behind the wheel and exercising activities requiring clear visual control, it is necessary to wait until visual acuity is fully restored.

With prolonged therapy, the growth of flora that is not sensitive to levofloxacin is possible. In the absence of positive results of treatment and when an additional infection is attached, it is worth contacting a doctor to change the antibacterial drug. A test for the sensitivity of pathogenic microorganisms would be ideal.

Drug interactions

Signicef ​​- eye drops, the price of which allows you to have them in the first-aid kit. They have not been tested for interactions with other drugs. The concentration of levofloxacin in the blood after their use is 1000 times lower than if the standard dose of the substance is taken internally. Consequently, the concentration is not enough for interaction with other substances and the occurrence of a systemic reaction.

Analogs

Signicef ​​will have several similar drugs in the form of eye drops with levofloxacin in the composition.

Name	Price in rubles	Description
L-Optic Rompharm	168	In terms of their composition, indications, contraindications and side effects, the drugs are similar to each other and Signicef.
Oftaquix	225
Levofloxacin	182
Buy Korfetsin-SOLOfarm	115

There are also eye drops with a basic substance related in origin to levofloxacin and belonging to the fluoroquinolone antibacterial group.

Name	Active substance	Price in rubles	Description
Tsipromed	Ciprofloxacin	132	Suitable for use from 1 year
Ciprofloxacin	21
Floxal	Ofloxacin	193	After consultation with a doctor, the drug can also be used in newborns.
Dancil	165	Suitable for use from 18 years of age
Vigamox	Moxifloxacin	221	Can be used from 1 year
Normax	Norfloxacin	202	Allowed to use from 18 years old

There are also analogs in the mode of action - antibacterial substances, but belonging to other families of antibiotics.

Name	Family of antibiotics	Active substance	Price	Peculiarities
Futsitalmik	Fusidins	Fusidic acid	345	Has a small number of side effects that rarely occur. After consultation with a doctor, it can be used from birth and during pregnancy. Tobrex is recommended as the first choice drug for the treatment of infants.
Tobrex	Aminoglycosides	Tobramycin	186
Dexa-Gentamicin	Gentamicin	177	Can be used in babies from birth.
Levomycetin	Amphenicols	Chloramphenicol	25	It can be used from 1 month, however, it is recommended to resort to the use of this drug as a last resort, due to the presence of side effects and toxicity, in situations where drugs of first choice for children do not have the desired actions.
Vitabact	Biguanides	Picloxidine	391	Application in newborns is possible.
Sulfacil sodium	Sulfonamides	Sulfacetamide	71	It is actively used in newborns, including for the prevention of inflammatory diseases of the organ of vision.
Azidrop	Macrolides and azalides	Azithromycin	359	Recommended for children from 1 year old

Terms, conditions of sale and storage

Signicef ​​- eye drops, the price of which does not differ much from the cost of analog drugs.

They have several conditions for proper storage:

• the ambient temperature should not exceed 30 degrees;
• no light should fall on the packaging of the drug;
• Signiceph must not be frozen, otherwise its medicinal properties may be lost;
• the stored packaging with the drug should be kept out of the reach of children.

After manufacturing, the drug retains its therapeutic properties if the package is closed for 2 years. After opening 1 month.

The medicine must be dispensed from pharmacies with a prescription from a doctor, as it is an antibacterial agent that must be prescribed by a specialist. It is unacceptable to use antibiotics without consultation, since the violation of the conditions of admission and uncontrolled use can provoke the formation of resistance of microorganisms and the emergence superbugs.

Price

The price of the drug will differ depending on the region of Russia and the city in which the drug is purchased. Also, the cost of the medicine will vary depending on the pharmacy chain. Pricing is influenced by a large number of factors.

City	Price in rubles
Moscow	246
St. Petersburg	233
Kaliningrad	233
Novosibirsk	230
Petropavlovsk-Kamchatsky	250
Chita	235
Krasnoyarsk	247
Novorossiysk	232
Irkutsk	233
Magadan	271

Signicef ​​is well established as an effective ophthalmic antibiotic. Drops can be used for children after 1 year of age, but there are also a large number of restrictions. Has a reasonable price. Often this drug is prescribed without a preliminary analysis of the sensitivity of the pathogen. However, its implementation is important, as it guarantees a speedy recovery.

Video about the drug Signicef

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